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골반종양 환자에서 수술 전 혈청 CA-125와 TPA 농도의 의의
심재호,김민관,배동한,선우재근,안금성,장경택 대한부인종양 콜포스코피학회 1997 Journal of Gynecologic Oncology Vol.8 No.2
We measured serum levels of CA-125 and Tissue polypeptide antigen(TPA) in 135 patients with pelvic tumors(129 benign pelvic tumors and 6 malignant ovarian tumors) preoperatively. Each tumor marker was measured by immunoradiometric assay. Serum CA-125 levels of 35.0U/ml, 65.0U/ml and TPA levels of 80.0U/ml, 100.0U/ml were determined as cut-off values. The results were evaluated by each tumor marker and two tumor markers coincidently. The results were as follows : 1. The mean value of serum CA-125 was 33.4U/ml in the benign pelvic tumors and 167.8U/ml in malignant ovarian tumors. The mean value of serum TPA was 24.6U/ml in the benign polvic tumors and 156.4U/ml in malignant ovarian tumors. 2. The highest value of serum CA-125 was 72.9U/ml in adenomyosis in benign pelvic tumors. The highest value of serum TPA was 38.7U/ml in adenomyosis and myoma uteeri in benign pelvic turmors, but not specific. 3. The highest value of serum CA-125 was 351U/ml in malignant ovarian tumors. The highest value of serum TPA was 502.6U/ml in malignant tumors. 4. In cut0off 35U/ml, the sensitivity of preoperative CA-125 was 100%, the specificity 75.1%, the positive value 15.8%, the negative predictive value 100%. In cut-off value 65U/ml, the sensitivity of preperative TPA was 83.3%, the specificity 86.8%, the positive predictive value 55.6%, the negative predictive value 99.2%. 5. In cut-off 80U/ml, the sensitivity of preoperative value 100%, In cut-off value 100U/ml, the sensitivity of preoperative CA-125 was 66.7%, the specificity 98.4%, the positive predictive value 66.7%, the negative predictive value 98.4%. 6. The sensitivity of preoperative CA-125 and TPA coincidently was 100%, the specificity 98.4%, the positive predictive value 75.0%, the negative predictive value 100% in cut-off level 35U/ml(CA-125) and 80U/ml(TPA). The sensitivity of preoperative CA-125 and TPA coincidently was 100%, the specificity 99.2%, the positive predictive value 85.7%, the negative predictive value 100% in cut-off level 35U/ml(CA-125) and 100U/ml(TPA). The sensitivity of preoperative CA-125 and TPA coinsidently was 100%, the specificity 90.2%, the positive predictive calue 85.7%, the negative predictive value 100% in cut-off level 65U/ml(CA-125) and 80U/ml(TPA). The sensitivity of preoperative CA-125 and TPA coincidently was 83.3%, the specificity 100%, the positive predictive value 66.7%, the negative predictive value 98.4% in cut-off level 65U/ml(CA-125) and and 100U/ml(TPA). 7. No significant correlation was observed between serum level of each tumor marker, clinical stage and pathologic diagnosis.
강준모(J . M . Kang),장경택(K . T . Jang),안금성(G . S . An),최규연(K . Y . Choi),배동한(D . H . Bae) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.11
Abdominal pregnancy is a very rare form of extrauterine pregnancy and potentially life threatening variation of ectopic gestation within the peritoneal cavity, and it is accompanied by high rates of maternal morbidity and motality. Primary abdominal pregnancy is very rare and in most instances abdominal pregnancy is secondary. Frequency has been estimated to be 10.9 abdominal pregnances per 100,000 live births and 9.2 per 1,000 ectopic pregnancies. The etiological factors in abdominal pregnancy are not clear, but conditions leading to ectopic pregnancy may apply to aMominal pregnancy as well. The delayed ovulation or fertilization, partially or totally occluded tubes, previous abdominal surgery, IVF-ET, PID and endometriosis are considered to be the most common etiology of ectopic pregnancy. The following case is the report of a primary abdominal pregnancy associted with intrauterine contraceptive device with a brief literature review.