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포스터 발표 : 포스터 연제 ; 한국인에서의 Endothelial Nitric Oxide Synthase의 유전적 다형성과 당뇨병성 신중과의 관계
신영신 ( Sin Yeong Sin ),백상흥 ( Baeg Sang Heung ),박철휘 ( Park Cheol Hwi ),고윤호 ( Go Yun Ho ),장기욱 ( Jang Gi Ug ),승기배 ( Seung Gi Bae ),장윤식 ( Jang Yun Sig ),최규보 ( Choe Gyu Bo ),방병기 ( Bang Byeong Gi ) 대한신장학회 2000 춘계학술대회 초록집 Vol.19 No.2
유혜영 ( Yu Hye Yeong ),신영신 ( Sin Yeong Sin ),우영식 ( U Yeong Sig ),최강현 ( Choe Gang Hyeon ),이정록 ( Lee Jeong Log ),이소영 ( Lee So Yeong ),박철휘 ( Park Cheol Hwi ),안명임 ( An Myeong Im ),장윤식 ( Jang Yun Sig ),방병기 ( 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.6
Patients undergoing maintenance dialysis show an increased susceptibility to tuberculosis because host immunity is decreased secondary to malnutrition, impaired cellular immunity, acidosis and etc. Extrapulmonary tuberculosis is more prevalent in patients with end stage renal disease than in normal subjects. Among the extrapulmonary tuberculosis in patients receiving hemodialysis, the diagnosis of tuberculous spondylitis is difficult because the symptoms are non specific and attributable to uremia, and the appearance of plain radiographs is often normal during the early phase of the disease. We experienced a case of tuberculous spondylitis in a hemodialysis patient. A 55 years old female admitted with fever, weight loss and back pain. Conventional radiograph of T-spine showed no definite abnormal finding. However, chest CT revealed heterogeneously enhancing soft tissue around the T8 vertebral body and T-spine MRI showed compatible finding to tuberculous spondylitis. She received radical excision of involved vertebra and confirmed tuberculous spondylitis with histologic finding from a surgical specimen. Following the administration of anti-tuberculosis medication(isoniazid, rifampin, pyraziamide, ethambutol) and radical excision, patient`s symptom and sign were improved. The patient is maintaining dialysis with anti-tuberculosis medication for 5 months.
유지한 ( Ji Han Yu ),신영신 ( Yeong Sin Shin ),정현주 ( Hyun Ju Jung ),윤유선 ( Yu Seon Yun ),김현경 ( Hyun Gyung Kim ),김영수 ( Yooung Soo Kim ),윤선애 ( Sun Ae Yoon ),김용수 ( Yong Soo Kim ),김영옥 ( Young Ok Kim ) 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.1
Purpose: Acute alcohol intoxication (AAI) causes various complications such as electrolyte imbalance, alcoholic ketoacidosis (AKA), rhabdomyolysis, and acute kidney injury (AKI). Although there have been some reports about AKA and rhabdomyolysis, AKI due to acute alcohol intoxication is rarely reported. Methods: We retrospectively evaluated the medical records of 371 patients with AAI between January 2004 and May 2010 in Uijeongbu St. Mary`s Hospital. We compared the clinical findings, morbidity and mortality rate between AKI and normal kidney function (NKF) groups. Results: Of the total 371 patients with AAI, AKI occurred in 107 patients (28.8%). The peak serum creatinine level in AKI patients was 2.9±1.9 mg/dL. Thirteen of the 107 patients (12.1%) received renal replacement therapy. AKI group had higher incidence of decreased mentality (29.0% vs 16.3%, p= 0.006), dyspnea (11.2% vs 4.9%, p=0.029) and hypotension (66.0% vs 41.7%, p<0.001), and lower incidence of gastrointestinal bleeding (22.4% vs 34.8%, p=0.019), compared to NKF group. The AKI group also had higher incidence of ketoacidosis (78.5% vs 28.8%, p<0.001), rhabdomyolysis (19.6% vs 4.2%, p<0.001), and pneumonia (22.4% vs 8.0%, p<0.001), compared to NKF group. The length of ICU stay was longer (7.4±10.8 vs 4.1±6.1 days, p=0.003) and the mortality rate was higher (17.8% vs 2.3%, p<0.001) in AKI group. Conclusion: This study demonstrated that incidence of AKI in patients with AAI was 28.8% and AKI was associated with high morbidity and mortality. And multivariate analysis demonstrated that independent risk factors of AKI were ketoacidosis and increased serum osmolality.
이정록 ( Lee Jeong Log ),신영신 ( Sin Yeong Sin ),이승우 ( Lee Seung U ),최현철 ( Choe Hyeon Cheol ),김형욱 ( Kim Hyeong Ug ),박철휘 ( Park Cheol Hwi ),최영진 ( Choe Yeong Jin ),장윤식 ( Jang Yun Sig ),방병기 ( Bang Byeong Gi ) 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.6
A 33-year-old man was admitted with macroscopic hematuria and systemic edema appearing after an acute upper respiratory tract infection. On admission, hypertension, nephrotic syndrome were evident together with a decreased renal function. Renal biopsy showed markedly increased mesangial cells acompanied with increase of endocapillary cells including neutrophils. Immunofluorescence microscopy showed granular deposits of C3 and IgA. Electron Microscopy revealed so-called hump on the subepithelial area. These features were consistent with the coexistence of IgA nephropathy (IgAN) and post-infections glomerulonephritis. It is not clear about the prognosis and the therapeutic regimen in the patient who develop above situation. Although the patient showed still persistent proteinuria, high dose steroid therapy was probably useful for improving the disease. (Korean J Nephrol 2003;22(6):773-776)