http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
담석의 병인에 있어서 담낭수축 기능의 의의에 관한 연구
이옥찬(Ock Chan Lee),박경근(Kyung Geun Park),안유헌(Yoo Hern Ahn),임헌길(Heon Kil Rhim),함준수(Joon Soo Hahm),이민호(Min Ho Lee),기춘석(Choon Suhk Kee),박경남(Kyung Nam Park) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.1
N/A Gallstone is the most common disease in the biliary system, and the incidence is increasing gradually. Furthermore, the composition of stones in Korea seems to be changed to approach that of stones formed in the west. Factors responsible for this change may include rapidly pro- ceeding urbanization and changing food habits. The method of medical therapies for gall- stones is also increasing and results in a number of clinical studies for pathogenesis of gall- stones such as stasis, supersaturation, and crystal formation of bile juice. We studied for 40 subjects, healthy controls were 20 (11 male, 9 female: mean age, 44.45 years, mean body mass index, 24.07), and gallstone patients were 20 (1 1 male, 9 female: mean age, 54.7 years, mean body mass index, 22.78). The gallbladder volumes were measured by real time ultrasonography using the ellipsoidal method. And then, we calculated ejection fraction (EF) by these results. The results were expressed as mean + standard deviation, and differ- ence in the mean values of each group were evaluated by the Students t test. Statistical sig- nificance was assigned if P was <0.05. There was no significant difference between gallstone patients and healthy controls in age, body mass index, and biochernical laboratories. Both fasting gallbladder volume and ejection fraction were not different between obese and non obese group. However, ejection fraction in gallstone patients was significantly lower than normal controls in obese group. Ejection frac- tion(EF, %) was significantly greater in controls than gallstone patients. No significant differ- ences were observed in fasting gallbladder volumes between gallstone patients and healthy controls, but gallbladder volume after fatty meal was significantly larger in gallstone patients than control subjects. Fasting gallbladder volumes were significantly reduced after fatty meal in both groups. The gallbladder motility rnay play a role on gallstone formation, and the estimation of its motility may be an important factor in deterrnining the response to medical therapy.(Korean J Gastroenterol 1994; 26: 143 150)
기춘석(Choon Suhk Kee),박동일(Dong Il Park),이오영(Oh Young Lee),한동수(Dong Soo Han),손주현(Joo Hyun Son),윤병철(Byung Chul Yoon),안유헌(Yoo Hern Ahn),함준수(Jun Su Ham),이민호(Min Ho Lee),박경남(Kyung Nam Park) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.5
N/A Gynecomastia occurs in about 30% to 50% of patients with cirrhosis of the liver. Since es- trogens stimulate breast tissue whereas androgens antagonize these effects, gynecomastia has long been considered the result of an imbalance between these hormones. Several mechanisms may operate to produce a relative estrogen excess in hepatic disorders, especially alcoholic cir- rhosis. We have studied the prevalence of gynecomastia and measured the estrogen/testoster- one ratio in cirrhotic subjects and control. Twenty male patients with hepatic cirrhosis were identified from the medical inpatient services of our institution and ten nonobese healthy rnedi- cal students with no history or physical findings of liver disease cornposed the noncirrhotic control group. The mean BMI in the control subjects was 21.3 + 0.8kg/m and that in the group with cirrhosis was 22.1 + l.lkg/m. Therefore, no statistical significance was found. Gy- necomastia was present in 30% of the control subjects and 25% of the cirrhotic subject. No significant correlation existed between breast tissue diameter and the BMI in the subjects with cirrhosis. In the control group, TT concentrations were higher and TE concentrations were lower than the cirrhotic groups, therefore the ratio of TE/TT were more decreased compared with the subjects with cirrhosis. In contrast, the mean total and free serum testosterone con- centrations were considerably lower and the mean total estrogen concentrations were higher in cirrhotic patients with gynecomastia compared with those without gynecomastia as were the ratio of TE/FT, E2/FT, TE/TT and E2/TT. In conclusion, the prevalence of gynecomastia in cirrhotic patients was 25%. Total and free serum testosterone concentrations did not differ statistically significant in the cirrhotic men with and without gynecomastia. Neither the TE FT ratio nor the E2 FT ratio was statistically increased in cirrhotic subjents with gynecomastia compared with those without gynecomastia. These findings imply that factors other than the estrogen testosterone ratio may play a role in the development of gynecomastia in both cirrhotic and control subjects. (Korean J Gastroente- rol 1994; 26: 842 849)
왕준광 ( Joon Kwang Wang ),박의순 ( Ui Soon Park ),이혜순 ( Hye Soon Lee ),엄완식 ( Wan Sik Uhm ),김태환 ( Tae Hwan Kim ),배상철 ( Sang Cheol Bae ),유대현 ( Dae Hyun Yoo ),안유헌 ( You Hern Ahn ),최윤영 ( Yun Young Choi ),주경빈 ( 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.4
Objective: Decrease in bone mineral density (BMD) occurs relatively early and is known to be correlated with disease activity in patients with ankylosing spondylitis (AS). We investigated BMD and its correlation factors in Korean patients with AS. Methods: Fifty patients with AS fulfilling modified New York criteria and age-, sex-, and body mass index-matched 100 normal controls were selected. Medical records were reviewed retrospectively. Lumbar and femur BMD was measured using a dual energy X-ray absorptiometry. Results: Both lumbar and femur BMD in patients with AS were significantly lower than BMD in control group. Although Bath ankylosing spondylitis disease activity index, C-reactive protein and erythrocyte sedimentation rate showed no correlation with BMD, lumbar BMD in patients with high disease activity in terms of inflammatory factors was significantly lower than that in patients with low disease activity. Conclusion: BMD in patients with AS was significantly lower than those in control group. Early detection and appropriate management will be necessary in patients with AS.
