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절제 불가능한 원발성 간세포암종에 대하여 DC beads(r)를 사용한 반복적인 경동맥 화학색전술 후 간절제술을 시행한 1예
송정엽 ( Jeong-yeop Song ),김영석 ( Young Seok Kim ),이재명 ( Jae Myeong Lee ),진수지 ( Soo Ji Jin ),최규성 ( Kyu Sung Choi,),이윤나 ( Yun Nah Lee ),김상균 ( Sang Gyune Kim ),정승원 ( Sung Won Jeong ),장재영 ( Jae Young Jang ) 대한간암학회 2013 대한간암학회지 Vol.13 No.1
In patients with unresectable hepatocellular carcinoma (HCC) and no anti-cancer treatment, the prognosis is quite poor. But in some cases, repeated sessions of transcatheter arterial chemoembolization (TACE) reduce the tumor size even to resectable, and post-TACE resection may prolong the survival time. We present a case of 50-year-old HBV carrier woman with abdominal distension. The diagnosis was huge HCC with intrahepatic metastasis. Repeated intra-arterial injections of adriamycin mixed lipiodol or DC beads(R) (100-300/300-500/500-700 μm, ⓒBIOCOMPATIBLES UK LTD) were instituted through ten sessions for 13 months. The tumor size became reduced with a partial response after 10th TACE and post-TACE resection was performed. No visible HCCs and decreased tumor markers were noted on the examinations 3 months after the resection.
대한간학회지 제6차 춘계학술대회 초록집 : 구연 ; Differential Gene Expression을 이용한 간세포암 형성에 관여하는 유전자 규명
송정엽 ( Song Jeong Yeob ),최정희 ( Choe Jeong Hui ),김유진 ( Kim Yu Jin ),이광재 ( Lee Gwang Jae ),유병무 ( Yu Byeong Mu ),함기백 ( Ham Gi Baeg ),김진홍 ( Kim Jin Hong ),조성원 ( Jo Seong Won ) 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.1(S)
유방암 환자의 말초혈액에서 역전사효소연쇄중합반응을 이용한 Human Mammaglobin 측정의 임상적 유용성
김재홍,강석윤,송정엽,최태영,임홍석,김선경,김영진,박준성,김현수,최진혁,임호영,김효철 대한조혈모세포이식학회 2001 대한조혈모세포이식학회지 Vol.6 No.2
Background: The mammaglobin gene encodes a novel protein that is secreted from the mammalian epithelium of normal breast tissue as well as malignant breast cancer tissues. In order to ascertain the prognostic value of mammaglobin gene in breast cancer patients, we measured the expression of human mammaglobin (hMAM) by RT-PCR method in various stages of breast cancer patients. Methods: Peripheral blood samples from forty healthy volunteers and 114 breast cancer patients were obtained. Peripheral blood stem cells (PBSC) collected for the purpose of autologous stem cell transplantation in five patients with metastatic breast cancer and ten patient with high risk for relapse and no evidence of disease were used for hMAM assay. Results: All samples from peripheral blood of forty healthy individuals (twenty males and twenty females) were negative for hMAM, whereas 43 of 114 samples (38%) from breast cancer patients were positive for hMAM mRNA. All the normal breast tissues were positive for hMAM mRNA. hMAM mRNA expression was detected in 11 of 42 (26%) in breast cancer patients who underwent for curative resection and had no evidence of disease, in 8 of 25 (34%) with chemo-sensitive relapsed disease, and in 16 of 32 (53%) with chemo-refractory progressive disease. Eight (53%) samples from peripheral blood of 15 breast cancer patients with metastatic disease at diagnosis were positive for hMAM. Three (20%) samples from peripheral blood stem cells of 15 breast cancer patients for high dose chemotherapy were positive for hMAM. Conclusion : In contrast to healthy volunteers, hMAM transcripts were detected in the peripheral blood of breast cancer patients. The frequency of hMAM expression in peripheral blood was correlated with the clinical stages of disease, but, was not significant. The contamination of hMAM expressing cells in the stem cell pool warrants additional effective purging method before the transplantation. The clinical relevance of hMAM RT-PCR-based tumor cell detection in the peripheral blood of breast cancer patients should be further evaluated in prospective studies.
재발성 구강내 진균감염증이 동반된 IgG3 아형 결핍증 1례
최정희,박해심,송정엽,이수걸,남동호,유상용,김선신 대한알레르기학회 2000 천식 및 알레르기 Vol.20 No.4
Common clinical manifestations in patients with IgG subclass deficiency include recurrent respiratory tract infection, recurrent otitis media and sinopulmonary infection by virus or bacteria. The administration of intravenous immunoglobulin(IVIG) has been regarded as the most effective therapy in these patients. We experienced a 22-year-old patient with IgG3 subclass deficiency and recurrent fungal infection of oral cavity and lips. IVIG was given at 0.2g/kg/dose twice a month for 6 months. After treatment with IVIG, the patient improved clinically.
