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왜모자반 (Sargassum yezoense)에서 분리한 화합물의 α-glucosidase 및 산화스트레스 억제효과
이은하,함정엽,안홍열,김민철,김철영,판철호,엄병헌,정상훈 한국생약학회 2009 생약학회지 Vol.40 No.2
We examined ethanol extracts prepared from the Korean marine algae belonging to the Sargassaceae family for their inhibitory effects on α-glucosidase activity and free radicals in vitro. Among five marine algae, the extracts of Sargassum yezoense were found to possess strongly α-glucosidase inhibition and free radicals scavenging activities. Two compounds were isolated via bioactivity guided isolation and tested for their effects on α-glucosidase, DPPH, ABTS + and Photochem® analysis. Their chemical structures were elucidated by spectral analysis and direct comparison with authentic compounds; their structures were identified as sargaquinoic acid (1) and sargahydroquinoic acid (2). The inhibitory effects of compound 1 and 2 (IC50 value: 14.2 and 12.8 µM, respectively) on α-glucosidase were more potent that of deoxynojirimycin as a positive control (IC50 value: 18.0 µM). All compounds displayed antioxidative activity which was measured by DPPH, ABTS + and Photoche ® apparatus.
Diospyros kaki Extract Inhibits Alkali Burn-Induced Corneal Neovascularization
양승재,조형,김경아,안홍열,강석우,정상훈 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.1
The purpose of this study was to evaluate the effect of ethanol extract of Diospyros kaki (EEDK) leaves on corneal neovascularization (CoNV) in rats. One week after the alkali burns in the corneas, the CoNV area coverage in the CoNV-positive control group, 100 mg/kg EEDK group, and 200mg/kg EEDK group was 43.3%±5.5%, 337.7%±2.5%, and 27.2%±4.3%, respectively. The areas of CoNV in the EEDK-treated groups were significantly different from those of the CoNV group. EEDK significantly attenuated the upregulation of vascular endothelial growth factor, fibroblast growth factor, interleukin-6, and matrix metalloproteinase-2 (MMP-2) protein levels. Orally administrated D. kaki inhibited CoNV development in rats.