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안정열,최명환,김광수,Solomon S. Senok,조동일,구교인,구용숙 대한약리학회 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.5
Electrical stimulation through retinal prosthesis elicits both short and long-latency retinal ganglion cell (RGC) spikes. Because the short-latency RGC spike is usually obscured by electrical stimulus artifact, it is very important to isolate spike from stimulus artifact. Previously, we showed that topographic prominence (TP) discriminator based algorithm is valid and useful for artifact subtraction. In this study, we compared the performance of forward backward (FB) filter only vs. TP-adopted FB filter for artifact subtraction. From the extracted retinae of rd1 mice, we recorded RGC spikes with 8×8 multielectrode array (MEA). The recorded signals were classified into four groups by distances between the stimulation and recording electrodes on MEA (200-400, 400-600, 600-800, 800-1000 μm). Fifty cathodic phase-1st biphasic current pulses (duration 500 μs, intensity 5, 10, 20, 30, 40, 50, 60 μA) were applied at every 1 sec. We compared false positive error and false negative error in FB filter and TP-adopted FB filter. By implementing TP-adopted FB filter, short-latency spike can be detected better regarding sensitivity and specificity for detecting spikes regardless of the strength of stimulus and the distance between stimulus and recording electrodes.
New Features of Receptive Fields in Mouse Retina through Spike-triggered Covariance
안정열,Bodo Rueckauer,유용석,Yongsook Goo 한국뇌신경과학회 2020 Experimental Neurobiology Vol.29 No.1
Retinal ganglion cells (RGCs) encode various spatiotemporal features of visual information into spiking patterns. The receptive field (RF) of each RGC is usually calculated by spike-triggered average (STA), which is fast and easy to understand, but limited to simple and unimodal RFs. As an alternative, spike-triggered covariance (STC) has been proposed to characterize more complex patterns in RFs. This study compares STA and STC for the characterization of RFs and demonstrates that STC has an advantage over STA for identifying novel spatiotemporal features of RFs in mouse RGCs. We first classified mouse RGCs into ON, OFF, and ON/OFF cells according to their response to full-field light stimulus, and then investigated the spatiotemporal patterns of RFs with random checkerboard stimulation, using both STA and STC analysis. We propose five sub-types (T1-T5) in the STC of mouse RGCs together with their physiological implications. In particular, the relatively slow biphasic pattern (T1) could be related to excitatory inputs from bipolar cells. The transient biphasic pattern (T2) allows one to characterize complex patterns in RFs of ON/OFF cells. The other patterns (T3-T5), which are contrasting, alternating, and monophasic patterns, could be related to inhibitory inputs from amacrine cells. Thus, combining STA and STC and considering the proposed sub-types unveil novel characteristics of RFs in the mouse retina and offer a more holistic understanding of the neural coding mechanisms of mouse RGCs.
DC모터 모델링을 이용한 선루프 제어기 자동반전 기법 개발
안정열 대한전기학회 2022 전기학회논문지 P Vol.71 No.1
In this paper aims to implement the enhanced performance of the existing controller and sunroof fitted to the motor controller using a calculation torque by DC motor modeling. Especially focuses on the development of the Anti-Pitch function, which is one of the most important features sunroof motor. The host computer using the RS232 communication observed directly to the state of the motor and Torque. Performance in a variety of environments were tested using the actual car. Experimental results were satisfied with the general information required and the performance of the Anti-pitch by sunroof
Synchrony of Spontaneous Burst Firing between Retinal Ganglion Cells Across Species
안정열,Huu Lam Phan,차성광,구교인,유용석,구용숙 한국뇌신경과학회 2020 Experimental Neurobiology Vol.29 No.4
Neurons communicate with other neurons in response to environmental changes. Their goal is to transmit information to their targets reliably. A burst, which consists of multiple spikes within a short time interval, plays an essential role in enhancing the reliability of information transmission through synapses. In the visual system, retinal ganglion cells (RGCs), the output neurons of the retina, show bursting activity and transmit retinal information to the lateral geniculate neuron of the thalamus. In this study, to extend our interest to the population level, the burstings of multiple RGCs were simultaneously recorded using a multi-channel recording system. As the first step in network analysis, we focused on investigating the pairwise burst correlation between two RGCs. Furthermore, to assess if the population bursting is preserved across species, we compared the synchronized bursting of RGCs between marmoset monkey (callithrix jacchus), one species of the new world monkeys and mouse (C57BL/6J strain). First, monkey RGCs showed a larger number of spikes within a burst, while the inter-spike interval, burst duration, and inter-burst interval were smaller compared with mouse RGCs. Monkey RGCs showed a strong burst synchronization between RGCs, whereas mouse RGCs showed no correlated burst firing. Monkey RGC pairs showed significantly higher burst synchrony and mutual information than mouse RGC pairs did. Comprehensively, through this study, we emphasize that two species have a different bursting activity of RGCs and different burst synchronization suggesting two species have distinctive retinal processing.