이경화,주욱일,송정엽,전양숙 한국분자세포생물학회 2014 Molecules and cells Vol.37 No.10
Histone modifications on major transcription factor target genes are one of the major regulatory mechanisms controlling adipogenesis. Plant homeodomain finger 2 (PHF2) is a Jumonji domain-containing protein and is known to demethylate the histone H3K9, a repressive gene marker. To better understand the function of PHF2 in adipocyte differentiation, we constructed stable PHF2 knock-down cells by using the mouse pre-adipocyte cell line 3T3-L1. When induced with adipogenic media, PHF2 knock-down cells showed reduced lipid accumulation compared to control cells. Differential expression using a cDNA microarray revealed significant reduction of metabolic pathway genes in the PHF2 knock-down cell line after differentiation. The reduced expression of major transcription factors and adipokines was confirmed with reverse transcription- quantitative polymerase chain reaction and Western blotting. We further performed co-immunoprecipitation analysis of PHF2 with four major adipogenic transcription factors, and we found that CCATT/enhancer binding protein (C/EBP) and C/EBP physically interact with PHF2. In addition, PHF2 binding to target gene promoters was confirmed with a chromatin immunoprecipitation experiment. Finally, histone H3K9 methylation markers on the PHF2-binding sequences were increased in PHF2 knock-down cells after differentiation. Together, these results demonstrate that PHF2 histone demethylase controls adipogenic gene expression during differentiation.
임영애,전희선,곽연식,송정엽 아주대학교 의과학연구소 1996 아주의학 Vol.1 No.1
Introduction: To evaluate the usefulness of Widal test requested only once during the clinical episode(single Widal test) in diagnosing typhoid fever, results of culture for Salmonella typhi were compared to the results of single Widal test. Materials and Methods: Widal tests were performed by rapid slide melhod(stained Salmonella suspensions, Murex, England) and the cutoff values of Widal test liter were ≤ 1:160 for 0 antigen, ≤ 1:320 for H antigen. After reviewing culture results of S.typhi the sensitivity, specificity and efficiency of the single Widal test were computed. Results: Culture results of S.typhi in positive Widal test were 7.1%(9/126) for 0 antigen, 7.6% (11/134) for H antigen, 10.9%(6/55) for 0 & H, therefore false positive results were 92.9% for 0, 92.4% for H, 89.1% for 0 & H combined and false negative results were 0.7%(7/1022) for 0, 0.5% (5/1003) for H, 0.2%(2/1093) for 0 & H. The sensitivity, specificity and efficiency of single Widal test were 56.3% (9/16), 89.7%(1015/1132) and 89.3%(1026/1148) for 0; 68.8%(l 1/16), 88.2% (998/1132) and 87.8%(1009/1148) for H; 37.5%(6/16), 95.7%(1083/1132) and 94.9%(1089/1148) for O & H, respectively. Also, Widal test results were positive on many occasions when group D Salmonella was isolated even if isolates were not S.typhi and some group B Salmonella isolates, Conclusion: The outcome of single Widal test showed more than a 90% false positive rate for both 0 and H antigens. Furthermore, Widal tests were positive when patients were infected with Salmonella groups other than S.typhi. Therefore, it is concluded that single Widal test is not a good diagnostic test for typhoid fever.
김민진,김영석,조윤희,장희윤,송정엽,이세환,정승원,김상균,장재영,김홍수,김부성,이형원,박정미,이재명,이민희,최득린 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.3
Background/Aims: 18F-Fluorodeoxyglucose positron-emission tomography (18F-FDG PET) has been used to assess the biological behavior of hepatocellular carcinoma (HCC). In this study, we investigated the usefulness of 18F-FDG PET for predicting tumor progression and survival in patients with intermediate Barcelona Clinic Liver Cancer (BCLC) intermediate-stage HCC treated by transarterial chemoembolization (TACE). Methods: From February 2006 to March 2013, 210 patients treated with TACE, including 77 patients with BCLC intermediate-stage HCC, underwent examination by 18F-FDG PET. 18F-FDG uptake was calculated based on the tumor maximum (Tmax) standardized uptake value (SUV), the liver mean (Lmean) SUV, and the ratio of the Tmax SUV to the Lmean SUV (Tmax/Lmean). Results: The mean follow-up period for the 77 patients (52 males, 25 females; average age, 63.3 years) was 22.2 months. The median time to progression of HCC in patients with a low Tmax/Lmean (< 1.83) and high Tmax/Lmean (≥ 1.83) was 17 and 6 months, respectively (p < 0.001). The median overall survival time of patients with a low and high Tmax/Lmean was 44 and 14 months, respectively (p = 0.003). Multivariate analysis revealed that the Tmax/Lmean was an independent predictor of overall survival (hazard ratio [HR], 1.96; 95% confidence interval [CI], 1.210 to 3.156; p = 0.006) and tumor progression (HR, 2.05; 95% CI, 1.264 to 3.308; p = 0.004). Conclusions: 18F-FDG uptake calculated by the Tmax/Lmean using PET predicted tumor progression and survival in patients with BCLC intermediate-stage HCC treated by TACE.