익위승양탕가감방을 통해 월경통이 호전된 자궁선근증 환자 1례

안뜰에봄,정현정,An, Tteul-E-Bom,Jung, Hyun-Jung 대한암한의학회 2017 大韓癌韓醫學會誌 Vol.22 No.2

Objective: The purpose of this study is to report the effect of Yikwiseungyang-tang-gagam-bang on Dysmenorrhea with Adenomyosis. Methods: The patient was a secondary dysmenorrhea with adenomyosis accompanied by menorrhagia. She took 2 packs of herbal medicine, Yikwiseungyang-tang-gagam-bang, a day, and received acupuncture treatment at point of CV 4, EX-CA1, CV 12, LI 4, LR 3, SP 6, ST 36 three times a week for two menstrual cycle. Results: After treatment, menstrual pain was reduced from VAS 10 to 1. In addition, menstrual fluid volume also were reduced from VAS 10 to 6. The quality of life is also improved, so sleep and digestion problems improved. Conclusion: This study suggests that Oriental medicine treatment including Yikwiseungyang-tang-gagam-bang may have the efficacy for the treatment of Dysmenorrhea with Adenomyosis.

Estradiol Valerate로 유발된 다낭성 난소 증후군의 한약치료에 대한 국내 실험연구 고찰

안뜰에봄 ( E Bom Tteul ),김동철 ( Dong Chul Kim ) 대한한방부인과학회 2014 大韓韓方婦人科學會誌 Vol.27 No.4

Objectives: To observe the effects of Herb medication on Polycystic Ovary (PCO) in rats. Methods: Riss (Research Information Sharing Service) was searched for Oriental medicine about PCO on 2000~2014. So, Experimental studies using PCO model induced by Estradiol Valerate (EV) was selected to analyze how effects they were. Consequently, 10 studies published on 2000~2014 were selected to analyze about weight of model and both ovaries, the number of follicle and corpus luteum, the level of serum Androstenedione (ADD) and total estrogen, the level of Nerve Growth Factor (NGF) and Corticotropin Releasing Factor (CRF), the crossover rate and the number of implantation. Results: Among them, there was significantly difference between treatment group and control group in weight of both ovaries, the number of follicle and corpora lutea, the crossover rate and the number of implantation. Conclusions: The effects of Herb medication was observed on making weight of ovaries with PCO to promote. The study about effect of Herb medication on NGF and CRF with PCOS had to be conducted. The further research have to focus on treatment of subfertility and infertility, that is field showing the advantage of Oriental medicine.

온청음 물 추출물의 세포독성, 피부재생, 주름개선, 미백 및 보습 효과

안뜰에봄 ( Tteul E Bom An ),김동철 ( Dong Chul Kim ) 대한한방부인과학회 2016 大韓韓方婦人科學會誌 Vol.29 No.1

