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안태훈,이영환,이규목,김유리,윤권하 대한자기공명의과학회 2017 Investigative Magnetic Resonance Imaging Vol.21 No.4
Primary mesenteric liposarcoma is rare. It is difficult to make an accurate preoperative diagnosis of the myxoid type of liposarcoma by using imaging such as ultrasound or computed tomography (CT) due to the very small amount of fat that is located in the tumor. We report a case of primary myxoid liposarcoma of the mesentery which was difficult to differentiate from other solid mesenteric tumors with a myxoid component such as low grade fibromyxoid sarcoma, myxoid leiomyosarcoma or myxoma. Use of chemical shift magnetic resonance (MR) imaging to detect small fat components and its cystic appearance with solid components on the MR images can be useful to differentiate myxoid liposarcoma from the other mesenteric tumors with a myxoid component.
안태훈 대한마취통증의학회 2010 Anesthesia and pain medicine Vol.5 No.1
The purpose of animal research in obstetric anesthesia is to find out the mechanisms of uterine contraction, to develop drugs for prevention of preterm labor, and to evaluate the effects of drugs on uterine contraction and the fetus in pregnant animals. Especially,anesthesiologists are interested in uterine contraction and fetal safety during pregnancy, labor, and cesarean section. As regional anesthesia and analgesia have come into widespread use for women in obstetric procedure, effects of local anesthetics on uterine contraction and umbilical blood flow that may be harmful to fetus are very important. A lot of animal studies about the effects of local anesthetics (e.g. lidocaine, bupivacaine, ropivacaine) on the uterine contraction and fetal safety have been carried. In addition,general anesthesia has also been still frequently utilized for cesarean delivery and nonobstetric procedure during pregnancy. A lot of animal studies about the effects of volatile and intravenous anesthetics on the uterine contraction and fetal safety have been carried. And there are many animal studies about the mechanisms of uterine contraction and effective drugs to prevent preterm labor. Animal research in obstetrics have been carried in vivo/vitro or during pregnancy/non-pregnancy. We need to study further in order to develop effective drugs for prevention of preterm labor, and also to develop neonatal extracorporeal membrane oxygenation (ECMO) or artificial placenta for achieving stable blood gas exchange and oxygen supply to the fetus.
Effect of hydroxyethyl starch on blood glucose levels
안태훈,정기태,심수빈,최우영 대한마취통증의학회 2016 Korean Journal of Anesthesiology Vol.69 No.4
Background: Hydroxyethyl starch (HES), a commonly used resuscitation fluid, has the property to induce hyperglycemia as it contains large ethyl starch, which can be metabolized to produce glucose. We evaluated the effect of 6% HES- 130 on the blood glucose levels in non-diabetic patients undergoing surgery under spinal anesthesia. Methods: Patients scheduled to undergo elective lower limb surgery were enrolled. Fifty-eight patients were divided into two groups according to the type of the main intravascular fluid used before spinal anesthesia (Group LR: lactated Ringer’s solution, n = 30 vs. Group HES: 6% hydroxyethyl starch 130/0.4, n = 28). Blood glucose levels were measured at the following time points: 0 (baseline), 20 min (T1), 1 h (T2), 2 h (T3), 4 h (T4), and 6 h (T6). Results: Mean blood glucose levels at T5 in the LR group and T4, T5 in the HES group, increased significantly compared to baseline. There were no significant changes in the serial differences of mean blood glucose levels from baseline between the two groups. Conclusions: Administration of 6% HES-130 increased blood glucose levels within the physiologic limits, but the degree of glucose increase was not greater than that caused by administration of lactated Ringer’s solution. In conclusion, we did not find evidence that 6% HES-130 induces hyperglycemia in non-diabetic patients.
Effects of PEEP on the thermoregulatory responses during TIVA in patients undergoing tympanoplasty
안태훈,Jung-Woo Yang 대한마취통증의학회 2011 Korean Journal of Anesthesiology Vol.61 No.4
Background: During general anesthesia, core temperature decreases, largely due to heat loss caused by peripheral vasodilation, resulting in heat redistribution to peripheral tissues. Multiple factors contribute to body temperature regulation during general anesthesia. It was reported that baroreceptor unloading by positive end-expiratory pressure (PEEP) attenuates anesthetically-induced hypothermia. So, we evaluated the effects of PEEP on thermoregulatory responses during total intravenous anesthesia (TIVA). Methods: Forty healthy patients scheduled for tympanoplasty were allocated two groups, Group ZEEP (zero end-expiratory pressure, n = 20) and Group PEEP (PEEP application of 5 cmH_2O, n = 20). Ambient temperature was maintained at 22-24℃, and anesthesia was induced and maintained with propofol-remifentanil. The core temperature and the temperature difference between forearm and fingertip skin were monitored before and after the induction of general anesthesia having a duration of 180 minutes. Results: The core temperature gradient (Ti-Tf ) was higher in patients with ZEEP than with PEEP. The core temperature was maintained at a higher level in patients with PEEP. Additionally, the vasoconstriction threshold was higher in patients with PEEP. Conclusions: It seems that PEEP attenuates anesthetically-induced hypothermia during TIVA.