임신중인 생쥐에 Bisphenol A 투여가 모체의 생식독성과 태아의 성비에 미치는 영향

박동헌(Dong-Heon Park),장현용(Hyun-Yong Jang),김정익(Choung-Ik Kim),정희태(Hee-Tae Cheong),박춘근(Choon-Keun Park),양부근(Boo-Keun Yang) 한국독성학회 2005 Toxicological Research Vol.21 No.2

Bisphenol A (BPA), a environmental endocrine disruptor, is considered to bind to estrogen receptors and to regulate the expressions of estrogen responsive genes. This study was to evaluate the effect of BPA administration on body weight, sex ratio and litter size on 18 days in prenatal periods, the effect of reproductive organ weight and blood hematological values on 24 days postpartum in pregnant mice. The female mice was administrated to low doses of BPA (0, 0.05, 0.5 and 5.0 ㎎/㎏ B.W.) by intraperitoneal injection in gestation days 0~15 with 5 times at 3 days interval. The maternal body weight, litter size and sex ratios were similar to in all experimental groups, but body weights of male and female offspring was significantly lower in 5.0 ㎎ BPA group when compared to any other groups (P<0.05). No treatment-related effects on body weight, ovary weight and blood hematological values were observed in dams on 24 days after delivery. The uterine weight in 5.0 ㎎ BPA group was slightly higher than those of any other groups, but not significantly difference. The histological evaluation of ovary in dam mice on 24 days after dilivery was not difference in all experimental groups, but the endometriosis of uterus in dam mice were significantly increased in 0.5 ㎎ BPA group when compared to control group. These results indicates that low concentration of BPA should not be considered as a selective reproductive toxicant.

임신중인 생쥐에 Bisphenol A 투여 후 태어난 차산자의 생식독성과 혈액성분에 관한 연구

박동헌(Dong-Heon Park),장현용(Hyun-Yong Jang),김정익(Choung-Ik Kim),정희태(Hee-Tae Cheong),박춘근(Choon-Keun Park),양부근(Boo-Keun Yang) 한국독성학회 2005 Toxicological Research Vol.21 No.2

Bisphenol A (BPA) is a monomer used in the manufacture of a multitude of chemical products, including epoxy resins and polycarbonate. The objective of this study was to evaluate the effects of BPA administration on reproductive characteristics and blood hematological and chemical values in offspring of pregnant dams treated with BPA. BPA was administrated to pregnant mice by intraperitoneally injection with 0, 0.05, 0.5 and 5.0 ㎎/㎏ B.W. for 5 times at 3 days interval on gestation days 1~16. There were no treatment-related effects of BPA on reproductive organ weight in male offsprings at 45 days-of-age, but body weight was the lowest in 5.0 ㎎ BPA group when compared to other groups (P<0.05). No differences in semen characteristics (sperm concentration, viability, motility and abnormality) were observed between the control and BPA treatment groups. The WBC, HB, HT, MCV, MCH, MCHC, albumin, BUN and total protein of blood hematological and chemical values in male offsprings were not difference for any treatment groups, but RBC value in BPA groups was significantly increased comparing to the control group (P<0.05). The PLT value was slightly higher in 5.0 ㎎ BPA groups than in any other group, but not significantly difference among the experimental groups. In female offsprings, the effects of BPA didn't affect to the body and ovary weight, but the uterus weight in 5.0 ㎎ BPA group was slightly heavier than that of control group (P>0.05). No statically significant difference in blood hematological values in female offsprings were observed between the control group and BPA groups, but the concentration of albumin and BUN were significantly higher in 0.5 ㎎ BPA group when compared to control and other BPA treatment groups (P<0.05). The histological evaluation of testis and ovary in growing offspring at 45 days-of-age was not difference between the control group and BPA groups, but endometriosis of the uterus in female offspring was dramatically increased in 0.5 and 5.0 ㎎ BPA groups. These founding suggest that low concentration of BPA might not have a important role on reproductive ability or blood metabolite in offspring of pregnant dams treated with BPA.

