Distribution of Disease Severity and Group A Rotavirus Genotypes (VP7 & VP4) in Children with Acute Rotavirus Gastroenteritis

오현주,강현식,강기수,김연우,홍정연,신경수,이진숙,이수현,이근화,조문제,서동인,Oh, Hyun-Ju,Kang, Hyun-Sik,Kang, Ki-Soo,Kim, Youn-Woo,Hong, Jung-Yun,Shin, Kyung-Sue,Lee, Jin-Sook,Lee, Su-Hyun,Lee, Keun-Hwa,Cho, Moon-Je,Suh, Dong-In The Korean Society of Pediatric Gastroenterology 2011 Pediatric gastroenterology, hepatology & nutrition Vol.14 No.2

목적: 저자들은 지역사회에서, 로타바이러스 장염에 걸린 소아들에서 질환의 중증도와 로타바이러스 VP7 유전형과 VP4 유전형의 분포에 대해 알아보고자 하였다. 방법: 2007년 12월부터 2008년 6월까지 로타바이러스 장염으로 병원에 입원한 156명의 소아들에서 대변 샘플을 수집하였다. 모든 환자들에 대한 질환 중증도는 Vesikari 점수를 이용하여 평가하였다. 로타바이러스 ds-RNA를 분리한 후, 역전사 중합효소 연쇄반응과 다중 중합효소 연쇄반응을 이용하여 cDNA를 합성하였다. 마지막으로 유전형을 확인하였다. 결과: 156명의 환자 샘플에서, VP7(G)는 147명(94.2%)에서 확인되었고 VP4(P)는 140명(89.7%)에서 확인되었다. G1 유전형(147명 중 116명; 78.9%)과 P[8] 유전형(140명 중 137명)이 각각 가장 많았다. VP7과 VP4 조합형은 138명에서 확인할 수 있었는데, G1P[8] 조합형이 111명(80.4)으로 가장 많았다. 다른 조합형들은 종류가 다양하였고 분포가 낮았다. 전체 조합형 중 9.4%가 새로운 로타바이러스 백신에 포함되지 않은 것이었다. 로타바이러스 장염의 질환 중중도는 $11.8{\pm}3.3$ ($mean{\pm}2SD$)였다. 전체 환자에서 경증 내지 중등도가 37.8%였고, 중증은 62.2%였다. 결론: 로타바이러스 유전자 조합형 중 가장 흔한 것은 G1P[8]이었다. 새로운 백신에 포함되지 않은 유전자 조합형은 9.4%였다. 로타바이러스 장염으로 입원한 소아들의 질환 중증도분포는 경증과 중등도보다 중증에서 높게 나타났다. Purpose: We aimed to study the distribution of rotavirus genotypes (VP7 and VP4) and disease severity of rotavirus gastroenteritis prevalent in our community. Methods: Stool samples were collected from 156 children who were hospitalized with rotavirus gastroenteritis from December 2007 to June 2008. The disease severity of all patients was scored using the Vesikari scale. After extraction of ds-RNA of the rotavirus, cDNA synthesis using reverse transcription and polymerase chain reaction (RT-PCR) and multiplex PCR was performed. Following this, the final identification of genotypes was performed. Results: Of the 156 samples, VP7(G) and VP4(P) genotypes were identified in 147 (94.2%) and 140 (89.7%) samples, respectively. G1 (116 of 147 samples; 78.9%) and P[8] (137 of 140 samples; 97.9%) were the most prevalent, respectively. Of the 138 samples identified of combination types of VP7 and VP4, G1P[8] (111 samples; 80.4%) was the most prevalent. Other combination types varied with very low distribution rates. 9.4% of genotypes were not included in the new vaccines. The disease severity score was $11.8{\pm}3.3$ ($mean{\pm}2SD$). The distribution of disease severity was mild or moderate in 37.8% and severe in 62.2% of patients. Conclusion: The most prevalent genotype combination of rotavirus was G1P[8] and genotypes not included in the vaccines represented 9.4% in our community. Disease severity distribution of hospitalized children with rotavirus gastroenteritis was higher in the severe than in the mild and moderate categories.

