구강암 발생 과정에서 TGF-α 및 TGF-β 발현에 관한 연구

양희창,이동근,김은철,Yang, Hee-Chang,Lee, Dong-Keun,Kim, Eun-Cheol 대한악안면성형재건외과학회 1997 Maxillofacial Plastic Reconstructive Surgery Vol.19 No.4

Though many genetic and epigenetic alterations have been identified in hamster oral carcinogenesis model, there is no information about the possible role of transforming growth factor related with oral cancer. The purpose of this paper was to find the expression patterns of transforming growth factor alpha and beta during the stages of complete oral carcinogenesis model in hamster. 0.5% 9, 10-dimethyl-1, 2-benzanthracene(DMBA) in mineral oil was topically applied to the buccal pouch of 75 hamster three times a week during the experimental periods. The experimental animals were subdivided into two groups of control and experiment. Only the mineral oil was applied to the control group. 0.5% DMBA in mineral oil was applied to the experimental groups of 6, 8, 10, 12, 14, 16, 18 and 20 weeks. The expression of the $TGF-{\alpha}$ and $TGF-{\beta}$ protein were evaluated by the distribution and intensity of positive cells during the carcinogenesis using the immunohistochemical study. The following results were obtained ; 1. The buccal pouch epithelium of hamster was histologically changed to the dysplasia at 6, 8, 10 weeks, carcinoma in situ at 12 weeks, and squamous cell carcinoma at 14 weeks. 2. The expression of the $TGF-{\alpha}$ was restricted to the parabasal and basal layers of the normal and dysplastic mucosa, but those positive cells were extended to the spinous layers of the epithelium in the carcinoma. 3. The degree of $TGF-{\alpha}$ expression was markedly decreased in the carcinoma at 16, 18, 20. The strong positive staining in the center of cancer islands and weak positive staining in periphery of tumor were seen at the stage of squamous cell carcinoma. 4. The positive index of the $TGF-{\alpha}$ had a tendency to increase with DMBA- applied time. There was a statistically significant difference between 12, 18, 20 experimental group and control group (p<0.05). 5. The expression of the $TGF-{\beta}$ was shown at the cytoplasm of all control and experimental groups, and the parabasal and basal layers of the normal and dyslastic mucosa, but it was shown at the basal layers of the epithelium in the carcinoma. 6. $TGF-{\beta}$ was expressed diffusely at 16, 18, 20 experimental group. The strong positive staining in the center of cancer islands and positive staining in periphery of tumor were seen at the stage of squamous cell carcinoma. From the above findings, the expression of $TGF-{\alpha}$ and ${\beta}$ in oral carcinogenesis model seems to have two formal stages, the first being an overexpression step as reaction to uncontrolled growth and the second being one in which external protein accumulate in the surrounding stroma and intracytoplasm. Overexpression of $TGF-{\alpha}$ and ${\beta}$ may have important cooperative roles for the promotion of cancer and factor of prognosis.

수술방법에 따른 부안검 수술의 결과

양희창(Hee Chang Yang),최웅철(Woong Chul Choi) 대한안과학회 1999 대한안과학회지 Vol.40 No.11

Kearns-Sayre 증후군 1예

양희창(Hee Chang Yang),최웅철(Woong Chul Choi) 대한안과학회 1999 대한안과학회지 Vol.40 No.3

하악골 골절선상 치아의 예후에 대한 임상적 연구

양희창(Hee Chang Yang),김수남(Soo Nam Kim),이동근(Dong Kuen Lee),임창준(Chang Joon Yim) 대한구강악안면외과학회 1990 대한구강악안면외과학회지 Vol.16 No.3

This article is a retrospective study on the 188 patients with 327 fracture lines and 502 teeth in the tooth-bearing mandibular fracture. The patients were treated at the Department of Oral and Maxillofacial Surgery in Wonkwang University Hospital from August, 1984 to Sepetmber, 1988. The total number of removed teeth in the mandibular fracture line were 104 (20.5%) and that of the retained teeth were 398(79.5%). The complications of the tooth-retained-group were 24.6% and those of the tooth-removed-group were 24.4%. Owing to the comparison of the complications of the fracture group in which the teeth were removed with the other fracture group in which the teeth were retained, it is suggested that removal of the teeth in the fracture line could not minimize the complications. The most common complication of the tooth-retained-group was acute infection (58.6%) and that of the tooth-removed-group was malocclusion(41.2%). It is concluded that the teeth in the mandibular fracture line can be preserved with the proper antibiotic therapy, except the case of the hopelessly traumatized teeth or severely complicated case.

