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Opiates에 의한 PRL과 LH분비의 억제와 촉진에 관한 연구
오세량,박광훈 대한산부인과학회 1990 Obstetrics & Gynecology Science Vol.33 No.4
내인성 opioid peptides가 뇌하수체전엽 hormone의 생산 및 분비에 깊이 관여한다는 견해에 따라 morphine과 opioids의 특수수용체 길항제인 naloxone을 따로, 혹은 동시에 혼합주사하여, 이들 물질에 의한 혈중 prolactin치와 LH치의 변동상황을 조사하여 다음과 같이 결과를 얻었다. 1. 백서(흰쥐)는 오후 prolactin-surge를 보여 오후 4:00에 최고치에 달한다(196.4 ± 12.3ng/ml). 2. Naloxone을 주사한 즉 오후 prolactin-surge가 완전히 억제되었다. 3. Morphine은 오후 prolactin-surge를 크게 촉진하여 16:00에 최고치인 236.3 ± 11.5 ng/ml에 달하였다. 4. Naloxone과 morphine을 동시에 투여하면 naloxone의 오후 prolactin-surge의 억제능력이 MOR에 의하여 완전히 봉쇄되어 대조군과 같은 prolactin-surge를 일으켰다. 5. LH-surge는 prolactin과 같이 오후 surge를 보여 최고치 184.4 ± 8.1ng/ml에 달하였다. 6. Naloxone은 오후 LH-surge를 크게 촉진하여 16:00에 282.9 ± 11.4 ng/ml에 달하였다. 7. Morphine은 오후 LH-surge를 완전히 봉쇄하였다. 8. Naloxone과 morphine을 동시에 투여하면 MOR이 NAL에게 억제되어 최고치(232.2 ± 16.5ng/ml)에 달하는 LH-surge를 보였다. The influences of opiates and their specific receptor antagonists on the secretion of the anterior pituitary hormones, prolactin and LH, were studied in the adult male rats. Rats demonstrated the afternoon prolactin and LH surges everyday as well as the other animals which reached the peak levels at 16:00 oclock. The surge of prolactin was completely inhibited by administration of naloxone , but was stimulated significantly by administration of morphine and increased from 40.3 ± 2.3 ng/ml to 236.3 ± 11.5 ng/ml. In the simultaneous administration of naloxone and morphine, the suppressive action of prolactin secretion of naloxone was completely blocked by morphine and prolactin release was significantly increased, reaching 198.0 ± 17.6 ng/ml at 16:00 oclock. In contrast to prolactin surge LH-surge was completely suppressed by administration of morphines and stimulated by administration of naloxone, reaching 282.9 ± 11.4 ng/ml at 16:00 oclock. When naloxone and morphine were simultaneously administered, the suppression of LH surge by morphine was completely inhibited by naloxone, and showed the significant afternoon Lh surge, reaching 232.2 ± 16.5 ng/ml at 16:00 oclock. It is concluded that endogenous opiates and their specific opiate receptor antagonists play an important role in the secretion of the anterior pituitary hormones, especially prolactin and LH.
방울비짜루(Asparagus oligoclonos) 로부터 분리한 스테로이드 사포닌의 항균활성
오세량,박승용,곽용호,성재덕,김금숙 한국농화학회 2000 Applied Biological Chemistry (Appl Biol Chem) Vol.43 No.2
Two steroidal saponins were isolated from MeOH extract of the rhizomes of Asparagus oligoclonos. Using the spectroscopic techniques of ¹H, ^(13)C NMR and 2D NMR, they were identified as 3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl]-(25S) -spirostan-3β-ol and 3-O-[β-D-glucopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→4)]-β-D-glucopyranosyl]-(25S)-spirostan-3β-ol, respectively. They were first isolated from A. oligoclonos. The in vitro antibacterial activities as well as antibacterial spectrums against 20 bacteria strains were investigated with MIC test. Both saponins inhibited the growth of 10 bacteria strains at the concentration of 100㎍/㎖.
Ectopic Gestation 시의 환부의 절제에 따른 hCG치의 감소상황
오세량,한세준,정종일,고성민,이용은,홍관표,김영미 대한산부인과학회 1992 Obstetrics & Gynecology Science Vol.35 No.10
자궁외임신에서 이환된 난관조직을 완전절제하는 수술과 난관을 보존할 수 있는 수술을 시행하여 융모조직으로 부터 생산되는 hCG량과 수술에 따라 hCG량의 감소를 관찰한 결과 다음과 같은 견해를 보였다. 즉 수술후 최초의 hCG량을 알아야만 hCG치가 계속되는 시간을 알 수 있으며 수술후 hCG량을 방사면역측정법으로 최소한 24일까지는 측정하여야 하고 hCG치의 감소 및 소실상황을 관측하여야하는 것으로 추정되었다. A Study was undertaken to determine the length of time serum of β-subunit of human chorionic gonadotropin (β-hCG) could be detected following removal of ectopic pregnancy. The disappearance pattern of β-hCG was almost equal in complete removal of trophoblastic tissue and in conservative surgical treatment. The initial hCG titer is the most significant factor determining the length of time in which positive titers will be detected.