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약물의 in vitro 투과 실험을 위한 사람의 비강점막상피세포 단층막의 일차배양
유진욱,김유선,이민기,노환중,이치호,김대덕 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.1
The primary culture of human nasal epithelial cell monolayer was performed on a Transwell. The effect of various factors on the tight junction formation was observed in order to develop an in vitro experimental system for nasal transport studies. Human nasal epithelial cells, collected from human normal inferior turbinates, were plated onto diverse inserts. After 4 days, media of the apical surface was removed for air-liquid interface (ALI) culture. Morphological characteristics was observed by transmission electron microscopy (TEM). A polyester membrane of 0.4 μm pore size was determined as the most effective insert based on the change in the transepithelial electric resistance (TEER) value as well as the ^14C-mannitol transport study. The ALI method was effective in developing the tight junction as observed in the further increase in the TEER value and reduction in the permeability coefficient (P_app) of ^14C-mannitol transport. Results of the transport study of a model drug, budesonide, showed that the primary culture system developed in this study could be further developed and applied for in vitro nasal transport studies.
등온 냉각액을 활용한 plug flow reactor 내의 과열점 제어를 위한 제어모델 개발
유진욱 ( Jinwook Rhyu ),김연수 ( Yeonsoo Kim ),이종민 ( Jong Min Lee ) 한국화학공학회 2021 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.59 No.1
Plug flow reactor (PFR) 내의 과열점(hot spot) 온도를 조절하는 것은 생성물의 수득률 및 순도, 안전성 측면에서 중요하다. 본 연구에서는 더 현실에 가깝게 모델링 하기 위하여 PFR 내부의 냉각액 온도를 상태변수로 설정하고 방사방향의 열 및 물질전달을 고려하였다. 모델은 반응물의 농도 및 온도와 냉각액의 온도 총 3개의 상태변수로 이루어져 있으며, 등온 냉각액의 유량을 조작변수로 가진다. 본 연구에서는 방사 방향의 열 및 물질전달을 고려한 제어식이 그렇지 않은 제어식보다 과열점의 온도를 set point 부근으로 더 효과적으로 유지한다는 것을 보였다. 본 연구에서 제안한 제어식은 냉각액의 온도가 반응물 온도의 약 0.7배 부근일 때 St가 1.3 이상이고 A<sub>c</sub>/A가 2.0 이하인 조건에서 강건성을 유지하였다. 이 조건에서 반응기로 유입되는 반응물의 온도가 5% 범위에서 바뀔 때 본 연구에서 제안된 제안식을 이용하면 과열점의 온도를 set point의 1% 이내로 유지할 수 있다. To control hot spot in a plug flow reactor (PFR) is important for the yield and purity of products and safety. In this paper, coolant temperature is set as a state variable, and radial distributions of heat and mass are considered to model the PFR more realistic than without considering radial distributions. The model consists of three state variables, reactant concentration, reactant temperature, and the coolant temperature. The flow rate of the isothermal coolant is a manipulated variable. This paper shows that the controller considering the radial distributions of heat and mass is more effective than the controller without them. Assuming that u<sub>3,0</sub> is 0.7, the suggested control equation was robust when St is bigger than 1.3, and A<sub>c</sub>/A is smaller than 2.0. Under this condition, the hot spot temperature changed within the relative error of one percent when the temperature of input altered within the range of five percent.
유진욱(Jin-Wook Yoo),이홍민(Hong-min Lee),이상훈(Sang-Hun Lee),정세훈(Se-Hoon Jung),장슈아이시앙(Zhang Shuaixiang),최예규(Ye-Gyu Choi),임양원(Yang-Won Lim),임한규(Hankyu Lim) 한국정보기술학회 2014 Proceedings of KIIT Conference Vol.2014 No.5
현재 많은 사람들이 스마트폰을 사용하고 있다 사용자들은 자신의 사생활 및 개인정보를 보호 받길 원한다. 본 논문에서는 스마트 기기의 마이크(Mic), 카메라(Camera), 터치스크린(Touch Screen) 등을 활용하여 스마트폰 보안 앱을 설계 하고자 한다 다양한 방법의 잠금장치를 설정하여 사용자들이 보다 더 안전하게 스마트폰을 사용하게 될 것을 기대할 수 있다. Recently, many people use smartphone. Smartphone users want to protect their privacy and personal information. In this paper, we design the security application by using microphone, camera, touch screen of smart devices. We anticipate the safe use of smartphone by a variety of ways of the locks.
유진욱(Jin Wook Yoo),최진석(Jin Seok Choi),최준식(Jun Shik Choi) 大韓藥學會 2011 약학회지 Vol.55 No.3
The present study was to investigate the effect of glipizide on the pharmacokinetics of losartan in rats. Losartan was administered intravenously (3 mg/kg) and orally (9 mg/kg) in the presence and absence of glipizide (0.3 and 1 mg/kg) to rats. The pharmacokinetic parameters of losartan were significantly altered by the presence of glipizide compared with the control group (given losartan alone). Presence of glipizide significantly (p