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초음파 분무 열분해법으로 제조한 ZnO막의 전기적, 구조적 특성에 미치는 인듐 확산 효과
심대근,배성찬,마대영 한국전기전자재료학회 2001 전기전자재료학회논문지 Vol.14 No.10
Zinc oxide (ZnO) films deposited on indium (In) films were post-annealed in a rapid thermal anealing (RTA) system. The ZnO/In films were RTA-treated in air or a vacuum ambient. The crystallographic properties and surface morphologies of the films were studied before and after the RTA by X-ray diffraction(XRD) and scanning electron microscopy (SEM), respectively. The resistivity variation of the films with RTA temperature and time was measured by the 4-point probe method. Auger electron spectroscopy (AES) was carried out to figure out the redistribution of indium atoms in the ZnO films. The resistivity of the ZnO/In films decreased to 2$\times$10$\^$-3/ Ωcm by diffusion of the In. The In diffusion into the ZnO films roughened the surface of ZnO films. The results of depth profile by AES showed a hump of In atoms around ZnO/In interface after the RTA at 800 $\^{C}$. The effects of temperature time and ambient during the RTA on the structural and electrical properties of the ZnO/In films were discussed.
칸디다뇨증 환자에 있어서 칸디다혈증 동반과 관련된 위험인자 분석
김창오(Chang Oh Kim),김명환(Myoung Hwan Kim),심대근(Dae Keun Shim),조정호(Jung Ho Cho),김병극(Byoung Keuk Kim),김창년(Chang Nyun Kim),송영구(Young Goo Song),김준명(June Myung Kim) 대한내과학회 2001 대한내과학회지 Vol.60 No.5
N/A Background : The early diagnosis of candidemia is critical for the management. The candidemia is known to be associated with 10% of candiduria. But the risk factors in patients with candiduria who are associated with candidemia are not known. We analyzed the risk factors in patients with candiduria who are associated with candidemia. Methods : We retrospectively reviewed 164 patients with candiduria in Yonsei Medical Center from January 1998 to December 1998. Candiduria patients were divided into two groups. Candiduria patients without candidemia (Group 1 , 147 patients) and candiduria patients with candidemia (Group 2 , 17 patients). Results : 1) The mean age of the patients were 57.5 years in group 1 and 62.5 years in group 2. There were no significant differences in the sex ratio between the two groups. 2) Central venous catheter insertion (53%, 100% in group 1 , 2 ), hypotension (14%, 59% in group 1, 2), other associated infections (64%, 100% in group 1, 2), intensive care (41, 76% in group 1, 2) and fever (46%, 82% in group 1, 2) were the very significant risk factors in patients with candiduria who were associated with candidemia. 3) Urinary tract procedure (11%, 88% in group 1, 2), urinary catheter insertion (63%, 94% in group 1, 2), thrombocytopenia (17%, 41% in group 1, 2) and DM (8%, 24% in group 1, 2) were the significant risk factors of candidemia. 4) Candida colony count (cfu/mL) of urine culture was not a significant risk factor 5 ) Mortality rate (27%, 59% in group 1, 2) was significantly high in patients with candidemia. Conclusion : Central venous catheter insertion , hypotension , other associated infections , intensive care and fever were the very significant risk factors of candidemia in patients with candiduria. (Korean J Med 60:479-484 , 2001)
인슐린비의존형 당뇨병환자에서 허혈성 심장질환의 선별검사로서 관상동맥 칼슘침착수치 측정의 유용성
임승길(Sung Kil Lim),이종호(Jong Ho Lee),이현철(Hyun Chul Lee),송영득(Young Duk Song),김경래(Kyung Rae Kim),허갑범(Kap Bum Huh),윤용석(Yong Seok Yun),이유미(Yu Mie Rhee),심대근(Dae Keun Sim),신성관(Sung Kwan Sin),박병규(Byung Ku Park 대한내과학회 1999 대한내과학회지 Vol.56 No.3
N/A Patients with NIDDM are at increased risk for the development of coronary atherosclerosis and experience more silent myocardial infarction than non-diabetic subjects. The screening tools for early detection of coronary artery disease without significant narrowing has been requested in diabetic patients. Coronary artery calcification (CAC) score, quantified by electron beam computed tomography (EBT), have been reported to correlate with the amount of atherosclerotic plaque and vascular luminal narrowing. We investigated the distribution of CAC score and associated risk factors in asymptomatic NIDDM patients and patients with ischemic heart disease to estimate the usefulness of CAC as a screenig tool for ischemic heart disease in asymptomatic diabetes. Method : 136 NIDDM patients without any symptom of coronary artery disease and 37 patients with significant coronary artery stenosis were included. CAC were measured by electron bean tomography (ultrafast CT). Forty contiguous 3-mm thickness transverse two-dimensional sections were obtained through root of aorta and heart. Coronary calcification were defined as the presense of at least two adjacent pixel within the border of visualized coronary artery with CT number of at least 130 HU. Body mass index, waist-hip ratio were measured and body fat components were counted by impedence method. Visceral fat versus subcutaneous fat ratio were calculated by abdominal computed tomography. Plasma lipid profile, fasting insulin, C-peptide level, HbA1c concentration were measured. Correlations between natural log of CAC score and clinical parameters were evaluated and multiple regression analysis with natural log of CAC score as a independent variable was performed. Coronary angiography were performed in 17 asymptomatic NIDDM patients.. Result : CAC score was significantly higher in male than female subjects and increased significantly with aging (p<0.01). In patients with hypertension, previous history of cerebrovascular or peripheral vascular disease (p<0.05), CAC score was significantly increased. The CAC score showed significant positive correlations with smoking amount, duration of diabetes and a negative correlation with HDL-cholesterol (p<0.05). There were no association between CAC score and total cholesterol, LDL-cholesterol, waist to hip circumference ratio, or fasting insulin levels. After adjustment of compounding variables (age, sex), duration of diabetes, amount of smoking and previous history of atherosclerotic vascular disease were shown to be associated with CAC score. In multiple logistic regression analysis with natural log of CAC score as dependent variable, age, HDL-cholesterol, duration of diabetes, male gender were found to be significant independent variables. Seventeen diabetic patients with high CAC score, were taken coronary angiography and significant luminal narrowings (more than 50%) of coronary artery were documented in 16 patients. But, In 7 out of 17 patients with coronary one-vessel disease, coronary calcification were not detected by EBT. Conclusion : coronary artery calcium score quantified by electron beam computed tomography may be useful for screening of preclinical or asymptomatic coronary artery disease in asymptomatic NIDDM patients.