굴곡-신연기법과 낙차 교정법이 허리 척추사이원반 탈출증 환자의 시각적 상사 척도 및 엉치뼈 각에 미치는 영향

오현주,최석주,이관섭,최지운,Oh, Hyun-Ju,Choi, Seok-Joo,Lee, Kwan-Sub,Choi, Ji-Oun 대한물리치료과학회 2018 대한물리치료과학회지 Vol.25 No.3

Background: In order to find out the effect of therapy methods through Flexion-distraction technique and drop technique on pain, sacral angle of patients with lumbar herniated intervertebral disc targeting patients with lumbar herniated intervertebral disc due to L5-S1. Method: This study was to present the directivity of the therapy method for lumbar herniated intervertebral disc by comparing and analyzing the spinal decompression therapy and provide an effective treatment method to patients with lumbar herniated intervertebral disc by identifying the therapeutic effect of Flexion-distraction technique and drop technique. The research period is March 1, 2018 to June 30, 2018 and subjects are the patients diagnosed as lumbar herniated intervertebral disc due to L5-S1 by their doctor through clinical findings and medical equipment such as X-ray, CT, MRI etc. Among patients who visited and hospitalized in S Orthopaedics located in Daegu and 30 female patients with sacral angle of more than $30^{\circ}$ were randomly classified into 15 people and we carried out treatment three times a week for 8 weeks for 15 people in the experimental group applying Flexion-distraction technique and drop technique and 15 people in the control group applying spinal decompression therapy to compare and analyze the changes in pain, sacral angle of patients with lumbar herniated intervertebral disc. Result: According to the results of this study, changes in the Visual Analogue Scale showed statistically significant differences in both the experimental group and control group(p<.05), while there was statistically significant difference in the comparison between groups before and after measurement of experimental group (p<.05). In the comparison within two groups of sacral angle, both groups showed statistically significant difference(p<.05) but there was no statistically significant difference in the comparison of scores between groups before and after measurement of each group(p>.05). Discussion: All those results the above proved that we need to confirm various benefits of the therapy with the flexion-distraction technique and drop technique, and the findings of the concerned study will possibly become useful information when doctors actually work on a therapy to treat patients with the lumbar herniated intervertebral disc.

만성중심장액맥락망막병증에서 절반 에너지보다 낮은 에너지를 이용한 광역학치료의 효과

오현주,장우혁,사공민,Hyun Ju Oh,MD,Woohyok Chang,MD,PhD,Min Sagong,MD,PhD 대한안과학회 2013 대한안과학회지 Vol.54 No.7

Purpose: To investigate the safe, effective light dose for photodynamic therapy (PDT) in the treatment of chronic central serous chorioretinopathy (CSC). Methods: Thirty-eight eyes of 37 patients with chronic CSC were recruited for this study. From November 2009 to July 2010 and from April 2011 to February 2012, PDT was performed using 50% and 25% of the full light dose in 27 eyes of 27 patients (group I) and 11 eyes of 10 patients (group II), respectively. The minimum follow-up period was 6 months. Mean change in best corrected visual acuity (BCVA) and central retinal thickness, hyperpermeability change from abnormal choriocapillaris, success rate, recurrence rate, and complications were analyzed. Results: Group I showed that BCVA (log MAR) improved significantly from 0.33 ± 0.17 to 0.14 ± 0.15 at 6 months (p < 0.001). However, there was no significant improvement of BCVA (p = 0.050) in group II. One eye out of 27 eyes (3.7%) in group I and 5 eyes out of 11 eyes (45.5%) in group II showed recurrence at the 6-month follow-up (p = 0.016). After initial PDT, hyperpermeability from abnormal choriocapillaris reduced or disappeared at 95.5% in group I and 54.5% in group II at month 3 (p = 0.016). No patient in either group experienced severe adverse events. Conclusions: PDT performed with 50% of the full light dose appears to be a more useful method in the treatment of chronic CSC, with less frequent recurrence, than PDT using 25% of the full light dose.

