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FAT10 Induces cancer cell migration by stabilizing phosphorylated ABI3/NESH
엄효진,정호임,이범구,김예린,이지현,노종성,이승근,박혜련,William H. Robinson,손동현 한국통합생물학회 2023 Animal cells and systems Vol.27 No.1
The WAVE regulatory complex (WRC) is involved in various cellular processes by regulating actinpolymerization. The dysregulation of WRC components is associated with cancer development. ABI family member 3 (ABI3)/new molecule including SH3 (NESH) is one of the WRC componentsand it has been reported that ABI3 phosphorylation can affect WRC function. Although severalresidues of ABI3 have been reported to be possible phosphorylation sites, it is still unclearwhich residues are important for the function of ABI3. Furthermore, it is unclear how thephosphorylated form of ABI3 is regulated. Here, we demonstrate that ABI3 is stabilized by itsinteraction with human leukocyte antigen-F adjacent transcript 10 (FAT10). Using phospho-deador phospho-mimetic mutants of ABI3, we showed that serine 213 and 216 are importantphosphorylation sites of ABI3. In particular, FAT10 has a higher affinity for the phosphorylatedform of ABI3 than the non-phosphorylated form, and it stabilizes the phosphorylated form morethan the non-phosphorylated form through this differential affinity. The interaction betweenFAT10 and the phosphorylated form of ABI3 promoted cancer cell migration. Therefore, ourresults suggest that FAT10 stabilizes the phosphorylated form of ABI3, which may lead to WRCactivation, thereby promoting cancer cell migration.
Using and Reporting of Modified Scales in Behavioral and Social Sciences
엄효진,이명진 한국조사연구학회 2019 조사연구 Vol.20 No.2
This paper is to suggest a checklist for defending or justifying the use of scales that have been modified for the specific purpose of the research in behavioral sciences. The checklist contains issues about two measurement related concepts, reliability and validity. Examples based on empirical data are presented to illustrate and demonstrate the issues in the checklist. Discussion about the practical implications of the checklist is presented.
엄효진 고려대학교 한국사회연구소 2018 한국사회 Vol.19 No.2
This study investigates the optimal number and identification of dimensions for measuring the meaning of social identities in Korean society. Two main procedures of factor analysis were applied to the semantic differential scales for the affective meaning of social identity in Korea (Choi, Lee, and Kim, 2003). The three indeterminacies in factor analysis (e.g., communality/factor extraction, the number of common factors, and factor rotation) were discussed. Especially, ways to determine the number of common factors for the data used in Choi et al. (2003) were investigated in conjunction with estimation/extraction methods (e.g., principal component and weight least squares). Two computer programs, SPSS and Mplus, were employed to obtain factor analysis results. Three factors in the three-dimensional space of evaluation, potency, and activity (EPA) seemed to be a reasonable choice regardless of the estimation/extraction methods. These findings have the benefit of enabling future researchers to harness existing theoretical tools for studying Korean society.