Recent advances in the diagnosis and management of childhood acute promyelocytic leukemia

유은선 대한소아청소년과학회 2011 Clinical and Experimental Pediatrics (CEP) Vol.54 No.3

Since the successful introduction of all-trans-retinoic acid (ATRA)and its combination with anthracycline-containing chemotherapy,the prognosis for acute promyelocytic leukemia (APL) has markedly improved. With ATRA and anthracycline-based-chemotherapy, the complete remission rate is greater than 90%, and the long-term survival rate is 70‒89%. Moreover, arsenic trioxide (ATO), which was introduced for APL treatment in 1994, resulted in excellent remission rates in relapsed patients with APL, and more recently, several clinical studies have been designed to explore its role in initial therapy either alone or in combination with ATRA. APL is a rare disease in children and is frequently associated with hyperleukocytosis, which is a marker for higher risk of relapse and an increased incidence of microgranular morphology. The frequency of occurrence of the promyelocytic leukemia/retinoic acid receptor-alpha (PML/RARα) isoforms bcr 2 and bcr 3 is higher in children than in adults. Although recent clinical studies have reported comparable long-term survival rates in patients with APL, therapy for APL in children is challenging because of the risk of early death and the potential long-term cardiac toxicity resulting from the need to use high doses of anthracyclines. Additional prospective,randomized, large clinical trials are needed to address several issues in pediatric APL and to possibly minimize or eliminate the need for chemotherapy by combining ATRA and ATO. In this review article,we discuss the molecular pathogenesis, diagnostic progress, and most recent therapeutic advances in the treatment of children with APL.

대학 입학사정관 직업 경험에 대한 질적 연구

유은선 (사)한국대학교육협의회 2023 고등교육 Vol.6 No.1

The purpose of this study as a qualitative study was to explore the researcher’s professional life as an admissions officer. Throughout this study, the researcher tried to clarify the important experiences and meanings experienced in the process of working as an admissions officer. For this purpose, the professional experiences of admissions officer were analyzed according to the social context in which university admissions policies change and the passage of time. At the onset of implementing the admissions-officer system, the researcher experienced a difficult time due to misunderstanding and distrust of the admissions officer. However, knowing that the admissions officer could bring meaningful changes to the university entrance environment, the researcher acquired identity as an admissions officer while giving social value and meaning to work. However, the researcher also experienced exhaustion caused by the hierarchical structure of university administration, excessive government intervention in college admission, and an attitude of excessive immersion in work. After that, while objectively looking at the job and work of the admissions officer, the researcher began to seek the job of the admissions officer as a universal job. Based on the these results,the meaning of the admissions officer's work experience was derived and implications were presented. 이 연구는 연구자의 입학사정관 직업 생애를 탐구한 질적 연구이다. 이 연구를 통해서 연구자는 입학사정관으로 일하는 과정에서 경험한 중요한 체험과 그 의미를 밝히고자 하였다. 이러한 목적을 위해 입학사정관의 직업 경험을 대입 정책이 변화되는 사회적 맥락과 시간의 흐름에 따라 분석하였다. 입학사정관제 시행 초기에 연구자는 입학사정관에 대한 오해와 불신으로 어려운 시기를 겪었다. 그러나 입학사정관이 대입 환경에 의미있는 변화를 가져올 수 있음을 알고 일에 대한 사회적 가치와 의미를 부여하면서 입학사정관으로서의 정체성을 획득해 나갔다. 그러나 대학 행정의 위계적 구조, 대입전형에 대한 정부의 과도한 개입, 무리하게 업무에 몰입하는 태도 등에서 오는 소진을 경험하기도 하였다. 그 후 입학사정관 직업과 일을 객관적으로 조망하면서 보편적 직업으로서 입학사정관 직업을 모색하였다. 이상의 결과를 바탕으로 입학사정관 직업 경험에 대한 의미를 도출하고 시사점을 제시하였다.

