이달의 X-선 : 악성 임파종의 항암 치료 후 빠르게 진행되는 범발성 폐침윤

손장원 ( Jang Won Sohn ),신동호 ( Dong Ho Shin ),양석철 ( Seok Chul Yang ),윤호주 ( Ho Joo Yoon ),박성수 ( Sung Soo Park ),이정희 ( Jung Hee Lee ),이영열 ( Young Yul Lee ),최요원 ( Yo Won Choi ),박문향 ( Moom Hyang Park ) 대한결핵 및 호흡기학회 1998 Tuberculosis and Respiratory Diseases Vol.45 No.2

인천의 근대건축물의 설계한 건축가에 관한 연구

손장원,박정란,Sohn, Jang-Won,Park, Jung-Lan 한국디지털건축·인테리어학회 2005 한국디지털건축인테리어학회 논문집 Vol.5 No.2

It extended in the opening after simultaneous strong point flag and to Incheon the building where the designer whom the many modem time building comes to build but becomes known was not many so. The research against these people did not become accomplished and not to be the back author research which analyzes the work propensity which is the possibility of doing the possibility of becoming accomplished there was not a basic of architectural design. The research which it sees it led and khu lu thu the road khey keyl the back the depths data, it confronted compared to it secured does not become known during that time the multi architect who and the plan office and and and it searched the result of the back which it puts out well it put to the architects who become known and.

근대기 인천지역 주거건축 연구

손장원,차동원,Sohn, Jang-Won,Cha, Dong-Won 한국디지털건축·인테리어학회 2005 한국디지털건축인테리어학회 논문집 Vol.5 No.1

In the study results, Incheon region, a classic house was consistently built in spite of having been the barrier which a foreign dwelling flowed into until 1960's. And met me in our dwelling habit and changed and used a house built by the Japanese. That is, the traditional dwelling format worked with a spindle accepting other dwelling culture and can do it. It was a too social change and was able to confirm the fact that it extended a room as necessary or it improved a classic house and used as West back various way whom it got cold, and exchanged it to a kitchen of a cause and effect life.

종설 : 급성 폐손상과 급성 호흡곤란 증후군의 내과적 치료

손장원 ( Jang Won Sohn ) 대한내과학회 2010 대한내과학회지 Vol.79 No.1

Over the past decade, the ventilator management for acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) have yielded improved outcomes. However, studies of the pharmacologic management of ARDS and ALI have been less effective. ARDS/ALI is a heterogeneous disease entity. Although most drug trials in ARDS or ALI have been demonstrated to be ineffective in improving outcomes, some studies suggest that targeting treatments at subgroups of patients may be beneficial. Corticosteroids have good short-term effects when given sooner than 2 weeks. Surfactant may be beneficial in direct lung injury patients. Anticoagulants may have improved outcomes in the severe patients with vascular disease. Recently, ARDS Networks reported the `conservative fluid management strategy`. This promising fluid strategy showed beneficial effect on outcomes without serious complications. This article reviews the recent research on the Nonventilatory pharmacologic managements for patients with ARDS/ALI.(Korean J Med 79:1-7, 2010)

동일한 상시 호흡량의 $N_2-O_2$ 및 Heliox 투여 시 가스교환지표의 비교

손장원,임채만,고윤석,이종덕,이상도,김우성,김동순,김원동,Sohn, Jang-Won,Lim, Chae-Man,Koh, Youn-Suck,Lee, Jong-Deog,Lee, Sang-Do,Kim, Woo-Sung,Kim, Dong-Soon,Kim, Won-Dong 대한결핵및호흡기학회 1998 Tuberculosis and Respiratory Diseases Vol.45 No.1

