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오성훈,김명정,김철권 대한신경정신의학회 1995 신경정신의학 Vol.34 No.5
Relapse warning signs(RWS) of schizophrenia are indicators of drug therapy for relapse prevention. The object of this study is to survey RWS of schizophrena and to use them for relapse prevention and education of the patients and their caretakers. The authors interviewed 74 remitted schizophrenic patients w ho had relapsed more than once and 67 patient caretakers. After introducing the concept of the RW S to the subjects, the RWS were investigated using open-ended questions and Early Sign Questionnaire(ESQ). The authors asked several additional questions, such as How long did it take from the appearance of the RWS to the hospitalization ?, , ‘Could you recognize it as RWS ? \ tW hat did you do when the RW S appeared ? ’ and ‘D o you think the RWS were same over each relapse ? ’ . The results were as follows ; A. The RW S obtained from open-ended questions 1) 53(72%) patients and 57(85%) caretakers reported the RWS spontaneously. 2) The patients reported 33 different signs and the caretakers reported 41. Four signs o f anxiety and nervousness, insomnia, irritability and decreased activity were the most frequent ones in both of the patient and caretaker groups. The patients tended to report subjective distress or discomforts whereas the caretakers tended to report changes in outwardly observable behaviors. 3) There were several RWS which were not listed in the ESQ, such as “talkativeness, soliloquy, changes in the appearance of the eyes, attempting to do something unusual, smiling when alone, peculiar behavior and senseless meddling in other people s affairs . B. The RW S obtained from E S Q 48(64.9%) patients and 51(76.1%) caretakers responded to the E SQ. The number of items responded by attending patients was 12.4 土 6.5 and that of caretakers was 9.3 土 3.7. The signs obtained from E S Q were similar to those obtained from open-ended questions. C. The rank order of RW S correlated significantly with that of Herz’s report obtained from American schizophrenic patients and caretakers in 1980. D . 51.3% of the patients and 59.7% of the caretakers responded that it took more than fifteen days from the appearance of RWS to the hospitalization. From these results the authors concluded that it should be possible to prevent schizophrenic relapse to a considerable extent in Korean, if the patients and their caretakers are given the education on the concept of the relapse warning signs and the appropriate coping strategies. The authors suggest to develope a Korean version of ESQ including the items of talkativeness, soliloquy, changes in the appearance of the eyes, attempting to do something unusual, smiling when alone, peculiar behavior and senseless meddling in other people’s affairs”
Alkaline Protease 고 생산성 세균의 선별 및 효소 특성
오성훈,오평수 한국미생물 · 생명공학회 1991 한국미생물·생명공학회지 Vol.19 No.1
A bacterial strain No.71, which produced alkaline protease, was isolated from soil and identified to the genus Bacillus. With the successive mutation, a mutant strain No. M-71, having high alkaline protease productivity, was obtanined from the parental strain No 71. Alkaline protease productivity of mutant strain No. M-71 was about 50 times as much as that of the parental strain No.71. The enzyme preparations showed strong activities toward casein, the optimum pH being 11.0 and the optimum temperature about $55^{\circ}C$.
점토광물을 이용한 산소환원의 전기화학적 촉매성에 관한 연구
오성훈,황진연,심윤보,이효민,윤지해 한국광물학회 2005 광물과 암석 (J.Miner.Soc.Korea) Vol.18 No.1
몇 가지 점토광물과 메틸바이올로젠 또는 메틸렌블루를 함유시킨 점토수식전극을 이용하여 산소환원에 대한 전기화학적 촉매성을 검토하였다. 점토광물로는 Na-몬모릴로나이트, Ca-몬모릴로나이트, 카오리나이트를 사용하였다. 점토수식전극은 유리탄소전극 표면에 점토 현탁액을 입히고 메틸바이올로젠을 흡착시킨 것을 사용하였으며, 전기화학적 산소환원의 정도는 순환 전압전류(cyclic voltammetry)으로 측정하였다. 실험결과, 다른 점토시료에 비하여 Na-몬모릴로나이트가 메틸바이올로젠의 흡착효과가 가장 크게 나타났고, 메틸바이올로젠을 흡착시킨 점토수식전극이 산소환원에 대한 촉매성이 월등히 우수하였다. 즉 촉매산소환원 피크가 242.6 ㎷ 만큼 +방향으로 이동하였다. 메틸바이올로젠을 흡착시킨 점토수식전극이 메틸렌블루를 흡착시킨 점토수식전극보다 산소환원에 대한 촉매성이 더 높게 나타났다. Ca-몬모릴로나이트의 경우는 변화가 없었으나 Na-몬모릴로나이트의 구조는 메틸바이올로젠의 흡착으로 변화되었다. 메틸바이올로젠- Na-몬모릴로나이트 점토수식전극을 현탁액의 점토 농도가 약 0.87 g/10 mL이고, 메틸바이올로젠의 수용액의 농도가 대략 2.5 mM일 때 산소환원 촉매 효과가 가장 탁월하였다. 지지전해질의 pH에 따른 점토수식 전극의 산소 환원 촉매성은 중성의 pH 범위(6.3과 8.3)에서보다 산성인 pH 3.7과 알칼리성인 pH12.7에서 월등히 크게 나타났다. The electrocatalytic reduction of O₂ was investigated with methyl viologen and methylene blue incorporated clay-modified electrodes. Clay suspensions were prepared with Namontmorillonite, Ca-montmorillonite, and kaolinite. The methyl viologen-clay modified electrodes were made by coating clay suspensions adsorbing methyl viologen on a glassy carbon electrode. Cyclic voltammetry were performed in aqueous media to investigate the electrocatalytic property of the modified electrode in reducing O₂. A Na-montmorillonite modified electrode showed the greatest adsorption capacity for methyl viologen. The modified electrode made of Na-montmorillonite suspension of 0.87 g/l0 mL and a 2.5 mM of methyl viologen solution showed the most effective electrocatalytic property, where the catalytic reduction potential was shifted by 242.6 ㎷ toward the positive potential. The electrocatalytic ability was more significant in acidic (pH=3.7) and alkaline (pH=12.7) media than the neutral pH range (6.3~8.3). The methyl viologen-Na-montmorillonite modified electrode had the good reproducibility and maintain the electrocatalytic property over 20 times reuse.