한국인 본태성혈소판혈증 환자에서 JAK2V617F 유전자 변이
안정열,유수진,방수미,박필환,서일혜,신동복,이재훈 대한진단검사의학회 2007 Annals of Laboratory Medicine Vol.27 No.2
배경 : 본태성혈소판혈증은 다능성 조혈모세포의 형질전환에의해 발생하나 정확한 분자유전학적 기전은 확실치 않다. 최근 만성골수증식성질환에서 티로신키나제 유전자 변이가 보고되며 분자유전학적 기전으로 대두되고 있다. 이에 저자들은 한국인 본태성혈소판혈증 환자와 반응성혈소판증가증 환자에서 세포질 티로신키나제인 JAK2의 유전자 변이를 조사하였다.방법 : 본태성혈소판혈증 환자 24명의 골수흡인액과 반응성혈소판증가증 환자 36명의 말초혈액에서 대립유전자특이중합효소연쇄반응(allele-specific PCR)으로JAK2 유전자 변이를 관찰하였다.결과 : 본태성혈소판혈증 환자 24명 중 1명 (46%)에서 JAK2유전자 변이 양성소견을 보였으며 반응성혈소판증가증 환자 36명모두 음성이었다. JAK2 유전자 변이 양성군이 고령과 높은 평균백혈구수를 보이는 경향은 있으나 통계적 유의성은 없었다(P=0.172, P=0.094). 그 외 성별, 혈소판수, 헤모글로빈, 비장종대,세포충실도 증가와 섬유증 및 혈관합병증은 두 군간에 유의한 상관관계는 없었다.
안정열,서일혜,박필환,김경희,박미정,정지훈,박순호,송영희 대한진단검사의학회 2012 Annals of Laboratory Medicine Vol.32 No.2
B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL) (intermediate DLBCL/BL), is a heterogeneous group with some features resembling DLBCL and others resembling BL. Here, we report a case of intermediate DLBCL/BL in a Korean child. A 2-yr-old male was admitted for evaluation and management of left hip pain. Immunohistochemistry of a biopsy of the femur neck revealed tumor cells positive for CD20, CD10, BCL2, BCL6, and Ki67. A bone marrow (BM) aspirate smear revealed that 49.3% of all nucleated cells were abnormal lymphoid cells, composed of large- and medium-sized cells. Immunophenotyping of the neoplastic cells revealed positivity for CD19, CD10, CD20, and sIg lambda and negativity for CD34, Tdt, and myeloperoxidase (MPO). Cytogenetic and FISH analyses showed a complex karyotype, including t(8;14)(q24.1;q32) and IGH-MYC fusion. Intensive chemotherapy was initiated, including prednisone, vincristine, L-asparaginase, daunorubicin, and central nervous system prophylaxis with intrathecal methotrexate (MTX) and cytarabine. One month after the initial diagnosis, BM examination revealed the persistent of abnormal lymphoid cells; cerebrospinal fluid cytology, including cytospin, showed atypical lymphoid cells. The patient was treated again with cyclophosphamide, vincristine, prednisone, adriamycin, MTX, and intrathecal MTX and cytarabine. The patient died of sepsis 5 months after the second round of chemotherapy.
안정열, 조남정 忠北大學校部設基礎科學硏究所 2013 自然科學硏究 Vol.27 No.-
Muscarinic acetylcholine receptor (mAChR)는 G protein-coupled receptor (GPCR)의 일원으로서 다양하고 중요한 생명현상에 관련되어 있다. mAChR의 기능은 세포 내 단백질들과의 상호작용을 통해 조절된 다. 본 실험에서는 꼬마선충 mAChR인 GAR-3와 상호작용하는 단백질을 찾기 위해 yeast two-hybrid 실험 을 수행하였다. MEP-1을 포함하여 여러 단백질들이 GAR-3와 양성반응을 보였다. MEP-1에 의한 세포내 변화를 관찰하기 위해 GAR-3를 발현하는 Chinese hamster ovary (CHO) cell에서 MEP-1을 발현시켰 다. MEP-1의 발현은 GAR-3가 매개하는 ERK1/2 활성화를 억제하였다. 위 결과를 종합하면, MEP-1은 GAR-3와 결합하여 그 기능을 억제하는 것으로 보인다.
안정열 ( An Jeong Yeol ),고광곤 ( Go Gwang Gon ),손지언 ( Son Ji Eon ),신미승 ( Sin Mi Seung ),유원석 ( Yu Won Seog ),안태훈 ( An Tae Hun ),신익균 ( Sin Ig Gyun ) 한국지질동맥경화학회 ( 구 한국지질학회 ) 2002 韓國脂質學會誌 Vol.12 No.1
Background : We have previously shown that conventional dose hormone replacement therapy (C-HRT) improved nitric oxide (NO) bioactivity and reduced markers of inflammation in postmenopausal women (PMW). The effects of low-dose hormone replacement therapy