다차원효율성분석을 활용한 경쟁분석에 관한 연구

양동헌(Dong-Heon Yang),유연우(Yen-Yoo You) 한국전자거래학회 2012 한국전자거래학회지 Vol.17 No.4

본 연구는 경쟁분석을 통해 효율적인 벤치마킹 대상을 파악 후 개선점을 도출하는 컨설팅기법의 활용에 관한 연구이다. 경쟁자 분석을 위해 상대적 효율성 분석도구인 DEA(Data Envelopment Analysis, 자료포락분석)을 이용하여 컨설팅현장 또는 기업 내부에서 효율적으로 적용이 가능한 컨설팅 분석기법을 개발하여 기존 경쟁분석 기법과 비요하여 제시하였다. 본 연구는 먼저 문헌고찰을 통해 컨설팅 방법론의 경쟁분석 기법과 상대적 효율성 분석 기법인 DEA에 대한 기존학자들의 연구를 살펴보고 DEA를 기반으로 한 경쟁분석인 다차원효율분석방법을 제시한 후 이 분석 방법의 적합성 및 실용성을 확인하기 위해 공기업 “A”를 대상으로 사례 연구를 실시하였다. This study focuses on the use of competitive analysis to identify the effective benchmarking target through consulting techniques to derive improvements. After developed using DEA(Date Envelopment Analysis) the relative efficiency analysis tool for competitor analysis to apply in consulting on-site or within the organization, this study compared the new techniques and the existing techniques. This study was carried out as follows. First, through a review of the literature, consulting competitive analysis techniques and methodologies relative efficiency analysis technique DEA for research scholars examined. Second, DEA-based competitive analysis, multidimensional efficiency analysis is presented. Third, The case study was conducted to determine the suitability and practicality of this analysis method for public company “A”

스마트워크기반의 컨설팅지원 서비스방법에 관한 연구 -6시그마 중심으로

양동헌 ( Dong Heon Yang ),유연우 ( Yen Yoo You ) 한국생산성학회 2013 生産性論集 Vol.27 No.1

This study focuses on using collective intelligence to develop the consulting service support process in the smart environments. We developed the concept after studying the theoretical literature and suggested the direction. this study developed according to the roadmap of the new product development process, DIDOV(Define-Identify- Design-Optimize-Verify) in DFSS (Design For Six Sigma). It was carried out in accordance with the procedures to draw out the needs of the customers through experts FGI, to establish service concept and business model and to verify the reliability of the new service with case study. Empirical Study compared smart AHP survey(smart AHP based on smartwork) with existing survey AHP. Therefore, this study is expected to contribute to SMEs consulting industry development and the SMEs received the benefit form the consulting service.

관동맥질환 치료의 최신 지견

양동헌 ( Dong Heon Yang ),채성철 ( Shung Chull Chae ) 대한핵의학회 2005 핵의학 분자영상 Vol.39 No.2

임신중인 생쥐에 DEHP 투여가 번식현상에 미치는 영향 Ⅱ. 임신중인 생쥐에 DEHP 투여가 자손의 번식특성과 혈액성분에 미치는 영향

박동헌,장현용,박춘근,정희태,김정익,양부근,Park, Dong-Heon,Jang, Hyun-Yong,Park, Choon-Keun,Cheong, Hee-Tae,Kim, Choung-Ik,Yang, Boo-Keun 한국발생생물학회 2004 발생과 생식 Vol.8 No.2

