四物湯의 抗癌劑 副作用 抑制에 關한 實驗的 硏究

안희덕 대한동의병리학회 1995 동의생리병리학회지 Vol.9 No.2

연구배경: 서의의 치료법인 抗癌劑 및 放射線療法이 癌細胞 뿐만 아니라 正堂細胞에까지 毒性을 나타내어 腫瘍細胞를 殺減하는 同時에 骨髓의 造血機能을 抑制하고 消化器官 및 全身에 反應하여 副作用을 일으키며, 人體의 免疫機能을 低下시키기 때문에 抗癌治療의 副作用을 減少시키면서도 癌細胞에 대해 特異的 作用을 나타내는 治療法의 開發이 要求되고 있어 最近 韓醫學界에서도 港癌劑의 副作用 減少에 대한 韓方療法의 硏究가 활발히 進行됨에 따라 저자도 化學療法劑에 의한 肝과 骨髓의 副作用을 抑制하기 위한 方法의 일환으로 四物湯의 效果에 대하여 硏究 檢討하고자 하였다. 방법 : 正堂白鼠에 化學療法劑의 하나인 cyclophosphamide를 注射하여 副作用을 誘發한 후 四物湯을 投與하고 GOT·GPT活性度와 BUN 및 creatininc 含量을 測定하고, 骨髓 副作用에 미치는 效果를 檢査하기 위하여 白血球數 赤血球數 血小板數를 測定하였으며, 다시 腹腔癌을 誘發시킨 雄性 생쥐에 cyclophosphamide를 多量 投與하여 副作用을 誘發하고 四物湯을 投與하여 혈액검사를 함실시함 결론 : GOT活性度는 有意性 있는 減少를 보였고, GOT活性度는 減少하는 傾向이 있었으나 有意性은 없었으며. BUN 및 creatinine 含量은 正堂群과 큰 差異를 보이지 않았다. 白血球·赤血球·血小板數를 測定한 結果 癌을 誘發하지 않은 白鼠의 경우에는 四物湯投與群에서 對照群에 北하여 各各 有意性있는 增加를 보였으나, 擔癌생쥐에 있어서는 모두 對照群과 별다른 差異가 없었다. 결과 : 四物湯은 cyclophsophamide에 의한 肝臟 賢臟 骨髓에 대한 副作用을 抑制하는 效果가 있을 것으로 推定할 수 있으며, 앞으로의 硏究를 通하여 癌治療에 應用될 수 있을 것으로 期待된다. In order to investigate the effects of Siwutang on reducing side-effects of anti-cancer agent to the rats, and mice which have abdominal tumor after Sarcoma-180 cells were transplanted, cyclophosphamide, the anti-cancer agent, was injected in onder to induce the side-effects, and the extract of siwutang was administrated through mouth from 5 days bfore the injection, and observe GOT, GPT, BUN, creatinine, number of leukocyte, erythrocyte and thrombocyte. The results are summarized as follows : 1. In the effects of the inhibition of the side-effect on the liver function, the GOT activity was proved to be reduced by the Siwutang, but GPT activity was not changed. 2. In the effect of the inhibitory effect on the side-effect on the kidney function, the BUN and creatinine remained unchanged in all groups. 3. In the number of leukocyte, erythrocyte and thrombocyte, in the study on the no cancer-carrier rats, sample group showed increase compared with the control group. While, there was no significant increase in the study on the cancer-carrier mice. As the result of above experiment, Siwutang has proven to have inhibitory effect on side-effects of anti-cancer agents. We can conclude that Siwutang will be useful for cure of the cancer.

절식요법이 비만환자의 체중조절에 미치는 영향

안희덕,이동수,정태영 대구한의대학교 제한동의학술원 2001 東西醫學 Vol.26 No.1

嘔吐의 病理에 관한 文獻的 考察

安圭錫,安熙悳 대한동의병리학회 1993 동의생리병리학회지 Vol.8 No.-

연구배경 : 소화기병을 비롯한 각종질환의 주요증상인 구토와 건구 등에 대한 역대 의가의 이론을 살펴보면서 의학이론의 변화와 진전을 발견하고, 임상에서 변증시치를 위한 기초를 마련하고자 하였다. 내용 : 황제내경, 상한론에서부터 현대 중의학의 교재로 쓰이고 있는 중의 내과학에 이르기까지 의사학적으로 의미가 있는 구내외의 각종 의서 중 '구토' 및 그와 유사한 증상에 대한 이론을 정리하고 이들 이론의 특성과 관점을 정리하였다. 결과 : 역대 의가들의 '구토'에 대한 이해와 각자의 특징적인 이론을 발견할 수 있었으며, 이들의 이론을 원인과 병리에 따라 정리함으로써 임상에서 활동하는데 도움이 되게 하였다. 결론 : '구토' 및 이와 유사한 증상의 개념의 차이점을 알 수 있었고, 구토의 원인, 분류, 증치에 대해 결론을 얻었다.

