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      • KCI등재

        Development of new on-line statistical program for the Korean Society for Radiation Oncology

        송시열,안승도,정원규,신경환,최은경,조관호 대한방사선종양학회 2015 Radiation Oncology Journal Vol.33 No.2

        Purpose: To develop new on-line statistical program for the Korean Society for Radiation Oncology (KOSRO) to collect and extract medical data in radiation oncology more efficiently. Materials and Methods: The statistical program is a web-based program. The directory was placed in a sub-folder of the homepage of KOSRO and its web address is http://www.kosro.or.kr/asda. The operating systems server is Linux and the webserver is the Apache HTTP server. For database (DB) server, MySQL is adopted and dedicated scripting language is the PHP. Each ID and password are controlled independently and all screen pages for data input or analysis are made to be friendly to users. Scroll-down menu is actively used for the convenience of user and the consistence of data analysis. Results: Year of data is one of top categories and main topics include human resource, equipment, clinical statistics, specialized treatment and research achievement. Each topic or category has several subcategorized topics. Real-time on-line report of analysis is produced immediately after entering each data and the administrator is able to monitor status of data input of each hospital. Backup of data as spread sheets can be accessed by the administrator and be used for academic works by any members of the KOSRO. Conclusion: The new on-line statistical program was developed to collect data from nationwide departments of radiation oncology. Intuitive screen and consistent input structure are expected to promote entering data of member hospitals and annual statistics should be a cornerstone of advance in radiation oncology.

      • 진행된 하인두암에서 유도항암화학요법 후 방사선치료의 결과

        송시열(Si Yeol Song),김성배(Sung Bae Kim),김상윤(Sang Yoon Kim),남순열(Soon Yuhl Nam),최은경(Eun Kyung Choi),김종훈(Jong Hoon Kim),안승도(Seung Do Ahn),제형욱(Hyoung Uk Je),이상욱(Sang-Wook Lee) 대한두경부종양학회 2008 대한두경부 종양학회지 Vol.24 No.2

        Purpose :To know the results after induction chemotherapy followed by curative radiation therapy for locally advanced hypopharyngeal cancer Methods and Materials :From August 1990 to December 2003, forty patients who were treated with in-duction chemotherapy and curative radiation therapy were analyzed retrospectively. Median age of patients was 60 years(range:40-78 years) and clinical stage was wholly stage 3 or 4. Induction chemotherapy used cisplatin with 5-FU or docetaxel, and its interval was 3 weeks. Irradiated radiation dose was 70 to 78Gy (median:70.8Gy). Results :Median follow-up time was 39.4 months(range:8-115 months). Treatment failures were ob-served in 52.5% patients, and main failure pattern was local recurrence in 16 patients. 3 and 5 year disease free survival were 52.6%, 48.2% respectively and values of overall survival were 60.0, 43.9% and median survival time was 44.7 months. Treatment response was only a prognostic factor for survival. Laryngeal preservation was observed in twenty-four(60.0%) patients. Conclusion :Initial primary tumor stage was a significant prognostic factor for laryngeal preservation, and response after radiation therapy was a prognostic factor for long-term survival after induction chemotherapy followed by curative radiation therapy for locally advanced hypopharyngeal cancer.

      • T1N0 성문암의 방사선치료관련 예후 인자 분석

        송시열(Si yeol Song),신성수(Seong Soo Shin),김수산(Su Ssan Kim),김종훈(Jong Hoon Kim),조경자(Kyung Ja Cho),최승호(Seung Ho Choi),남순열(Soon Yuhl Nam),김상윤(Sang Yoon Kim),최은경(Eun Kyung Choi),이상욱(Sang wook Lee),안승도(Seung Do 대한두경부종양학회 2003 대한두경부 종양학회지 Vol.19 No.1

