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Rhei Rhizoma and Chunghyuldan Inhibit Pancreatic Lipase
Yang, Hyung-Kil,Kim, Young-Suk,Bae, Hyung-Sup,Cho, Ki-Ho,Shin, Ji-Eun,Kim, Nam-Jae,Kim, Dong-Hyun WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-
Pancreatic lipase-inhibitory activity of the rhizome of Rhei Rhizoma and its antihyperlipidemic activity were measured Rhei Rhizoma inhibited pancreatic lipase with IC_(50) value of 6.5 ㎎/㎖ (triolein as a substrate). Rhei Rhizoma significantly inhibited serum TG level in corn oil feeding-induced mice, and serum TG and cholesterol in Triton WR-1339-induced hyperlipidemic mice. However, Rhei Rhizoma did not show the hypolipidemic activity in high cholesterol diet-induced hyperlipidemic mice. When in vitro pancreatic lipase-inhibitory and in vivo antihyperlipidemic activities of Whangryunhaedoktang (WT) and Chunghyuldan (DC) which is consisted of ingredients of WT and Rhei Rhizoma, were measured, CD exhibited more potent inhibitory activities than WT. Therefore these results suggest that antihyperlipidemic activity of Rhei Rhizoma and CD may be more or less originated from the inhibition of pancreatic lipase.
대황황련해독탕의 사염화탄소 유발 간장해 보호효과 미치 급성독성
김영석,정은아,장종철,양형길,김남재,조기호,배형섭,이경섭,김동현 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2002 東西醫學硏究所 論文集 Vol.2002 No.-
ABSTRACT - This study was performed to evaluate hepatoprotective effect of daewhang-whangryunhaedok-Tang(DWT) on liver injured rats induced by CCI_4 and the acute oral toxicity of it in mice. The activities of serum transaminase(ALT/AST), alkaline phosphatase(ALP) and lactic dehydrogenase(LDH), the levels of serum total cholesterol(TC) and triglyceride(TG), change of liver enlargement, and inhibitory activities of lipid perotidation, catalase and glutathione-S-transfrease(GST) in liver microsome were determined in hepatotoxic rats induced by CCI_4. DWT was significantly reduced the serum ALT, AST, ALP, LDH. TC and TG lecels. And, the increase of lipid peroxidation, decrease of catalase and GST activities in the liver microsome of CCI_4-intoxicated rat were significantly improved by the treatment of DWT. Male and female mice were administered maximum dosages of 5.000 mg/kg b.w. of DWT. After single oral administration of DWT to mice, we observed them daily for 2 weeks.DWT did not induce any toxic signs in the mortalitie, clinical signs, body weight changes, and gross necropsy finfings of mice. Based in these results. It is concluded that DWT may have the hepatoprotective effect on CCI_4 induced hepatotoxicity in rats. Also. DWT may have no side effect and its LD_50 value may be over 5.000mg/kg b.w. in mice.
Daio-Orengedokuto Inhibits HMG-CoA Reductase and Pancreatic Lipase
KIM, Young-Suk,JUNG, Eun-Ah,SHIN, Ji-Eun,CHANG, Jong-Chul,YANG, Hyung-Kil,KIM, Nam-Jae,CHO, Ki-Ho,BAE, Hyung-Sup,MOON, Sang-Kwan,KIM, Dong-Hyun WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2002 東西醫學硏究所 論文集 Vol.2002 No.-
To evaluate the actihyperlipidemic activities of Oreagedokuto (OT) and Daio-Orengedokuto (DOT), the in hibitory effects of these polyprescriptions on HMG-CoA reductase aud pancrealic lipase ond on the rat hyper-lipidemic model induced by Triton WR-1339 were metsured. 0T potently inhibited HMG-CoA reductase but did not inhibit lipose. Among their ingredient. Coptidis Rhizoma was the most potent inhibitor, followed by Rhei Rhiaoma. The HMC-CoA reductase-inhibitory activity of 80% EtOH extract was superior to that of water extrart. However, DOT potently inhibited HMG CoA-reductase as well as pancreatic lipise. In the rat hyperlipidemic model induced by Triton WR-1339, 0T and DOT decreased serum total cholesterol and low-density lipoprotein cholesterol levels. DOT also decreased serum triglyceride levels, but 0T did not decrease it. These re-sults suggest that the antihrperlipidemic activity of DOT may originate from the inhibition of pancreatic lipase as well as HMG CoA redctase.
김영석,정은아,장종철,양형길,조기호,배형섭,이경섭,김동현,김남재,Kim, Young-Suk,Jung, Eun-Ah,Chang, Jong-Chul,Yang, Hyung-Kil,Cho, Gi-Ho,Bae, Hyung-Sup,Lee, Kyung-Sup,Kim, Dong-Hyun,Kim, Nam-Jae 한국생약학회 2001 생약학회지 Vol.32 No.2
Whangryunhaedok-Tang (WT) is formulated with Coptidis Rhizoma, Phellodendri Cortex, Scutellariae Radix and Gardeniae Fructus, and Daewhang-whangryunhaedok-Tang (DWT) is made by the combination of Rhei Rhizoma, a wellknown anticostipation drug in WT. Therefore, DWT has been evaluated for antihyperlipidemic effects on experimental hyperlipidemic rats and mice induced by corn oil and high cholesterol-diet. Oral administration of DWT significantly inhibited the increase of serum triglyceride and LDL-cholesterol levels, and the decrease of serum HDL-cholesterol levels in hyperlipidemic rats induced by corn oil. Also, oral administration of DWT significantly prevented the increase of serum total cholesterol, triglyceride and LDL-cholesterol, and liver total cholesterol and triglyceride in 1% cholesterol-diet fed mice. These results suggest that DWT is effective for the treatment of hyperlipidemia.
김영석,정은아,장종철,양형길,김남재,조기호,배형섭,이경섭,김동현 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2001 No.-
Whangryunhaedok-Tang (WT) is formulated with Coptidis Rhizoma, Phellodendri Cortex, Scutellariae Radix and Gardeniae Fructus, and Daewhang-whangryunhaedok-Tang (DWT) is made by the combination of Rhei Rhizoma, a wellknown anticostipation drug in WT. Therefore, DWT has been evaluated for antihyperlipidemic effects on experimental hyperlipidemic rats and mice induced by corn oil and high cholesterol-diet. Oral administration of DWT significantly inhibited the increase of serum triglyceride and LDL-cholesterol levels, and the decrease of serum HDL-cholesterol levels in hyperlipidemic rats induced by corn oil. Also, oral administration of DWT significantly prevented the increase of serum total cholesterol, triglyceride and LDL-cholesterol, and liver total cholesterol and triglyceride in 1% cholesterol-diet fed mice. These results suggest that DWT is effective for the treatment of hyperlipidemia.