증례(證例) : 추나치료를 이용한 특발성 척추측만증 치험 1례

안희덕 ( Hee Duk An ),우창훈 ( Chang Hoon Woo ),권오곤 ( O Gon Kwon ),정만진 ( Man Jin Jeong ) 대구한의대학교 제한동의학술원 2012 제한동의학술원논문집 Vol.10 No.1

Objectives: This study is designed to evaluate the effectiveness of chuna therapy on patients with idiopathic scoliosis. Methods: The patient had been treated with chuna therapy. We measured Cobb`s angle, Visual Analog Scale(VAS) before and after treatment. Results: After treatment, we confirmed these improvement: Cobb`s angle from 20 to 5; VAS from 10 to 2. Conclusions: The result suggest that chuna therapy was effective treatment on patients with idiopathic scoliosis.

SAGD 생산기법을 이용한 오일샌드 플랜트 생산시설 현황

안희덕(Hee Deok.Ahn),김용헌(Yong Heon Kim),이량규(Lyang Kyu Lee),김태홍(Tae Hong) 대한설비공학회 2020 대한설비공학회 학술발표대회논문집 Vol.2020 No.6

오일샌드 회수방법 중 상업적으로 가장 널리 사용되는 SAGD 기법을 이용한 비튜멘 생산 플랜트의 주요 생산시설은 저류층으로 스팀을 주입하여 비튜멘(Bitumen)과 생산수(Produced water)의 혼합물인 에멀션(Emulsion)을 처리하는 Well Pad 지역과 생산된 에멀션과 스팀/컨덴세이트 등을 이송하는 GD(Gathering and Distribution) 라인, 그리고 에멀션으로부터 비튜멘을 분리, 처리하는 중앙처리시설(CPF) 지역으로 구성된다. Well Pad 지역 주요 장치로는 주입정, 생산정, 그리고 에멀션과 생산 가스를 분리하는 분리기(Separator) 등이 설치되며 중앙처리시설 지역에는 Well Pad 지역으로부터 도입되는 에멀션(비튜멘과 생산수 혼합물)을 분리하여 처리하는 시설, 오일-물 분리효과를 높이기 위해 사용하는 희석제의 회수시설, 생산수를 처리하여 보일러공급수(BFW)를 생산하는 수처리시설, 그리고 비튜멘 유동성 발생을 위해 저류층에 주입하는 스팀을 발생시키기 위한 보일러설비 등 비튜멘 생산을 위한 핵심시설들이 위치한다.

양 한방 협진 시스템의 의의와 협진 방안

정대규,안희덕,조성경,변준석,정태영,김종대,지선영,허준영 대구한의대학교 제한동의학술원 2005 東西醫學 Vol.30 No.4

추나요법을 병행한 한방치료로 호전된 만성 긴장성 두통 치험 1례

원제훈,안희덕,우창훈,Won, Je-Hoon,Ahn, Hee-Duk,Woo, Chang-Hoon 척추신경추나의학회 2013 척추신경추나의학회지 Vol.8 No.2

Objectives : The purpose of this study is to evaluate the Korean medical treatment for chronic tension-type headache, especially chuna manual therapy on cervical vertebrae. Methods : One patient was treated with acupuncture, herbal medication and chuna manual therapy on cervical vertebrae. To evaluate the pain of head and neck, visual analog scale(VAS) was measured. Results : After treatment for 1 week, the pain of head and neck was declined from VAS 10 to VAS 3. Conclusions : Korean medical treatment including acupuncture, herbal medication and cervical chuna manual therapy is effective for chronic tension-type headache. But further studies are required to prove the effectiveness of chuna manual therapy on cevical vertebrae.

