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손장원,장혁재,이진경,정희정,송란영,김영진,Saurabh Datta,허란,신상훈,조인정,심지영,홍그루,정남식 한국심초음파학회 2013 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.21 No.2
Background: Accurate assessment of mitral regurgitation (MR) severity is crucial for clinical decision-making and optimizing patient outcomes. Recent advances in real-time three dimensional (3D) echocardiography provide the option of real-time full volume color Doppler echocardiography (FVCD) measurements. This makes it practical to quantify MR by subtracting aortic stroke volume from the volume of mitral inflow in an automated manner. Methods: Thirty-two patients with more than a moderate degree of MR assessed by transthoracic echocardiography (TTE)were consecutively enrolled during this study. MR volume was measured by 1) two dimensional (2D) Doppler TTE, using the proximal isovelocity surface area (PISA) and the volumetric quantification methods (VM). Then, 2) real time 3D-FVCD was subsequently obtained, and dedicated software was used to quantify the MR volume. MR volume was also measured using 3)phase contrast cardiac magnetic resonance imaging (PC-CMR). In each patient, all these measurements were obtained within the same day. Automated MR quantification was feasible in 30 of 32 patients. Results: The mean regurgitant volume quantified by 2D-PISA, 2D-VM, 3D-FVCD, and PC-CMR was 72.1 ± 27.7, 79.9 ±36.9, 69.9 ± 31.5, and 64.2 ± 30.7 mL, respectively (p = 0.304). There was an excellent correlation between the MR volume measured by PC-CMR and 3D-FVCD (r = 0.85, 95% CI 0.70-0.93, p < 0.001). Compared with PC-CMR, Bland-Altman analysis for 3D-FVCD showed a good agreement (2 standard deviations: 34.3 mL) than did 2D-PISA or 2D-VM (60.0 and 62.8mL, respectively). Conclusion: Automated quantification of MR with 3D-FVCD is feasible and accurate. It is a promising tool for the real-time 3D echocardiographic assessment of patients with MR.
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Phytochemical constituents of Aconitum pseudo-laeve var. erectum
김대근,류정희,홍승우,박진성,송란영,곽종환,이강노,지옥표 한국생약학회 1995 생약학회지 Vol.26 No.1
진범 (Aconitum pseudo-laeve var. erectum)은 우리나라 산지의 응당에서 흔히 자생하고 있는 다년초로서, 한방에서 해열, 진통, 진경, 이뇨약으로 사용하고 있으며 본 식물에 대한 성분연구로는 지하부에서 diterpene계 alkaloid 및 aromatic amide가 보고되었다. 본 실험은 진범의 면역활성 성분연구의 일환으로 수행되어졌으며, 즉, 진범 전초의 EtOH 냉침 extracts를 n-hexane, EtOAc 및 n-BuOH로 분획하고 쟁침잔사는 열수 추출하였다. 이중 유기용매 분획을 silica gel 및 sephadex LH-20 column chromatography하여 10종의 화합물을 분리하였다. 이화학적 성상 및 기기분석 방법을 통하여 compound 1∼4는 steroids, 5는 flavonoid 그리고 aromatic amide인 6∼8의 구조를 확인하였으며 이중 compound 9, 10의 구조 및 분리된 각 화합물에 대한 면역활성 연구는 진행중에 있다.
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