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5-Fluorouracil-induced changes of intestinal integrity biomarkers in BALB/C mice
송민경,성미경,박미영 대한암예방학회 2013 Journal of cancer prevention Vol.18 No.4
Background: Intestinal mucositis is a most frequently occurring toxicity in cancer chemotherapy, and consequent malnutrition reduces tolerance to cancer therapies. Therefore it is important to lessen the severity of mucotitis and to develope complementary agents capable of reducing mucotitis-related symptoms. This study was conducted to determine 5-fluorouracil (5-FU) induced intestinal damage to understand intestinal damages due to chemotherapy and to provide information on biomarkers which can be used to screen complementary agents in future studies. Methods: BALB/c mice were divided into three experimental groups and subjected to the intraperitoneal injection of either 100 mg/kg or 200 mg/kg of 5-FU. The third group was used as PBS controls. Body weights and the consistency of the stools were recorded every day, and the animals were sacrificed on the 7th day post 5-FU administration. The expressions of intestinal tight junction proteins and mRNAs of tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) were determined. Results: The body weight of the animals treated with 5-FU was significantly decreased in a dose-dependent manner. However, mice given 100 mg/kg 5-FU rapidly recovered the original body. Symptom of diarrhea was also more severe in 200 mg/kg 5-FU treated group than that of the 100 mg/kg 5-FU treated animals. The expressions of occludin and claudin-1, not ZO-1 protein expressions in 200 mg/kg 5-FU treated animals were significantly reduced compared to those of the control group or 100 mg/kg 5-FU group. The expression of Nuclear factor-kappa B p65 (NF-κB p65) protein and TNF-α mRNA were significantly higher in 5-FU treated group compared to those of control group. No difference was observed with IL-1β expression. Conclusion: These results suggested that selected tight junction proteins and inflammatory cytokines are related to 5-FU induced mucositis, and thereby can be used as targets of developing complementary agents.
Global Citizenship(지구시민성)에 관한 연구
송민경 한국청소년학회 2014 청소년학연구 Vol.21 No.12
The purpose of this study was to explore the notion of global citizenship and the conceptual framework of global citizenship education for youths. In this global era, global citizenship has been emphasized that a globalized world and national-states characterized by diversity while requiring a primary commitment to the nation-state. The study examined global citizenship of youths who participated international work camp while applying the pre-test and post-test design with the scale of global citizenship for youths. Data were collected from 45 youths who joined international work camps in July, 2010. The global citizenship scale consists of social justice and human rights, environment issues and sustainable developments, diversity-national, regional, ethnic, cultural with respect to knowledge and understanding, skills, and values and attitudes. A key finding was that the level of global citizenship of youths was substantially improved. The implications of the study was that international exchange programs for youths might be global citizenship education that improved multicultural notions and experiences; and, NGOs efforts for global citizenship education might contribute to conceptualize global citizenship in field activities. 본 연구에서는 거대 담론적 차원에서 global citizenship(지구시민성)의 개념과 구성요인을 살펴보고, 지구시민성교육의 주요한 특성을 고찰하였다. 또한, 청소년 국제교류활동을 통한 global citizenship(지구시민성) 함양을 측정하기 위하여 Oxfam(1997)이 제시한 지식 및 이해, 가치 및 태도, 실천 및 실천의지의 3가지 차원으로 ① 사회정의, ② 환경 보전 및 지속가능한 발전, ③ 타(이)문화 이해와 수용, 다문화 감수성 및 다양성 함양을 측정하였다. 분석대상은 2010년 7월 동안 12박 13일 동안에 인도, 캄보디아, 필리핀 각지에서 국제워크캠프로 해외봉사캠프활동을 경험한 중․고등학생 및 대학생 47명을 대상으로, 캠프 활동 이전과 이후에 변화된 지구시민성 함양 효과를 분석하였다. 분석결과, 지구시민성의 모든 구성요인에서 체험활동 이후 긍정적인 향상을 보이고 있었다. 이에 따라 NGOs의 국제교류활동이 수행하는 지구시민성교육으로서 기능과 역할을 기대할 수 있으며, 청소년의 지구시민성 함양의 필요성과 함의를 제안하고자 한다.
