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우현영,이지원 한국무용교육학회 2018 韓國舞踊敎育學會誌 Vol.29 No.4
The study aims to examine dance passion and devotion and historical significance by tracing the footsteps of Giordano, G., the master of jazz dance history in the U.S. and recognized as a godfather. Giordano's unique resume, which established jazz dance moves as the son of immigrants, created the Jazz Dance World Congress and devoted to education, is a non-existent research in Korea that explores the receptive aspects and meanings of the movements shown in Korea. In this study, the great stroke of jazz dance in the U.S. has great significance in checking the heritage and lighting the value of jazz dance through the life of Giordano.
우현영,최종영,윤승규,서동진,백승운,한광협,엄순호,김병익,이헌주,조몽,이천균,김동준,황재석 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.2
Background/Aims: Adefovir dipivoxil (ADV) is a nucleotide analogue that is effective against lamivudine-resistanthepatitis B virus (HBV). The aim of this study was to determine the long-term clinical outcomes after ADV rescuetherapy in decompensated patients infected with lamivudine-resistant HBV. Methods: In total, 128 patients with a decompensated state and lamivudine-resistant HBV were treated with ADV at adosage of 10 mg/day for a median of 33 months in this multicenter cohort study. Results: Following ADV treatment, 86 (72.3%) of 119 patients experienced a decrease in Child-Pugh score of at least 2points, and the overall end-stage liver disease score decreased from 16±5 to 14±10 (mean ± SD, P<0.001) during thefollow-up period. With ADV treatment, 67 patients (56.3%) had undetectable serum HBV DNA (detection limit, 0.5 pg/mL). Virologic breakthrough occurred in 38 patients (36.1%) and 9 patients had a suboptimal ADV response. Theoverall survival rate was 89.9% (107/119), and a suboptimal response to ADV treatment was associated with both noimprovement in Child-Pugh score (≥2 points; P=0.001) and high mortality following ADV rescue therapy (P=0.012). Conclusions: Three years of ADV treatment was effective and safe in decompensated patients with lamivudine-resistant HBV.
Two Cases of Candida inconspicua Infection in Neutropenic Patients with Acute Leukemia
우현영,박선희,이동건,조현선,민창기,김명신,한경자 대한감염학회 2006 Infection and Chemotherapy Vol.38 No.3
최근 진균이 면역약화환자의 기회감염의 원인으로 그 빈도가 증가하고 있다. 그 중에서 Candida albicans가 중증 진균 감염의 흔한 원인이지만, 최근에는 암 환자에서, 특히 치료과정에서 예방적으로 azole계 항진균제를 투여 받는 환자에게서 azole을 포함한 통상적인 항 진균 제재에 잘 반응하지 않는 non-albicans Candida 종에 의한 기회감염이 증가하고 있다. Candida inconspicua는 fluconazole에 내성인 non-albicans Candida 종 중 하나로 최근 칸디다혈증의 원인으로 드물게 보고 되었고 아직 국내에서는 그 보고 예가 없었다. 저자들은 항진균 예방화학요법으로 fluconazole을 경구 투여 받았던 급성 백혈병 환자에게 발생한 C. inconspicua 칸디다혈증 2예를 보고하고자 한다. 두 증례 모두 급성백혈병 항암치료 시 fluconazole을 예방적으로 경구 투여한 환자로, 호중구감소성 발열이 발생하여 광범위 항생제를 사용하였으나 발열이 지속되어 경험적 항진균제를 투여하였으며, 혈액배양에서 C. inconspicua가 배양되었다. 두 증례 모두 C. inconospicua의 감염경로는 위장관 감염으로 추정되었으며, amphotericin B deoxycholate 정주 후에 임상 양상의 호전을 보였다. Non-albicans Candida species which are resistant to azole are emerging as important pathogens in patients with hematological malignancies who received antifungal prophylaxis. C. inconspicua is one of rare Candida spp. and resistant to fluconazole and deep infection due to C. inconspicua has not been reported in Korea so far. We reported here two cases of candidemia due to C. inconspicua in neutropenic patients with acute leukemia. C. inconspicua were presumed to be originated from gastrointestinal tract in both cases. The antifungal susceptibility test of C. inconspicua in case 1 showed resistance to fluconazole and itraconazole. Both cases were successfully treated by amphotericin B deoxycholate. Clinicians should keep in mind that non-albicans Candida species would be emerging pathogen in immunocompromised hosts and early recognition and appropriate use of antifungal agents is necessary.