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흰쥐 해마에서 일과성 전뇌 허혈-재순환 손상 후 세포고사에 대한α-Lipoic Acid의 효과
안훈철,송진호,김광석,유수진 대한응급의학회 2007 大韓應急醫學會誌 Vol.18 No.2
Purpose: The purpose of this study was to evaluate effect of α-lipoic acid on apoptotic cell death in rat hippocampal neuron following transient forebrain ischemia-reperfusion (I/R) injury. Methods: The four-vessel occlusion method was used to induce transient I/R injury in the forebrain of Sprague- Dawley rats. In the treatment group, α-Lipoic acid (LA) was administered subcutaneously at 50 mg/kg/day for 7 days before induction of I/R injury. Results: Pretreatment with LA significantly reduced the number of TUNEL-positive neurons in the pyramidal cells layer of the hipocampal CA1 region 5 days after the ischemia, suggesting a marked reduction of apoptotic cell death. Pretreatment with LA also resulted in marked suppression at the transcript level of mRNA for caspase-3 at 24 hours, and decreased concentration of the active form of caspase-3 protein in the hippocampus at 1, 3, and 5 days after I/R injury. Furthermore, as indicated by western blot analysis, the concentration of apoptosis-inducing factor (AIF) in the hippocampus was reduced at 1 and 3 days after a transient I/R injury by pretreatment with LA. Conclusion: The results of this study suggest that LA has the potential to prevent neuronal cell death in the hippocampus by inhibiting intracellular signaling pathways responsible for apoptosis following transient I/R injury.
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저산소증-허혈손상 후에 성숙한 백서의 전뇌에서 pERK1/2 단백의 발현에 관한면역화학적 연구
한용재,안훈철,박재황,유수진 대한응급의학회 2008 大韓應急醫學會誌 Vol.19 No.3
Purpose: The purpose of this study was to evaluate spatiotemporal evaluation of pERK1/2 protein expression in the forebrain following hypoxic-ischemic (HI) injury in adult Sprague-Dawley rats. Methods: HI injury was induced by occlusion of the bilateral common carotid artery (CCA) and respiration with 5% O2 hypoxic gas for 8 minutes, followed by unilateral release of CCA. Results: Immunoreactivity for pERK1/2 protein in the bilateral cortex began to increase at 2 hours, reached peak levels at 6 hours, and then decreased by 24 hours after HI injury. In a cortical neuron, the expression of pERK1/2 protein was observed in all cellular components and processes including dendrites, cell body and nuclei at 6 hours, but persisted only in the cell body by 24 hours after HI injury. Temporal changes in the immunoreactivity for pERK1/2 protein in the hippocampus was very similar to that of the cortex following HI injury. In contrast, the temporal changes in the cellular distribution of pERK12 protein in hippocampal neurons was largely different from that of the cortex following HI injury. Conclusion: The results of the present study suggest that HI injury causes an early activation of ERK1/2 signaling with a differential cellular distribution of pERK1/2 protein among different forebrain structures. Further study needs to be done in order to elucidate a possible role of ERK1/2 signaling for neural damage in the adult rodent HI model.
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부분층 화상 환자에서 Aquacel?을 이용한 드레싱의 유용성
박재현,나영천,조규성,유수진,안훈철 대한성형외과학회 2005 Archives of Plastic Surgery Vol.32 No.4
In partial thickness burn injuries, silver sulfadiazine cream 1%(SSD, Silvadene) is the most commonly used topical agent worldwide. But silver sulfadiazine cream 1% has no exudate absorption property. Usually after escar is removed from wound surface, Silvadene is changed to saline wet gauze dressing to promote epithelization.Aquacel(ConvaTec, UK) is a 100% sodium carboxymethylcellulose Hydrofiber material. It absorbs exudates directly into the hydrofibers by vertical wicking which allows rapid uptake of liquid into the fibers. The absorbed exudate fluid can be distributed to the entire dressing rather than just over the wound surface, which results in larger fluid absorption capacity.From April, 2003 to July, 2004 a study was done with 40 patients who had variable partial thickness burns. Aquacel dressing was compared in 21 cases to silver sulfadiazine cream 1% and saline wet gauze dressings in 19 cases. In the Aquacel cases, the average healing time on the face was 5.36±1.69 a day; on the hands was 8.46±2.15 a day; and, on the neck was 6.0±2.0 a day. With the Silvadene and Saline wet gauze dressing, the average healing time on the face was 6.44±1.74 a day; on the hands was 13.79±5.35 a day; and, on the neck was 11.17±3.31 a day. As a result, the Aquacel group showed a shorter healing time compared to the Silvadene and saline wet gauze dressing group and patients were satisfied because of less pain and improved comfort.In conclusion, Aquacel is a better choice for partial thickness burn injuries because of shorter healing time, less pain and more confortable dressing.
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