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대계와 실리비닌의 Mouse BV2 Microglial Cells에서 Lipopolysaccharide에 의해 유발된 염증반응에 대한 신경보호 효과
여현수,김동우,전찬용,최유경,박종형,Yeo, Hyun-Soo,Kim, Dong-Woo,Jun, Chan-Yong,Choi, You-Kyung,Park, Chong-Hyeong 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.1
Objectives : This study was designed to evaluate the neuroprotective effect of Cirsium japonicum and Silibinin on lipopolysaccharide-induced inflammation in BV2 microglial cells. Methods : We studied on the neuroprotective effect of lipopolysaccharide-induced inflammation using MTS assay, western blot, and nitric oxide detection on mouse BV2 microglial cells. Results : Cirsium japonicum dose-dependently (50${\mu}g/ml$${\sim}$$250{\mu}g/ml$) inhibited nitrite production and iNOS expression in lipopolysaccharide-induced BV2 microglia and also significantly reduced lipopolysaccharide-induced COX-2 activation in western blot. Silibinin dose-dependently (10${\mu}M$${\sim}$$100{\mu}M$) inhibited nitrite production and iNOS expression in lipopolysaccharide-induced BV2 microglial cells. Silibinin also significantly reduced lipopolysaccharide-induced COX-2 activation in western blot. Conclusion : These effects of neuroprotection related to anti-inflammation suggest that Cirsium japonicum and Silibininmay be useful candidates for the development of a drug for related neurodegenerative diseases.
급성기 중풍 환자의 사상체질과 안면피부에 관한 상관성 분석
여현수,이시형,하유군,정기용,백종우,최유경,김동우,박종형,조기호,고성규,한창호,방옥선,전찬용,Yeo, Hyeon-su,Rhee, See-hyung,Hsia, Yu-chun,Jung, Ki-yong,Baik, Jong-woo,Choi, You-kyung,Kim, Dong-woo,Park, Jong-hyung,Cho, Ki-ho,Ko, Seung-gyu,Han 대한중풍순환신경학회 2007 대한중풍.순환신경학회지 Vol.8 No.1
Objectives : This study was done to investigate the relationship between Sasang constitution and the facial skin in acute stroke patients Methods : In the time of period Mar. 2007 to Jun. 2007, 103 patients with stroke admitted in the department of Internal Medicine of Kyungwon University Seoul Oriental Medical Hospital, Kyungwon University Incheon Oriental Medical Hospital, Kyunghee University Oriental Medical Hospital, Dongguk Il-san Oriental Medical Hospital were included. We assessed the type of Sasang constitution, and the type of Sasang constitution of 51 patients were confirmed. We investigated general characteristics, stroke type and the relationship between Sasang constitution and the facial skin. Results : The color of face have no significant differences by Sasang constitution. But So-yang have blue and purple colored lips than So-eum and Tae-eum have. Conclusions : In this study, we found the relationship between Sasang constitution and the facial skin in acute stroke patients. But it seems necessary to investigate more cases to concrete conclusion on this theme.
황기, 당귀, 칠피, 천화분의 역형성갑상선암세포 SNU-80에 대한 항암효과
여현수,이민혜,고성규,최유경,전찬용,박종형,Yeo, Hyun Soo,Lee, Min Hye,Ko, Seong Gyu,Choi, You Kyung,Jun, Chan Young,Park, Jong Hyeong 대한예방한의학회 2014 대한예방한의학회지 Vol.18 No.1
Objective : This study was performed to investigate the antineoplastic effect of Astragalus membranaceus, Angelica gigas, Rhus verniciflua Stokes and Trichosanthes kirilowii on SNU-80 anaplastic thyroid carcinoma cell line. Method : We examined whether our herbal medicines decreases cell growth rate of SNU-80 using MTT assay. We performed western blot analysis to verify that our herbal medicines induces apoptosis via caspase-dependent mechanism. We also performed wound healing assay and transwell invasion assay to investigate whether our herbal medicines affects the migration and invasion of anaplastic cancer cells, SNU-80. We also carried out ELISA assay to know our herbal medicines suppresses the expression of proinvasive molecules, such as VEGF and MMP-2 secreted from SNU-80. Results : MTT assay demonstrates that Angelica gigas, Rhus verniciflua Stokes, and Trichosanthes kirilowii suppressed strongly the growth of SNU-80. Western blot analysis demonstrates that Trichosanthes kirilowii induces apoptosis activating the cleavages of caspases (caspase-8, caspase-3) and PARP. Wound healing assay demonstrates that Rhus verniciflua Stokes, and Trichosanthes kirilowii inhibited the migration of SNU-80. Transwell invasion assay demonstrates that Rhus verniciflua Stokes, and Trichosanthes kirilowii inhibited the invasion of SNU-80. Elisa assay demonstrates that Astragalus membranaceus, Angelica gigas, Rhus verniciflua Stokes, and Trichosanthes kirilowii suppressed the expression of VEGF and MMP-2. Conclusion : We could conclude that several herbal medicines suppresses the growth and inhibits the migration and invasion of SNU-80 which is anaplastic thyroid cancer cells. Especially, Rhus verniciflua Stokes, Trichosanthes kirilowii had stronger anti-cancer effect suggesting that we can apply them to treat anaplastic thyroid cancer.