        Objective: To analyze the treatment-related parameters after the radiotherapy of T1N0 squamous cell carcinoma of the glottic larynx. Materials and Methods: Between October 1989 and August 2000, 54 patients with histologically proven T1N0 squamous cell carcinoma of the glottic larynx who received definitive radiation therapy in Department of Radiation Oncology, Asan Medical Center were analyzed. They were all males with age ranged from 31 to 80 years (median 61 years). 1997 AJCC stages were 31 T1a, 23 T1b. Patients were treated with 4-MV X-rays with a parallel-opposed two-field technique. Ten patients received 66.0-68.4Gy at 1.2Gy per fraction twice daily, 21 patients received 64.8-66.6Gy at 1.8Gy per fraction once daily, and 23 patients received 66.0Gy at 2.0Gy per fraction once daily. Follow-up period was 16-119 months (median 56 months). Results: 5-year overall survival and local control rates for patients with T1 lesions were 87.0% and 88.5%, respectively. 5-year local control with larynx preservation rate was 90.5%. Host and tumor-related prognostic factors including age, stage, anterior commissure involvement and tumor bulk proved not to be significant. Only shorter overall treatment time among treatment-related factors had correlation with imporved local control. Conclusion: Comparable high local control rate with organ preservation was achieved with primary radiation therapy and salvage surgery. Shortening of overall treatment time is related to improved local control rate. To determine the optimal fractionation scheme, randomized trial is mandatory.

      • 광주ㆍ전남지역축제 활성화 방안에 관한 연구

        송시열(Song Si-Youl) 조선대학교 지식경영연구원 2003 지역개발연구 Vol.8 No.2

        Culture policy has become an increasingly significant component of socioeconomic and physical regeneration strategies in many countries. Cultural attractions, facilities, resources, and activities as a management for tourism, have become important complementary factors in the inter-urban and inter-region competition. Culture is regarded as the symbol of the local community's renewed dynamism. Cultural events and festivals became important also as an instrument for the mobilization of tourism. The purpose of this study is to show the development plans of Gwangiu and Chonnam's cultural events and festivals. As a result, this thesis suggest the 11 ways of development plans.

      • KCI등재

        스쿼시 코트 특성에 따른 세계 프로스쿼시 남자선수의 경기내용 비교 분석

        송시열(Song, Si-Youl),최옥진(Choi, Ok-Jin) 한국체육과학회 2021 한국체육과학회지 Vol.30 No.4

        This study aimed to compare and analyze international men"s professional squash players" games played on courts with two different characteristics-those with walls made of plaster and those with walls made of glass. In order to achieve the purpose of the study, the world"s top 50 men"s professional squash matches were the subject of study, which were played either on plaster courts or glass courts in the Allam British Open and El Gouna International Squash Open in 2019 and CIB Egyptian Open in 2020. 162 sets of 43 games on plaster courts and 184 sets of 48 games on glass courts were analyzed. In data processing, a χ² test and an independent sample t-test was conducted using the SPSS/PC Window V23.0 program for the comparative analysis of the skill and technique attempt rates, scoring types and scoring areas etc. As a result of this analysis, the results were concluded as follows: First, the skill and technique attempt rates were found to show the same order of probability for both plaster and glass courts; the drive shot showed the highest attempt rate, followed by the volley, drop, service, volley drop, boast, lob, and volley boast shots. Second, the technical success was generally the highest, followed by the opponent"s mistake and the referee"s decision. Third, the scoring areas were found to have the same order of probability for both plaster and glass courts; the C area was the highest followed by the D, A, B, E and F areas. Fourth, the rallying frequency for the plaster courts (average of 15.96) was found to be higher than that for the glass courts (average of 14.37).