과학과 유사과학에 대한 기독교인들의 인식 연구

유은선,맹성렬 한국신종교학회 2022 신종교연구 Vol.47 No.-

This study is about Korean Christians’ perception of science and similar science. The following facts were confirmed through a statistical approach using the questionnaire method for a total of 201 people. Those who participated in the survey said that 45.3% of them “generally agree” and 35.5% “disagree” that modern science contradicts Christian creed. These results show that domestic Christians are somewhat at odds between modern science and Christian creed. 41.2% agreed with the survey on the “Young Earth Creation Hypothesis” on Earth’s age, which means that Korean Christians believe more in the doctrine of literally deciphering the Bible. 88.0 percent agreed with the survey asking whether the Earth is round, indicating that most Christians in Korea have no major disagreement on the issue. 42.0% agreed and 30.8% disagreed with the survey on the possibility of life elsewhere on Earth. 58.2% agreed with the question of whether infectious diseases such as COVID-19 were related to God’s warning, indicating that domestic Christians tended to follow more religious perspectives on this issue. The 63.2% positive response to the questionnaire on whether the intermediate prayer is scientifically meaningful reflects the belief of domestic Christians that the intermediate prayer should be viewed from a scientific perspective. The rate of affirmation of the reality of UFOs at the boundary between science and similar science was 26.9%, less than the rate of negation of 44.3%. The proportion of respondents who believed in the existence of hyperpsychological phenomena treated as pseudoscience was 49.7%, more than the proportion of respondents who did not believe, 27.9%. However, 85.1% of respondents believe that demons and ghosts, which are considered more pseudo-scientific objects, are more likely to be in line with previous studies showing that believers are more fond of pseudo-science than ordinary people. However, the rate of affirmation of past life or reincarnation, a representative similar science cited by scientists, was 11.5%, much less than 75.6%. Through this study, it was found that domestic Christians agreed or disagreed with science and similar science based on the criteria for judging whether it was related to Christian doctrine or not. As in this study, confirming Christians’ perspectives on scientific or pseudoscientific worldviews will provide a good opportunity to gauge the future of Christianity through rapidly changing times. 본 연구는 국내 기독교인들의 과학과 유사과학에 대한 인식에 관한 것이다. 총 201 명 대상으로 설문지법을 이용한 통계적 접근을 하여 다음과 같은 사실을 확인했다. 설문에 참여한 이들은 현대과학이 기독교 신조와 상호 모순된다는 데 대체로 동의한다 45.3%와 동의하지 않는다 35.5%라고 응답했다. 이 결과는 국내 기독교인들이 현대 과학과 기독교 신조 사이에서 어느 정도 갈등하고 있음을 보여준다. 지구 나이에 대한 ‘젊은 지구 창조가설’에 대한 설문에 41.2%가 동의한 것으로 보아 우리나라 기독교인들이 성경을 문자 그대로 해독한 교리를 더 신봉함을 의미한다. 지구가 둥근지 여부를 묻는 설문에 동의하는 의견이 88.0%에 달하여 대부분의국내 기독교인들이 이 문제에 큰 이견이 없음을 보여주었다. 지구 이외의 다른 곳에생명체가 존재할 가능성에 대한 설문에 대해 동의하는 의견이 42.0%, 동의하지 않는 의견도 30.8%나 되었다. 코로나 19와 같은 전염성 질환이 하나님1)의 경고와 관계있다고 생각하는지에 대한 질문에 대해 동의하는 비율이 58.2%로 국내 기독교인들은 이 사안에 관해서 신앙적 관점을 더 따르는 성향이 있음을 알 수 있었다. 중보기도가 과학적으로 의미가있느냐는 설문에 대해 긍정적인 응답 비율 63.2%의 결과는 중보기도를 과학적 관점에서 바라봐야 한다는 국내 기독교인들의 신념을 반영하고 있다. 과학과 유사과학의 경계에 있는 UFO의 실재에 대해 긍정하는 비율이 26.9%로 부정하는 비율인 44.3%보다 적었다. 유사과학으로 취급되는 초심리 현상의 존재를 믿는 응답자 비율은 49.7%로 믿지 않는 응답자 비율 27.9%보다 많았다. 그런데, 보다 더 유사과학적 대상이라고 보는 마귀, 귀신, 유령 등이 존재한다고 믿는 응답자 비율이 85.1%로 이는 신앙인들이 일반인들보다 유사과학에 좀 더 호감을 보인다는 이전 연구결과와 일치하는 것으로 보인다. 하지만, 과학자들이 꼽는 대표적인 유사과학인 전생이나 환생에 대해선 긍정하는 비율이 11.5%로 부정하는 비율 75.6%보다 훨씬 적었다. 이번 연구를 통해 국내 기독교인들은 과학과 유사과학에 대해 기독교 교리와 관련성 유무에 어느 정도 그 판단 기준을 두고 동의나 비동의를 함을 알 수 있었다. 본 연구와 같이 과학적 또는 유사과학적 세계관에 대한 기독교인들의 관점을 확인하는 것은 급변하는 시대를 헤쳐가는 기독교의 미래를 가늠해볼 좋은 기회를 제공해 줄 수 있을 것이다.