PNF 목 패턴이 전방머리자세를 가진 성인의 목 움직임 및 목 장애 지수에 미치는 영향

오현주,송귀빈,Oh, Hyun-Ju,Song, Gui-Bin 대한고유수용성신경근촉진법학회 2016 PNF and Movement Vol.14 No.3

Purpose: The purpose of this study was to investigate the effects of neck patterns in proprioceptive neuromuscular facilitation (PNF) for neck movement and the neck disability index (NDI) among adults with forward head posture. Methods: Thirty-nine subjects were randomly assigned into two groups. Subjects in the proprioceptive neuromuscular facilitation exercise group (PNFG, n = 20) received 20 minutes of PNF neck pattern (flexion-Rt. lateral flexion-Rt. rotation followed by extension-Lt. lateral flexion-Lt. rotation) 3 times weekly for 4 weeks. Outcomes were measured using absolute rotation angle (ARA), anterior weight bearing (AWB), range of flexion and extension motions (RFEM), and neck disability index (NDI) methods before and after the 4-week intervention period. Results: There were significant effects for the PNFG, pre- and post-intervention, in ARA, AWB, RFEM, and NDI. There were significant differences in ARA, AWB, RFEM, and NDI compared with CG. Conclusion: The results of this study suggest the PNF neck pattern could be beneficial for adults with forward head posture.

Salmonella enteritidis 위장관염에 합병된 급성 비결석성 담낭염 1예

오현주,강현식,강기수,김승형,김봉수,김광식,Oh, Hyun-Ju,Kang, Hyun-Sik,Kang, Ki-Soo,Kim, Seung-Hyung,Kim, Bong-Soo,Kim, Kwang-Sig 대한소아소화기영양학회 2009 Pediatric gastroenterology, hepatology & nutrition Vol.12 No.1

저자들은 평소 건강하던 9세 남아에게서 Salmonella enteritidis 위장관염에 합병된 급성 비결석성 담낭염을 임상증상, 혈액 검사 및 배양 검사, 복부 초음파 검사등을 통하여 진단 할 수 있었다. 또한 항생제 치료와 비수술적 방법인 경피경간 담낭배액술을 통하여 성공적으로 치료 하였기에 이에 보고하는 바이다. We report a rare case of acute acalculous cholecystitis (ACC) caused by Salmonella enteritidis infection in a previously healthy 9-year-old boy. Salmonella enteritidis was isolated from stool and bile culture. The diagnosis of ACC was established upon clinical, laboratory, and ultrasonographic findings. The patient was successfully treated using percutaneous transhepaticcholecystic drainage (PTCCD) in combination with antibiotics therapy.

듀안안구후퇴증후군의 얼굴돌림과 내전시 과도한 상하전에 대한 수술적 치료

오현주,문성혁,김명미,Oh Hyun Ju,Sung Hyuk Moon,Myung Mi Kim 대한안과학회 2013 대한안과학회지 Vol.54 No.6

Purpose: To present the results of patients undergoing surgical treatment and determine clinical guidelines for the face turn, and up and down shoot in Duane retraction syndrome (DRS). Methods: Thirty-four patients with DRS were treated with single horizontal rectus muscle recession, lateral rectus (LR) recession with Y-splitting, or LR recession with Y-splitting combined with medial rectus (MR) recession. The different treatment approaches were based on the angle of deviation in the primary position, versions, and ductions. In all patients, ocular alignment, face turn and up and down shoot were assessed preoperatively and postoperatively. Results: The average standard deviation reduced from 18.5 ± 6.5 prism diopters (PD) to 4.6 ± 5.8 PD in horizontal rectus muscle recession and 14.4 ± 5.5 PD to 1.6 ± 2.8 PD in LR recession with Y-splitting. LR recession with Y-splitting combined with MR recession was effective in reducing globe retraction. Postoperative 4-mm LR recession with Y-splitting did not change ocular alignment; 7-mm LR recession with Y-splitting showed an average correction of 12.8 PD. Postoperatively, all patients presented a reduction in face turn; however, there was no statistically significant difference between the 2 procedures (Mann-Whitney U test, p = 0.620). Conclusions: Decisions regarding surgical approaches in DRS should be based on the amount of deviation in primary eye position, the expression of up and down shoot, and the degree of face turn. Surgeons planning Y-splitting of LR with MR recession must consider modifying the MR recession amount due to the smaller LR recession effect of Y-splitting compared with conventional LR recession.