연구배경: Heliox는 기도 저항이 증가된 환자에서 분시환기량의 증가와 호흡일의 감소로 인해 $PaCO_2$가 감소함이 알려져 있다. 이러한 효과 이외에도 최고 호기 유량비의 증가와 가스 분포의 호전에 의한 사강 호흡률의 감소효과도 있을 것으로 기대된다. 이에 저자등은 공기($N_2-O_2$)호흡 시와 통일한 분시환기량과 호흡일의 조건에서 heliox투여로 $PaCO_2$가 감소하는지 연구하였다. 대상 및 방법: 호흡 부전으로 기계호흡 중인 환자 중 기관지 천식이나 상기도 협착이 있으며 근 이완제 투여로 자신의 호흡일이 없는 8명(남 : 여 =5 : 3, 평균 68세)을 대상으로 하였다. 연구는 각 15분씩 기저 $N_2-O_2$투여, heliox투여 및 washout순으로 진행하였다. Heliox는 Servo 900C기종의 저압입구(low pressure inlet)를 통해 공급하였다. 호흡 역학 지표는 CP-100 monitor(Bicore, USA)로 측정하였고 heliox 투여시 동일한 일호흡량 유지을 위해 $N_2-O_2$에 대한 상대유량 비로 상시 호흡량을 보정하였다. 사강 호흡률용 Bohr의 공식으로 구하였다. 결 과: 일호흡량, 분시환기량, 최고 흡기압 및 최고 흡기 유량 비는 $N_2-O_2$와 heliox투여 군 사이에 차이가 없었다. 최고 호기 유량 비는 heliox투여 군에서 ($0.52{\pm}0.19$L/sec) $N_2-O_2$투여 군($0.44{\pm}0.13$L/sec)보다 높았다 (p=0.024). $PaCO_2$는 heliox투여 군 ($56.1{\pm}14.1$mmHg)이 $N_2-O_2$투여 군 ($60.5{\pm}15.9$mmHg) 보다 낮았고 (p=0.027), 사강 호흡률은 heliox투여군 ($71{\pm}10%$)이 $N_2-O_2$ 투여 군 ($73{\pm}9%$)보다 낮았다. 결 론: 분시환기량과 호흡일이 동일한 조건에서도 heliox투여 시 $N_2-O_2$투여에 비해 $PaCO_2$의 감소가 관찰되며 이는 사강 호흡률의 감소와 관련이 있을 것으로 사료된다. Background: Heliox is known to decrease $PaCO_2$ in patients with increased airway resistance by increasing minute ventilation and reducing work of breathing(WOB). Besides these effect, heliox is expected to decrease functional anatomic dead space owing to improvement of peak expiratory flow rate(PEFR) and enhancement of gas distribution. We investigated whether heliox can decrease $PaCO_2$ even at the same minute ventilation (VE) and WOB with $N_2-O_2$ to speculate the effect of the heliox on the anatomic dead space. Material and Method: The subjects were 8 mechanically ventilated patients with asthma or upper airway obstruction(M : F=5 : 3, $68{\pm}10$years) who were under neuromuscular paralysis. The study was consisted of three 15-minutes phases: basal $N_2-O_2$ heliox and washout Heliox was administered via the low pressure inlet of servo 900C, and respiratory parameters were measured by pulmonary monitor(CP-100 pulmonary monitor, Bicore, Irvine, CA, USA). To obtain the same tidal volume(Vt) in heliox phase, the Vt on monitor was adjusted by the factor of relative flow rate of heliox to $N_2-O_2$. Dead space was calculated by Bohr equation. Results: 1) Vt, VE, peak inspiratory pressure(PIP) and peak inspiratory flow rate(PIFR) were not different between $N_2-O_2$ and heliox. 2) PEFR was higher on heliox($0.52{\pm}0.19$L/sec) than $N_2-O_2$($0.44{\pm}0.13$L/sec)(p=0.024). 3) $PaCO_2$(mmHg) were decreased with heliox($56.1{\pm}14.1$) compared to $N_2-O_2$($60.5{\pm}15.9$)(p=0.027). 4) Dead space ventilation(%) were decreased with heliox($73{\pm}9$ with $N_2-O_2$ and $71{\pm}10$ with heliox)(p=0.026). Conclusion: Heliox decreased $PaCO_2$ even at the same VE and WOB with $N_2-O_2$, and the effect was considered to be related with the reduction of anatomic dead space.