초박막 채널을 갖는 n-type MOSFET 소자의 비준정적 CV 특성 분석

유은선,조성재,박병국 대한전자공학회 2016 대한전자공학회 학술대회 Vol.2016 No.11

In this work, capacitance-voltage (CV) characterization of n-type ultra-thin-body (UTB) metal-oxide-semiconductor field-effect transistor (MOSFET) device is performed. First, imaginary simulation works are carried out in terms of minority carrier mobility, gate oxide thickness, and substrate thickness for independently identifying their individual effects on CV characteristics of MOS capacitor (MOSCAP). The body thickness of the MOSCAP is controlled from the thickness larger than the maximum depletion region width (Wdm) down to values thinner than Wdm. Finally, the UTB MOSFETs with different body thicknesses are simulated for CV characterization by non-quasi-static (NQS) analysis.

운전지속시간을 고려한 고속도로의 교통사고 요인분석 : 구조방정식을 이용하여

유은선,이영인 한국ITS학회 2018 한국ITS학회 학술대회 Vol.2018 No.04

Si‐core/SiGe‐shell channel nanowire FET for sub‐10‐nm logic technology in the THz regime

유은선,손백모,감병민,조용상,박상준,이원준,정종완,조성재 한국전자통신연구원 2019 ETRI Journal Vol.41 No.6

The p‐type nanowire field‐effect transistor (FET) with a SiGe shell channel on a Si core is optimally designed and characterized using in‐depth technology computer‐aided design (TCAD) with quantum models for sub‐10‐nm advanced logic technology. SiGe is adopted as the material for the ultrathin shell channel owing to its two primary merits of high hole mobility and strong Si compatibility. The SiGe shell can effectively confine the hole because of the large valence‐band offset (VBO) between the Si core and the SiGe channel arranged in the radial direction. The proposed device is optimized in terms of the Ge shell channel thickness, Ge fraction in the SiGe channel, and the channel length (Lg) by examining a set of primary DC and AC parameters. The cutoff frequency (fT) and maximum oscillation frequency (fmax) of the proposed device were determined to be 440.0 and 753.9 GHz when Lg is 5 nm, respectively, with an intrinsic delay time (τ) of 3.14 ps. The proposed SiGe‐shell channel p‐type nanowire FET has demonstrated a strong potential for low‐power and high‐speed applications in 10‐nm‐and‐beyond complementary metal‐oxide‐semiconductor (CMOS) technology.