공동체의식, 정당한세상에 대한 믿음, 다문화수용성, 통합교육 인식간의 구조적 관계: 비장애 초등학생 어머니를 대상으로
송민경,이은설 이화여자대학교 교육과학연구소 2020 교육과학연구 Vol.51 No.3
The perception of inclusive education among mothers of non-disabled elementary school students' is one of the crucial factors in successful inclusive education. This study explored how community consciousness, belief in a just world, multicultural acceptability, and perception of inclusive education are associated among mothers of elementary school students without disabilities. To do so, we collected survey data from 368 mothers of non-disabled elementary school students in Korea. Based on this data, we examined structural relations among a set of variables using structural equation modeling. The research model assumed that community consciousness and belief in a just world had direct effects on the perception of inclusive education and multicultural acceptability. We also assumed that multicultural acceptability is directly associated with perception of inclusive education. Additionally, the mediating effect of multicultural acceptability in the links between perception of inclusive education and community consciousness as well as belief in a just world were assumed. The results suggest that the hypothesized model is suitable for the data of mothers of non-disabled elementary school students. More specifically, community consciousness and multicultural acceptability were positively associated with perception of inclusive education. Also, the findings confirmed that the belief in a just world is significantly related to the perception of inclusive education through the mediation of multicultural acceptability. Based on these results, implications for educational intervention and methodology that could contribute to improve perception of integrated disability education are discussed. Finally, limitations of the present study and implications for future research are discussed. 비장애 초등학생 자녀 어머니의 통합교육에 대한 인식은 통합교육의 확대에 영향을 미치는 주요 요인 중 하나이다. 본 연구에서는 선행연구에 바탕을 두어 비장애 초등학생 자녀를 둔 어머니의 장애학생들에 대한 인식 및 통합교육에 대한 인식에 영향을 주는 요인으로 공동체의식, 정당한세상에 대한 믿음, 다문화수용성을 설정하고 이들 변인과 통합교육에 대한 인식 간의 구조적관계를 검증하였다. 이를 위해 초등학생 자녀를 둔 어머니 368명을 대상으로 자료를 수집하였다. 수집된 자료를 바탕으로 구조방정식 모형을 사용하여 연구 모형의 적합성 및 변인 간 직․간접적인 관계를 분석하였다. 연구결과, 공동체의식과 정당한세상에 대한 믿음을 다문화수용성이 매개하여 통합교육 인식에 영향을 미치는 것으로 설정된 연구모형이 연구대상인 비장애 초등학생 자녀 어머니의 자료에 적합한 것으로 나타났다. 구체적으로, 비장애인 초등학생 자녀를 둔 어머니의 공동체의식과 다문화수용성은 통합교육에 대한 인식에 직접적인 정적연관성을 보였으며 정당한세상에 대한 믿음과 통합교육에 대한 인식 간의 관계를 다문화수용성이 매개하는 간접경로가 유의미한 것으로 확인되었다. 이러한 결과를 바탕으로, 통합교육에 대한 인식을 향상시키는데 기여할 수 있는 교육적 개입 및 방법론에 대한 함의를 논의하였다. 마지막으로, 본 연구의 제한점을 바탕으로 후속연구에 대해 제언하였다.
