http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
류마티스관절염 환자의 활막세포에서 Stat 단백의 발현에 관한 연구
심승철 ( Seung Cheol Shim ),이인홍 ( In Hong Lee ),정자헌 ( Ja Hun Jung ),김태환 ( Tae Hwan Kim ),전재범 ( Jae Bum Jun ),송강원 ( Kang Won Song ),배상철 ( Sang Cheol Bae ),유대현 ( Dae Hyun Yoo ),김성윤 ( Seong Yoon Kim ) 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.1
Objective: To characterize Stat activity in synovial tissue in rheumatoid arthritis (RA) in order to see if Stat molecule contributes to the pathogenesis of RA by regulatory expression of genes that play an important role in inflammation and tissue destruction. Methods: Synovial tissue were obtained immediately after operative excision. Immuno-histochemistry was done with the antibodies for Stat 3 and Stat 5. Cells were stimulated with interleukin 6 (IL-6) and soluble interleukin 6 receptor (sIL-6R) or steroid using chambered slide. In supershift experiment, cell extracts were incubated with 0.5ng of 32P-labelled double-stranded oligonucleotide probe. Samples were resolved on 4.5% polyacrylamide gels, which was transferred to polyvinylidene fluoride membranes. Anti-phosphotyrosine Stat 3 antibody was used for Western blotting. Results: Stat 3 was not shown on the synovial tissue section done by immuno-histochemistry. However, activated Stat 3 was expressed on cultured synovial cell stimulated with IL-6 and sIL-6R, and also with IL-6 and dexamethasone using chambered slide. In contrast to Stat 3, activated Stat 5 was expressed on the synovial tissue section, especially around blood vessel. Conclusion: Stat is activated in cultured synovial cells as shown in other immune associated cells, and IL-6 is the strong activator of Stat 3. Further analysis of the regulation of Stats in synovitis and the role of Stats in driving synovial inflammation will yield insight into the pathogenesis of RA and the development of novel therapeutic modality.
남자 류마티스 관절염 환자에서 Androgen 보충요법의 치료 효과
심승철(Seung Cheol Shim),장대국(Dae Kuk Chang),김종필(Jong Phil Kim),정성수(Sung Soo Jung),이인홍(In Hong Lee),배상철(Sang Cheol Bae),유대현(Dae Hyun Yoo),최웅환(Woong Hwan Choi),김성윤(Seong Yoon Kim) 대한내과학회 1994 대한내과학회지 Vol.46 No.2
N/A Objectives: Recently, attention has been focused on the androgenic status of male rheumatoid arthritis patients. A hypogonadic condition, which is characterized by low serum testosterone concentration. seems to be associated at least with the activity of rheumatoid arthritis. Methods: We reviewed 46 cases of male RA patients who were admitted or visited to Hanyang University Hospital since Jannuary 1992 and five male RA patients who had low serum testosterone levels were treated for 24 weeks with testosterone in an attempt to evaluate the role of sex hormone in rheumatoid arthritis. Overall clinical and laboratorial results were obtained. Result: 1) The average serum testosterone level was 5.56 ng/ ml in male RA patients and 6.99 ng/ml in male OA patients. 2) In male RA patients, the range of serum testosterone concentration was 2.2~7.3 ng/ml and the range of serum DHEA-S concentration was 134~2313ng/ml. Both data were within normal limits. 3) Male RA patients who had low serum testosterone level were treated with testosterone and significant hormonal changes were not found. 4) After androgen replacement therapy there were no signficant changes in Ritchie articular index, grip strength of hands, global assessement of patients and physician, ESR etc. 5) During androgen replacement therapy only one case completed 24 weeks of this trial and another 3 cases were stopped due to abnormal liver function and the other one was stopped for aggravation of symptoms. Conclusion: Laboratory parameters of disease activity and overall clinical status not improved significantly with androgen replalcement in male rheumatoid arthritis patient having low testosterone.
류마티스 관절염 환자에서 미립체로 구성된 거대 견봉하 점액낭염
심승철 ( Seung Cheol Shim ),전재범 ( Jae Bum Jun ),장대국 ( Dae Kook Chang ),이제경 ( Je Kyung Lee ),유태석 ( Tae Seok Yoo ),고희관 ( Hee Kwan Koh ),김태환 ( Tae Hwan Kim ),정성수 ( Sung Soo Jung ),이인홍 ( In Hong Lee ),배상철 ( 대한류마티스학회 1998 대한류마티스학회지 Vol.5 No.1
Rice bodies are numerous small fibrinous, cartilaginous-like materials which were first described in tuberculous joints. Rice bodies are common findings in joints afflicted with rheumatoid arthritis or other seronegative arthropathy. But less commonly, those can be seen in periarticular bursae or at the sites of tendon or ligament insertion. Rice bodies, thought to be a nonspecific response to synovial inflammation, probably evolve from ischemia in a proliferative synovium. Some of these bodies contain a core of collagen with a mantle of fibrin, others contain only fibrin. Subacromial bursa are sometimes involved in the patients with rheumatoid arthritis and can reach impressive dimensions before becoming clinically detectable because significant constrain is lacking. Subacromial arthrography or magnetic resonance imaging accurately delineated the existence of cartilaginous loose bodies before surgical exision. We experienced a man with rheumatoid arthritis who had massive subacromial bursitis with rice bodies. His shoulder had been swollen since 5 years ago. He felt no pain and had only mild limitation of motion. Subacromial arthrography or magnetic resonance imaging of right shoulder showed multiple rice bodies in enlarged subacromial bursa. Operation finding showed a large encapsulated mass in the subacromial bursa, and hundreds of fibrinous rice bodies were revealed, which were resected. We report this patient with a review of literatures.
