가족복지와 지역사회 통합돌봄 정책 그리고 사회복지관의 역할 - 케어안심주택 중심으로

신용규 한국가족사회복지학회 2019 한국가족사회복지학회 학술발표논문집 Vol.2019 No.2

습식법으로 제조한 수산화아프타이트의 침전과 그 분말에 대한 Ca/P 몰비의 영향

신용규,정형진,김병호 한국세라믹학회 1988 한국세라믹학회지 Vol.25 No.6

Effect of Ca/P mole ratio on the precipitates and powder properties of hydroxyapatite was investigated. Powder and precipitates of hydroxyapatite were synthesized by the reaction of Ca(NO3)2.4H2O and (NH4)2 HPO4 solutions at room temperature. The pH value and compositions (Ca/P mole ratio) in starting solutions were 11 and 1.64-1.79(or 1.85), respectively. Rodlike hydroxyapatite precipitates were agglomerated together. The average agglomerated particle size was ranged from 2-8${\mu}{\textrm}{m}$. Among compositions, the minimum agglomerated particle size was shown at the Ca/P mole ratio 1.75. CO2 was contained in hydroxyapatite powders and these ultrafine powders had poor crystallinity. The specific surface area and specific total pore volume of hydroxyapatite powders were 104-137$m^2$/g and 0.396-0.467cc/g, respectively. When the Ca/P mole ratio was 1.75, these values were the maximum. And water content increased with the Ca/P mole ratio(Ca/P mole ratio>1.67). In most cases, hydroxyapaite was stable to 130$0^{\circ}C$. However, in the case of Ca/P mole ratio 1.64, hydroxyapatite was changed to $\alpha$-whitlockite at 120$0^{\circ}C$.

Effects of Amitriptyline and Imipramine on Superoxide Generation, Myeloperoxidase Release, Leukotriene $B_4$ in Human Neutrophils

신용규,이정수,이광수,Shin Yong-Kyoo,Lee Chung-Soo,Lee Kwang-Soo The Korean Society of Pharmacology 1995 대한약리학잡지 Vol.31 No.1

삼환계 항우울제들은 calmodulin 억제 작용을 갖고 있으며, 칼슘 유입, 산화성 인산화 반응 및 ATPase 활성도를 억제하는 것으로 제시되고 있지만 사람 호중구에서의 기능 표현에 대한 효과는 밝혀져 있지 않다. 본 연구에서는 amitriptyline, imipramine과 doxepine이 superoxide와 $H_2O_2$ 생성, myeloperoxidase 유리, leukotriene $B_4$ 생성과 세포내 칼슘의 상승에 나타나는 효과를 조사하였다. 변성된 IgG에 의하여 활성화된 호중구에서 superoxide와 $H_2O_2$ 생성은 amitriptyline, imipramine과 doxepine에 의하여 억제되었고 EDTA, EGTA, verapamil과 bepredil은 superoxide 생성을 억제하였다. Chlorpromazine, trifluoperazine, staurosporine 및 H-7 또한 superoxide 생성을 억제하였다. PMA에 의한 superoxide 생성은 amitriptyline, imipramine과 doxepine, chlorpromazine과 H-7에 의하여 억제되었다. Amitriptyline, imipramine, chlorpromazine과 trifluoperazine은 변성된 IgG에 의한 myeloperoxidase 유리를 억제하였다. 변성된 IgG에 의하여 활성화된 호중구에서 $LTB_4$와 5-HETE 형성은 amitriptyline, imipramine과 doxepine에 의하여 억제되었다. 변성된 IgG에 의한 세포내 칼슘의 증가는 amitriptyline, imipramine, doxepine, chlorpromazine과 EGTA에 의하여 억제되었고, verapamil은 세포내 칼슘의 증가를 약간 억제하였으나 H-7은 세포내 칼슘의 증가에 영향이 없었다. 이상의 결과로부터 변성된 IgG에 의하여 활성화된 호중구에서의 respiratory burst, myeloperoxidase 유리와 LTB, 생성에 대한 amitriptyline, imipramine과 doxepine의 억제효과는 칼슘동원, calmodulin과 protein kinase C의 억제에 기인할 것으로 추정된다. A number of tricyclic antidepressants appear to have inhibitory action on calmodulin. Although amitriptyline, imipramine and doxepine have been shown to inhibit calcium uptake, oxidative phosphorylation and ATPase activities, effects of amitriptyline, imipramine and doxepine on functional responses of human neutrophils have not been elucidated. In this study, effects amitriptyline, imipramine and doxepine on superoxide and hydrogen peroxide generation, myeloperoxidase release, leukocriene B4 formation and intracellular calcium level were investigated. Superoxide and hydrogen peroxide production in heat aggregated IgG-activated neutrophils were inhibited by amitriptyline, imipramine and doxepine. EDTA, EGTA, verapamil and bepredil inhibited heat aggregated IgG-induced superoxide production. Chlorpromazine, trifluoperazine, staurosporine and H-7 also inhibited it. PMA-induced superoxide production was inhibited by amitriptyline, imipramine, doxepine, chlorpromazine and H-7. Amitriptyline, imipramine, chlorpromazine and trifluoperazine inhibited the myeloperoxidase release by heat aggregated IgG. Productions of $LTB_4$, and 5-HETE in heat aggregated IgG-activated neutrophils were inhibited by amitriptyline, imipramine and doxepine. In neutrophils, elevation of intracellular calcium induced by heat aggregated IgG was inhibited by amitriptyline, imipramine, doxepine, chlorpromazine and EGTA, while verapamil slightly inhibited increase of intracellular calcium and H-7 did not inhibit it. These results suggest that the inhibitory effect of amitriptyline, imipramine and doxepine on respiratory burst, myeloperoxidase release and LTB4 production in heat aggregated IgG-activated neutrophils appears to be ascribed to the inhibition of calcium mobilization, calmodulin and protein kinase C.