수종 한약 복합물의 역형성갑상선암세포 SNU-80에 대한 항암효과
여현수,이민혜,최유경,전찬용,박종형,Yeo, Hyun-Soo,Lee, Min-Hye,Choi, You-Kyung,Jun, Chan-Young,Park, Jong-Hyeong 대한한방내과학회 2014 大韓韓方內科學會誌 Vol.35 No.4
Objectives: The purpose of this study was to investigate the antineoplastic effect of several herbal medicine mixtures (compositions of Astragalus membranaceu, Angelica gigas, Trichosanthes kirilowii, Panax ginseng, Rhus verniciflua Stokes) on the SNU-80 anaplastic thyroid carcinoma cell line. Methods: MTT assay was used to examine whether our herbal medicine mixtures decreased cell growth rate of SNU-80. Wound healing assay and Transwell invasion assay was performed to investigate whether our herbal medicine mixtures affect the migration and invasion of anaplastic cancer cells, SNU-80. ELISA assay was performed to know if our herbal medicine mixtures suppressed the expression of pro-invasive molecules, such as vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) secreted from SNU-80. Results: MTT assay demonstrated that A. membranaceus:A. gigas:T. kirilowii=1:1:1 or 3:1:1, A. membranaceus:A. gigas :T. kirilowii:P. ginseng=1:1:1:1 or 3:1:1:1, A. membranaceus:A. gigas:T. kirilowii:P. ginseng:R. verniciflua Stokes=1:1:1:1:1 or 3:1:1:1:1 strongly suppressed the growth of SNU-80. Wound healing assay demonstrated that A. membranaceus:A. gigas=3:1, A. membranaceus:A. gigas:T. kirilowii=1:1:1 or 3:1:1, A. membranaceus:A. gigas:T. kirilowii:P. ginseng=1:1:1:1 or 3:1:1:1, A. membranaceus:A. gigas:T. kirilowii:P. ginseng:R. verniciflua Stokes=1:1:1:1:1 or 3:1:1:1:1 inhibited the migration of SNU-80. Transwell invasion assay demonstrated that A. membranaceus:A. gigas=1:1, A. membranaceus:A. gigas:T. kirilowii =1:1:1 or 3:1:1, A. membranaceus:A. gigas:T. kirilowii:P. ginseng=1:1:1:1, A. membranaceus:A. gigas:T. kirilowii:P. ginseng :R. verniciflua Stokes=1:1:1:1:1 or 3:1:1:1:1 inhibited the invasion of SNU-80. ELISA assay demonstrated that A. membranaceus :A. gigas:T. kirilowii=1:1:1 or 3:1:1, A. membranaceus:A. gigas:T. kirilowii:P. ginseng:R. verniciflua Stokes=1:1:1:1:1 suppressed the expression of VEGF. Also, A. membranaceus:A. gigas=1:1, A. membranaceus:A. gigas:T. kirilowii=1:1:1 or 3:1:1, A. membranaceus :A. gigas:T. kirilowii:P. ginseng=1:1:1:1 or 3:1:1:1, A. membranaceus:A. gigas:T. kirilowii:P. ginseng:R. verniciflua Stokes =1:1:1:1:1 or 3:1:1:1:1 suppressed the expression of MMP-2. Conclusions: The results obtained in this study suggest that several herbal medicine mixtures suppresse the growth and inhibit the migration and invasion of SNU-80, which is anaplastic thyroid cancer cells. Especially, A. membranaceus:A. gigas: T. kirilowii=1:1:1 mixture had a stronger anti-cancer effect.
