추나요법을 병행한 한방치료로 호전된 만성 긴장성 두통 치험 1례

원제훈,안희덕,우창훈,Won, Je-Hoon,Ahn, Hee-Duk,Woo, Chang-Hoon 척추신경추나의학회 2013 척추신경추나의학회지 Vol.8 No.2

Objectives : The purpose of this study is to evaluate the Korean medical treatment for chronic tension-type headache, especially chuna manual therapy on cervical vertebrae. Methods : One patient was treated with acupuncture, herbal medication and chuna manual therapy on cervical vertebrae. To evaluate the pain of head and neck, visual analog scale(VAS) was measured. Results : After treatment for 1 week, the pain of head and neck was declined from VAS 10 to VAS 3. Conclusions : Korean medical treatment including acupuncture, herbal medication and cervical chuna manual therapy is effective for chronic tension-type headache. But further studies are required to prove the effectiveness of chuna manual therapy on cevical vertebrae.

긴장성 두통에 대한 추나요법 치험 3례

원제훈,김영준,안희덕,우창훈,Won, Je-Hoon,Kim, Young-Jun,An, Hee-Duk,Woo, Chang-Hoon 척추신경추나의학회 2015 척추신경추나의학회지 Vol.10 No.1

Objectives: The Purpose of this study is to report three cases on tension-type headache treated by Chuna manipulative therapy. Methods: Three patients diagnosed tension-type headache were treated with Chuna manipulative therapy only. To evaluate effect of treatment, visual analogue scale(VAS) and headache impact test(HIT) were used. We checked VAS and HIT score three times(pretreatment, post-treatment, follow-up). An interval among each evaluation time is 4 weeks. Results: At post-treatment evaluation, VAS and HIT score declined significantly compared with pre-treatment. At follow-up evaluation, the pain did not increased. Conclusions: These results suggests that Chuna manipulative therapy may be effective for tension-type headache.

창상을 유발한 흰쥐에서 김은화 추출물의 치료 효과

원제훈 ( Je-hoon Won ),우창훈 ( Chang-hoon Woo ) 한방재활의학과학회 2020 한방재활의학과학회지 Vol.30 No.1

Objectives This study is carried out to investigate the effects of Lonicera japonica in wound-induced rats. Methods Rats were divided into 5 groups; normal (Nor), control (Veh), positive comparison (PC), Lonicera japonica 100 mg/kg (LL), Lonicera japonica 200 mg/kg (LH), each n=8. Total polyphenol and flavonoid were quantified. 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3 ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radical scavenging activation were measured. Reactive oxygen species (ROS) was measured in serum. Antioxidant factors and inflammatory factors were measured in skin tissue, and also hydroxyproline content. Skin tissue was analyzed by Hematoxylin & Eosin and Masson’s trichrome staining method. Results Total polyphenol and flavonoid were 32.86±0.14 mg/g and 67.17±0.57 mg/g. The IC₅₀ values of DPPH and ABTS free radical scavenging activation were 26.69±1.50 μg/mL and 49.33±4.52 μg/mL. ROS was significantly lower in LL and LH groups. Nuclear factor-erythroid 2-related factor 2 (Nrf2) was significantly higher in LH group and higher in LL group but not significant. Superoxide dismutase 1 (SOD-1), catalase, and heme oxygenase 1 (HO-1) were significantly higher in LL and LH groups. Nuclear factor kappa-B p65 (NF-κBp65), phosphorylated iκBα (p-iκBα), cyclooxygenase 2 (COX-2), and tumor necrosis factor alpha (TNF-α) were significantly lower in LL and LH groups. Hydroxyproline was significantly higher in LL and LH groups. The histopathologic analysis showed that skin tissue had recovered further more in LL and LH groups than in Veh group. Conclusions These results suggest that Lonicera japonica has the anti-oxidant, anti- inflammatory and healing effects in wound-induced rats. (J Korean Med Rehabil 2020; 30(1):47-61)