전자무역 : 수정된 원형/행동경향 모형을 통한 SNS이용자들의 상호작용성이 이용저하에 미치는 영향

박수홍 ( Soo Hong Park ),조희영 ( Hee Young Cho ),양희창 ( Hoe Chang Yang ) 한국통상정보학회 2014 통상정보연구 Vol.16 No.3

본 연구는 최근 SNS의 폭발적인 성장에도 불구하고 공개형 SNS에 비해 폐쇄형 SNS가 활성화되고 있는 것이 장기적으로는 SNS 콘텐츠를 제공하는 기업이나 SNS를 이용해 마케팅전략을 구사하는 기업들에 모두 부정적인 영향을 미칠 것이라는 점에 주목하고 SNS 이용저하의 원인을 찾고자 하였다. 연구수행을 위해 대학생 이상의 남녀 성인 총 205명을 대상으로 설문을 실시하고 이중 불성실한 응답을 한 8명을 제외한 197명의 유효설문지를 분석에 활용하였다. 수정된 원형/행동경향 모형에서 제안한 두 가지의 경로인 즉흥적이거나 상황에 반응하여 행동하는 행동경향의 경로와 합리적으로 생각하여 행동하는 경로가 각각 존재한다는 것을 확인하였다. 이론적 근거와 수정지수를 사용한 수정모형 분석결과 상호작용성은 즉흥적이거나 상황에 반응하여 행동하는 행동경향 경로 뿐 아니라, 합리적으로 생각하여 행동하는 행위의도 경로에 영향을 미치는 양면성을 지니고 있다는 것을 확인할 수 있었다. This study focused on causes of use reluctant intention because closed SNS was more active than open SNS was despite tremendous growth of SNS to have negative influence upon not only SNS contents suppliers but also marketing business using SNS. The survey were conducted a total of 205 participants with adult over colleague student, 197 copies that excluded questionnaire with unfaithful answer were used in the analysis, and we used path analysis of structural equation modeling. The results of modified path model showed that interactivity was influenced by value, and then affecting “trust → satisfaction → using reluctant intention” path and “satisfaction → using reluctant intention”path. These result reflected that interactivity have a double-edged sword and value is very important standard to make a positive of negative role of interactivity. These results suggested that interactivity was found to have influence upon not only behavioral willingness that took actions depending upon either improvisation or situation but also behavioral intention path that thought and took actions in reasonable way. The interactivity had double-edged sword to help develop SNS and to produce negative results.

PILOMATRICOMA 치험 1례

김은철,이창우,임창준,이동근,김수남,양희창 大韓顎顔面成形再建外科學會 1990 Maxillofacial Plastic Reconstructive Surgery Vol.12 No.3

The pilomatricoma (calcifying epithelioma of Malherbe) is rare benign hard, spherical and freely movable cutaneous tumor, which was differentiated from hair cells, particulary hair cortex cells. It is usually occured as a single, asymptomatic, 0.5 cm to 3.0 cm sized, deep seated, firm nodule, covered by normal or pink skin. It arises chiefly in young people, including children, and most often in the head, neck and upper extrimites. The authers experienced a case of pilomatricoma which occured in preauricular region. This case was summarized as follows. 1. 10 years old female has suffered from hard subepidermal mass on preauricular area and she visited our out patient clinic. So we performed surgical extirpation and the excised specimen was pathologically examined. 2. Grossly the tumor measures 2.0 cm in diameter and firm, bosselated, spherical shaped which covered by a thin layer of fibrous tissue. On cut section, it shows spicular gritty surfaces, well encapsulation, interwoven and keratotic lamellae. 3. Histopathologically, the epithelial masses of the tumor are composed of two type of cells, basophilic cells and shodow cells. The basophilic cells resemble hair matrix cells which posses round or elogated, deeply basophilic nuclei and scanty cytoplasm.The shadow cells show a central, unstained shadow at the site of the lost nucleus. Gradual development of basophilic cells into shadow cells can be observed. Foci of calcification are present within the lobule of shadow cells. The stroma of the tumor shows a considerable foreign body giant cell reaction adjacent to the shadow cells. 4. No recurrence was observed until post - operative 40 months.

