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Cellular-level Biomechanics of Ultrasound
엄원석,Ohm, Won-Suk The Acoustical Society of Korea 2010 韓國音響學會誌 Vol.29 No.e1
This article reviews recent developments in the emerging field of cellular-level biomedical ultrasonics with the specific focus on the mechanics of ultrasound-cell interaction. Due to the nature of the field at its relative infancy, the review poses more questions than it provides answers. Discussed are topics such as the basic structure of a biological cell, the origin of cell's elasticity, a theoretical framework for ultrasound-cell interaction, and shape deformation of cells and its measurement, Some interesting problems for future study are proposed.
파라메트릭 어레이 음원의 전기적 빔 조향 현상 예측을 위한 수치 해석 기법 연구
빈경훈,엄원석,문원규,Been, Kyounghun,Ohm, Won-Suk,Moon, Wonkyu 한국음향학회 2019 韓國音響學會誌 Vol.38 No.5
파라메트릭 어레이란 매질의 비선형성을 이용하여 작은 크기의 방사판에서 고지향성 저주파음을 발생시키는 현상을 말한다. 이러한 파라메트릭 어레이의 유용성을 높이기 위해 저주파 음향 빔 조향 연구가 진행 되고 있으며, PD(Product Directivity) 모델을 이용하여 빔 조향 현상이 간편하게 예측되고 있다. 그러나 PD 모델은 준선형 조건에서 가우시안 음원만 적용이 가능하며, 저주파 음향 빔 폭의 예측 정확성이 떨어진다. 본 논문에서는 PD 모델의 한계를 극복할 수 있는 파라메트릭 어레이의 빔 조향 특성 예측 방법에 대해 연구하였다. 이를 위해 파라메트릭 어레이 현상 예측에 널리 사용되는 KZK(Khokhlov-Zabolotskaya-Kuzentsov) 방정식의 수치 해석 알고리즘을 개선하였다. 그리고 전기적 조향 조건을 적용하여 빔 조향 특성을 계산, 실험 결과와 비교 하였다. 그 결과 개선된 알고리즘을 이용하면 준선형 조건에 해당되지 않는 파라메트릭 어레이 음원에서도 저주파 빔 조향 특성 예측이 가능함을 확인하였다. The parametric array phenomenon refers to the generation of a high directivity low frequency wave from a small size radiation plate using the nonlinearity of the medium. In order to improve the usability of parametric array, the beam steering method of low frequency wave is researched, and the beam steering phenomenon is predicted easily using the PD (product directivity) model. However, the PD model can only be applied to Gaussian sources under quasi-linear conditions. Also, the prediction accuracy of low frequency wave beam width is poor. In this paper, a method for predicting the beam steering characteristics of a parametric array that can overcome the limitation of the PD model is investigated. For this purpose, the numerical analysis algorithm of the KZK (Khokhlov-Zabolotskaya-Kuzentsov) equation widely used for parametric array phenomenon prediction is improved. Thus, the beam steering characteristics are calculated by applying the electrical beam steering condition and comparing experimental results. As a result, the numerical analysis using the modified KZK equation algorithm in this study confirms that the beam steering phenomenon can be predicted even in a parametric array source that does not correspond to the quasi-linear condition.
애완토끼에서 발생한 Cheyletiellosis 피부염에 대한 selamectin 치료 1례
허우필,오원석,오현호,이근우,엄기동,오태호 한국임상수의학회 2005 한국임상수의학회지 Vol.22 No.1
An about 5-month-old, female rabbit was presented with pruritus, alopecia and mucopurulent ocular discharge. On physical examination mild to moderate scales on whole body were observed. Dermatological lesions such as alopecia, erythema, papules, pustules and crusts were observed in the eyelids, nose, inner pinna, medial sites of four feet, metacarpal and metatarsal areas, and cranial site of left stifle joint. Also, mild conjunctivitis, blepharitis and keratitis were found. For extensive dermatologic diagnostic evaluation skin scraping, tape stripping, impression smear, combing, wood' light, bacterial culture and fungal culture were performed. Finally, Cheyletiella spp. was found by combing. Many heterophils and eosinophills were appeared in impression smear. The result of fungal culture was negative. Pasteurella spp was cultured. Definitive diagnosis of Cheyletiellosis and secondary Pasteurella spp infection were established. The rabbit was treated with 6 mg/kg of selamectin topically every two weeks and restricted in cage for one month. During one month of initial treatment, clinical signssuch as pruritus, alopecia, scales, papules, pustules and crusts were remarkably improved. However, in spite of good therapeutic response of selamectin the rabbit was dead suddenly at 22 days after second administration of selamectin. This case showed that selamectin was possibly effective for cheyletiellosis in rabbit; safety of selamectin for rabbit was not identified.