본 연구는 임신한 생쥐에 DEHP의 투여가 자손의 번식특성과 혈액성분에 미치는 영향을 검토하였으며 그결과는 다음과 같다. 임신기에 DEHP의 투여가 웅성 자손의 체중, 번식기관 무게 및 정액 성상에 미치는 결과는 투여구간에 커다란 차이가 없었다. 임신기에 DEHP의 투여가 웅성 자손의 혈액 성상에 미치는 영향을 조사한 결과, WBC, HB, HT, MCH 및 albumin은 투여구간에 차이가 없었으나, RBC MCV, MCHC, PLT 및 total protein은 각 투여구간에 통계적으로 유의적인 차이가 나타났다. 임신기에 DEHP의 투여가 자성 자손의 체중, 자궁 및 오른쪽 난소의 무게에 미치는 영향을 조사한 결과, 각 투여구간에 커다란 차이가 없었지만, 왼쪽 난소의 무게는 10.0mg 투여구가 대조구와 0.5mg 투여구에 비해 통계적으로 유의하게 높은 무게를 나타냈다. 임신기에 DEHP의 투여가 자성 자손의 혈액성상에 미치는 영향을 조사한 결과, RBC, HB 및 HT는 각 투여구간에 커다란 차이가 없었다. 임신기에 DEHP의 투여가 자손의 정소, 난소 및 자궁의 조직에 미치는 영향을 조사한 결과,정소에서는 투여구간에 차이가 없었으며, 난소에서는 10.0mg 투여구가 여타구보다 많은 황체를 가지고 있었으며, 자궁에서는 대조구에 비해 DEHP의 투여농도가 증가할수록 자궁내막층이 감소했으며, 1.0mg 투여구와 10.0mg 투여구는 대조구에 비해 뚜렷한 자궁내막층의 감소가 있었다. The objective of this study was to assess that the effects of DEHP administration on reproductive characteristics and blood hematological and chemical values in pups born after DEHP administration in pregnant mice. DEHP was administrated to pregnant mice by intraperitoneally injection with 0, 0.5, 1.0 and 10.0mg/kg B.W, 5 times at 3 days interval from Day 1 to Day 16 in the gestation period. The body weight and reproductive organ weight(testis, epididymis and coagulating gland) in male pups on 45 day after birth was not affected in all experimental groups, but vesicular gland in DEHP groups was significantly lower than that of control group(P<0.05). The semen characteristics of male pups were not affected in DEHP treatment groups. The WBC, HB, HT, MCH and albumin values in male pups were not affected in all experimental groups, but RBC MCV, MCHC, PLT and total protein values were significantly different among the experimental groups(P<0.05). In female pups, the effects of DEHP administration were not affected the body and uterus weight, but the left ovary in 10.0mg DEHP group was significantly heavier than in control and 0.5mg DEHP group(P<0.05). The WBC, MCV, MCH, MCHC, PLT, albumin, BUN and total protein values in female were not different in all experimental groups. The RBC, HB and HT values were significantly different among the experimental gruop(P<0.05). The historical evaluation of testis in male pups that were grown to 45 days after birth was not different in all experimental groups. The ovary in female pups had many corpus luteum in 10.0mg DEHP group. The endometriosisi of uterus was significantly decreased in DEHP group. There results suggest that low concentration of DEHP administration in pup born after DEHP administration in pregnant mice was not affered on reproductive characteristic, but was affected on blood hematological and chemical values.

임신중인 생쥐에 DEHP 투여가 번식현상에 미치는 영향 Ⅰ. 임신중인 생쥐에 DEHP 투여가 분만 후 번식특성과 혈액성분에 미치는 영향

박동헌,장현용,박춘근,정희태,김정익,양부근,Park, Dong-Heon,Jang, Hyun-Yong,Park, Choon-Keun,Cheong, Hee-Tae,Kim, Choung-Ik,Yang, Boo-Keun 한국발생생물학회 2004 발생과 생식 Vol.8 No.2

본 연구는 임신한 생쥐에 DEHP의 투여가 분만 후 생쥐의 번식기능과 태아의 성비에 미치는 영향을 검토하였다. 임신한 자성 생쥐에 DEHP을 투여한 후 임신 19일째에 임신한 자성의 체중, 태아의 체중, 태아수 및 태아성비를 조사한 결과, 실험개시시와 실험종료시 임신한 자성의 체중은 각 투여구간에 차이가 없었으며, 자${\cdot}$웅성태아의 체중, 평균 태아수 및 태아의 자${\cdot}$웅성 성비는 투여구간에 커다란 차이가 없었다. 임신기에 DEHP의 투여가 분만한 후 어미의 번식기관무게와 혈구화학치에 미치는 효과를 검사한 결과, 각 투여구간에 커다란 차이는 없었다. 임신기에 DEHP의 투여가 분만한 후 난소와 자궁의 조직에 미치는 영향을 조사한 결과, 난소에서는 모든 투여구간에 커다란 차이는 없었으나, 자궁에서는 0.5mg 투여구가 대조구에 비해 자궁내막층과 부종이 감소했으며, 1.0mg 투여구와 10.0mg 투여구는 일부에서 자궁내막층이 감소했지만 0.5mg 투여구에서의 감소보다는 적었다. 임신중인 생쥐에 저농도의 DEHP의 투여는 임신중인 모체와 태어난 자손의 번식 특성과 혈구화학치에 영향을 미치지 않았다. This study is illustrated that 1) the effects of DEHP administration on body weight, sex ratio and litter size on 19 days in the prenatal period 2) the effects of reproductive organ weight and blood hematological values on 25 days postpartum in pregnant mice. DEHP was administrated to pregnant mice by intraperitoneal injection at 0, 0.5, 1.0 and 10.0mg/kg B.W from day 1 to day 16 in the gestation period with 5 times at 3 days interval. There were no significantly differences in the material body weight, litter size and sex ratio on 19 days in the prenatal period. The body weight of the fatal male mice was slightly lower in 1.0 and 10.0mg DEHP groups than in any other groups. The reproductive organ weight and hematological values in dam mice on 25 days postpartum were not affected by DEHP administration. The histological evaluation of ovary in dam mice on 25 days after dilivery was not different in all experimental groups, but the endometriosis and edema of uterus in dam mice were significantly decreased in 0.5mg DEHP group than that of control group.These results indicate that the administration of low concentration of DEHP was not affected on reproductive characteristic and blood hematological values in pregnant mice.

