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Immunopotentiator가 마우스의 網內系 機能 및 Rosette 形成能에 미치는 影響
申一均,金福伊,崔三任,李惠洙,金象皓 의과학연구소 1987 全北醫大論文集 Vol.11 No.4
This experiment was performed to evaluate the effect of immunopotentiator(picibanil) on the function of reticuloendothelial system(RES), changes of peripheral blood, and rosette formation of the spleen cells pretreated with sheep erythrocytes(SRBC) in mice. Picibanil(1KE/kg of body weight in group 1 and successive injection of 0.1, 0.25 and 0.5 KE/kg of body weight in group 2) were administered intravenously on SRBC pretreated mice. The phagocytic activity of the RES was evaluated by carboa clearance methods, and the rosette formation test of spleen cells to SRBC was also made. The results were as follows : 1. The phagocytic activity of RES and the weight of liver and spleen were increased significantly at 3rd, 5th, and 7th days than control group after treatment of picibanil. 2. The peripheral polymorphonuclear leukocytes, lymphocyte and monocyte were increased, but no significant in statistical analysis. 3. The E-rosette formation rate of picibanil treated group showed an increased level by passing the time of 5th days after injection. Trereafter, it returned gradually to the control level by the time of 10th days.
신일균 전북대학교 의과학연구소 1977 全北醫大論文集 Vol.1 No.-
In modern society, characterized by variability of daily life and complicated industrial structure, the danger of unexpected accident is alwas threatening the people. About two thirds of the patients with traffic accident have had injury of various forms. Among the patients with head injury due to traffic accident, the most common cause of death is head injury itself, about 70%. I have studied 71 cases of head injury patients, who were admitted and managed at Department of neurosurgery, Jeonbug National University Hospital from July 1975 to October 1976, in clinical aspect, and also have compared with other articles. Followings are results. 1. There were 56 men and 15 women; male to female ratio was about 4:1. 2. The most common cause of head injury was traffic accident. 3. The favorable site of linear skull fracture was occipital bone, and that of depressed skull fracture was frontal bone. 4. Altered consciousness of various form was observed in about 66% of total head injury patients. Lucid interval was observed in about 37% of the cases with intracranial hemorrhagic lesions. 5. Convulsive seizure was observed in 7% and vomiting occured in about 24% of total head injury patients. 6. Half of the cases with skull fracture were accompanied by intracranial hemorrhagic lesions. About 79% of cases with intracranial hemorrhagic lesion were accompanied by skull fracture. 7. Mortality rate of the patients with head injury was 19.7% and their operative mortality rate was 28.6%. Operative mortality rate in the cases with subdural hematoma was 45.5%. All the operated case of epidural hematoma was survived. 8. Sequelae were noted in 25.4%. 9. Associated injury with head injury was found in about 42% of the total patients.
신일균 전북대학교 의과학연구소 1978 全北醫大論文集 Vol.2 No.-
Meningiomas are occassionally seen in the cauda equina, arising in most instances from the inner surface of the dura mater or from the arachnoid membrane. The are usually a bit softer and occassionally are vascular than neurofibromas and are more likely to fit over the surface of the cauda equina and conform to its irregularities. Cauda equina meningiomas are reported to be rare. We have experienced a case of meningioma of the cauda equina in a 54 years old man. A brief literature review was also presented.
各種 腦腫瘍 組織의 Neuron-Specific Enolase, Glial Fibrillary Acidic Protein 및 S-100Protein 에 對한 免疫組織化學的 檢索
申一均,沈載桓,李惠洙,吳敬烈,金象皓 의과학연구소 1988 全北醫大論文集 Vol.12 No.2
To help the diagnosis and classification of the grain tumors and investigate the origin of their cells, immunohistochemnical studies for neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP), and S-100 protein in the 58cases of various brain tumors were performed by means of immunoperoxidase technique with peroxidase-antiperoxidase (PAP) method. The results were as follows ; 1. Collected brain tumors were 10 cases of astrocytoma, 10 cases of meningioma, 8 cases of glioblastoma multiforme, 6 cases of oligodendrogloima, 5 cases of neurilemmoma, 4 cases of ependymoma, and 3 cases of craniopharyngioma. And other neurogenic and nonneurogenic tumors were 12 cases. 2. NSE activities were observed in the tissues of astrocytoma, gloiblastoma multiforme, oligodemdroglioma. neurilemmoma, ependymoma, menihgioma, craniophrayngioma, and pituitary adenoma with various pattern. But in the nonneurogenic tumor tissues, most of them were negative for NSE staining although there were a few cases weakly positive reactions. 3. In astrocytoma and glioblastoma multiforme, relatively strong positive reaction were observed for GFAP staining, but any correlations between the degree of the positivity and the differentiation of the tumors were not recognized. And except a few cases of meningioma and craniopharyngioma with weakly positive reactions, most of the neurogenic an nonneurogenic tumors were negative for GFAP staining. 4. S-100 proteins were detected in most of the neurogenic tumors, e.g., astrocytoma, glioblastoma multiforme, oligodemdroglioma, neurilemmoma, ependymoma, meningioma, and craniopharyngioma, but the positivities were not related to the degree of differentiation of the tumors. And nonneurogenic tumors were negative for S-100 protein staining. These results indicate that immunohistochemical demonstration of the specific antigens for nervous tissue such as NSE, GASP, and S-100 protein by PAP method might be useful tool in diagnosis of brain tumors and origin of tumor cells. (Key words : Brain tumors, Neuron-specific enolase, Glial fibrillary acidic protein, S_100 protein, Immunohistochemical study)
Spasmodic Torticollis의 외과적 시험 1례 보고
신일균 中央醫學社 1975 中央醫學 Vol.28 No.5
A case of spasmodic torticollis treat(d surgically is presented. The surgical procedures consists of bilateral intracranial section of the spinal roots of spinal accessory nerve, bilateral intradural rhizotomy of spinal nerves from C1 to C3, -and unilateral intradural rhizotomy of C4 on the affected side, those were followed -by peripheral division of the spinal accessory nerve and myotomy of sternoclei,domastoid muscle in a secondary operation. For the completeness of the procedure, occipital bone should by removed up to 2 cm above the posterior rim of the foramen magnum and correct identification of C1 root was essential.