급성기 중풍 환자의 음주 여부와 습담 변증의 상관관계 연구
여현수,이시형,하유군,정기용,백종우,최유경,김동우,박종형,조기호,고성규,한창호,방옥선,전찬용,Yeo, Hyeon-su,Rhee, See-hyung,Hsia, Yu-chun,Jung, Ki-yong,Baik, Jong-woo,Choi, You-kyung,Kim, Dong-woo,Park, Jong-hyung,Cho, Ki-ho,Ko, Seung-gyu,Han 대한중풍순환신경학회 2007 대한중풍.순환신경학회지 Vol.8 No.1
Objectives : This study was done to investigate the relationship of drinking and Dampness-Phlegm pattern in acute stroke patients. Methods : In the time of period Mar. 2007 to Jun. 2007, 103 patients with stroke admitted in the department of Internal Medicine of Kyungwon University Seoul Oriental Medical Hospital, Kyungwon University Incheon Oriental Medical Hospital, Kyunghee University Oriental Medical Hospital, Dongguk Il-san Oriental Medical Hospital were included. Patients were hospitalized within a month after the onset of stroke. Stroke patients were interviewed by residents who studied standard operation procedures in Fundamental Study for Standardization and Objectification of Differentiation and Pattern Identification of Syndrome of Oriental Medicine for Stroke. A questionnaire was completed by a question-and-answer form between patients and residents after explanation details to patients and the agreement of patients. Results : Drinking subjects have tendency of Dampness-Phlegm Pattern(p=0.096), but don't have statistical significance(p<0.05). Conclusions : In this study, we found the relationship of drinking and Dampness-Phlegm Pattern. To acquire more concrete conclusion on this theme, we need more research.
여현수,전찬용,최유경,고성규,고호연,박종형,Yeo, Hyeon-Su,Jun, Chan-Yong,Choi, You-Kyung,Ko, Seung-Gyu,Ko, Ho-Yeon,Park, Jong-Hyeong 대한예방한의학회 2008 대한예방한의학회지 Vol.12 No.3
Objective : This study was conducted to integrate the results of studies which show the relationship between risk factors(smoking, drinking, intaking coffee, exercise, BMI, family history, hypertension, DM, hyperlipidemia, heart disease, TIA) and the incidence of stroke in Korean adults. Methods : We surveyed 17 stroke-related articles, published between 1995 and 2007, and conduct meta-analysis. And we estimated common odds ratio(OR). Results : The overall OR of risk factors associated CVD were as follow : Smoking had a 2.488 OR, no regular exercise had a 1.942 OR, $BMI{\geq}25$ had a 1.848 OR, hypertension had a 6.053 OR, DM had a 2.931 OR, heart disease had a 5.455 OR, and TIA had a 5.238 OR. Conclusion : The result of this study suggest that smoking, no regular exercise, $BMI{\geq}25$, hypertension, DM, heart disease, and TIA are important risk factor of stroke.