한우 후보종모우에 selenium과 vitamin E 투여가 정액성상에 미치는 영향

이성수,박노형,원유석,박동헌,김종복,양부근,Lee, Seoung-soo,Park, No-hyoung,Won, You-seog,Park, Dong-heon,Kim, Jong-bok,Yang, Boo-keun 대한수의학회 2000 大韓獸醫學會誌 Vol.40 No.2

To improve the semen production, the selenium(Se) and vitamin E(Vit. E) were administrated into Hanwoo young sire for intensification an antioxidant system and the taurine were supplemented into semen extender for improving the semen characteristics. The 16 heads ranging from twenty to thirty two months of age were randomly assigned to control group, Se-admistrated group(Se-group), Vit. E-administrated group(Vit. E-Group) and Se and Vit. E administrated group(Se and Vit. E-group). Se and Vit. E dministrated 3 times every 30 days by intramuscular injection. The administration of Se, Vit. E, and Se and Vit. E didn't affect on semen volume, sperm concentration, and total sperm number among all groups(p>0.05). Adiministration of Se improved sperm motility and viability. Motility of Se-group and control were 26.01% and 19.20%, respectively(p<0.05). Viability of Se-group(47.07%) was higher than control group(35.73%), Vit. E group(36.55%)(p<0.05). The administration of Se and Vit. E didn't affect sperm capacitation and acrosome reaction. The 100mM taurine supplement into semen extender increased the motility of frozen/thawed semen in the Vit. E-group(p<0.05) and had a beneficial effects on decreasing abnormality of frozen/thawed semen in all groups(p<0.05). These results indicate that Se administration improve sperm motility and viability, and the taurine supplement into semen extender decrease abnormality in Hanwoo young sire.

포탈의 검색 트렌드를 활용한 인천공항 출국자 수 예측 연구

신의섭(Euiseob Shin),양동헌(Dong-Heon Yang),손세창(Sei Chang Sohn),허문행(Moonhaeng Huh),백석철(Seokchul Baek) 한국전기전자학회 2017 전기전자학회논문지 Vol.21 No.1

공항의 안정적인 운영을 위하여 승객의 단기예측은 매우 중요하다. 본 논문에서는 인천공항의 출입국자 예측을 위하여 출입국자의 대부분을 차지하는 한국인과 중국인의 출국자의 예측 모델링을 수행하였다. 예측 모델링 정확도 향상을 위해 네이버와 바이두 검색 트렌드 데이터를 활용하였다. 출국자 수들과 관련 검색 트렌드 데이터 간 Granger Causality 테스트를 수행하여 상관관계가 있음을 확인하였다. “출국자 수“ 단독으로 예측하는 것보다 “출국자 수”와 “검색어 트렌드” 자료를 합하여 예측하는 것이 정확도가 향상됨을 알 수 있었다. 이는 검색이 어떤 일을 수행하기 전에 하는 행위이기 때문이고, 검색 트렌드 데이터 내에 태생적으로 예측 기재가 존재함을 본 연구를 통하여 확인할 수 있었다. Short-term prediction of the number of passengers at the airport is very essential for the efficient and stable operation of the airport. Here, to forecast the immigration of Incheon International Airport, we perform the predictive modeling of Korean and Chinese outbound travelers comprising most of immigration. We conduct the Granger Causality test between the number of outbound travelers and related search trend data to confirm the correlation. It is found that the forecasting with both "outbound travelers" and "search term trends" data outperforms the one only with "outbound travelers" data. This is because search activities are done before doing something and this study confirms that search trend data inherently possess the potential for prediction.

