익위승양탕가감방을 통해 월경통이 호전된 자궁선근증 환자 1례

안뜰에봄,정현정,An, Tteul-E-Bom,Jung, Hyun-Jung 대한암한의학회 2017 大韓癌韓醫學會誌 Vol.22 No.2

Objective: The purpose of this study is to report the effect of Yikwiseungyang-tang-gagam-bang on Dysmenorrhea with Adenomyosis. Methods: The patient was a secondary dysmenorrhea with adenomyosis accompanied by menorrhagia. She took 2 packs of herbal medicine, Yikwiseungyang-tang-gagam-bang, a day, and received acupuncture treatment at point of CV 4, EX-CA1, CV 12, LI 4, LR 3, SP 6, ST 36 three times a week for two menstrual cycle. Results: After treatment, menstrual pain was reduced from VAS 10 to 1. In addition, menstrual fluid volume also were reduced from VAS 10 to 6. The quality of life is also improved, so sleep and digestion problems improved. Conclusion: This study suggests that Oriental medicine treatment including Yikwiseungyang-tang-gagam-bang may have the efficacy for the treatment of Dysmenorrhea with Adenomyosis.

난소적출 마우스를 이용한 골다공증 개선효과를 나타내는 巴戟天과 肉蓗蓉 熱水 抽出物의 복합 최적 조성 선택 실험

안뜰에봄,김동철 대한한방부인과학회 2019 大韓韓方婦人科學會誌 Vol.32 No.3

Objectives: To select the optimal ranges showing obvious synergic anti-osteoporotic potential after adjust mixed formula consisted of Morindae Radix (MR) and Cistanchis Herba (CH) as compared with those of each single formula or risedronate sodium (RES) using bilateral ovariectomized (OVX) female mice. Methods: Fourteen groups, total eight sham or 104 OVX mice were selected based on the body weights at 34 days after OVX surgery. After that, 9 types mixed compositions, single formula of MR and CH, and RES were orally administered for 35 days. And we measured changes in body weight and gain, femur weight, bone mineral density (BMD), bone strength (failure load) and mineral content - calcium (Ca) and inorganic phosphorus (IP), osteocalcin contents and bone specific alkaline phosphatase (bALP) activities of all mice. Results: The OVX-induced estrogen-deficient osteoporotic signs were significantly inhibited by 35 days of continuous oral treatment of all treated mice as compared with OVX control mice. Especially, MR:CH 1:3 and 1:1 mixed formula treated mice showed significantly more favorable inhibitory activities against estrogen-deficient osteoporosis symptoms as compared to those of each single formula of MR and CH. Although RES also ameliorated the decreases of the femur BMD, strength and trabecular bone architectures through the inhibited the increases of bone turnover, but they did not critically influenced on the bone formations. Conclusions: The results suggest that MR:CH 1:3 mixed formula showed somewhat lower anti-resorptive effects as compared to those of RES, but they also showed bone formation effects. therefore, it is expected that MR:CH 1:3 mixture will be promising as a potent protective agents for relieving the osteoporosis in menopausal women.

일개 한방병원에 내원한 갱년기 여성의 연령에 따른 적외선체열분포(DITI)와 Kupperman’s Index(KI), Menopause Rating Scale(MRS)간의 상관성 연구

안뜰에봄,김동철,An, Ddeul-E-Bom,Kim, Dong-Chul 대한한방부인과학회 2015 大韓韓方婦人科學會誌 Vol.28 No.4

Objectives : To study correlation between Digital Infrared Thermal Imaging, Kupperman’s Index (KI) and Menopause Rating Scale (MRS) of Postmenopausal Women Methods : We analyzed 114 patients visiting Pohang Oriental Hospital from 1 ^st January 2014 to 30 ^th September 2015. The evaluating indexed of this trial were Age, DITI, KI, MRS. Temperature and different of temperature, such as In-dang (HN3), dan-Jung (CV17), gwan-won (CV4), hyup-back (LU4), no-gung (PC8), bock-to (ST31), and tae-chung (LR3). Results : Age was no correlation with DITI, KI, and MRS. There were positive correlation with KI and MRS significantly. DITI was not correlated with Age, KI and MRS, while ⊿T1 (LU4-PC8) was correlated with ⊿T2 (ST31-LR3) and ⊿T3 (CV17-CV4). Conclusions : There were non-significant correlation between DITI and Menopausal scale, but significant correlation in DITI themselves, Menopausal themselves. The More studies ar needed for the more accurate oriental medical diagnosis