한국표준질병사인분류의 개정에 관하여

오현주,OH, Hyun-Ju 한국생명보험의학회 2008 保險醫學會誌 Vol.27 No.1

The 5th revision of Korean Classification of Diseases(KCD) became effective on January 1, 2008. It has reflected the changes made to the tenth revision of International Classification of Diseases (ICD-10) between 1998 and 2005 and the suggestions of academic and related societies in Korea. Two important alterations seem to have a major implication in the insurance industry. One would be the official introduction of a Korean version of International Classification of Diseases for Oncology, third edition(ICD-O-3). The borderline ovarian tumor is classified as a borderline neoplasm, which was classified as a malignant neoplasm in the previous edition of International Classification of Diseases for Oncology. The other would be the appearance of non-C-code malignant neoplasm for the diseases, such as polycythemia vera, newly classified as a malignant neoplasm by the current edition of International Classification of Diseases for Oncology. The National Office of Statistics(NSO) adopted the way of implementation used in the Australian Modification of International Classification of Diseases(ICD-10-AM), instead of assigning them into corresponding C code. Overall, the changes made in this revision doesn't seem to have a serious impact on the insurance industry since it has only reflected updates made to ICD-10.

2004년 하계 남해안 해황과 식물플랑크톤의 분포 특성

오현주 ( Hyun Ju Oh ),이용화 ( Yong Hwa Lee ),양준혁 ( Jun Hyuk Yang ),김승한 ( Seung Han Kim ) 한국지리정보학회 2007 한국지리정보학회지 Vol.10 No.3

2004년 하계 한국의 남해안에서 수온, 식물플랑크톤, 동물플랑크톤, 영양염류 등 자료를 분석하여 해양환경과 식물플랑크톤의 관계를 분석하였다. 조사해역에서 수온은 20.5~31.5℃범위로 거제남부해역 및 거문도 해역에서 20.0~25.0℃의 수온전선대가 형성되었으며, 특히, 수온전선대가 강하게 형성된 거제도 남부해역에서는 영양염류의 농도가 높았으며, 식물플랑크톤 색소 중 가장 높은 비율로 나타나는 클로로필-α의 농도가 전선역의 내측에서 0.4㎍/L 이상의 분포를 보였고, 동물플랑크톤 현존량은 500㎎/㎡ 이상의 분포를 보였다. We analyze relation between phytoplankton and marine environment based on data such as water temperature, phytoplankton, zooplankton, nutrient collected from the southern coast of Korea in the summer, 2004. The water temperature range of the study area was 20.5~31.5℃ and there was formed a water temperature frontal zone from 20.0℃ to 25.0℃ in Geojedo southern coast and Geomundo island. Especially, high density of nutrients were shown in the southern coast of Geojedo in which water temperature frontal zone was formed strongly, the concentration of chlorophyll-α which is appeared at the highest rate among the phytoplankton pigments was shown more than 0.4㎍/L in the inside of frontal zone and zooplankton biomass was than 500㎎/㎡ in that area.

시판 된장을 이용한 식빵 제조 : 1. 된장의 이화학적 특성 및 된장을 첨가한 식빵의 물리적 특성

오현주(Hyun-Ju Oh),문혜경(Hye-Kyung Moon),김창순(Chang-Soon Kim) 한국식품영양과학회 2003 한국식품영양과학회지 Vol.32 No.7