소아 및 청소년에서 24시간 활동 혈압 측정의 임상적 유용성

황영주,박효정,양은애,조민현,고철우,양동헌,황현희,Hwang, Young-Ju,Park, Hyo-Jung,Yang, Eun-Ae,Cho, Min-Hyun,Ko, Cheol-Woo,Yang, Dong-Heon,Hwang, Hyun-Hee 대한소아신장학회 2011 Childhood kidney diseases Vol.15 No.2

목적 : 소아 청소년에서 고혈압의 유병률이 증가하면서 혈압의 측정에 대한 관심이 증가하고 있다. 활동 혈압 감시는 진성 고혈압과 백의 고혈압의 진단에 유용하다고 알려져 있어 우리나라 소아 청소년을 대상으로 활동 혈압 감시의 임상적 유용성을 알아보기 위해 본 연구를 시행하였다. 방법: 2002년 1월부터 2010년 2월까지 경북대학교병원 소아청소년과 및 내과를 방문하여 활동 혈압 감시를 시행한 6세부터 18세까지의 소아 및 청소년 51명을 대상으로 하였다. 외래에서 측정한 수시 혈압과 활동 혈압 감시 결과로 계산된 평균 혈압, 혈압 부하 및 야간 하강 정도를 환자들의 임상적 특징과 진단 별로 비교하였다. 결과:전체 51명의 환자 중 남자가 49명이었으며 평균연령은 $17.8{\pm}1.8$세였고 19명(37.3%)이 비만이었다. 활동 혈압 감시 시행 중 평균 유효 측정횟수는 37.8회, 유효 측정률은 94.3%이었다. 활동 혈압 감시 결과 진성 고혈압 환자가 37명(72.5%)이 었고 이 중 1명이 가면 고혈압이었다. 7명(14%)은 백의 고혈압으로 진단되었으며 나머지 7명은 수시혈압과 24시간 활동 혈압 모두 정상이었다. 백의 고혈압으로 진단된 7명 중 5명이 고혈압 전 단계였다. 진성 고혈압 환자에서 평균 수축기와 이완기 혈압 부하는 정상 혈압 소아에 비해 유의하게 높았고(P<0.001) 야간 강하는 10% 이하였으나 통계적 유의성은 없었다. 비만 환자에서 평균 수축기, 이완기 혈압 및 혈압 부하가 유의하게 높았다(P<0.001). 결론 : 본 연구에서 소아 청소년에서 활동 혈압 감시가 진성 고혈압 및 백의 고혈압을 진단하는데 유용하였으며 백의 고혈압을 가진 소아의 상당수가 고혈압 전 단계에 해당되어 향후 이들에 대한 지속적인 추적 관찰이 필요한 것으로 생각된다. Purpose: With increasing prevalence of hypertension (HTN) in children and adolescent, pediatricians have become more interested in blood pressure (BP) measurements. The ambulatory blood pressure monitoring (ABPM) is known to be useful to differentiate true HTN and white coat HTN. The object of this study is to assess the clinical usefulness of ABPM in Korean children and adolescents. Methods: A retrospective review of 51 patients in Kyungpook National University Hospital from January 2002 to February 2010 was done. All patients were 6-18 years old and underwent ABPM. We calculated the mean value of ABP, BP load, nocturnal dip and compared the results with the patients' diagnosis and characteristics. Results: The mean age of the 51 patients was $17.8{\pm}1.8$ years and 19 children were obese. 37 patients (72.5%) were truly hypertensive and 1 patient was diagnosed as masked HTN and 7 children (14%) as white coat HTN. The rest of the patients were normotensive. Among patients with white coat HTN, 5 were in a prehypertensive state. Mean systolic and diastolic BP load of patients with true HTN were significantly higher than non-hypertensive children (P<0.001). Although the nocturnal dip of all patients were below 10%, there was no statistical significance. The obese patients showed higher systolic and diastolic BP. Their systolic and diastolic BP load were significantly higher than non-obese patients (P<0.001). Conclusion: ABPM in children and adolescents seems to be a valuable tool in the assessment of white coat HTN and in the confirmation of true HTN. A considerable number of white coat HTN patients are revealed to be in a prehypertensive state and need close follow-up.