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안필수,방형돈,정진호,김규한,박경찬,윤재일 대한천식알레르기학회 1996 천식 및 알레르기 Vol.16 No.3
Recent studies have suggested decreased interferon gamma(IFN r) but high interleukin 4 (IL - 4) production in patients with atopic dermatitis(AD). Based on the fact that the relative activities of IL 4 and IFN r seem to regulate the amplitude of IgE response, we tried rIFN r in the treatment of severe AD. Patients with severe AD(n=ll) were treated with recombinant IFN y 2.0 million IU/ml by subcutaneous injection for 12 weeks. During the study basic local therapy with low potency corticosteroid or emollient ointment and oral medication of antihistamine were allowed. Ten patients completed the treatment course and one patient discontinued the treatment before completion due to high fever. Seven patients(64% ) showed marked clinical improvement after 12 weeks of systemic IFN r therapy. Headache or mild fever were observed in 6 patients but they were improved by acetaminophen. Elevated SGOT and SGPT was observed in one patient but improved by temporary discontinuation of rIFN r. Our results suggested that rIFN r treatment may be one of the effective therapeutic regimens in patients with severe AD.
변형 Ingram법에 의한 건선의 치료 효과 및 호전기간
안필수,윤재일 ( Phil Soo Ahn,Jai Il Youn ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.6
N/A Background : The Ingram regimen has been advocated for t.he treatment of psoriasis. It is an effective therapeutic moiality, but its complexity and frequent side reactions have restricted its use for therapy. There are several modified Ingrarn regimen, change of vehicle, shortening of application time, low-strerigth anthralin, combination with emollient. Previously, we have reportved the effectiveness of mocified Ingram regimen for psoriasis, however, the remission time and relapse rate of psoriasis h;is not been reported in Korea. Objective : This study was performed to evaluate the efficacy of the modified Ingram region for the treatment of psoiasis and the remission time and relapse rate of psoriasis following moclified Ingram therapy. Methods : Sixty patients with plaque-form psoriasis were treated with the modified Ingra,n therapeutic regimen. They were divided into two groups, a moderate group which included 39 patients, and 21 patients in a severe group. Results : The follwing results were obtained from this study. 1. Among 60 patients, 52 patients(86.6%) were successfully healed and 8 patients(13.3%) showed failure in their t eatment. 2. In 52 patients, 44 patients(73.3%) showed a clearing of psoriasis, 8 patients(13.3%) showed some improvement. 3. In 44 cleared patients mean numbers and duration of therapy reaching grade 4 were 13.0 and 21.0 days for the trunk and 15.1 and 24.7 days for the extremities, the difference was not significant statistically(p$gt;0.05). The difference between the total dose in trunk and extremitis was significant statistica,ly(p$lt;0.05). 4. In 44 cleared patients mean numbers, duration and total dose of therapy reaching grade 4 in the severe group were significantly higher than those in the moderate group (p$lt;0.05). 5. There were some rotable side effects such as staining(17.3%), erythema(15.4%) and pruitus(13.5%), but in no case therapy was terminated. 6. According to the everity in 33 of the cleared patients, we observed 10 patients(17.4%) with early relapse((6 months), 7(21.7%) with late relapse($gt;6 months) and 14(60.9%) with riorelapse($gt;12 months) in the moderate group and also observed 10 patients(70.0%) with early IP, lapse, 2(20.0%) with latrelapse and 1(10.0%) with no relapse in the severe group. 7. In 33 pat,ients who were followed up at least one year later, the mean time of remission was 31.4 months in the moderate group and 6.0 mont,hs in the severe group. There were signilicant differences in the two groups(p$lt;0.05). Conclusion : The results of this study suggest that the modified Ingram regimen is one of the effective therapeutic mocialities for cases of moderate psoriasis. (Kor J Dermatol 1995;33(6): 1014-1020)
안필수(Phil Soo Ahn),이주흥(Joo Heung Lee),이호균(Ho Gyun Lee),은희철(Hee Chul Eun) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.5
Pigmented contact dermiatitis is a disease resulting from recirrent contact dermatitis due to hypersensitivity to cosmetic components, which produces secondery bizarre dark brown hyperpigmentation. Histological examinaition of this condition reveals liquefaction degeneration of the basal cells of the epidermis and melanopbages in the upper dermis. We report a case of pigmented contact dermatitis from musk tibeten, which was diagnosed by the histological examination, the patch and photopatch tests. Residul hisperpigmentation was seen on the region of the patch testing. (Kor J Dermatol 1994;32(5):899-902)
안필수 ( Phil Soo Ahn ),조광현 ( Kwang Hyun Cho ),윤재일 ( Jai Il Youn ),문상은 ( Sang Eun Moon ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.4
Background : Lichen planus is a papulosquarnous disease characterized by pruritic violaceous papules most commonly an the extremities of middle-aged adults. It may or may not be accompanied by oral and genital mucous membrane involvement. Its course is generally self-limited for a period of several months to years, but it may last indefinitely. Objectiye : This study was performed to find the clinical characteristics of lichen planus. Methods : Thirty-five cases of lichen planus comfirrned clinically and histopathologically were analyzed. Results. The incidenc of lichen planus was 0.073% of the total number of dermatologic patients. The age distribution was in the range of 14-63 years old being most prevalent in the 6th decade and there was ariequal sex ratio. The most common site of involvement was the mucous membrane, and the extremities were more common than the trunk. Pruitus or pain and discomfort developed in 28 pat,ients(80% ). In most cases, the treatment was topical corticosteroid and antihistamine. Sixteen cses improved within 1 month to 2 years. Five cases recurred in the improved cases. Conclusion : The clinical analysis of 35 patients with lichen planus was performed. The incidence of lichen planus was 0.073% of the total number of dermatologic patients. Males and females were equally affected Mucous membrane involvement was detected in 21 patients(60%). (Kor J Dermatol 1995;33(4): 655-660)
서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1994)
김재홍,안진균,정성재,김영태,김중환,김시영,이석종,이홍렬,서호석,김경훈,권혁진,정우권,고우석,이용석,안필수,오준규,오용섭 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.1
Background : In recent years gonorrhoea has been panendemic and remains one of the most common Sexually Transmitted Diseases in the world, especially in developing countries. Objective & Method : For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria Gonorrhoeae(PPNG), Ive have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1994, 168 strains of N. gonorrhoeae were isolated, among which 109 (64,9% ) were PPNG. Conclustion : Our results suggests that the prevalence of PPNG in Seoul is still increasing.