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유종한,이종원,손병호,김성원,박수경,이민혁,김이수,노우철,김은규,윤대성,이지연,정진향,정상설,공경엽,안세현 한국유방암학회 2014 Journal of breast cancer Vol.17 No.2
Purpose: Mutations in BRCA genes are the main cause of hereditarybreast cancer in Korea. The aim of this study was to investigatethe characteristics of breast cancers involving BRCA1(BRCA1 group) and BRCA2 (BRCA2 group) mutations. Methods:We retrospectively reviewed the medical records of patients withBRCA1 (BRCA1 group) or BRCA2 (BRCA2 group) mutation positivebreast cancer from multiple centers and compared the datato that of the Korean Breast Cancer Society registry (registrygroup). Results: The patients of the BRCA1 group were diagnosedat a younger age (median age, 37 years) and had tumorsof higher histological (61.3% with histological grade 3) and nuclear(37.5% with nuclear grade 3) grade than those of the registrygroup. In addition, the frequency of ductal carcinoma in situin the BRCA1 group was lower (3.7%) than in the registry group,and the BRCA1 group were more likely to be triple-negativebreast cancer (61.3%). Patients in the BRCA2 group were alsoyounger at diagnosis (mean age, 41 years) and were more likelyto have involvement of the axillary node than the registry group(45.5% vs. 33.5%, p=0.002). The BRCA1 and BRCA2 groupsdid not show a correlation between tumor size and axillary nodeinvolvement. Conclusion: We report the characteristics of BRCAmutation positive breast cancer patients in the Korean populationthrough multicenter data and nation-wide breast cancerregistry study. However, BRCA-mutated breast cancers appearhighly complex, and further research on their molecular basis isneeded in Korea.
유종한,Jae-Ho Shin,Min Sung An,Tae Kwun Ha,Kwang Hee Kim,배기범,Tae Hyeon Kim,최창수,Kwan Hee Hong,Jeong Kim,정수진,Sun Hee Kim,Kuk Hwan Rho,김종태,양영일 대한대장항문학회 2012 Annals of Coloproctolgy Vol.28 No.3
Purpose: This experimental study verified the effect of adipose-tissue-derived stem cells (ASCs) on the healing of ischemic colonic anastomoses in rats. Methods: ASCs were isolated from the subcutaneous fat tissue of rats and identified as mesenchymal stem cells by identification of different potentials. An animal model of colonic ischemic anastomosis was induced by modifying Nagahata’s method. Sixty male Sprague-Dawley rats (10-week-old, 370 ± 50 g) were divided into two groups (n = 30 each): a control group in which the anastomosis was sutured in a single layer with 6-0 polypropylene without any treatment and an ASCtreated group (ASC group) in which the anastomosis was sutured as in the control group, but then ASCs were locally transplanted into the bowel wall around the anastomosis. The rats were sacrificed on postoperative day 7. Healing of the anastomoses was assessed by measuring loss of body weight, wound infection, anastomotic leakage, mortality, adhesion formation,ileus, anastomotic stricture, anastomotic bursting pressure, histopathological features, and microvascular density. Results: No differences in wound infection, anastomotic leakage, or mortality between the two groups were observed. The ASC group had significantly more favorable anastomotic healing, including less body weight lost, less ileus, and fewer ulcers and strictures, than the control group. ASCs augmented bursting pressure and collagen deposition. The histopathological features were significantly more favorable in the ASC group, and microvascular density was significantly higher than it was in the control group. Conclusion: Locally-transplanted ASCs enhanced healing of ischemic colonic anastomoses by increasing angiogenesis. ASCs could be a novel strategy for accelerating healing of colonic ischemic risk anastomoses.
유종목 한국중국어문학회 2001 中國文學 Vol.35 No.-
從北宋神宗元豊三年到八年的五年多期間,蘇東坡在黃州等地過了第一次貶謫生活;從北宋哲宗紹聖元年到元符三年的七年期間,他在惠州ㆍ?州等地過了第二次貶謫生活. 我們一般想:他在第二次貶謫時期,比第一次貶謫時期年輪也更多了,處世態度也更圓熟了,因而他的詞風可能也更淸曠了. 可是筆者親自考察的結果不太這樣. 筆者却可以說:第二次貶謫時期的東坡詞不比第一次貶謫時期的詞淸麗曠達,而帶着更多的哀愁與悲凉. 換言之,第一次貶謫時期的東坡詞多半是淸曠風格,而第二次貶謫時期的東坡詞一半是淸曠風格一半是婉約風格. 原因何在? 筆者的看法如下:不?`仙而人者`的李白一樣,蘇東坡是一位`人而仙者`的人. 有的時候他雖然好像是一位仙人似的,但他究竟是一位`多情多感仍多病`的富有人情味的凡人. 表現在第一次貶謫時期詞的那些超脫現實的淸曠風格是他積極努力的産物. 在第一次貶謫時期他還抱着東山再起的希望和信心,所以還能擁有一定要克服危机的心態,而克服那種危机的唯一方法就是超脫現實而讓自己的心靈游於物外. 在第一次貶謫時期,積極努力的結果,他的心態在相當程度上獲得寧靜沈着,他的詞風因此也能堅持淸麗曠達. 可是在第二次貶謫時期,他不復有東山再起的希望和信心,因此再也不能擁有要克服困難的心態. 要是說第一次貶謫時期的詞風是積極努力的産物,第二次貶謫時期的詞風是沒有屈折的自然狀態,這才算是蘇東坡的眞面目.