목 적: 본 연구에서는 한의학에서 다양한 피부질환과 대사질환에 빈번히 사용되고 있는 온청음 물 추출 동결건조물(수율=13.82%)의 피부 노화 개선 효과 평가의 일환으로 세포독성, 피부재생, 주름개선, 미백 및 보습 효과를 각각 평가하였다. 방 법: 본 연구에서는 human normal fibroblast(CRL-2076) 및 B16/F10 murinemelanoma(CRL-6475) 세포에 대한 온청음의 세포독성을 MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium Bromide) 방법으로 평가하였으며, 피부 재생 및 주름 개선 효과를 transforming growth factor(TGF)-β1와 비교한 fibroblast의 collagentype I 합성능, phosphoramidon disodium salt(PP)와 비교한 elastase 활성 억제, oleanolic acid(OA)와 비교한 hyaluronidase, collagenase 및 matrix metalloproteinase(MMP)-1 활성 억제를 통해 각각 평가하였고, 미백효과를 B16/F10 murine melanomacells의 melanin 생성 억제 정도 및 tyrosinase 활성 억제를 통해 arbutin과 비교 평가하였으며, 모든 실험은 OCE의 농도별로 군을 나누어 농도에 따른 효과의 변화를 함께 분석하였다. 보습효과는 흰쥐의 피부 수분함량 변화를 통해 평가하였다. 결 과: 본 실험의 결과, 온청음은 human normal fibroblast 및 B16/F10 murinemelanoma 세포에 대해 의미 있는 세포독성을 나타내지 않았으며, fibroblast의 collagentype I 합성을 증가시켰고, 세포외 기질의 파괴에 관여한다고 알려진 hyaluronidase,elastase, collagenase 및 MMP-1 활성을 억제하였으며, 피부의 색을 결정하는 melanin의 생성에 관여하는 tyrosinase의 활성 및 B16/F10 murine melanoma cells의 melanin생성을 억제하는 것으로 관찰되었다. 이 반응의 효과들은 모두 농도에 비례하여 증가하였고, 이와 함께 정상 매체 대조군에 비해 흰쥐의 피부 수분 함량이 세 용량의 온청음 경구 투여군 모두에서 투여용량 의존적으로 의미 있는 증가를 보였다. 결 론: 이상의 결과에서, 온청음은 세포 독성 없이 비교적 우수한 피부 재생,주름개선, 미백 및 보습 효과를 나타내는 것으로 관찰되어, 차후 피부 노화 억제개선제 또는 기능성 화장품의 주요 소재로서 그 가치가 매우 높을 것으로 판단되나, 금후 개별 구성 약재 각각에 대한 효능 및 생리활성을 나타내는 화학성분의 검색과 더불어 다양한 방면으로 기전적인 연구와 피부 보호 효과에 대한 in vivo평가를 체계적으로 수행해야 할 것으로 판단된다. Objectives: The objective of this study was to evaluate the effects of cytotoxicity, skin regeneration, anti-wrinkle, whitening and skin moisturizing of Oncheongeum (OCE). Methods: The cytotoxicity of OCE lyophilized aqueous extracts (yield=13.82%) was observed against human normal fibroblast cells and B16/F10 murine melanoma cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium Bromide (MTT) assay, and skin regeneration and anti-wrinkle effects were also evaluated through the assay of collagen type I synthesis compared to the transformation of the growth factor (TGF)-β1, hyaluronidase, collagenase and matrix metalloproteinase (MMP)-1 inhibitory assays compared to oleanolic acid (OA), and elastase inhibitory effects compared to phosphoramidon disodium salt (PP). In addition, OCE``s whitening effects were measured by a tyrosinase inhibitory assay and melanin formation test in B16/F10 murine melanoma cells compared to arbutin, and skin moisturizing effects were observed through a mouse skin water content test, respectively. Results: No OCE treatment-related cytotoxic effects appeared on human normalfibroblasts and B16/F10 murine melanoma cells. OCE concentration-dependently increased the collagen Type I synthesis on human normal fibroblast cells, and also effectively inhibited hyaluronidase, elastase, collagenase and MMP-1 activities. In addition, OCE inhibited melanin production of B16/F10 murine melanoma cells and activity of tyrosinase. And significant and dose-dependent increases of skin water content were detected in OCE-treated mouse skin compared to vehicle control skins. Conclusions: OCE showed favorable and sufficient effects in skin regeneration, anti-wrinkle, whitening and skin moisturizing in this experiment. But more detail mechanisms and studies on the skin protective efficiency of in vivo are needed with the screening of active biological compounds in individual OCE herbs.

소복축어탕가감방과 온침요법으로 호전된 월경통 환자 8례에 대한 보고

안뜰에봄 ( Tteul-e-bom An ),김동철 ( Dong-chul Kim ) 대한한방부인과학회 2016 大韓韓方婦人科學會誌 Vol.29 No.3

Objectives: This paper was aim to report the effects of Sobokchukeo-tang-gagambang and warm needle therapy on the dysmenorrhea patients. Methods: The patients having treated with Sobokchukeo-tang-gagambang and warm needle therapy, from January 1st in 2014 until May 31st in 2016, was enrolled in this study. We collected and analyzed their age, accessory complaint except dysmenorrhea, treatment period, dosage of herbal medicine, diagnosed gynecological disease, remedies`` effectiveness, etc. Results: All of the patients treated with Sobokchukeo-tang-gagambang and warm needle therapy in this study were recovered. Also, correlation between the characteristic and recovery status of patients was not confirmed. Conclusions: Sobokchukeo-tang-gagambang and warm needle therapy is effective on patients having variable gynecological diseases. But the cases are very deficient, so we need to study about availability of Sobokchukeo-tang and warm needle therapy on dysmenorrhea more systematically.