족부 골절수술 후 한방 재활치료의 효과: 증례보고

박나리,이윤진,안희덕,양두화 한방재활의학과학회 2019 한방재활의학과학회지 Vol.29 No.3

The objective of this study is to propose postoperative rehabilitation for foot fracture in Korean Medicine and to report its effectiveness. There were three patients who were got foot fracture surgery received korean medicine with acupuncture, herbal medicine, cupping and exercise treatment. Patients were evaluated numeric rating scale (NRS), range of motion (ROM), American Orthopaedic Foot and Ankle Society (AOFAS) ankle hindfoot score, foot function index (FFI) and EuroQol-5 dimension (EQ-5D) index. Case 1 and 2 were improved NRS from 6 to 3. Case 3 was improved NRS from 5 to 2. These cases were improved ROM in all directions, AOFAS score, FFI, EQ-5D and walking status. This study suggest that Korean medicine rehabilitation could be effective for patients who have received foot fracture operation. (J Korean Med Rehabil 2019;29(3):165-172)

긴장성 두통에 대한 추나요법 치험 3례

원제훈,김영준,안희덕,우창훈,Won, Je-Hoon,Kim, Young-Jun,An, Hee-Duk,Woo, Chang-Hoon 척추신경추나의학회 2015 척추신경추나의학회지 Vol.10 No.1

Objectives: The Purpose of this study is to report three cases on tension-type headache treated by Chuna manipulative therapy. Methods: Three patients diagnosed tension-type headache were treated with Chuna manipulative therapy only. To evaluate effect of treatment, visual analogue scale(VAS) and headache impact test(HIT) were used. We checked VAS and HIT score three times(pretreatment, post-treatment, follow-up). An interval among each evaluation time is 4 weeks. Results: At post-treatment evaluation, VAS and HIT score declined significantly compared with pre-treatment. At follow-up evaluation, the pain did not increased. Conclusions: These results suggests that Chuna manipulative therapy may be effective for tension-type headache.

眞武湯이 MIA 유도 골관절염 흰쥐 모델에 미치는 영향

양두화,우창훈,안희덕 한방재활의학과학회 2018 한방재활의학과학회지 Vol.28 No.1

Objectives The object of this study was to investigate the antioxidative and antiinflammatory effects of Jinmu-tang extract (JMT) on the Monosodium iodoacetate (MIA)-induced rat osteoarthritis. Methods To investigate the antioxidant capacities of JMT, we measured the total polyphenol and flavonoid, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2’-Azino-bis(3-ethyl- benzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activity. To evaluate the antioxidative and antiinflammatory effects of JMT, the rats were divided into 5 groups (n=8). Normal group was not induced by MIA and treated at all (N), control group was induced by MIA and not treated at all (Con), positive control group was induced by MIA and orally administered indomethacin 5 mg/kg (Indo) and experimental groups were induced by MIA and orally administered JMT 100 mg/kg (JMT100) and JMT 200 mg/kg (JMT200) for 4 weeks. The changes of anti-type II collagen antibody in serum, heme oxygenase-1 (HO-1), phosphorylated inhibitor of κBα (p-IκBα), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and tumor necrosis factor alpha (TNF-α) in knee joint tissue and histopathological observation (Hematoxylin & Eosin and Safranin-O stain) were measured. Results Total polyphenol and flavonoid levels of JMT were 26.90±0.33 mg/g and 6.02±0.34 mg/g. IC50 of L-ascorbic acid and JMT of DPPH radical scavenging activity were 1.35±0.07 μg/ml and 52.95±0.97 μg/ml. IC50 of L-ascorbic acid and JMT of ABTS radical scavenging activity were 3.18±0.02 μg/ml and 91.49±1.74 μg/ml. In serum, the anti-type II collagen antibody levels of JMT100 and JMT200 groups were decreased significantly. In knee joint tissue, the HO-1 level of JMT200 was increased significantly. The p-IκBα and TNF-α levels of JMT200 were decreased significantly. The COX-2 and iNOS levels of JMT groups were decreased significantly. In histopathological observation, in comparison with Con, synovial tissue, cartilage and proteoglycan of JMT100 and JMT200 were well preserved. Conclusions According to the results, It is considered that JMT has antioxidant and antiinflammatory effects for MIA-induced rat osteoarthritis, so it could be applied to osteoarthritis treatment. (J Korean Med Rehabil 2018;28(1):19-31)