구강암 발생 과정에서 TGF-α 및 TGF-β 발현에 관한 연구

양희창,이동근 원광대학교 생체재료·매식연구소 1997 원광생체재료·매식 Vol.6 No.1

Though many genetic and epigenetic alterations have been identified in hamster oral carcinogenesis model, there is no information about the possible role of transforming growth factor related with oral cancer. The purpose of this paper was to find the expression patterns of transforming growth factor alpha and beta during the stages of complete oral carcinogenesis model in hamster. 0.5% 9, 10- dimethyl-1, 2-benzanthracene(DMBA) in mineral oil was topically applied to the buccal pouch of 75 hamsters three times a week during the experimental periods. The experimental animals were subdivided into two groups of control and experiment. Only the mineral oil was applied to the control group. 0.5% DBMA in mineral oil was applied to the experimental groups of 6,8,10,12,14,16,18 and 20 weeks. The expression of the TGF-α and TGF-β protein were evaluated by the distribution and intensity of positive cells during the carcinogenesis using the immunohistochemical study. The following results were obtained; 1. The buccal pouch epithelium of hamster was histologically changed to the dysplasia at 6, 8, 10 weeks, carcinoma in situ at 12 weeks, and squamous cell carcinoma at 14 weeks. 2. The expression of the TGF-α was restricted to the parabasal and basal layers of the normal and dysplastic mucosa, but those positive cells were extended to the spinous layers of the epithelium in the carcinoma. 3. The degree of TGF-α expression was markedly decreased in the carcinoma at 16, 18, 20. The strong positive staining in the center of cancer islands and weak positive staining in periphery of tumor were seen at the stage of squamous cell carcinoma 4. The positive index of the TGF-α had a tendency to increase with DBMA- applied time. There was a statistically significant difference between 12, 18, 20 experimental group and control group (p<0.05). 5. The expression of the TGF-β was shown at the cytoplasm of all control and experimental groups, and the parabasal and basal layers of the normal and dysplastic mucosa, but it was shown at the basal layers of the epithelium in the carcinoma. 6. TGF-β was expressed diffusely at 16, 18, 20 experimental group. The strong positive staining in the center of cancer islands and positive staining in periphery of tumor were seen at the stage of squamous cell carcinoma From the above findings, the expression of TGF-α and β in oral carcinogenesis model seems to have two formal stages, the first being an overexpression step as reaction to uncontrolled growth and the second being one in which external protein accumulate in the surrounding stroma and intracytoplasm. Overexpression of TGF-α and β may have important cooperative roles for the promotion of cancer and factor of prognosis.

桂枝의 芳香性物質이 家兎의 腎·脾 및 循環系機能에 미치는 影響

梁熙昌,具本泓 경희대학교 1989 慶熙醫學 Vol.5 No.1

하악 과두 골절 환자에서 Lag Screw를 이용한 치료시 예후에 관한 임상적 연구

민승기,이동근,배진오,양희창 大韓顎顔面成形再建外科學會 1997 Maxillofacial Plastic Reconstructive Surgery Vol.19 No.2

Treatment of condylar fracture is still controversial, but the indication of surgical mangement is increased due to improved fixation methods and surgical techniques. In this article, we report our clinical and radiological results with the use of lag screw osteosyn-thesis for fixation of fractured mandibular condyle. 12 case of condyle fracture treated by open reduction and fixation with lag screw were monitored for an average of 10 months (range from 6 months to 19 months) postoperatively. The obtained results are as follows : 1. Postoperative maximum mouth opening is achieved over 40mm except one patient. 2. Although slight crepitus and deviation of mandible during mouth opening were found, Tempo-romandibular joint problem is satisfactory in all but one patient. 3. Distal migration of screw and resorption of fractured fragment were found in each 2 patients, but good functional recovery was achieved in all. According to the above results, we think that lag screw osteosynthesis is relatively indicated in level III or IV condylar fracture.

"안면골 골절의 임상적 고찰"

양희창,이동근,임창준 大韓顎顔面成形外科學會 1989 Maxillofacial Plastic Reconstructive Surgery Vol.11 No.1

This is a retrospective study on 452 patients with maxillofacial bone fracture. The patients were treated at the Dept. of Oral and Maxillofacial Surgery WON KWANG UNIV. HOSPITAL from Aug. 1. 1984 to Sept. 30, 1988. The results were as follows. 1. The facial bone fractures occured most frequently in the twenties (35.3%) and male were predominant(75%) than female. 2. The most frequent etiologic factor was traffic accident. 3. The most common location of facial bone fracture was mandible(57%). Zygomatic bone & arch(39.9%) were most common on middle 1/3 of the face and symphysis(37.1%) were most common on the mandible. 4. The time from injury to treatment was variable from under the 1 week (65%) to over the 1 week(35%). In most case of the patients were treated beyond the 3 days(51.5%). 5. The relationship of intermaxillary fixation period and treatment method was an intimate relationship. The IMF period was reduced by the use of plate and screw osteosynthesis. 6. The weight loss was proportioned to intermaxillary fixation period.