사상체질의학회지에 10년간 게재된 태음인 증례연구 논문 분석 - 2006년부터 2015년까지 -

성수현,안뜰에봄,박종현,한창현,Sung, Soo-Hyun,An, Tteul-E-Bom,Park, Jong-Hyun,Han, Chang-Hyun 사상체질의학회 2016 사상체질의학회지 Vol.28 No.2

Objectives This study aimed to provide a basis for treatment of taeeum person by analysing published case reports and case series in Journal of Sasang Constitutional Medicine.Methods We reviewed case reports and case series of taeeum person in the Journal of Sasang Constitutional Medicine from 2006 to 2015.Results Of the forty papers, reporting 182 cases of taeeum person. Thirty-five papers reported 6 types of Sasang Constitutional Medicine pattern. A total of 10 types of interventions were described, of which herbal medicine (100%) was most frequently used. A total of 30 types of outcome measeure were used in papers, for which symptom change (79.2%) was most frequently used. A total of 8 types of diagnosis criteria were used in 38 papers.Conclusions A sufficient number of clinical studies are warranted to provide a clinical evidence for treatment of taeeum person.

사상체질의학회지에 10년간 게재된 소음인 증례연구 논문 동향분석 - 2006년부터 2015년 까지 -

성수현,홍승민,안뜰에봄,Sung, Soo-Hy+un,Hong, Seong-Min,An, Tteul-E-Bom 사상체질의학회 2016 사상체질의학회지 Vol.28 No.1

Objectives This study aimed to provide a basis for treatment of soeum person by analysing published case reports and case series in Journal of Sasang Constitutional Medicine.Methods We have reviewed case reports and case series of soeum person in the Journal of Sasang Medicine from 2006 to 2015.Results Of the Twenty-four papers, reporting were reported in twenty-four papers. A total of 13 interventions were described, of which herbal medicine (100%) was most frequently used. Twenty-four papers reported herbal medicine, of which Palmulgunjatang (25%) was most frequently used. A total of 24 Sasang Constitutional Medicine pattern were used in 24 papers, for which soeum person kidney heat affection induced exterior heat disease depression frantic syndrome (25%) was most frequently used.Conclusions A sufficient number of clinical studies are warranted to provide a clinical basis for treatment of soeum person.

骨度法과 同身寸法에 의한 穴位 선정 비교 : 上肢部ㆍ腹部ㆍ下肢部의 經穴을 중심으로

이봉효(Bonghyo Lee),안뜰에봄(Tteul-E-Bom An),임명아(Myunga Lim),정준길(Joon-gil Jeong),조정윤(Jeongyoon Cho),황민혁(Minhyuk Hwang),이경민(Kyungmin Lee),박지하(Jiha Park) 한국한의학연구원 2010 한국한의학연구원논문집 Vol.16 No.2

Objectives : The bone proportional cun and body cun have been used widely for the location of acupoints in oriental medical clinic. The aim of this study is to compare the two location methods. Methods : 21 students were examined for the location of 6 acupoints (each 2 points in the 3 parts of upper limb, abdomen, and lower limb) using the twe methods. The data of location were analyzed with t-test. Results : In the upper limb, the data from bone proportional cun and body cun were proved to be different significantly. However, there was no significant difference between the data from the two methods in the abdomen and lower limb. Conclusion : The results of this study demonstrate that the oriental medical doctors should be more careful in the choice of appropriate method for the location of acupoints in the upper limb, while it is not important whether they use bone proportional cun and body cun in the abdomen and lower limb.