심승철(Seung Cheol Shim),전재범(Jae Bum Jun),정성수(Sung Soo Jung),이인홍(In Hong Lee),배상철(Sang Cheol Bae),유대현(Dae Hyun Yoo),김성윤(Seong Yoon Kim),정화순(Wha Soon Chung),정낙은(Nak Eun Chung) 대한내과학회 1994 대한내과학회지 Vol.47 No.6
N/A Objectives : Anemia is the most common extra-articular manifestation of rheumatoid arthritis (RA). However neither the frequency of anemia in the patients of RA nor the role of erythroid abnormalities in various types of anemia have been reported previously in Korean population. Methods : To establish the frequency of anemia and the role of erythropoietin in the pathophysiology of anemia, 500 patients with RA were selected randomly from the patients who were diagnosed at Rheumatism center of Hanyang university hospital from January 1993. Results : 1) In the series of 500 RA patients, 196 patients (39.2%) had anemia, and 127 of 196 patients with anemia had mild anemia (Hb more than 10.0 g/dl), the other 69 patients (35%) had moderate to severe anemia. 2) 92 (77.3%) of 120 patients with anemia had anemia of chronic disease (ACD) and iron deficiency anemia (IDA) was observed in 26 patients (22.7%). Other types of anemia were also found: one case had vitamin B12 deficiency anemia, the other case had autoimmune hemolytic anemia. 3) 17 patients with ferritin between 20~100 ng/ml were examined bone marrow aspiration and biopsy. The results of bone marrow biopsy were identical with that of Iron index (=-0.00446×TIBC+1.22765×Log ferritin-0.07824) except one case, 4) ACD had higher value of Ritchie index, ESR, functional class than IDA (p<0.01), Serum iron had no significant differences between ACD and IDA, but TIBC and ferritin had significant differences between two groups (p<0.01). 5) Ritchie index versus Hb (r=-0.38. p<0.01)'and ESR versus Hb (r=-0.53, p<0.01) were negatively related but there were no significant differences in disease duration. 6) Serum erythropoietin was 17.27±1.3 mu/ml in ACD and 35.64±1.7 mu/ml in IDA, and there were significant differences between these two groups (p<0.01). Conclusions : Iron index is a useful method for differential diagnosis between ACD and IDA. In ACD, erythropoietin may be effective in rheumatoid arthritis with moderate to severe anemia.
Breakdown of the vaginal ecosystem in patients with rheumatoid arthritis
심승철 ( Seung Cheol Shim ),김태환 ( Tae Hwan Kim ),전재범 ( Jae Bum Jun ),정성수 ( Sung Soo Jung ),이인홍 ( In Hong Lee ),배상철 ( Sang Cheol Bae ),황정혜 ( Jung Hye Hwang ),문영진 ( Young Jin Moon ),조수현 ( Soo Hyun Cho ),최태 대한내과학회 1998 대한내과학회 추계학술대회 Vol.1998 No.1
Breakdown of the Vaginal Ecosystem in Patients with rheumatoid arthritis
심승철(Seung Cheol Shim),김태환(Tae Hwan Kim),전재범(Jae Bum Jun),정성수(Sung Soo Jung),이인홍(In Hong Lee),배상철(Sang Cheol Bae),황정혜(Jung Hye Hwang),문영진(Young Jin Moon),조수현(Soo Hyun Cho),최태열(Tae Yeal Choi),유대현(Dae Hy 대한내과학회 1998 대한내과학회 추계학술대회 Vol.55 No.-
Systemic Lupus erythematosus initially presented with moyamoya disease
심승철 ( Seung Cheol Shim ),김태환 ( Tae Hwan Kim ),장대국 ( Dae Kook Chang ),고희관 ( Hee Kwan Koh ),전재범 ( Jae Bum Jun ),정성수 ( Sung Soo Jung ),이인홍 ( In Hong Lee ),배상철 ( Sang Cheol Bae ),유대현 ( Dae Hyun Yoo ),김성윤 대한내과학회 1998 대한내과학회 추계학술대회 Vol.1998 No.1
Mesna 사용 후 협부 발진양 알레르기 반응을 보인 2예
서정철 ( Jeong Cheol Seo ),배상철 ( Sang Cheol Bae ),심승철 ( Seung Cheol Shim ),김태환 ( Tae Hwan Kim ),전재범 ( Jae Bum Jun ),정성수 ( Sung Soo Jung ),이인홍 ( In Hong Lee ),유대현 ( Dae Hyun Yoo ),김성윤 ( Seong Yoon Kim ) 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.2
Hemorrhagic cystitis is potentially life-threatening sequellae of chemotherapy using oxazaphosphorine alkylating agents (cyclophosphamide and ifosfamide). Mesna contains a sulfhydryl group that is believed to bind acrolein within the urinary collecting system and reduce the hemorrhagic cystitis without affecting the chemotherapeutic potential. To date, about thirty cases of hypersensitivity or allergic reactions of the delayed and urticarial type associated with mesna have been reported. We reported two patients with systemic lupus erythematosus who developed facial rash and flushing associated with mesna which imitate malar rash.