온청음 물 추출물의 세포독성, 피부재생, 주름개선, 미백 및 보습 효과

안뜰에봄 ( Tteul E Bom An ),김동철 ( Dong Chul Kim ) 대한한방부인과학회 2016 大韓韓方婦人科學會誌 Vol.29 No.1

목 적: 본 연구에서는 한의학에서 다양한 피부질환과 대사질환에 빈번히 사용되고 있는 온청음 물 추출 동결건조물(수율=13.82%)의 피부 노화 개선 효과 평가의 일환으로 세포독성, 피부재생, 주름개선, 미백 및 보습 효과를 각각 평가하였다. 방 법: 본 연구에서는 human normal fibroblast(CRL-2076) 및 B16/F10 murinemelanoma(CRL-6475) 세포에 대한 온청음의 세포독성을 MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium Bromide) 방법으로 평가하였으며, 피부 재생 및 주름 개선 효과를 transforming growth factor(TGF)-β1와 비교한 fibroblast의 collagentype I 합성능, phosphoramidon disodium salt(PP)와 비교한 elastase 활성 억제, oleanolic acid(OA)와 비교한 hyaluronidase, collagenase 및 matrix metalloproteinase(MMP)-1 활성 억제를 통해 각각 평가하였고, 미백효과를 B16/F10 murine melanomacells의 melanin 생성 억제 정도 및 tyrosinase 활성 억제를 통해 arbutin과 비교 평가하였으며, 모든 실험은 OCE의 농도별로 군을 나누어 농도에 따른 효과의 변화를 함께 분석하였다. 보습효과는 흰쥐의 피부 수분함량 변화를 통해 평가하였다. 결 과: 본 실험의 결과, 온청음은 human normal fibroblast 및 B16/F10 murinemelanoma 세포에 대해 의미 있는 세포독성을 나타내지 않았으며, fibroblast의 collagentype I 합성을 증가시켰고, 세포외 기질의 파괴에 관여한다고 알려진 hyaluronidase,elastase, collagenase 및 MMP-1 활성을 억제하였으며, 피부의 색을 결정하는 melanin의 생성에 관여하는 tyrosinase의 활성 및 B16/F10 murine melanoma cells의 melanin생성을 억제하는 것으로 관찰되었다. 이 반응의 효과들은 모두 농도에 비례하여 증가하였고, 이와 함께 정상 매체 대조군에 비해 흰쥐의 피부 수분 함량이 세 용량의 온청음 경구 투여군 모두에서 투여용량 의존적으로 의미 있는 증가를 보였다. 결 론: 이상의 결과에서, 온청음은 세포 독성 없이 비교적 우수한 피부 재생,주름개선, 미백 및 보습 효과를 나타내는 것으로 관찰되어, 차후 피부 노화 억제개선제 또는 기능성 화장품의 주요 소재로서 그 가치가 매우 높을 것으로 판단되나, 금후 개별 구성 약재 각각에 대한 효능 및 생리활성을 나타내는 화학성분의 검색과 더불어 다양한 방면으로 기전적인 연구와 피부 보호 효과에 대한 in vivo평가를 체계적으로 수행해야 할 것으로 판단된다. Objectives: The objective of this study was to evaluate the effects of cytotoxicity, skin regeneration, anti-wrinkle, whitening and skin moisturizing of Oncheongeum (OCE). Methods: The cytotoxicity of OCE lyophilized aqueous extracts (yield=13.82%) was observed against human normal fibroblast cells and B16/F10 murine melanoma cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium Bromide (MTT) assay, and skin regeneration and anti-wrinkle effects were also evaluated through the assay of collagen type I synthesis compared to the transformation of the growth factor (TGF)-β1, hyaluronidase, collagenase and matrix metalloproteinase (MMP)-1 inhibitory assays compared to oleanolic acid (OA), and elastase inhibitory effects compared to phosphoramidon disodium salt (PP). In addition, OCE``s whitening effects were measured by a tyrosinase inhibitory assay and melanin formation test in B16/F10 murine melanoma cells compared to arbutin, and skin moisturizing effects were observed through a mouse skin water content test, respectively. Results: No OCE treatment-related cytotoxic effects appeared on human normalfibroblasts and B16/F10 murine melanoma cells. OCE concentration-dependently increased the collagen Type I synthesis on human normal fibroblast cells, and also effectively inhibited hyaluronidase, elastase, collagenase and MMP-1 activities. In addition, OCE inhibited melanin production of B16/F10 murine melanoma cells and activity of tyrosinase. And significant and dose-dependent increases of skin water content were detected in OCE-treated mouse skin compared to vehicle control skins. Conclusions: OCE showed favorable and sufficient effects in skin regeneration, anti-wrinkle, whitening and skin moisturizing in this experiment. But more detail mechanisms and studies on the skin protective efficiency of in vivo are needed with the screening of active biological compounds in individual OCE herbs.