보육교사의 다문화수용성 향상을 위한 교육사례

유은선 다문화아동청소년연구원 2018 다문화아동청소년연구 Vol.3 No.3

본 연구는 보육교사의 다문화수용성 향상을 위한 다문화 교육을 보육교사에게 실시하고 다문화교육 실시 과정 중에 나타나는 보육교사들의 다문화수용성의 변화를 알아보고자 하는 데 목적이 있으며 그를 위해 다문화개념의 기본적인 내용을 구성하여 수업하였고 질적연구 방법을 선택하여 연구를 진행하였다. 연 구대상으로 선정된 보육교사들은 모두 다문화교육을 받은 경험이 없었으며 평 택시 관내 민간어린이집에 근무하고 있다. 교육 효과를 보면 보육교사들은 첫 째, 다문화에 대한 개념을 알게 되었고 둘째, 다문화에 대한 개념을 알게 되면 서 본인들이 가지고 있는 편견과 고정관념을 알게 되었고, 셋째, 본인들의 편 견과 고정관념에 대해 반성하는 모습을 보였으며, 넷째, 다문화 교육은 다문화 부모, 비다문화부모 모두가 대상이 되어 실시되어야 한다는 인식을 할 수 있었다. The purpose of this study is to investigate the changes in the multicultural acceptivity of Childcare teachers who are in the course of a multicultural education that has been commenced for the Childcare teachers to enhance their multicultural acceptivity. For this, lectures have been prepared by constituting basic concepts of multiculture, and qualitative study methods have been selected. All the Childcare teachers who were selected as the subjects had no experience in receiving multicultural education in the past, and are currently working in private daycare center located within the city of Pyeongtaek. The effects of the education are as follow. First, the subject Childcare teachers came to know and understand the concept of multiculture. Second, they came to learn their own prejudice and stereotype while studying the concept of multiculture. Third, they showed an introspection on the prejudice and stereotype they have had so far. Fourth, it was found that both the parents from multicultural backgrounds and those who are not should all participate in the multicultural education as subjects.

진도씻김굿 소재 콘텐츠 현황 및 제작에 관한 제언

유은선 국립국악원 2012 국악원논문집 Vol.26 No.-

‘Jindo Ssitgim-gut’ is a shaman ritual from Jindo performed to relieve the resentments of the dead in a wish that the dead could leave for the other world in peace. Apart from being a religious ritual, ‘Jindo Ssitgim-gut’ is also a work of art that is moral and valuable cultural heritage. In this paper, I have examined various on-line and off-line contents based on ‘Jindo Ssitgimgut’and made some suggestions for expanding and diversifying the forms of contents that are produced on the basis of Jindo Ssitgim-gut. The results are as follows:First, I suggest utilizing multinational approach to overcome its limitation and genres, while applying story-telling method based on Jindo Ssitgimgut to various genres of contents. Second, it should be vitalized to produce contents for children such as a fairy tale by utilizing the mythical elements of Jindo Ssitgim-gut. Third, it is necessary to develop a cultural production that can enhance its value to be music for healing, not just for appreciating. Fourth, it is necessary to lead the enculturation of the unique funeral rites of islands that are different from funeral rites of Korea in general. Fifth, it is necessary to plan and film a documentary on masters of Jindo Ssitgimgut, to provide multinational contents that are in tune with Global Era. By applying a multilateral approach, Jindo Ssitgim-gut can be turned into a cultural production through which one can reflect his or her life and death and go through a healing process directly and indirectly. Therefore, Jindo Ssitgim-gut will be positioned as excellent cultural contents with infinite potentials. ‘진도씻김굿’은 이승에서 풀지 못한 죽은 사람의 원한을 풀어주고, 저승 세계로 갈 수 있도록 기원하는 진도지역의 굿이다. ‘진도씻김굿’은 제의적인 의식을 떠나서, 예술작품으로서의 가치와 교훈을 주는 교육적인 의미를 가진 문화자원이기도 하다. 본 연구는 ‘진도씻김굿’을 바탕으로 만들어지고 발표된 온ㆍ오프라인의 콘텐츠물 현황을 살펴보고, 나아가 ‘진도씻김굿’을 토대로 확장되고 다양화 된 형태의 콘텐츠물이 만들어지는 것에 대한 방안을 제시해 보았다. 그 결과는 다음과 같다. 첫째, ‘진도씻김굿’을 소재로 한 스토리텔링 기법을 다양한 콘텐츠에 사용하되, 단순한 극적인 변화차원이 아닌, 장르와 한계를 넘어설 수 있는 다국적 스토리텔링 기법이 활용되어야 한다. 둘째, ‘진도씻김굿’에 등장하는 신화적인 요소를 활용하여, 아이들을 대상으로 한 동화 같은 콘텐츠 제작이 활성화 되어야 한다. 셋째, 단순한 감상만이 아닌 치유음악으로서의 가치를 높일 수 있는 문화상품을 개발하여야 한다. 넷째, 한국의 일반적 장례문화와는 다른 섬 지역만의 독특한 장례의 문화화(文化化)를 선도하는 작업이 필요하다. 다섯째, ‘진도씻김굿’의 명인들을 주제로 한 다큐멘터리 영화를 기획ㆍ제작하고, 콘텐츠로 만들어 글로벌 시대에 맞는 다국적 작품으로 연계 및 기획되어야 한다. 우수한 전통문화인 ‘진도씻김굿’은 다각적 접근을 통해 현대인들이 직접 접해볼 뿐만 아니라 간접적으로 자신의 삶과 죽음을 투영해 봄으로써 치유의 과정을 거칠 수 있다. 이를 통해 진도씻김굿은 무한한 가능성이 있는 우수한 문화 콘텐츠로 자리매김할 것이다.