      • KCI등재후보

        비인강암에서 방사선치료의 예측인자로써 Ku70 발현의 의의

        송시열(Si Yeol Song),이상욱(Sang-wook Lee),유은실(Eunsil Yu),조경자(Kyung-Ja Cho),박진홍(Jin-hong Park),김상윤(Sang Yoon Kim),남순열(Soon Yuhl Nam),이봉재(Bong-Jae Lee),김성배(Sung Bae Kim),최승호(Seung-Ho Choi),안승도(Seung Do Ahn) 대한방사선종양학회 2005 Radiation Oncology Journal Vol.23 No.1

        목 적: 방사선치료를 시행 받은 비인강암 환자에서 Ku70과 DNA-PKcs의 발현 정도가 국소제어율과 치료 실패 양 상에 미치는 영향을 알아보고자 하였다. 대상 및 방법: 1995년 6월부터 2001년 12월까지 서울아산병원에서 방사선치료 단독 또는 동시항암화학-방사선치료를 시행 받은 66명의 원격전이가 없는 비인강암 환자를 후향적으로 분석하였다. 진단 시 얻은 조직검사 표본에서 Ku70과 DNA-PKcs의 면역활성도를 분류하였는데, 그 기준은 면역활성도가 50% 이상 Ku (+)과, 50% 미만 Ku(-) 이었다. Ku70과 DNA-PKcs의 면역활성도와 방사선치료에 대한 종양의 반응 정도와 재발양상과의 상관관계를 알아보았으며, 비인강암의 국소제어율에 영향을 미치는 예후인자를 알아보기 위하여 단변량분석을 시행하였다. 결 과: Ku (-) 환자에서 Ku (+) 환자보다 높은 5년 국소제어율(85% vs. 42%, p=0.042)을 보였으나, 원격전이율은 두 집단간에 차이를 보이지 않았다(78% vs. 82%, p=0.8672). 단변량분석결과 Ku70의 과발현이 기존에 알려진 비인 강암의 예후인자보다 우위에 있음을 알 수 있었다. 국소재발을 보였던 22명의 환자 중 18명의 환자에서 Ku70 (+) 으로 관찰되었다. DNA-PKcs의 발현 정도는 방사선치료 결과에 영향을 미치지 않는 것으로 나타났다. 결 론: Ku70은 원격전이가 없는 비인강암 환자에서 방사선치료 단독 또는 동시항암화학-방사선치료 시행 이후 종양의 반응과 국소제어율을 예측할 수 있는 분자생물학적인 예측인자로 사용될 수 있을 것으로 생각한다. Purpose: The objective of this study was to determine whether the expressions of the two components of DNA-dependent protein kinase, Ku70 and DNA-PKcs, influence the response to radiotherapy (RT) and outcome of treatment of non-disseminated nasopharyngeal carcinoma (NPC) in patients who received definitive RT. Materials and Methods: Sixty-six patients with NPC who were treated with radiotherapy alone or with concurrent chemotherapy between June 1995 and December 2001 were divided into groups based on the levels of immunoreactivity for Ku70 and DNA-PKcs in pretreatment biopsy specimens. The over-expression of Ku70 or DNA-PKcs groups included patients whose biopsy specimens showed at least 50% immunopositive tumor cells; patients in which less than 50% of the tumor cells in the biopsy tissues were immunopositive were placed in the low Ku70 and DNA-PKcs groups. The immunoreactivities for Ku70 and DNA-PKcs were retrospectively compared with the sensitivity of the tumor to radiation and the patterns of therapy failure. Univariate analyses were performed to determine the prognostic factors that influenced locoregional control of NPC. Results: The five-year locoregional control rate was significantly higher in the low Ku70 group (Ku(-)) (85%) than in the high Ku70 group (Ku(+)) (42%) (p=0.0042). However, there were no differences in the metastases- free survival rates between the two groups (Ku70 (+), 82%; Ku70 (-), 78%; p=0.8672). Univariate analysis indicated that the over-expression of Ku70 surpassed other well-known predictive clinocopathologic parameters as an independent prognostic factor for locoregional control. Eighteen of 22 patients who had locoregional recurrences of the tumor displayed an over-expression of Ku70. No significant association was found between the level of DNA-PKcs expression and the clinical outcome. Conclusion: Our data suggest that the level of Ku70 expression can be used as a molecular marker to predict the response to RT and the locoregional control after RT and concurrent chemotherapy in patients with non-disseminated NPC.

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