계지가부자탕(桂枝加附子湯)이 MIA로 유도된 골관절염 Rat모델에 미치는 영향

원제훈 ( Je Hoon Won ),우창훈 ( Chang Hoon Woo ) 한방재활의학과학회 2015 한방재활의학과학회지 Vol.25 No.2

Objectives This study was carried out to investigate the effects of Gyejigabuja-tang extracts on the Monosodium iodoacetate (MIA) induced osteoarthritis in rats. Methods Osteoarthritis was induced by injection of MIA into knee joint cavity of rats. Rats are divided into 4 groups (normal, control, positive comparison group, GBT group, each n=5). Normal group was injected by normal saline into knee joint cavity only. Control group was induced for osteoarthritis by MIA and oral medicated with distilled water. Positive comparison group was injected with MIA and taken Joins tablet 25 mg/kg. GBT group was injected with MIA and taken Gyejigabuja-tang extracts 300 mg/kg. Positive comparison group and GBT group were oral medicated for each substance once a day for 4 weeks. ALT, AST and creatinine were evaluated for hepatotoxicity and nephrotoxicity. Hind paw weight bearing ability was examined and inflammatory cytokines (IL-1β, IL-6, TNF-α), PGE2, LTB4, osteocalcin and deoxypyridinoline (DPD) within serum were analysed. Knee joint structures were observed by Hematoxylin & Eosin (H&E), Safranin-O staining method. Results 1. Function of liver and kidney was not affected. 2. Hind paw weight bearing ability was significantly improved. 3. IL-1β, IL-6 and TNF-α in experimental group were significantly decreased compared with control group. 4. PGE2, LTB4, Osteocalcin and DPD in experimental group were decreased compared with control group. 5. In histopathologic observation, injury on synovial membrane and cartilage of experimental group was lesser than control group (H&E, Safranin-O staining). Conclusions Based on these results, it can be suggested that Gyejigabuja-tang has anti-inflammation effects on the MIA-induced osteoarthritis in rats. (J Korean Med Rehab 2015;25(2):51-64)

봉침요법과 침전기자극술을 적용한 족근관 증후군 치험 1례

원제훈 ( Je Hoon Won ),안희덕 ( Hee Duk Ahn ),우창훈 ( Chang Hoon Woo ) 대구한의대학교 제한동의학술원 2014 東西醫學 Vol.39 No.1

Tarsal tunnel syndrome is a compression neuropathy and painful foot condition in which the tibial nerve is compressed as it travels through the tarsal tunnel. Patients with tarsal tunnel syndrome typically complain of numbness, dullness, pain, burning and tingling over the base of the foot and heel. Treatments typically include medication, casting with a walker boot and corticosteroid injections. In invasive way, tarsal tunnel release surgery may be recommended to decompress the area. In this report, one patient diagnosed as tarsal tunnel syndrome was treated by Korean medical treatment as bee venom and electro-acupuncture therapy. To evaluate the pain and dullness of both sole, visual analog scale(VAS) was measured. After treatment for 10 times, the pain and dullness of both sole was declined from VAS 10 to VAS 3. The results suggest that Korean medical treatment as bee venom and electro-acupuncture therapy may be effective for tarsal tunnel syndrome.

완관절 결절종의 한의학적 치료에 대한 연구 경향 분석

원제훈 ( Je Hoon Won ),김영준 ( Young Jun Kim ),안희덕 ( Hee Duk Ahn ),우창훈 ( Chang Hoon Woo ) 한방재활의학과학회 2014 한방재활의학과학회지 Vol.24 No.4

ObjectivesThe purpose of this study is to analyze research trends on the Korean medi-cal treatment of wrist ganglion and to develop the way of treatment.MethodsWe searched the papers with a key word of ``wrist ganglion`` in Korean data-base (NDSL, KISS, Korean traditional knowledge portal) and Pubmed.ResultsTotal 5 studies were found. Major treatment method was the acupuncture in-cluding electroacupuncture, pharmacopuncture and acupotomy. Minor treatments were moxibustion, wet cupping, herbal medicine and percutaneous aspiration.ConclusionsVarious treatment methods were used for curing wrist ganglion and they were effective. To map out the systemic treatment of Korean medicine on wrist ganglion, more clinical reports are needed. (J Korean Med Rehab 2014;24(4):111-116)

압박손상으로 발생한 비골신경마비 환자 치험 1례

김정아,지민정,원제훈,안뜰에봄,김동철,Kim, Jung-Ah,Ji, Min-Jung,Won, Je-Hoon,An, Tteul E Bom,Kim, Dong-Chul 척추신경추나의학회 2014 척추신경추나의학회지 Vol.9 No.1

Objectives: The Purpose of this study is to report the effects of Korean medical treatment on patient of peroneal neuropathy caused by sitting cross-legged. Methods: The patient diagnosed as peroneal neuropathy was treated by Acupuncture, Bee Venom therapy, Herbal medicine. To evaluate the effects of Korean treatment, we used Range of Motion(ROM) of Ankle, Visual Analog Scale(VAS), Numeric Rating Scale(NRS), Ankle-Hind-foot Scale(AHS), Digital Infrared Thermal Imaging(DITI). Results: After treatment, ROM of Ankle, VAS, NRS, AHS were improved. Temperature Difference(${\Delta}T$) was decreased on DITI. Conclusions: This study suggests that Korean medical treatment might be effective on sitting cross-legged patient diagnosed as Peroneal Neuropathy.

