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신세현,J.X. How,서장수 한국유변학회 2007 Korea-Australia rheology journal Vol.19 No.2
The aggregation characteristics of red blood cells (RBCs) are known as important factors in the microvascular flow system, and increased RBC aggregation has been observed in various pathological diseases, such as thrombosis and myocardial infarction. This paper describes a simple microfluidic device for measuring the RBC aggregation by integrating a microfluidic slit rheometry and laser-backscattering technique. While a decreasing-pressure mechanism was applied to the microfluidic rheometry, a syllectogram (the light intensity versus time) showed an initial increase and a peak caused by the high shear stress-induced disaggregation, immediately followed by a decrease in the light intensity due to RBC aggregation. The critical shear stress (CST) corresponding to the peak intensity was examined as a new index of the RBC aggregation characteristics. The CST of RBCs increased with increasing aggregation-dominating protein (fibrinogen) in the blood plasma. The essential feature of this design was the combination of the rheometric-optic characterization of RBC aggregation with a microfluidic chip, which may potentially allow cell aggregation measurements to be easily carried out in a clinical setting.
A noble RBC aggregometer with vibration-induced disaggregation mechanism
신세현,J.H. Jang,M.S. Park,구윤희,서장수 한국유변학회 2005 Korea-Australia rheology journal Vol.17 No.1
The aggregation of red blood cells (RBCs) is a major determinant of blood flow resistance passing through various veins. Available techniques for measuring RBC aggregation often require pretreating and washing after each measurement, which is not optimal for day-to-day clinical use. A laser reflection technique has been combined with a vibration-aided disaggregation mechanism, which shows significant advances in aggregometer design, operation and data analysis. The essential features of this design are in its simplicity and a disposable element that is in contact with the blood sample. Using extremely small quantities of blood, the RBCs subjected to vibrations can be quickly and completely disaggregated. This is followed by measuring the backscattered light intensity. The measurements with the present sensor were compared with those of a commercial aggregometer and a strong correlation was found between them. The newly-developed optical aggregometer can measure the RBC aggregability difference between young and old cell suspension with ease and accuracy.
전단율에 의존적인 비뉴턴 유체의 열전도율이 열전달 향상에 미치는 영향
신세현,이성혁,손창현,Sin, Se-Hyeon,Lee, Seong-Hyeok,Son, Chang-hyeon 대한기계학회 1996 大韓機械學會論文集B Vol.20 No.5
The present study investigates the effect of the shear rate-dependent thermal conductivity of non-Newtonian fluids on the heat transfer enhancement in a pipe flow. An axially-constant heat flux boundary condition was adopted in the thermal fully developed region. The present analytical results of Nusselt numbers for various non-Newtonian fluids show heat transfer enhancement over those of a shear rate-independent thermal conductivity fluids. The present analytical results showed good agreement with the previous experiments which excluded the temperature-dependent viscosity effect on heat transfer. This study also proposes the use of a shear rate-dependent thermal conductivity fluids in the design of a heat exchanger for heat transfer enhancement as well as reduction of fouling.