키치패션의 조형적 특성에 관한 연구- K-Pop 아이돌 패션을 중심으로 -
송민경,조문희 한국니트디자인학회 2013 패션과 니트 Vol.11 No.1
This study aims to explore the formative characteristics of Kitsch fashion appearing in costumes of K-pop idols and discover its positive value in modern society, breaking free with negative perceptions of the past. For the study, based on the formative elements of Kitsch fashion, analyzed the formative characteristics represented in Kitsch fashion in 2000 S/S∼2012 F/W Collections under the grounds of preceding studies according to the types of expansion, resistibility, incompatibility, enjoyment, nostalgia, and sexuality. The results showed that expansion was represented as a collection form which allowed coexistent styling with apparels with printed patterns that do not match the exaggeration of closely attached subsidiary materials such as buttons and studs. Resistance was represented as a satirical form which suggests a somewhat gloomy and aggressive impression along with apparels made with easily accessible materials like paper including imitation, wire, and chain. Incompatibility was represented as a incompatible form in practical, functional, and esthetic aspects by using inflexible or strange materials, or tearing parts of the apparel. Enjoyment showed a playful form by wearing colorful and charming designs and toys as accessories. Scent stimulated a scent of the past by wearing school uniforms worn in the past or retro dance fashion apparels. A yearn for a natural and exotic life was shown by wearing traditional clothing of other nations or folksy patterns and accessories. Sexuality was represented as a form which emphasizes bodily beauty by using see-through or mesh materials on parts of the apparel to expose parts of the body rather inwardly or revealing parts of the body like legs or upper body explicitly, or stressing body line and structure. To modern people who wish to direct their own individual styles, K-Pop idol fashion is being accepting as one of the fashion styles, and Kitsch fashion is being represented as a new style for them to express their individuality in a variety of ways. Based on this, Kitsch fashion escapes from resistive and cheap images of the past to be anticipated to show positive, and it can be expected various styles in the fashion of general public as long as the idols.
소아청소년에서 비만동반질환 위험성 검사 시 당화혈색소의 사용
송민경,배재욱,김용혁,정소정 대한소아내분비학회 2012 Annals of Pediatirc Endocrinology & Metabolism Vol.17 No.2
Purpose: The aim of this study is to investigate differences in hemoglobin A1c (HbA1c)levels according to degree of obesity, clinical findings on HbA1c 5.7% and factors affecting HbA1c in growing children and adolescents. Methods: 168 children and adolescents (M/F, 93/75; age, 10.2±2.6 years) who visited an obesity clinic were included in the study. Participant's body mass index (BMI),percent weight for height (PWH), height z score (HTZ), weight z score (WTZ), and BMI z score (BMIZ) were calculated. Their blood glucose, insulin, total cholesterol, triglyceride,HDL-cholesterol (HDL-C), aspartate aminotransferase (AST), alanine aminotransferase (ALT), insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 (IGFBP-3) levels were checked. Confirmed cases of diabetes and endocrine disease were excluded. Participants were divided into two groups based on whether their HbA1c levels were higher or lower than 5.7%. The difference in HbA1c between the groups based on the BMIZ 2 and PWH 20 were analyzed. A correlation analysis involving HbA1c and metabolic parameters was conducted, and factors contributing