습식법으로 제조한 수산화아파타이트 분말의 소결과 그 미세구조에 미치는 Ca/P몰비의 영향

신용규,정형진,김병호 한국세라믹학회 1989 한국세라믹학회지 Vol.26 No.1

Hydroxyapatite powders were syntehsized by the reaction of Ca(NO3)2.4H2O and (NH4)2HPO4 in aqueous solution. The effect of the Ca/P mole ratio in the starting solution on the sintering of the powders and its microstructure was studied. When the Ca/P mole ratio in the starting solution was 1.69, the relative density of the sintered bodies was more than 95%. The sinterability was decreased as the Ca/P mole ratio in the starting solution was increased (Ca/P mole ratio >1.67). Hydroxyapatite sintered bodies obtained from the Ca/P mole ratio=1.69 had very excellent bending strength. The best bending strength was obtained at 110$0^{\circ}C$ and its value was 1220kg/$\textrm{cm}^2$. The average grain size was 0.277${\mu}{\textrm}{m}$. Most of sintered bodies were almost shown 100% hydroxyapatite phase. However, in case of the Ca/P mole ratio=1.64 hydroxyapatite was decomposed to $\alpha$-whitlockite above 120$0^{\circ}C$.

친환경 쌀 생산을 위한 포트육묘 이앙의 경제성 분석

신용규,최인영,권영립,문영훈,최동칠,이왕휴 한국작물학회 2012 한국작물학회지 Vol.57 No.4

친환경 식품이 소비자의 마음을 사로잡으면서 농업의 목표가 생산성 유지 및 향상과 환경의 질을 보존하는 새로운 패러다임으로 변화하고 있다. 따라서 환경친화적 농업(environmentally sound agriculture)이 강조되면서 친환경쌀 생산단지에서 공동으로 이용하고 있는 포트육묘 재배가 농가관행 산파육묘 재배에 비해 얼마나 효율적인지 경제성을 분석한 결과는 다음과 같다. 1. 포트육묘 이앙은 관행이앙 방법에 비해 이앙모판, 파종 및 이앙기 등의 가격이 245% 높았다. 따라서 감가상각비 역시 관행농법에 비해 포트육묘 이앙에서 1.9배 높았다. 2. 10a 당 투입된 노동시간, 노동력 및 비용은 포트육묘 이앙재배에서 각각 13%, 4% 높았다. 그러나 이앙 및 재배에 투입되는 농자재는 종자 및 상토비를 각각 44.0%와 49.2% 절감할 수 있기 때문에 관행농법 대비 4.4% 낮았다. 3. 또한, 포트육묘 이앙재배는 관행 산파육묘 이앙재배에 비해 수량증수에 의한 조수입의 증가(6.7%)와 이앙 후 초기 활착이 빠르고, 성묘이앙으로 초기생육이 양호하여 잡초방제에 유리한 점은 친환경 벼 재배에 적합한 요인으로 작용하였다. 4. 10a 당 육묘와 이앙단계에서의 경영비는 포트육묘 이앙재배에서 229.8% 높았으나 정부에서 80% 기기보조가 된 경우 관행 산파육묘 이앙재배 대비 경영비가 45.4% 절감되었다. In the new changing scenario, the goal of agriculture is shifting from traditional to sustainable and environment-friendly agriculture. Therefore, in this experiment, we analyzed economic efficiency of two methods of rice cultivation i.e. new cultural metIn the new changing scenario, the goal of agriculture is shifting from traditional to sustainable and environment-friendly agriculture. Therefore, in this experiment, we analyzed economic efficiency of two methods of rice cultivation i.e. new cultural method and conventional method, at farmers' fields. In the new cultural method, cost of materials and machines (rice-transplanting and sowing machine) was found 245% higher than the conventional method. Depreciation of cost and working hours were also higher in the new cultural method by 1.9 and 1.1 time, respectively. However, cost of seeds and seedbed soil were 44.0% and 49.2% lower and total material cost was 4.4% lower than the conventional method. In the new cultural method, overall working cost of nursery raising and transplanting per 10a was 229.8% higher than the conventional method. However, in spite of high input cost, yield of rice in new cultural method was higher by 6.7% than the conventional method. Our results showed that new cultural method was better than the conventional method except the input cost. If government provide 80% subsidy for machine cost then its input cost will be reduced by 45.4% than the conventional method.

