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위서리,한지은,Yeon Hee Kim,Gi-eun Rhie,이나경 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.4
Anthrax is an acute infectious disease causedby Bacillus anthracis. We previously reported that theadjuvant CIA06B, which consists of TLR4 agonist CIA05and aluminum hydroxide (alum), enhanced the immuneresponse to anthrax protective antigen (PA) in mice. Thisstudy was carried out to determine whether CIA06B canenhance long-term immune responses to PA in mice. BALB/c mice were immunized intramuscularly three timesat 2-week intervals with recombinant PA alone or PAcombined with alum or CIA06B. At 8 and 24 weeks postimmunization,the immunological responses includingserum anti-PA IgG antibody titer, toxin-neutralizing antibodytiter, splenic cytokine secretion and the frequency ofPA-specific memory B cells were assessed. Compared withmice injected with PA alone or PA plus alum, miceinjected with PA plus CIA06B had higher titers of serumanti-PA IgG antibodies, and higher frequencies of PAspecificmemory B cells and interferon-c secreting cells. Furthermore, anti-PA antibodies induced by CIA06B weremore effective in neutralizing anthrax toxin. These resultsdemonstrated that CIA06B is capable of providing longtermimmunity when used as an adjuvant in a PA-basedanthrax vaccine.
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고아라,위서리,Ji In Ryu,Hien Thi Thu Do,이연정,임수정,이인모,정대인,박진아,최정아,송만기,이나경 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.2
Adjuvants are essential vaccine componentsused to enhance, accelerate, and/or prolong adaptiveimmunity against specific vaccine antigens. In this study,we compared the adjuvanticity of two adjuvant formulationscontaining de-O-acylated lipooligosaccharide(dLOS), a toll-like receptor 4 agonist, on the Japaneseencephalitis (JE) vaccine in mice. Mice were immunizedonce or twice at a two-week interval with inactivated JEvaccine in the absence or presence of adjuvant. We foundthat both the alum- and the liposome-based formulationinduced significantly faster and higher serum IgG antibodyresponses as compared with the non-adjuvanted vaccineafter either one or two immunizations. The antibody titersof the mouse immune sera correlated with 50% plaquereduction neutralization test (PRNT50) antibody titers. Inaddition, the dLOS/liposome formulation was more effectivein inducing a Th1-type immune response than thedLOS/alum formulation, as suggested by a strong antigenspecificinterferon (IFN)-c response. Based on theseresults, we suggest that both alum- and liposome-basedadjuvant formulations containing dLOS may be used forthe development of JE vaccines with improvedimmunogenicity.
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