to HbA1c were evaluated through a regression analysis. Results: HbA1c was higher in subjects with impaired fasting glucose (5.3±0.3, 5.4±0.2;P = 0.018). HbA1c and the homeostasis model assessment of insulin resistance (HOMAIR)were not significantly different in the groups based on BMIZ 2.0. Based on PWH 20, HOMA-IR was significantly different (1.8±0.7, 2.3±1.1; P < 0.05), although HbA1c was not. Levels of TG (107.4 ±69.4, 154.1±77.7; P = 0.006), HDL-C (53.6±11.9, 47.4±6.6; P = 0.024), AST (29.7±11.4, 39.2±24.6; P = 0.004), and ALT (32.4±32.0, 53.9±58.8;P = 0.014) indicated significant differences between the groups. There were positive correlations between HbA1c and height, weight, BMI, gender, AST, ALT, glucose, and HOMA-IR, but no significant correlation with HTZ, WTZ, and BMIZ. The contributing factors for HbA1c were gender, ALT, BMI, and IGFBP-3. Conclusions: HbA1c level is associated with metabolic syndrome parameters, but is not correlated with degree of obesity. Along with HbA1c, other factors should be considered in evaluating the risk of complications related to obesity in children and adolescents. 목적: 비만 소아청소년에서 비만도에 따른 HbA1c의 차이가 있는지 알아보고, 최근 당뇨병전단계의 지표로 사용되는HbA1c 5.7%을 기준으로 할 때 임상소견의 차이가 있는지 살펴보고, HbA1c에 영향을 미치는 인자에 대하여 알아봄으로써 비만 소아청소년에서 HbA1c의 임상적 의의에 대하여 알아보고자 하였다. 방법: 비만 검진을 위하여 내원한 소아 총 168명 (남/녀 93/75, 평균연령 10.2±2.6세)를 대상으로 하였다. 신장 및 체중을 측정하여 BMI 및 PWH를 구하였고 신장, 체중, BMI의 Z-값(HTZ, WTZ, BMIZ)를 구하였다. 혈당, 인슐린농도,총콜레스테롤, 중성지방, HDL-C, AST, ALT, IGF-1, IGFBP-3를 분석에 사용하였다. 당뇨병 및 내분비질환이 확인된 경우를 제외하였다. BMIZ 2 및 PWH 20을 기준으로 비만군과 비비만군으로 구분하여 HbA1c의 차이를, HbA1c 5.7%를 기준으로 임상소견의 차이를 Student's t -test로 분석하였다. HbA1c와 대사 인자들 사이의 상관분석을 시행하였으며, 다중회귀분석으로 HbA1c에 영향을 주는 인자를 알아보았다. 결과: HbA1c는 공복혈당장애를 보인군에서 더 높게 나타났다(5.3±0.3, 5.4±0.2, P =0.018). BMIZ 2.0 이상의 비만군과 2.0 미만의 비비만군의 HbA1c와 HOMA-IR은 유의한 차이가 없었다. PWH 20 이상의 비만군과 20 미만의 비비만군의 비교에서 HOMA-IR (1.8±0.7, 2.3±1.1 P<0.05)은 유의한 차이를 보였지만, HbA1c는 유의한 차이가 없었다. HbA1c 5.7%를 기준으로 두 그룹으로 나누어 비교하였을 때 두 군간에 체중, BMI, PWH, 혈당, 인슐린은 차이가없었고 triglyceride (TG) (107.4±69.4, 154.1±77.7, P =0.006), HDL-C (53.6±11.9, 47.4±6.6, P =0.024), AST (29.7±11.4, 39.2±24.6, P =0.004), ALT (32.4±32.0, 53.9±58.8, P =0.014)는 두 군간에 유의한 차이를 보였다.. HbA1c는 신장, 체중, BMI, 성별, 혈당, AST, ALT, HOMA-IR과 양의 상관관계가 있었고 HTZ, WTZ, BMIZ와는 유의한 상관관계가 없었다. HbA1c에 영향을 주는 인자는 성별, ALT, BMI, IGFBP-3였다. 결론: HbA1c는 대사증후군 관련 인자들과 연관이 있지만 비만에 따른 차이는 없었다. 비만 소아청소년에서 HbA1c와함께 다른 대사증후군 관련인자를 고려하여 위험성의 평가가 이루어져야 할 것으로 생각된다. 추후 HbA1c에 성별, 사춘기, 성장상태, 체성분의 영향 등에 대하여 더 많은 연구가 진행되어야 하겠다.
한양방 동시 치료를 통하여 회복되지 않은 양측성 돌발성 난청 환자 1례
송민경,홍승욱,Song, Min-Kyung,Hong, Seung-Ug 대한한방안이비인후피부과학회 2010 한방안이비인후피부과학회지 Vol.23 No.1
Back ground & Objectives : Bilateral sudden sensorineural hearing loss(SSNHL) is very rare disease. This is the first case report in the oriental medical literature. This study describes a case of bilateral SSNHL with incomplete recovery. Methods : We treated 1 patient who had SSNHL sequentially in both ears. He received oriental and western medical treatments for more than 2 weeks and measured the hearing recovery. For diagnosis on this case, pure tone audiometry was used. The degree of improvement was evaluated by Siegel's Criteria. Results & Conclusions : This patient discharged without hearing improvement. For bilateral SSNHL patients, the result of treatment is important for their qualities of life. But the recovery rate of hearing in bilateral SSNHL is lower than unilateral SSNHL. The oriental medical therapy had some theraputic effects on SSNHL and the theraputic effects on bilateral SSNHL requires further study.