생리활성이 우수하다고 알려진 된장의 소비확대를 위하여 시판 된장을 이스트 발효 식빵 제조에 이용하고자 식빵 배합비에 7종(A; 재래식 된장, B~E; 시판 개량식 된장, F; 시판 Miso type 된장, G; Japanese Miso)의 동결건조한 된장분말을 2.5~10.0% 첨가하여 발효력과 오븐팽창력을 관찰하고 빵품질을 물리적 측면에서 조사하였다. 사용된 시판된장 7종의 이화학적 특성치로는 일반성분을 비롯하여 아미노태질소, 총산도, 환원당, 유리당, 염도, 유기산 함량 및 단백질 분산지수(PDI)를 제시하였다. 빵 배합비에 된장분말 5.0% 이하의 첨가는 오븐팽창력의 현저한 증가로 모든 된장 첨가식빵 부피가 증가하여 무첨가구에 비하여 최대 13%까지 높게 나타났다. 또한 된장첨가로 기계적 조직감 측정치인 경도(hardness), 검성(gumminess), 씹힘성(chewiness) 등이 감소하여 전반적으로 부드러워졌고, 빵의 색은 어두워졌다. 그러므로 식빵제조에 시판된장의 사용은 빵의 물리적 품질 향상에 매우 긍정적인 효과를 가져왔다. 이때 식빵의 부피나 조직감은 된장 종류나 첨가수준에 의하여 독립적으로 영향을 받을 뿐만 아니라 이들 처리조합의 상호작용에 의하여도 크게 영향을 받는 것으로 나타났다. This study was carried out to develope yeast leavened pan bread using the commercial Doenjangs (Korean soybean pastes). Physicochemical properties of the Doenjang products were measured such as aminonitrogen, pH, titratable acidity and salinity, reducing sugar, total free sugar, total organic acid, PDI (protein dispersibility index) and color. Seven products of Doenjang were freeze-dried and powdered to be used in bread formula at the levels of 2.5, 5.0, 7.5 and 10.0%. When the Doenjang powder was added up to 5.0%, the ovenspring during baking remarkably increased resulting in increased loaf volume. However, with Doenjang powder more than 7.5%, the loaf volume became smaller than the control as the dough expansion and ovenspring decreased. Thus when Doenjang was added to bread dough, the loaf volume was highly correlated with ovenspring (r=0.92) but it was not with dough expansion during 1st fermentation (r=0.56). The browning color of bread crust and crumb became deeper with decrease in L value as the addition of Doenjang powder increased. From the mechanical texture measurements of bread crumb, hardness, gumminess and chewiness decreased with addition of Doenjang powders. Regardless of the kinds of Doenjang, the Doenjang powders could be added into the bread dough up to 5.0%, improving the loaf volume and texture of yeast leavened pan bread and demonstrating the possibility of producing a functional bread using the Doenjang powders.

돼지불고기용 과채열수추출액 함유 고추장양념소스 최적 배합비 개발

오현주(Hyun Ju Oh),김창순(Chang Soon Kim) 한국식품영양과학회 2008 한국식품영양과학회지 Vol.37 No.4

고추장, 고춧가루, 과채열수추출액 첨가에 의한 돼지불고기양념육의 항산화 증진 효과와 혼합물 실험설계법을 이용한 돼지불고기용 양념소스 재료의 최적 혼합 비율을 확립하고자 하였다. 냉동저장(-25oC, 5개월) 동안 간장양념을 사용한 대조구와 고추장양념첨가구(KG), 고추장양념·과채열수추출액첨가구(KFVEG)의 TBA가는 저장기간 동안 원료육에 비해 모든 돼지불고기 양념육에서 낮게 유지되었다. 양념육 중에서는 대조구보다 고추장양념첨가구의 항산화력이 크게 우수하였으며, 고추장양념첨가구의 물 사용량을 과채열수추출액으로 대체함으로써 항산화 상승작용이 유의적으로 나타났다. 따라서 양념소스에 고추장, 고춧가루, 과채열수추출액 첨가로 돼지불고기양념육의 지방산화 안정성이 증진되었다. 양념육의 기호성은 고추장과 함께 사용된 고춧가루와 과채열수추출액 사용 비율이 증가함에 따라 향상되는 것으로 나타났다. 혼합물 실험 설계법에 의하여 추적된 돼지불고기용 고추장양념소스의 최적 혼합 비율은 고추장 0.04, 고춧가루 0.20, 과채열수추출액 0.39, 물 0.37로 나타났다. This study was carried out to investigate the antioxidative effect of Kochujang seasoning sauce with the addition of fruit and vegetable extract (FVE) for pork Bulgogi, as well as to establish the optimum mixture ratio of ingredients using mixture experimental design (MED). During 5 months of storage at -25℃, the thiobarbituric acid (TBA) values of the seasoned pork containing soy sauce (control), Kochujang added group (KG) and Kochujang and FVE added group (KFVEG) were remarkably lower than that of unseasoned pork. Among the seasoned porks, the antioxidative effect of KG was much higher than the control. Moreover, TBA values of KFVEG were significantly lower than those of KG. Therefore, the lipid oxidation stability of seasoned pork Bulgogi was improved by the addition of Kochujang, red pepper powder and FVE into the seasoning sauce. When Kochujang was used in seasoning sauce, the preference scores of pork Bulgogi increased with the increasing amount of red pepper powder and FVE. The optimum mixture ratios of seasoning sauce for pork Bulgogi established by the MED were Kochujang 0.04, red pepper powder 0.20, FVE 0.39 and water 0.37.