갑상선 유두암 환자의 갑상선엽절제술 후유증에 대한 증례 보고 3례

조수연 ( Su-yuncho ),안뜰에봄 ( Tteul-e-bom An ),김동철 ( Dong-chulkim ) 대한한방부인과학회 2018 大韓韓方婦人科學會誌 Vol.31 No.3

Objectives: This paper aims to report the effects of Korean medical treatment on three patients who underwent thyroid lobectomy for thyroid cancer. Methods : Three patients were hospitalized at hospital to treat pain and general weakness after thyroid lobectomy. The patients took Korean medical treatment including herbal medicine and acupuncture. Numerical Rating Scale (NRS) of symptoms was measured every morning. Results : After the treatment, the pain and general weakness following surgery decreased, and general conditions improved. Conclusions: This cases show that Korean medical treatment is effective for a patients who underwent thyroid lobectomy for thyroid cancer.

東醫寶鑑 處方을 통해 살펴본 舍巖鍼法 正格의 의미 : 肝正格을 중심으로

이봉효(Bonghyo Lee),안뜰에봄(Tteul-e-bom An),정준길(Joon-gil Jeong),조정윤(Jeong-yoon Cho),황민혁(Minhyuk Hwang),이경민(Kyungmin Lee),박지하(Jiha Park) 한국한의학연구원 2011 한국한의학연구원논문집 Vol.17 No.1

Objectives : We have little desirable study and standardization about the meaning of the fixed-pattern of Saam acupuncture treatment. This study was performed to find out the desirable meaning and function of the fixed-pattern of Saam acupuncture treatment, at first through Liver Supplementation Acupuncture (Ganjeonggyeok) mentioned the most in the 『Saamdoinch'imguyogyeol 』 and used widely in oriental medicine clinic nowadays. Methods : The cases of Liver Supplementation Acupuncture (Ganjeonggyeok) were excerpted from 『Saamdoinch'imguyogyeol 』. 2. The same of similar syndromes were excerpted from 『Donguibogam』 and the herb medicines used for them were investigated. 3. The function, kwigeong, and classification of herb medicines were investigated from the textbook of herbology. 4. The physiological meaning of liver was excerpted from 『Donguisaengnihak』, the textbook of physiology oriental medicine. 5. The research about comprehensive meaning of Liver Supplementation Acupuncture (Ganjeonggyeok) was performed based on the results of above. Results and Conclusions : 1. In the function of Liver Supplementation Acupuncture (Ganjeonggyeok), the major is to run the qi and blood and to regulate the fluid metabolism, while reproductive and spiritual aspect is minor. 2. The function of Liver Supplementation Acupuncture (Ganjeonggyeok) is not limited to the liver as one of the organs or the LR as one of the meridians, but related with the metabolism and the function of whole body. 3. Liver Supplementation Acupuncture (Ganjeonggyeok) needs sufficiency of qi and the function of it is shown through spleen qi.

압박손상으로 발생한 비골신경마비 환자 치험 1례

김정아,지민정,원제훈,안뜰에봄,김동철,Kim, Jung-Ah,Ji, Min-Jung,Won, Je-Hoon,An, Tteul E Bom,Kim, Dong-Chul 척추신경추나의학회 2014 척추신경추나의학회지 Vol.9 No.1

Objectives: The Purpose of this study is to report the effects of Korean medical treatment on patient of peroneal neuropathy caused by sitting cross-legged. Methods: The patient diagnosed as peroneal neuropathy was treated by Acupuncture, Bee Venom therapy, Herbal medicine. To evaluate the effects of Korean treatment, we used Range of Motion(ROM) of Ankle, Visual Analog Scale(VAS), Numeric Rating Scale(NRS), Ankle-Hind-foot Scale(AHS), Digital Infrared Thermal Imaging(DITI). Results: After treatment, ROM of Ankle, VAS, NRS, AHS were improved. Temperature Difference(${\Delta}T$) was decreased on DITI. Conclusions: This study suggests that Korean medical treatment might be effective on sitting cross-legged patient diagnosed as Peroneal Neuropathy.