비디오자기모델링 기법을 적용한 동작관찰훈련이 뇌졸중으로 인한 편마비 환자의 상지기능, 상지의 근활성도에 미치는 영향 : 예비 연구
여현수,박주형 한국콘텐츠학회 2023 한국콘텐츠학회논문지 Vol.23 No.8
본 연구는 비디오자기모델링 기법을 적용한 동작관찰훈련이 뇌졸중으로 인한 편마비 환자의 상지기능, 상지의 근활성도에 미치는 영향에 대해 알아보고자 하였다. 본 연구는 총 22명의 뇌졸중 환자를 대상으로 비디오자기모델링 기법을 적용한 동작관찰훈련군과 타인을 관찰한 전통적인 동작관찰훈련군으로 무작위 배정하여 사전-사후설계의 적용을 통해 두 그룹의 변화를 비교하였다. 중재는 두 그룹 모두 동일하게 1일 1회 30분, 주 5회, 4주간 총 20회기를 진행하였다. 측정은 상지기능을 평가하기 위해 FMA-UE, ARAT, MFT를 사용하였고, 상지의 근활성도를 평가하기 위해 sEMG를 사용하였다. 그룹 별 중재 전 후 점수 비교에서 두 그룹 모두 FMA-UE, ARAT, MFT에서 유의미한 향상이 나타났다(p<.05). 중재 후 그룹 간 점수 변화량 비교에서는 실험군이 대조군보다 FMA-UE, ARAT, MFT에서 유의미한 향상이 나타났으며(p<.05), sEMG에서는 더 높은 평균 점수의 향상이 나타났다. 따라서, 비디오자기모델링 기법을 적용한 동작관찰훈련이 기존의 전통적인 동작관찰훈련보다 뇌졸중 환자의 상지기능과 상지의 근활성도 향상에 더욱 효과적인 중재 방법임을 알 수 있었다.
이시형,정기용,여현수,하유군,백종우,최유경,전찬용,김동우,박종형,Rhee, See-hyung,Jung, Ki-yong,Yeo, Hyun-soo,Hsia, Yu-chun,Baek, Jong-woo,Choi, You-kyung,Jun, Chan-yong,Kim, Dong-woo,Park, Chong-hyeong 대한중풍순환신경학회 2007 대한중풍.순환신경학회지 Vol.8 No.1
Objectives : This study was prepared for investigating the clinical features of stroke patients. Methods : We retrospectively reviewed the medical records of 75 patients who were admitted to Department of Internal Medicine, College of Oriental Medicine, Kyung-Won University with a diagnosis of stroke from Jan. 1, 2005 to Dec. 31, 2005. Results : Ischemic stroke(include TIA, 93.3%) was more common than hemorrhagic stroke(6.7%). The incidence in male was 36.0%, in female was 64.0% and the most prevalent age group is over-sixties. Cerebral infarction was most frequently noticed in MCA-infarction and hemorrhage in putamen & thalamus. Hypertention, the most preceding diseases, followed by diabetes mellitus and CVA. The rate of recurrence was 21.3%. Cerebral infarction and cerebral hemorrhage was much occurred after rising. The most patients visited the hospital within 24 Hours. The most common symptoms in admission time were motor weakness and speech disorder. The complication was mostly urinary tract inflamation. Conclusions : Our study on CVA patients was similar to previous studies from 1994 to 2004. In most cases, western and oriental treatment and medicine were given synthetically.
급성기와 회복기 중풍 환자의 변증 유형의 상관관계 연구
백종우,하유군,여현수,박종형,최유경,고호연,조기호,고성규,한창호,방옥선,전찬용,Baik, Jong-Woo,Hsia, Yu-Chun,Yeo, Hyeon-Su,Park, Jong-Hyung,Choi, You-Kyung,Ko, Ho-Yeon,Cho, Ki-Ho,Ko, Seung-Gyu,Han, Chang-Ho,Bang, Ok-Sun,Jun, Chan-Yong 대한중풍순환신경학회 2008 대한중풍.순환신경학회지 Vol.9 No.1
Objectives : This study was done to investigate the relationship of differentiation of the patten identification in stroke patients between acute and convalescent stage. Methods : In the time of period Apr. 1st 2007 to Sep. 29th 2008, 903 patients with stroke admitted in the department of Internal Medicine of Kyungwon University Oriental Medical Hospital, Kyunghee University Oriental Medical Hospital, Dongguk University Oriental Medical Hospital were included. Patients were hospitalized within a month after the onset of stroke. Stroke patients were interviewed by doctors who studied standard operation procedures. A questionnaire was completed by a question-and-answer form between patients and doctors after explanation details to patients and the agreement of patients. Results : The frequency of fire-heat patten was the highest in acute stage of stroke and the one of deficiency of Yin group was the highest in convalescent stage of stroke. This result doesn't have statistical significance. (p<0.05) Conclusions : In this study, we found the relationship of differentiation of the patten identification in stroke patients between acute and convalescent stage. Further, we have concluded that this difference should be considered in the management for stroke patients.