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혈소판 증다증과 고열을 보인 PCR 로 진단된 비전형적 만성 골수성 백혈병 1 예
김기찬,정성균,지현숙,김열홍,유승박,이재동,안승혜 대한내과학회 1994 대한내과학회지 Vol.47 No.1
Chronic myelocytic leukemia (CML) is the one of myelophroliferative disorders which is characterized by increased leukocyte counts, abnormal granulocytes with frequent thrombocytosis on periphreral blood study and the presence of Philadelphia chromosome on chromosamal study, Now bcr/abl gene translocation in CML is an well known phenomenon on molecular biologic study and occasionally it is positive even in Philadelphia chromosome negative CML. Sometimes CML presents atypical findings in blood cell counts and morphology. In this case, molecular biologic study is very helpful to differentiate CML with other disease showing similar hematologic changes. Recently we experienced one case of CML with tuberculus lymphadenitis representing unusual peripheral blood findings. This 29-year-old male patient had thrombocythemia, splenomegaly, low leukocyte alkaline phosphatase score and bcr/abl gene translocation which was confirmed by PCR technique.
복수의 감별에 있어 혈청과 복수내 CEA 및 CA19-9의 가치에 관한 연구
김선민 ( Kim Seon Min ),박경식 ( Park Gyeong Sig ),마상인 ( Ma Sang In ),김휘정 ( Kim Hwi Jeong ),유승박 ( Yu Seung Bag ),조준환 ( Jo Jun Hwan ),이재동 ( Lee Jae Dong ),이중건 ( Lee Jung Geon ) 대한내과학회 1992 대한내과학회지 Vol.42 No.4
1989년 4월 1990년 12월까지 본원 내과에서 입원하였던 복수 환자 81예를 대상을 그 원인 악성 질환에 의한 것인지 양성 질환에 의한 것인지를 감별하기 위해 혈청 및 복수내의 CEA, CA19-9의 농도를 측정 비교하여 그 임상적 의의에 대해 다음과 같은 결과를 얻었다. 1) 악성 질환에서의 CEA의 혈청내 평균치는 양성질환보다 의의있는 상승을 보였으며(p<0.05), 복수내 평균치 또한 유의한 상승을 보였다(p<0.01)> 2) CA19-9의 혈청과 복수에서의 평균치는 악성 복수군에서 현저한 상승을 보였으나 통계적 유의성은 없었다.(p>0.05). 3) 복수의 감별진다에 있어 CEA의 복수내의 민감도는 84%였으며 혈청에서는 71%이였으며 CA19-9는 복수내의 민감도가 68% 혈청에서는 60%로 CEA보다는 전체적으로 민감도가 낮았다. 4) 혈청과 복수에서 CEA 병합 검사시 민감도는 86%로 상승하였으며 CA19-9병합 검사시 민감도 또한 73%로 상승 하였으며 모두 병합 검사시 민감도는 92%로 의의있는 상승을 보였다. 5) 혈청내 CEA 복수내 CEA 혈청내 CA19-9 및 복수내 CA19-9 검사간에는 유의한 상관관계가 있었다(p<0.005, p<0.001). 이상과 같이 혈청과 복수에서의 CEA와 CA19-9 농도 측정은 복수의 원인이 악성 질환에 의한 것인지를 아는데 도움이 될 것으로 사료된다. Ascites may be caused by various benign and malignant disease, but it is sometimes difficult to determine whether it is caused by benign disease or malignant diseases. In order to determine whether CEA, CA 19-9 in ascitic fluid and serum assist in the diagnosis of malignant disease that causing ascites, we studied 38 cases of malignant ascites and 43 cases of benign ascites patients who were admitted to Seoul Adventist Hospital from April 1989 to December 1990. The results were obtained as follows: 1) The mean value of CEA in serum and ascitic fluid of the malignant ascites group were significantly higher than that of the benign ascites group in serum (p<0.05), in ascites (p<0.01). 2) The mean value of CA 19-9 in serum and ascitic fluid of the malignant ascites group was signficantly higher than that of the benign ascites group was significantly higher than that of the benign ascites group, there was no significance in statistical aspects(p>0.05). 3) The sensitivity of CEA was 81% in ascites, 78% in serum, the sensitivity of CA 19-9 was 63% in ascites, 65% in serum. 4) The sensitivity of CEA was increased to 87% in serum and ascites combinations, the sensitivity of CA 19-9 was also increased to 81% in serum and ascites combinations. The sensitivity was significantly elevated to 92% in case of all tumor marker combinations. 5) There was a significant correlations between serum CEA and ascites CEA, serum CA 19-9 and ascites CA 19-9. (p<0.01, in all cases) It was concluded that the measurement of serum and ascites CEA, CA 19-9 levels is useful lin differention between ascites caused by benign and malignant diseases. Combinantions of each tumor markers in serum and ascites were more accurate than single test.
대장 내시경 후 발생한 장중첩증을 동반한 Peutz - Jeghers 증후군
이재동(Jae Dong Lee),박경식(Kyeong Sik park),정보윤(Bo Yun Jung),정성균(Seong Kyoon Cheong),조준환(Jun hwan Jo),유승박(Seung Park Yoo),김휘정(Hwi Jung Kim),김열홍(Yul Hong Kim) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.4
N/A Peutz-Jeghers syndrome has three cardinal features, gastrointestinal polyposis, mucocutaneous pigmentation and autosomal dominant inheritance. This syndrome is clinically important because of the complication of gastrointestinal polyps, leading to abdominal pain, anemia due to gastrointestinal bleeding, intussusception, and a certain risk of malignant change. We experienced a case of Peutz-Jeghers syndrome combined with intussusception after colonoscopy.