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오승헌,최청갑,노정은,이나연,정용우,전익수,신정민,김지혜,김호진,이지민,김현숙,김옥준,송지환 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
The human umbilical cord is a promising source of mesenchymal stromal cells (MSCs). Intravenous administration of human umbilical cord-derived MSCs (IV-hUMSCs) showed a favorable effect in a rodent stroke model by a paracrine mechanism. However, its underlying therapeutic mechanisms must be determined for clinical application. We investigated the therapeutic effects and mechanisms of our good manufacturing practice (GMP)-manufactured hUMSCs using various cell doses and delivery time points in a rodent model of stroke. IV-hUMSCs at a dose of 1 × 106 cells at 24 h after stroke improved functional deficits and reduced neuronal damage by attenuation of post-ischemic inflammation. Transcriptome and immunohistochemical analyses showed that interleukin-1 receptor antagonist (IL-1ra) was highly upregulated in ED-1-positive inflammatory cells in rats treated with IV-hUMSCs. Treatment with conditioned medium of hUMSCs increased the expression of IL-1ra in a macrophage cell line via activation of cAMPresponse element-binding protein (CREB). These results strongly suggest that the attenuation of neuroinflammation mediated by endogenous IL-1ra is an important therapeutic mechanism of IV-hUMSCs for the treatment of stroke.
한국형 중독 치료지침서(Ⅲ) : 알코올 사용장애의 정신사회 치료
오승헌,이계성,한창우,서정석,조근호,이해국,윤홍균,최삼욱,김현수,이보혜 대한신경정신의학회 2014 신경정신의학 Vol.53 No.4
Objectives The aim of this study is to develop guidelines for psychosocial treatment of alcoholuse disorder. Methods According to the ADAPTE manual, the Korean alcohol use disorder treatment guidelineswere developed by the guideline development committee. Recommendations from foreignguidelines were evaluated regarding the applicability and acceptability to domestic circumstances. In addition, a survey from experts was conducted, along with a review of Korean literature. By these means, recommendations of psychosocial treatment for alcohol use disorder were established. Results The main findings of the survey were as follows : 1) Although Group therapy was notrecommended by foreign clinical guidelines, it was considered as a first-line treatment by Koreanexperts. 2) Among many psychosocial treatment programs, cognitive behavior therapy (CBT),coping skills training, 12-step facilitation, and Group therapy were commonly used programs inKorea. Finally, the following treatment methods were selected for recommendations : Grouptherapy, motivational enhancement treatment, CBT, behavioral self-management, alcoholicanonymous, 12-step facilitation, psychodynamic psychotherapy, psychoeducational intervention,continuous case management, and community residential rehabilitation program. Conclusion Just as in treatment of chronic diseases such as hypertension, continuity is importantfor management of alcohol use disorder. Therefore, not only pharmacological treatment butalso psychosocial treatment should be provided comprehensively after treatment of acute withdrawalsymptoms.
국내 근육디스트로피 환자의 임상양상, 장애 및 사회경제학적 실태
오승헌,최영철,최병옥,김대성,정두신,박경석,문기태,김승민,김병준,임정근,주인수,손은희,노학재,이영배,김남희,서범천,강대룡,김진호,김종국 대한신경과학회 2009 대한신경과학회지 Vol.27 No.4
Background: Since 2001, the Ministry of Health and Welfare in Korea has designated muscular dystrophy (MD) to be a rare and intractable disease, and has ensured that patients with this condition obtain support from the National Health Insurance Corporation for their medical expenditure. However, the health-related and socioeconomic status of Korean patients with MD has yet to be established. Methods: We selected 441 patients with MD who received medical services at 17 neuromuscular centers during 2005. The medical records of selected patients were analyzed, and the subtype of MD was classified by its clinical course and diagnostic tests. A total of 95 patients or their family members participated in this health-related and socioeconomic status survey. Results: Medical record analysis showed similar clinical and diagnostic characteristic data to those published previously in other countries: male predominance, being young at onset, and muscular weakness of the extremities as a predominant symptom in most patients. The diagnostic tests for MD were based on laboratory and electrophysiological studies. The most frequent form of MD among our cohort was Duchenne/Becker muscular dystrophy (42%). Our survey revealed the effect of the patients’ profound disability on their activities of daily living. One-half of the patients were dissatisfied with the medical expenditure support service that was made available to them, and most patients suffered from a financial burden. The most important medical services to be developed in the future are expansion of the public health service or development of a rehabilitation hospital. Conclusions: This is the first multicenter-based epidemiologic study on the health-related and socioeconomic status of patients with MD in Korea. The findings indicate that medical coverage and public health service are currently inadequate and hence should be expanded in the future. Background: Since 2001, the Ministry of Health and Welfare in Korea has designated muscular dystrophy (MD) to be a rare and intractable disease, and has ensured that patients with this condition obtain support from the National Health Insurance Corporation for their medical expenditure. However, the health-related and socioeconomic status of Korean patients with MD has yet to be established. Methods: We selected 441 patients with MD who received medical services at 17 neuromuscular centers during 2005. The medical records of selected patients were analyzed, and the subtype of MD was classified by its clinical course and diagnostic tests. A total of 95 patients or their family members participated in this health-related and socioeconomic status survey. Results: Medical record analysis showed similar clinical and diagnostic characteristic data to those published previously in other countries: male predominance, being young at onset, and muscular weakness of the extremities as a predominant symptom in most patients. The diagnostic tests for MD were based on laboratory and electrophysiological studies. The most frequent form of MD among our cohort was Duchenne/Becker muscular dystrophy (42%). Our survey revealed the effect of the patients’ profound disability on their activities of daily living. One-half of the patients were dissatisfied with the medical expenditure support service that was made available to them, and most patients suffered from a financial burden. The most important medical services to be developed in the future are expansion of the public health service or development of a rehabilitation hospital. Conclusions: This is the first multicenter-based epidemiologic study on the health-related and socioeconomic status of patients with MD in Korea. The findings indicate that medical coverage and public health service are currently inadequate and hence should be expanded in the future.
Identification of a Dysferlin Gene Mutation in a Korean Case with Miyoshi Myopathy
오승헌,김태승,최영철 연세대학교의과대학 2004 Yonsei medical journal Vol.45 No.5
Recent genetic and immunohistochemical analyses have shown that Miyoshi myopathy (MM) is caused by a mutation in the DYSF gene, which induces dysfunction of dysferlin. The author described one patient showing characteristic MM phenotype with deficiency of dysferlin on immunohistochemistry. Direct DNA sequencing of whole exons of DYSF gene revealed one homozygous missense mutation (G1165C) on exon 12, which let to an amino acid substitution from the glutamic acid to glutamine at the 389 of the peptide sequence in this patient. This is the first reported case of MM confirmed by immunohistochemical and genetic analyses in Korea.