Estradiol Valerate로 유발된 다낭성 난소 증후군의 한약치료에 대한 국내 실험연구 고찰

안뜰에봄 ( E Bom Tteul ),김동철 ( Dong Chul Kim ) 대한한방부인과학회 2014 大韓韓方婦人科學會誌 Vol.27 No.4

Objectives: To observe the effects of Herb medication on Polycystic Ovary (PCO) in rats. Methods: Riss (Research Information Sharing Service) was searched for Oriental medicine about PCO on 2000~2014. So, Experimental studies using PCO model induced by Estradiol Valerate (EV) was selected to analyze how effects they were. Consequently, 10 studies published on 2000~2014 were selected to analyze about weight of model and both ovaries, the number of follicle and corpus luteum, the level of serum Androstenedione (ADD) and total estrogen, the level of Nerve Growth Factor (NGF) and Corticotropin Releasing Factor (CRF), the crossover rate and the number of implantation. Results: Among them, there was significantly difference between treatment group and control group in weight of both ovaries, the number of follicle and corpora lutea, the crossover rate and the number of implantation. Conclusions: The effects of Herb medication was observed on making weight of ovaries with PCO to promote. The study about effect of Herb medication on NGF and CRF with PCOS had to be conducted. The further research have to focus on treatment of subfertility and infertility, that is field showing the advantage of Oriental medicine.

일개 한방병원에 내원한 갱년기 여성의 연령에 따른적외선체열분포(DITI)와 Kupperman`s Index(KI), Menopause Rating Scale(MRS)간의 상관성 연구

안뜰에봄 ( Ddeul E Bom An ),김동철 ( Dong Chul Kim ) 대한한방부인과학회 2015 大韓韓方婦人科學會誌 Vol.28 No.4

Objectives: To study correlation between Digital Infrared Thermal Imaging, Kupperman``s Index (KI) and Menopause Rating Scale (MRS) of Postmenopausal Women Methods: We analyzed 114 patients visiting Pohang Oriental Hospital from 1st January 2014 to 30th September 2015. The evaluating indexed of this trial were Age, DITI, KI, MRS. Temperature and different of temperature, such as In-dang (HN3), dan-Jung (CV17), gwan-won (CV4), hyup-back (LU4), no-gung (PC8), bock-to (ST31), and tae-chung (LR3). Results: Age was no correlation with DITI, KI, and MRS. There were positive correlation with KI and MRS significantly. DITI was not correlated with Age, KI and MRS, while □T1 (LU4-PC8) was correlated with □T2 (ST31-LR3) and □T3 (CV17-CV4). Conclusions: There were non-significant correlation between DITI and Menopausal scale, but significant correlation in DITI themselves, Menopausal themselves. The More studies ar needed for the more accurate oriental medical diagnosis