국악기의 복원 및 개량의 현황과 전망

유은선 세계음악학회 2022 음악과 문화 Vol.- No.46

This study examines the reproduction and improvement cases of the Korean musical instruments undertaken by the Musical Instrument Research Center of NGC. It is found that the Korean musical instruments have been reproduced either by referring to relic instruments or by utilizing literature materials. The study also figures out the achievements and problems in the tasks. presenting their periodic features from the 1960s to 2010s to seek a desirable direction in the modernization of Korean instruments. The study results can be summarized as the following: Firstly, the reproduction cases of string instruments by relics include the string instrument from Shinchangdong, gayageum from Wolpyeongdong, yogo from Yiseongsanseong Fortress, buk from Hwawangsanseong Fortress, five instruments engraved in Gilt-bronze Incense Burner of Baekje, and geomungo of Yunseondo (Gosan by pseudonym). Secondly, the literature materials utilized for the reproduction of the Korean musical instruments include Sejongsillok (Annals of King Sejong), Akhakgwebeom (Musical Encyclopedia), Sinchuk Jinchanuigwe (Royal Protocols on Queen Myeongheon's 70th Birthday Celebration), Geumhapjabo (Tablature Manuscript for Geomungo), and Injeongjeon Akgijoseongcheong Uigwe (Royal Protocols for the Manufacture of Musical Instruments). Thirdly, the Korean musical instruments should be modernized to the extent to which does not undermine their essence, and also the mere transplantation of the western style should be avoided. Fourthly, not only the gugakgi materials and their structures but also the acoustic performance in performance halls need consistent research and improvement. Lastly, it is also necessary to continue seeking ways to enhance musical effects through the development of the playing techniques, along with the modernization of the Korean musical instruments. .

소아기 호중구 감소증

유은선 대한소아청소년과학회 2009 Clinical and Experimental Pediatrics (CEP) Vol.52 No.6

Neutropenia is defined as an absolute neutrophil count (ANC) of <1,500/µL, and the severity of neutropenia generally can be graded as mild (1,000-1,500/µL), moderate (500-1,000/µL), or severe (<500/µL). This stratification aids in predicting the risk of pyogenic infection because the susceptibility to life-threatening infections is significantly increased in patients with prolonged episodes of severe neutropenia. Especially cancer-related neutropenia carry significant mortality. Neutropenia can develop under various conditions such as decreased bone marrow production, the sequestering of neutrophils, and increased destruction of neutrophils in the peripheral blood. Neutropenia is classified according to the etiology as congenital or acquired, with the latter further defined according to the etiology or pathology. The clinical result is increased risk for infection, which is directly proportional to the severity and duration of the neutropenia. The typical workup of neutropenia starts with a 6-week period in which complete blood counts are measured twice weekly to document the persistence of the neutropenia and whether a cyclic pattern is present. When persistent neutropenia is diagnosed and no spontaneous recovery occurs within 3 months, a more extensive evaluation is advised. Treatment is usually unnecessary for most patients with severe neutropenia, as the majority of patients have a good prognosis. However, for patients who have severe and frequent infections, treatment with filgrastim may prevent infectious complications and improve quality of life.