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송명관,김선훈,Song, Myung-Kwan,Kim, Sun-Hoon 한국전산구조공학회 2007 한국전산구조공학회논문집 Vol.20 No.3
본 논문에서는 적응적 h-유한요소 세분화에 의한 박스형 절판 구조물의 선형좌굴 유한요소해석법을 제안한다. 면내회전 자유도를 갖는 변절점 평판쉘유한요소를 사용하여 유한요소의 거동을 개선하고 6자유도를 갖는 다른 유한요소와의 자유도의 연결을 용이하게 한다. 이와 같이 개발된 평판쉘유한요소에 의하여 박스형 절판구조물의 정확한 구조해석이 가능한데, 변절점유한요소를 정식화함으로써 적응적 h-유한요소 세분화시에 발생하는 다른 패턴의 사각형 유한요소 세분화망의 연결을 용이하게 해결한다. 오차평가에 대한 개선된 응력장을 얻기 위하여 상위수렴 조각회복법을 적용한다. 이와 같이 상위수렴 조각회복법에 의한 개선된 응력장에 의하여 구성된 유한요소 세분화망을 이용하여 좌굴하중과 좌굴모드를 자동적으로 구할 수 있도록 한다. The finite element linear buckling analysis of folded plate structures using adaptive h-refinement methods is presented in this paper. The variable-node flat shell element used in this study possesses the drilling D.O.F. which, in addition to improvement of the element behavior, permits an easy connection to other elements with six degrees of freedom per node. The Box-typed structures can be analyzed using these developed flat shell elements. By introducing the variable-node elements some difficulties associated with connecting the different layer patterns, which are common in the adaptive h-refinement on quadrilateral mesh, can be overcome. To obtain better stress field for the error estimation, the super-convergent patch recovery is used. The convergent buckling modes and the critical loads associated with these modes can be obtained.
송명관,김세경,윤현식,권순조 한국생물공학회 2017 Biotechnology and Bioprocess Engineering Vol.22 No.5
The inflammatory response is an indispensable bodily reaction, but excessive inflammation is known to result in diseases such as atopic disease, bronchitis, rheumatoid arthritis, and inflammatory bowel disease. Ceramide is the basic structure of sphingolipids and ceramides have been industrially used in functional cosmetics as anti-aging agents, as well as for moisturizing skin and calming skin irritation. It also has been recently used in medicinal fields as an anti-inflammatory as well as for atopic and skin wound healing, and for skin barrier restoration. In this study, we used genetically modified Saccharomyces cerevisiae to produce ceramides. Ceramide mixture was produced by gene manipulation that amplifies the original yeast gene. To investigate their anti-inflammatory effects, nitric oxide (NO) concentrations in cell culture supernatant were measured by using the Griess reaction and the expression levels of pro-inflammatory markers, cyclooxygenase-2 (COX-2) and tumor necrosis factor-α (TNF-α), were determined by using qRT-PCR. When cells were treated with the ceramide mixture, cell viability was not reduced, but NO production was inhibited. In addition, expressions of COX-2 and TNF-α were inhibited. Based on these results, we conclude that ceramide biosynthesized from recombinant yeast can effectively reduce the expression of inflammatory enzymes and cytokines. We expected that ceramides biosynthesized in genetically modified yeast is a novel preventive or therapeutic agent for inflammatory diseases without the risk of foreign gene introduction.
Highly transparent and conductive AgNW electrode for versatile applications
송명관 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.0
Highly flexible transparent conducting electrodes are especially desired for the development of next generation flexible optoelectronic devices. However, indium tin oxide (ITO) films are currently adopted in those industries, the issues of cost and flexibility drive to develop alternatives. There are several emerging materials that have shown promise for the replace-ment of ITO such as carbon nanotubes (CNTs), graphene, metal nanowires, and metal mesh electrodes. Among these materials, metal nanowires have been attracting increasing attention because of its effective combination of electrical and optical properties.