반응성 산소 대사물에 의한 지질과산화에 Harmaline과 Harmalol의 효과

신용규,강호만,이무훈 공군본부 의무감실 1992 항공의학 Vol.40 No.1-2

현장과 학교의 사회복지교육 수요

신용규 한국사회복지학회 2023 한국사회복지학회 학술대회 자료집 Vol.2023 No.10

청소년 범죄 기사 내용 분석

신용규,나철,이길홍 중앙대학교 의과대학 의과학연구소 1997 中央醫大誌 Vol.22 No.4

The present study was performed to identify the socio-psychiatric aspects of adolescent criminal offences reported on daily newspapers and to use them as basic materials for prevention of adolescent criminal offences. The author analysed 609 cases of adolescent criminal offence who reported on Dong-a Ilbo and Chung-Cheong Ilbo, from 1991 to 1995. The total numbers of cases were 609, including 573 males and 36 females. In data analysis, the subjects were devided into three subgroups as the student group(221 cases), the working group(70 cases), and the jobless group (318 cases). and the result of the study were as follows. 1. The cases of adolescent criminal offences were more common in male. Their mean ages were the youngest in the student in contrast to late subgroup of the working or the jobless. 2. The antisocial personality was the most common in the jobless, while the dramatic cluster including the borderline or masochistic personality was more prevalent in the working, and the anxious cluster was more in the student. In psycho-social stressors, the student was suffered from various stress in school, home and their social life, while the working showed more serious stress in their hetero-sexual and business life, or more experienced maladjustment in their social and job life, and the jobless group showed more stressful burden due to economical problems, or more experienced maladjustment in their family life. 3. In subtypes of criminal offences, violence, fatal assult, fatal injury, parricide, and their or group offences were more common in the student, while murder, rape and raising the penalty or solitary offences were more frequently observed in the working, and felony was the most prominent offence in the jobless. 4. The incidence of student's offences reported in daily newspapers was remarkably increased, while those of the working or the jobless were decreased. The most vulnerable time of criminal offence in adolescents was from 7-12 PM, and these trends were prominent in the jobless compared with the student in afternoon, and the working in midnight. 5. In motivation of crimes, the psychological conflicts were the most in the student, while the curiosity, the various personality problems, and the heterosexual conflicts were common in the working, and the economical problems or the absence of motivations were prominent in the jobless. 6. In the tools of crime, the sharp materials were the most ones in the student compared with the fists, knives or guns in the working, and the absence of tools in the jobless. In the methods of crime, the latent aggression or physical aggression were the most ones in the student, compared with the forced aggression or direct aggression in the working. 7. In terms of accompanied person participating in criminal offence, group offence was prevalent(60.9%). The numbers of accompanied persons were more than 4 persons in the student, compared with the 2 persons in the working group, and the 1 person in the jobless. In the age ranges of accompanied persons, the student showed the youngest, while the jobless showed the oldest ones. 8. Males(63.2%) were more common in victims of adolescent criminal offences, about 40% of victims was the absence of job, and adults older than 21 years old(34.6%) was the most prevalent, followed by children younger than 11 years old(21.8%). Most of the victims in the student were their friends, lovers or parent with minor injury, while those in the working were passengers with more serious injury. The 67.8% of abusers was unknown persons with victims, and these trends were prominent in the jobless compared with more known persons in the student. 9. In the characteristics of the abuser, the working used more various psychoactive substances or alcohols, and more frequently experienced hallucination or delusion at the time of criminal offence compared with the other groups.

배양된 사람 다형핵 백혈구에서 apoptosis의 연구

신용규 중앙대학교 의과대학 의과학연구소 1997 中央醫大誌 Vol.22 No.1

Human polymorphonuclear leukocytes(PMN) are the primary effector cells in acute inflammation and have been implicated in the pathogenesis of a large variety of diseases. These cells have a well-established regulation and role in inflammatory response but morphologic change of human cultured PMN leukocytes is relatively uncertain. Thus, in this study, PMN leukocytes are isolated from healthy donor and cultured with times, we exammed morphologic changes of PMN leukocytes by light microscope and electron microscope and investigated DNA fragmentation and superoxide anion generation. Survival of PMN leukocytes decreased with times. It was shown here that with time increasing number of PMN leukocytes underwent characteristic morphological changes, nuclear condensation, cytoplasmic vacuolation, nucleolar prominence and a chromatin fragmentation pattern indicative of programmed cell death or apoptosis. DNA fragmentation in cultured PMN leukocytes with time-related increased in low molecular weight chromatin. Superoxide anion generation was little decreased but decreasing rate is not more than apoptotic rate. These results suggest that we deduce relationship between apoptotic morphologic changes and some function on removal mechanism of PMN leukocytes in inflammatory site.

사회서비스 공급체계에 대한 비판과 대안 찾기에 대한 토론문

신용규 한국사회복지행정학회 2012 한국사회복지행정학회 학술대회 자료집 Vol.2012 No.11