태백층군 세송층과 화절층의 후기 캄브리아기 삼엽충 생층서대 재정립

손장원(Jang Won Sohn),최덕근(Duck K. Choi) 한국고생물학회 2005 고생물학회지 Vol.21 No.2

한국 성인 순환기질환의 빈도 및 변동추이

손장원(Jang Won Sohn),이재웅(Jae Ung Lee),윤석남(Seok Nam Yoon),이상(Sahng Lee),김경수(Kyung Soo Kim),김정현(Jeong Hyun Kim),임헌길(Heon Kil Lim),이방헌(Bang Hun Lee),이정균(Chung Kyun Lee) 대한내과학회 1995 대한내과학회지 Vol.49 No.6

N/A Objectives: By rapid socioeconomic progress, recent change in disease pattern was marked in Korea. Herein, we reviewed statistical data to evaluate the changes in incidence and trend of each cardiovascular disease. Methods: Statistical observation was made on the adult patients with cardiovascular diseases who were admitted in the Han Yang University Hospital for 12 years(1982-1993). These results were compared with previous report in same hospital(1972-1981). Results: 1) The increments of frequency of each cardiovascular disease were observed in consecutive years, especially in hypertension, ischemic heart disease, valvular heart disease, arrhythmia and pericarditis(p<0.01). 2) Hypertension was the most common form of cardiovascular problem, accounting for 44.8 per 1000 inpatients. Incidense of hypertension was high in the fifth and sixth decade. The male to female ratio was I:1.07 3) Ischemic heart disease made incidence of 15.3 per 1000 inpatients. The male to female ratio was I:0.9. The increment of incidence of ischemic heart disease was marked in male patients, Female patients were older than male in general. 4) Incidence of valvuler heart disease was 8.5 per 1000 inpatients. The male to female ratio was 1:1.5. 5) Incidences of the remaining forms of cardiovascular diseases per 1000 inpatients were arrhythmia in 23.4, congenital heart disease in 2.7, heart failure in 4.2, endocarditis in 0.3, pericarditis in 2.3, and cor pulmonale in 0.8. Conclusion: Incidences of majorcardiovascular diseases increased significantly in Han Yang University Hospital. We advocate establishing preventive measures and performing continuous epidemiologic study.

동일한 최고 흡기압(Peak inspiratory pressure)에서 기관 내관 풍선(Endotracheal tube cuff)의 최소 밀폐압(Minimal occlusion pressure)에 대한 상시량의 영향

손장원 ( Jang Won Sohn ),김태형 ( Tae Hyung Kim ),윤호주 ( Ho Joo Yoon ),신동호 ( Dong Ho Shin ),박성수 ( Sung Soo Park ) 대한결핵 및 호흡기학회 2004 Tuberculosis and Respiratory Diseases Vol.57 No.5