소복축어탕가감방과 온침요법으로 호전된 월경통 환자 8례에 대한 보고

안뜰에봄 ( Tteul-e-bom An ),김동철 ( Dong-chul Kim ) 대한한방부인과학회 2016 大韓韓方婦人科學會誌 Vol.29 No.3

Objectives: This paper was aim to report the effects of Sobokchukeo-tang-gagambang and warm needle therapy on the dysmenorrhea patients. Methods: The patients having treated with Sobokchukeo-tang-gagambang and warm needle therapy, from January 1st in 2014 until May 31st in 2016, was enrolled in this study. We collected and analyzed their age, accessory complaint except dysmenorrhea, treatment period, dosage of herbal medicine, diagnosed gynecological disease, remedies`` effectiveness, etc. Results: All of the patients treated with Sobokchukeo-tang-gagambang and warm needle therapy in this study were recovered. Also, correlation between the characteristic and recovery status of patients was not confirmed. Conclusions: Sobokchukeo-tang-gagambang and warm needle therapy is effective on patients having variable gynecological diseases. But the cases are very deficient, so we need to study about availability of Sobokchukeo-tang and warm needle therapy on dysmenorrhea more systematically.

소아 성장에 대한 한의학 치료: 국내 임상연구에 대한 문헌적 고찰

한지은,안뜰에봄,박장경,성현경,연지혜,성수현 대한한방소아과학회 2021 대한한방소아과학회지 Vol.35 No.1

Objectives: The purpose of this study is to provide evidence of treatment of growth disorder Methods: We have reviewed clinical studies of growth disorder in children and adolescent through 6 databases until February, 2020. The searching keywords were “short stature OR dwarfism OR growth disorder” AND “acupuncture OR electric acupuncture OR electroacupuncture OR moxibustion OR herb medicine OR cupping OR Korean medicine OR oriental medicine OR chuna OR pharmacopuncture OR qigong OR traditional medicine OR traditional Korean medicine OR Korean medicine”. There was no limit to time and language. Results: As a result of the initial search, a total of 270 papers from six domestic databases were found. Among these papers, 156 papers were selected after excluding duplicated papers, and 109 of them were further excluded after checking the title and the abstract. Additionally, 28 papers were excluded by reviewing the full text. The author, year, number of patients, treatment, evaluation tools, and results of a total of 19 papers were included in this study and were summarized. 90.5% of the studies have shown that herbal remedies have improved childhood growth. Conclusions: Random control studies and large-scale observational studies are needed in future to show high-quality evidence for the treatment of Korean medicine in pediatric growth.

사상체질의학회지에 10년간 게재된 태음인 증례연구 논문 분석 - 2006년부터 2015년까지 -

성수현,안뜰에봄,박종현,한창현,Sung, Soo-Hyun,An, Tteul-E-Bom,Park, Jong-Hyun,Han, Chang-Hyun 사상체질의학회 2016 사상체질의학회지 Vol.28 No.2

Objectives This study aimed to provide a basis for treatment of taeeum person by analysing published case reports and case series in Journal of Sasang Constitutional Medicine.Methods We reviewed case reports and case series of taeeum person in the Journal of Sasang Constitutional Medicine from 2006 to 2015.Results Of the forty papers, reporting 182 cases of taeeum person. Thirty-five papers reported 6 types of Sasang Constitutional Medicine pattern. A total of 10 types of interventions were described, of which herbal medicine (100%) was most frequently used. A total of 30 types of outcome measeure were used in papers, for which symptom change (79.2%) was most frequently used. A total of 8 types of diagnosis criteria were used in 38 papers.Conclusions A sufficient number of clinical studies are warranted to provide a clinical evidence for treatment of taeeum person.

[은상] 지역별 강우 상관 계수를 고려한 빗물 저류 시설 입지 선정 최적화

배성재,심소연,안뜰에봄,유형우,이충목 대한산업공학회 2015 ie 매거진 Vol.22 No.4