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PCR 을 이용한 인슐린 수용체 β - 소단위의 DNA 측정에 관한 연구
최웅환(Woong Hwan Choi),유계수(Ge Soo Yoo),고근아(Keun Ah Koh),정형진(Hyung Jin Chung),김해엽(Hae Youp Kim),신현호(Hyun Ho Shin),한인권(In Kwon Han),문인걸(In Gul Moon) 대한내과학회 1991 대한내과학회지 Vol.40 No.6
N/A Insulin resistance is one of the most important mechanisms of type II diabetes, which may result from acquired or genetic abnormalities in the pathway of insulin action. As the develoment of cloning method of human insulin receptor precursor cDNA, it has become possible to investigate the insulin receptor at the genetic level. We used the modified PCR technique method that permitted us to employ small amounts of cellular RNA as the initial template to amplify the region that encodes the intracellar β-subunit of the human insulin receptor and C-terminal region of β-subunit. We think that this PCR method will facilitate a definite determination to what degree insulin resistance can be ascribed to genetic alterations in the structure of the insulin receptor molecule in type II diabetes.
Tc-Phytate로 확인된 복막 투석액 전이성 수흉에서 흉막 유착술 치험
이태원,김명재,황이숙,김권기,유계수 대한신장학회 1989 Kidney Research and Clinical Practice Vol.8 No.1
Acute or recurrent massive hydrothorax as a complication of CAPD was first reported in 1967 by Unger et al. After that, several additional cases were reported. Talc poudrage and intrapleural tetracycline induced pleurodesis have been attempted to solve the problem. We report a successful case of intrapleural instillation of tetracycline to pleural symphysis and prevent recurrence of CAPD-related hydrothorax which was proved by radioisotope scanning with$quot; Tc-phytate in a patient who refused to change the mode of dialysis.
윤세옥(Sei Ok Yoon),김은주(Eun Joo Kim),신현욱(Hyun Wook Shin),유계수(Ge Soo Yoo) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.2
Virilization may occur during pregnancy as the result of an ovarian Krukenberg tumor. Mechanism of the androgen over-production in this exceptional condition is still poorly understood. A new case is reported in which clinical, endocrine and endoscopic studies led to the diagnosis of an ovarian Krukenberg tumor secondary to a gastric carcinoma. The mother and female infant appeared virilization. In the hormonal studies, testosterone and DHEA-S were increased markedly before orphorectomy and returned to almost normal 7 days after surgical removal. The testosterone level was also elevated right after birth, but returned to normal 7 days later in the infant. The upper G-I series and endoscopic studies showed advancd cancer in the mid-body of the stomach. At microscopic examination, numerous typical signet rigng cell were observed both in the endoscopic biopsy of the gastric tumor and the ovaries. In the ovaries there were also profound stromal cell hyperplasia. The role of metastatic ovarian cancer to develop virilization in pregnent woman was discussed.