위절제술이 골대사 및 골밀도에 미치는 영향 - 예검법으로서 의미있는 지표
권성준(Sung Joon Kwon),신동일(Donng Ill Shin),원치규(Chi Kyooh Won),전규영(Kyu Young Jun),곽진영(Jin Young Kwak),이광수(Kwang Soo Lee),정파종(Pa Jong Jung),안유헌(Yoo Hern Ahn),함준수(Joon Soo Hahm),김목현(Mok Hyun Kim) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.2
N/A Background/Aims: Abnormalities of bone metabolism occur to gastrectomised patients in the form of a late complication. Nowadays, many biochemical and radiologic measurements are applied to detect these abnormalities. The aim of this study was to determine the parameter for an appropriate screening test during the long-term follow-up period and define the usefulness of new biochemical markers for bone metabo]ism by comparing them with traditional markers. Methods: Among the patients gastrectomised(Billroth II) in the surgica] department of Hanyang University Hospital since 1982, 10 patients were randomly selected with exclusion criteria by measuring several biochemical and radiologic tests. Ten age-matched volunteers who led a healthy normal life were selected with the consent of subjects. Results: Comparing the data with those of a corresponding control group, the ]umbar bone density tneasured by quantitative cornputed tornography(QCT) was statistically significantly lower in the patient group(p0.01). In addition, urinary deoxypyridinoline (DPD), a biochemical marker for bone resorption, was statistica]ly higher in the patient group(p -0.025). Osteocalcin, P1CP, and 1CTP were slightly but not significant]y bigher in the patient group. The serum PTH and 25-hydroxyvitamin D levels were sitnilar in both groups. Conclusiions: Although the nurnber of cases was smal] for data evaluation, we suggest that urinary deoxypyridinoline and QCT were appropriate parameters for tbe screening test for the detection of bone metabolism abnormalities in gastrectomised patients during the long-term follow-up. Furthermore, urinary deoxypyridinoline is a simple and rapid test which can replace cumbersome 24-hour urinary hydroxypro]ine. (Korean J Gastroenterol 1996; 28:172 178)
김인순,김호중,안유헌,이동석,유용걸,김목현,정철현,이옥찬,조온구 대한내분비학회 1994 Endocrinology and metabolism Vol.9 No.1
Lipomas are among the most common of all benign neoplasma and occur more frequently over the back, between the shoulders, and on the back of the neck. They are usually subcutaneous in origin, and characteristically multilobulated masses of fatty tissue that vary from small nodules to large masses weighing several kilograms. A mass in the anterior part of the neck may be initially thought to be thyroid nodules and then other cervical masses should be considered. Ultrasonographic examination of benign lipoma demonstrates solid and echogenic mass and may differentiate nonthyroid from thyroid masses. When lipoma is clinically suspected, the use of CTs can establish the correct diagnosis without the use of thyroid hormone suppression or the need for urgent surgery. We experienced a case of anterior cervical mass in a 51-year-old male patient presenting a non-tender and soft mass rapidly growing for recent several months and moved with swollowing, and diagnosed his case as benign lipoma using ultrasonography, computed tomographic scan, and fine niddle asperation biopsy and therefore when we encounter patients with anterior neck mass, we should consider benign lipoma mimicking thyroid nodule(J Kor Soc Endocrinol 9:32-34, 1994).
김정호,김인순,안유헌,유용걸,김목현,손정일,고영혜,윤석남 대한내과학회 1994 대한내과학회지 Vol.47 No.4
Amyloidosis is a disease of unknown cause characterized by the accumulation of an amorphous, proteinaceous material in various organs and tissue of the body. We had recently experienced a 31-year-old man presented with subacute thyroiditis like symptoms, diarrhea and proteinuria. He had tender, diffuse, firm goiter, low normal limit of thyroid function, and increased erythyrocyte sedimentation rate. On the basis of history, clinical settings, and laboratory findings, the diagnosis of subacute thyroiditis was initially made. Steroid therapy resulted in dramatic improvement of thyroid symptoms, Histological examinations of the patient's thyroid gland, colon and kidney revealed amyloid deposition. Retrospectively, we concluded that amyloid depasition in thyroid gland, colon, and kidney was secondary to ankylosing spondylitis from which he had suffered for 14 years. He has achieved clinical improvement with steroid and thyroid hormone replacement therapy and being followed-up. In conclusion, when patients with clinical features of subacute thyroiditis have an unusual course, the possibility of thyroid amyloidosis should be considered.
세포막 Capacitance 측정을 이용한 단일 백서 췌장 β 세포의 분비기전 연구
박용수,이창범,김동선,최웅환,안유헌,김태화 한양대학교 의과대학 2000 한양의대 학술지 Vol.20 No.1
The relationship between depolarization-induced exocytosis and inward Ca^2+ current (I_ca) in single isolated rat pancreatic β cells was investigated in perforated patch recordings. I_ca was elicited by depolarization and change in cell membrane capacitance (C_m) was monitored as an indicator of resultant exocytosis. Although there was significant variety of change in C_m and Ca^2+ influx, the increase in C_m had positive correlation with Ca^2+ influx and also with duration of depolarization. Removal of extracellular Ca^2+ or inclusion of extracellular Cd^2+ (100uM) completely eliminated both I_ca and increase in C_m following depolarization. Dihydropyridine(DHP), Ca^2+ channel blocker (5uM) partly and in parallel suppressed depolarization-induced peak I_ca, Ca^2+ influx, and change in C_m. These data suggest that rat pancreatic β cell expresses at least two types of Ca^2+ channels; Ca^2+ entry through these DHP-sensitive, presumably L-type, and DHP-insensitive channels trigger exocytosis with similar efficacy.