인천신사국팔십팔영장(仁川新四国八十八霊場) 연구

손장원(Sohn Jang-won) 인천대학교 인천학연구원 2016 인천학연구 Vol.24 No.-

개항이후 유입된 일본종교는 우리나라에 여러 가지 영향을 미쳤다. 우리나라 사람들은 일본종교에 대해 호의적이지 않았다. 이러한 이유에서 일본종교는 일본의 패망과 함께 그 세력을 잃고, 관련 시설물도 훼손되거나 철거되었지만, 전국 각지에 그 흔적이 남아 있어 이에 대한 대한 규명이 필요하지만 이에 대한 연구는 활성화되어 있지 않다. 특히 근대 개항기에서 일제강점기에 이르는 시기 일본인의 위세가 등등했던 인천에서 벌어진 종교침탈과 그와 관련된 유적을 정확하게 살펴보는 것은 중요한 의미가 있다. 일제강점기에 작성된 인천지도에 ‘八十八ヶ所’라는 표기가 있지만, 이를 명확하게 다룬 자료는 없었다. 또한 이 일대를 속칭 ‘부처산’으로 부르지만, 정확한 유래는 밝혀지지 않은 상태였다. 본 연구는 이러한 문제를 해결할 수 있는 타당한 근거를 찾아 이를 밝혔고, 국내 다른 지역에 있었던 유사 사례도 살펴보았다. 본 연구는 이론적 배경을 확립하기 위해 문헌조사를 통해 인천지역에 설치되었던 일본종교 시설과 일본불교의 특징인 영장순례에 대해 살펴보았다. 이어 국가기록원 소장자료를 통해 인천에 설치되었던 영장의 실체를 규명하고, 일제강점기 인천지도에 표기된 ‘八十八ヶ所’와 ‘부처산’의 유래를 밝혔다. 또한 부산, 인천, 마산, 목포, 청진, 주을온천 등 6개 도시에 7개의 신사국영장이 설치되었던 사실도 확인하여 관련 연구의 폭을 넓혔다. This study aims to overview and review about Incheon Shin Shikoku Reijyo(仁川新四国靈場) in Korea. Japan is Japanese occupation in Korea a lot of influence and had made many facilities. This was liberated after disappearance, but still remains. History always repeats itself because Japanese invasion to record accurately is important. The study examines Japan that was a Japanese Buddhist ruins in the Incheon. Incheon is the Japanese occupation were many activities of Japan. Was introduced in lots of Japan. Thus, in Incheon, Korea, Japan is important to look at the religion. There are many sites related to Japan in Incheon. Japanese people made 88 sacred in Incheon. Characteristic of the Buddhist pilgrimage, Japan. 88 sacred place is traceable to Buddhism of Japan"s Shikoku Reijyo. The Japanese have made 88 sacred place for the faith of Buddhism in Songnim-dong, Dong-gu, Incheon. Meanwhile there are many misunderstandings about this. The study begins to solve these problems. The research results as follows : ‘Bucheosan’부처산 was caused because there are many Japanese Buddhist Statue in 88 sacred place. Shin Shikoku Reijyo新四国靈場built in Incheon, Busan and Masan, Mokpo and Chongjin. The study is Busan and Masan, Chongjin was installed in newly announced.

Surfactant Protein A , B 와 C 유전자 발현의 Circadian Rhythm에 관한 실험적 연구

손장원(Jang Won Sohn),양석철(Seok Chul Yang),윤호주(Ho Joo Yoon),신동호(Dong Ho Shin),박성수(Sung Soo Park),김정미(Chung Mi Kim) 대한내과학회 2001 대한내과학회지 Vol.60 No.6

N/A Background : All organisms have developed an internal timing system capable of reacting to and anticipating environmental stimuli with a program of appropriately timed metabolic, physiologic, and behavioral events. The alveolar epithelial type II cell of mammalian lung synthesizes, stores, and secretes a lipoprotein pulmonary surfactant, which functions to stabilize alveoli at low lung volumes. Methods : The authors investigated the diurnal variation of surfactant protein A, B and C mRNA accumulation. The diurnal variation on gene expression of surfactant protein A, B and C were analysed using filter hybridization at 9 AM, 4 PM and 11 PM. Lung SP-A protein content was determined by double sandwich ELISA assay using a polyclonal antiserum raised in rabbits against purified rat SP-A. Results : 1. The accumulation of SP-A mRNA at 4 PM was significantly decreased 23.5% compared to the value at 9 AM (p<0.05). 2. The accumulation of SP-B mRNA at 4 PM and 11 PM was decreased by 15.1% and 5.7%, respectively, compared to the value at 9 AM (p=0.07, p=0.69). 3. The accumulation of SP-C mRNA at 4 PM and 11 PM was decreased by 6.8% and 7.7%, respectively, compared to the value at 9 AM (p=0.38, p=0.57). 4. Total lung SP-A content at 4 PM and 11 PM was increased by 5.3% and 15.9%, respectively, compared to the value at 9 AM (p=0.64, p=0.47). Conclusion : These findings represent diurnal variation of surfactant proteins mRNA expression in vivo. This results suggested the diurnal variation of hydrophilic surfactant protein rather than hydrophobic surfactant proteins.(Korean J Med 60:547-554, 2001)