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Serotonin이 통각유발물질에 의해 유발된 척수반사에 미치는 영향
오석전,한희철,남숙현 고려대학교 의과대학 1987 고려대 의대 잡지 Vol.24 No.1
This present study was performed to investigate the effect of 5-hydroxytryptamine (5-HT, serotonin) on spinal flexion reflex evoked by algestic substance (KCI) in cat. This experiment was done on 26 α-motoneurons and 31 γ -motoneurons which showed responses to intra-arterial injection of KCI in gastrocnemius-soleus muscle. The results are as follows: 1. Potassium ion 3.8 ㎎ injected as a form of KCI increased the impulse discharges of α-and γ- motoneurons, which meant the flexion reflex. 2. The intra-arterial injection of 135 ㎍ 5-hydroxytryptamine (5-HT) increased the impulse discharges of α and γ flexor motoneurons of which responses had latency of 21 ± 3.3 sec. and duration of 81 ± 21.8 sec. 3. The intra-venous injection of 5-HT showed similar effects on the impulse discharges of spinal motoneurons. 4. The responses of α flexor motoneurons to KCI began to decrease at 5-6 min. after intra-arterial injection of 135 ㎍ 5-HT. The latency was increased to 5.2 ± 1.2 sec. and the duration was decreased to 57±10.3 sec. The changed responses were recovered at 52 min. after 5-HT injection. 5. 135 ㎍ 5-HT also reduced the responses of γ flexor motoneurons to KCI at 5-6 min. after injection. The latency was increased to 6.1±1.5 sec., the duration was decreased to 57±10.7 sec. and the changed responses were recovered at 58 min. after 5-HT injetion. To summarize the above results, 5-HT indirectly excites the spinal motoneurons but decreases the response of spinal motoneurons to KCI. It suggests that the 5-HT could reveal the analgesic effects by inhibition of the pain transmission in the spinal cord.