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만성폐쇄성폐질환의 급성악화와 회복기에서 유도객담 내 Nuclear Factor-κB (NF-κB)의 활성도와 IL-6, IL-8 및 TNF-α의 농도 변화
송소향 ( So Hyang Song ),김치홍 ( Chi Hong Kim ),권순석 ( Soon Seog Kwon ),김영균 ( Young Kyoon Kim ),김관형 ( Kwan Hyoung Kim ),문화식 ( Hwa Sik Moon ),송정섭 ( Jeong Sup Song ),박성학 ( Sung Hak Park ) 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.58 No.2
연구배경 : COPD의 급성악화는 세균에 의한 감염, 바이러스성 상기도 감염, 대기오염, 기후변화 등에 의하며, COPD의 급성악화 시에 객담 내 호중구의 증가, IL-6와 IL-8 농도의 증가, 그리고 산화질소의 증가는 NF-κB의 활성화와 관련된 것으로 알려져 있다. 그러므로 COPD의 병인 및 급성악화의 기전에 NF-κB 활성도와 IL-6, IL-8 및 TNF-α가 관련이 있는지 연구하고자 하였다. 방법 : 정상대조군 및 COPD로 입원하였던 환자 Background : Exacerbations of chronic obstructive pulmonary disease (COPD) are thought to be associated with increased airway inflammation, and the NF-κB is known to be an indicator of cellular activation and of inflammatory mediator production. This stud
내과적 질환에 병발된 반사성 교감신경계 위축 증후군 20 예의 분석
송소향(So Hyang Song),이정득(Jeong Deuk Lee),이상헌(Sang Heon Lee),홍연식(Yeon Sik Hong),조철수(Chul Su Cho),박동준(Dong Joon Park),정수교(Soo Kyo Chung),김호연(Ho Yun Kim) 대한내과학회 1993 대한내과학회지 Vol.45 No.5
N/A Reflex sympathetic dystrophy syndrome (RSDS) is an distinct symptom complex characterized by diffuse distal-limb pain, edema, vasomotor skin change and dystrophic skin change. It has been associated with limb-trauma, acute stoke, myocardial ischemia, peripheral neuropathy, phamacological agents such as phenobarbital and antituberculosis agents and malignancy. We report the clinical and radiological features of 20 patients who were diagnosed of RSDS at Kangnam Saint Mary's Hospital between January 198S and May 1991. The results were as fo1lows: 1)According to Kozin's criteria, seven (35%) are diagnosed of definite RSDS, eight (40%) of probable RSDS, and five (25%) of doubtful RSDS. 2) Disorders associated with RSDS were cerebrovascular disease (7 patients), malignancy (4 patients), myocardial ischemia (4 patients) and antituberculosis drug (2 patients). The remaining 6 padtients (30%) had no specific precipitating events. 3) Review of the Three phase bone scitigraphy (TPBS) for 20 patients indicated that nineteen of twenty patients (95%) has asymmetric and abnormal blood flow in TPBS. 4) Most patients were diagnosed early, therefore, had symptomatic relief without sequele such as flexion contracture of skin or subcutaneous atrophy by analgesics, steroid, calcitonin and physical therapy. In summary, the TPBS is a potentially sensitive and specific test to corroborate the diagnosis of RSDS and we can expect to have symptomatic relief without sequence if this disorder could be diagnased and treated, early.
기관지천식 마우스에서 기저막하 섬유화와 관련된 인자들: TGF-β1및 IL-17에 대한 CpG-oligodeoxynucleotides의 영향
송소향 ( So Hyang Song ),김치홍 ( Chi Hong Kim ),문화식 ( Hwa Sik Moon ),송정섭 ( Jeong Sup Song ),박성학 ( Sung Hak Park ) 대한천식알레르기학회 2006 천식 및 알레르기 Vol.26 No.2
Background: Important features of airway remodeling in asthma include the formation of subepithelial fibrosis and increased deposition of collagen. Profibrotic cytokines such as TGF-β1 and IL-17 are involved in the formation of subepithelial fibrosis and are increased in patients with asthma, particularly in these severe disease. Previous reports have represented that administration of CpG-oligodeoxynu-cleotides (CpG-ODN) before allergen sensitization or challenge inhibits chronic inflammation and remodeling of airway in mice with chronic asthma, but the effect of CpG-ODN on TGF-β1 and IL-17 have not been evaluated. Objective: To evaluate the effect of CpG-ODN on the expression of these profibrotic cytokines and on collagen deposition, this study was performed in mice with chronic asthma. Method: Mice were subjected to repetitive ovalbumin (OVA) challenge for 2 months. CpG-ODN was administered intraperitoneally for sensitization. After the final challenge, airway hyperresponsiveness, peribronchial fibrosis, and levels of lung hydroxyproline were assessed. Levels of TGF-β1 and IL-17 in bronchoaveolar lavage (BAL) were assessed by ELISA and the number of TGF-β1+cells and IL-17+cells in peribronchial area by immumohistochemistry. Result: CpG-ODN significantly reduced airway hyperresponsiveness, eosinophil infiltration, and peribronchial fibrosis. Levels of TGF-β1 in BAL fluid (353±94 vs 270±66 pg/mL, OVA vs OVA+CpG, P<0.05) and peribronchial TGF-β1+cells (46±10 vs 27±5 TGF-β1+ cells/bronchus, OVA vs OVA+CpG, P<0.01) were significantly reduced in mice treated with CpG-ODN. Levels of IL-17 in BAL fluid (62±30 vs 34±10 pg/mL, OVA vs OVA+CpG, P=0.074) were not significantly reduced, but peribronchial IL-17+cells (27±7 vs 7.5±5.3 IL-17+ cells/bronchus, OVA vs OVA+CpG, P<0.01) and levels of lung hydroxyproline (13.1±5.3 vs 9.1±2.71ug/mL, OVA vs OVA+CpG, P<0.01) were significantly reduced in mice treated with CpG-ODN. Conclusion: CpG-ODN significantly reduced the levels of allergen-induced peribronchial fibrosis and collagen deposition. The reduction in peribronchial fibrosis and collagen deposition mediated by CpG-ODN might be due to several mechanisms including inhibition of profibrotic cytokines of TGF-β1 and IL-17 and a reduction in the number of peribronchial inflammatory cells expressing TGF-β1. (Korean J Asthma Allergy Clin Immunol 2006;26:136-144)
유수은,주강,송소향,김치홍,Yu, Su-Eun,Joo, Kang,Song, So-Hyang,KIim, Chi-Hong 대한기관식도과학회 2002 大韓氣管食道科學會誌 Vol.8 No.2
Actinomycosis is a chronic infectious disease, which is produced by Gram-positive anaerobic organisms, actinomycetes, normally inhabit in the mouth, bowel and female genital tract. Primary endobronchial actinomycosis is relatively rare infection and can be misdiagnosed as endobronchial tuberculosis or malignancies. We experienced a case of primary endobronchial actinomycosis in a 49-year-old man presented with fifteen-days history of hemoptysis and cough. He had a past history of extraction of teeth because of dental caries six months ago. Chest X-ray showed irregular consolidation ad bronchoscopic findings revealed nearly obstruction by tumor mass with active bleeding in RLL. Pathologic finding of the bronchial mass showed sulfur granule with granulation tissue formation. Intravenous administration of penicillin G followed by oral ampicillin therapy for 6 months resulted in marked improvement in symptoms and chest X-ray findings. We report this case with review of literature.