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급각자가 천식모델 생쥐의 면역세포 및 사이토카인에 미치는 영향
송상진,박양춘,Song, Sang-Jin,Park, Yang-Chun 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.1
Objective : The purpose of this research is to examine the effects of Gleditsiae Spina (GS) extract on immune cells and cytokines in ovalbumin (OVA)-induced asthmatic mice. Methods : In vivo, C57BL/6 mice were sensitized and handicapped by OVA for 12 weeks. During this experiment, the one group was then treated with GS extract for the later 8 weeks (3 times per week) and analyzed by ELISA, flow cytometer and RT-PCR. Results : In vivo, there were significant decreases in eosinophils, IL-4, IL-5, IL-13, IgE in BALF (bronchoalveolar lavage fluid). However, $IFN-{\gamma}$ in BALF of GS group increased significantly, compared with that of control group. Additionally, the population of $CD3e^-/CCR3^+,\;CD69^+/CD3e^+,\;IgE^+/B220^+,\;CD11b^+/Gr-l^+$ cells in the GS group decreased. Conclusion : The results of this study support a role for GS as an effective treatment for asthma in its experimental success in significantly decreasing inflammation and asthma reactions, and in increasing $IFN-{\gamma}$, which helps prevent such reactions.
임플란트 식립 시 관찰된 하악의 방사선학적 골수 결손부위에 대한 감별진단
송상진,장희영,유형근,피성희 대한구강악안면병리학회 2019 대한구강악안면병리학회지 Vol.43 No.5
Recently, a number of recent reports have reported cases of bone marrow defect (BMD) in the mandible. Among the diseases seen by BMD in radiographs, focal osteoporotic bone marrow defect(FOBMD) is asymptomatic, which is discovered incidentally and localized radiolucency. Because it varies in size, shape, trabeculae and border definition, it needs to biopsy to differential diagnose other intraosseous lesions that show radiological bone marrow defects. This cases report discusses the pre-operation considerations in patients planning to implant the mandible and suspected to have FOBMD in radiographs. The following 4 cases in Dental Hospital of Wonkwang University were taken in panoramic and Cone beam computed tomography(CBCT). In all cases, there were radiolucent lesion diagnosed with FOBMD under radiologic differential diagnosis. In three of cases the implant were placed without treatment plan change and one case changed the treatment plan with removable partial denture. BMD is anatomical state that can affect primary stability of implant fixture. During implant placement, it can lead to unexpected results that fixture is fallen into BMD and the nerve may be damaged after implant fixture removal to cause hyperesthesia. Preoperative diagnosis of these lesions by differential diagnosis with panoramic and CBCT can prevent the complications by changing the treatment plan or paying attention to the manipulation during surgery.
?角刺가 천식모델 생쥐의 면역세포 및 사이토카인에 미치는 영향
송상진,박양춘 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.1
Objective : The purpose of this research is to examine the effects of Gleditsiae Spina (GS) extract on immune cells and cytokines in ovalbumin (OVA)-induced asthmatic mice. Methods : In vivo, C57BL/6 mice were sensitized and handicapped by OVA for 12 weeks. During this experiment, the one group was then treated with GS extract for the later 8 weeks (3 times per week) and analyzed by ELISA, flow cytometer and RT-PCR.Results : In vivo, there were significant decreases in eosinophils, IL-4, IL-5, IL-13, IgE in BALF (bronchoalveolar lavage fluid). However, IFN-γ in BALF of GS group increased significantly, compared with that of control group. Additionally, the population of CD3e-/CCR3+, CD69+/CD3e+, IgE+/B220+, CD11b+/Gr-1+ cells in the GS group decreased. Conclusion : The results of this study support a role for GS as an effective treatment for asthma in its experimental success in significantly decreasing inflammation and asthma reactions, and in increasing INF-γ, which helps prevent such reactions.
송상진,김병탁,박양춘 대한동의생리학회,대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.6
To evaluate the effect of Kamisaganmahwang-tang(KSMT)vto the allergy studies were done experimentally. The IgE level induced by LPS was decreased in KSMT extract feeding group compared with control group. In the cross regulation pattern between Th1 and Th2, the INF-γ from Th1 was increased, but the changes of IL4, IL10, IL12, IL13 expression levels are smaller than INF-γ. These results indicated KSMT extracts can produce the high level induction INF-γ. This study suggest that KSMT may act as antagonist to the Th2 and B cell for IgE production.
동결보존된 생쥐 고환조직 세포의 광학 및 전자현미경적 관찰
한상철,송상진,이선희,오승한,궁미경,박용석,Han, Sang-Chul,Song, Sang-Jin,Lee, Sun-Hee,Oh, Seung-Han,Koong, Mi-Kyung,Park, Yong-Seog 대한생식의학회 2003 Clinical and Experimental Reproductive Medicine Vol.30 No.2
Objective: The aim of this study was to investigate the morphological aspects of testicular tissue before and after freezing-thawing by light and transmission electron microscopy. Methods: Tissue biopsies were carried out on mouse testis for freezing. Samples in medium containing 20% glycerol were frozen by computer-controlled freezing program. The effect of freezing-thawing on the structural change of testicular tissues were examined by light and electron microscopy. Results: The freezing-thawing procedure had no significant effect on tubular diameter. However, it caused folding of the lamina propria, and notable damage to Sertoli cells, spermatogonia and spermatocytes. The cells were detached, desquamated from the basal lamina and had increased vacuolization. Round spermatids, elongated spermatids and spermatozoa were less affected, and most of them maintained their normal structure. Conclusions: The structure of spermatogonia, spermatocyte and basal compartments in seminiferous epithelium was significantly altered by freezing-thawing procedure of mouse testicular tissues. Thus, we need to develop a more reliable method for the cryopreservation of testicular tissues.