출부탕(朮附湯) 추출물의 항산화 및 항염증에 대한 효과

형균 ( Kyun Hyeong ),원제훈 ( Je-hoon Won ),우창훈 ( Chang-hoon Woo ) 한방재활의학과학회 2020 한방재활의학과학회지 Vol.30 No.3

Objectives Even though the various alternative herbal medicine has applied for osteoarthritis (OA) treatment, its scientific proof remains uncertain. The aim of the present study evaluates the effects of Chulbu-tang on inflammatory responses in a monosodium iodoacetate (MIA)-induced osteoarthritis rat model. Methods OA rat model was established by MIA injection in intra-joint of rats. 7 days after, OA rats except OA control rats were administrated Chulbu-tang (100 or 200 mg/kg) or Indomathacin (5 mg/kg) once a day for 14 days. The weight-bearing ability of hind paws were measured when group isolation 0, 7, and 14 days. Western blotting was performed to examine the knockdown/overexpressing efficiency of Chulbu-tang. In addition, cartilage destruction was measured histologically. Results Chulbu-tang treatment significantly reduced the protein expressions of inflammatory mediators such as inducible nitric oxide synthase and cyclooxygenase 2, and inhibited inflammatory cytokines including tumor necrosis factor alpha, interleukin (IL)-1β, and IL-6 through nuclear factor-kappa B (NF-κB) inactivation. Moreover, anti- oxidant enzymes such as superoxide dismutase and glutathione peroxidase-1/2 through nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway significantly increased. Our findings indicate that Chulbu-tang has the potential therapeutic effect on OA through inhibiting the inflammatory responses via inactivating NF-κB signaling pathway. In addition, upregulation of Nrf2 led to anti-oxidant effects. Conclusions Taken together, Chulbu-tang is believed to have antioxidant, anti-inflammatory effects, and cartilage protection for arthritis-causing rats. (J Korean Med Rehabil 2020;30(3):71-87)

회전근개 파열 수술 후 한방재활치료 치험 1례

김영준 ( Young Jun Kim ),원제훈 ( Je Hoon Won ),안희덕 ( Hee Duk Ahn ),우창훈 ( Chang Hoon Woo ) 대구한의대학교 제한동의학술원 2014 東西醫學 Vol.39 No.3

Objectives : The purpose of this study was to report the effects of Korean medicine treatment on a patient recovering after arthroscopic rotator cuff surgery. Methods: From August 25th 2014 to September 17th 2014, the patient received rotator cuff surgery was treated with acupuncture treatment, herbal medicine, moxibustion, cupping therapy, and physical treatment. Improvement of the patient``s condition was evaluated by NRS and ROM. Results: After 24 days of treatment, the patient showed reduction of shoulder pain, and improvement of shoulder ROM. Conclusions: This results suggest that Korean medicine treatment may be effective for pain control and ROM increase. Therefore this treatment is expected to shorten the postoperative recovery period and improve patients I satisfaction.

보안만령단(保安萬靈丹)의 임상적 부작용에 대한 후향적 연구

김영준 ( Young Jun Kim ),원제훈 ( Je Hoon Won ),안희덕 ( Hee Duk Ahn ),우창훈 ( Chang Hoon Woo ),이종훈 ( Jong Hoon Lee ) 대구한의대학교 제한동의학술원 2015 東西醫學 Vol.40 No.1,2

Objectives: This study aimed to assess the safety of Boanmanryeong-dan. Methods: A retrospective analysis of the electronic medical records of Daegu Haany University Korean Medicine Hospital from March 2014 to October 2014 was performed. 431 outpatients who took Boanmanryeong-dan in Department of Rehabilitation Medicine of Korean Medicine were enrolled. The study was completed through medical records review. Results: 1. There were 6 side effect cases on male, and 3 side effect cases on female out of 431 outpatients. The incidence of side effect was 2.1%. 2. The most common side effect was obtundation of tongue and lips. 3. There is no statistical significance between incidence of side effect and dosage of Boanmanryeong-dan. Conclusion: The symptom of side effects on outpatients who took Boanmanryeong-dan was not as other adverse drug reactions often seen in Western medication. We suggest that our results contribute towards confirming the safety of Boanmanryeong-dan by offering clinical evidence.