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환경오염원인 납의 신경독성에 대한 NMDA 수용체 길항제의 보호 효과
손영우,임요섭,서영미,Kim, Young-Wo,Rim, Yo-Sup,Seo, Young Mi 한국산업보건학회 2017 한국산업보건학회지 Vol.27 No.3
Objectives: This study was performed to evaluate the neurototoxicity of the environmental pollutant lead acetate(LA) and the protective effect of the D-2-amino-5-phosphonovaleric acid(APV), N-methyl-D-aspartate(NMDA) receptor antagonist on LA-induced cytotoxicity in cultured C6 glioma cells. Materials and Methods: For this study, cell viability in cultured C6 glioma cells was assessed by XTT assay and antioxidative effect, such as lactate dehydrogenase(LDH) activity, by LDH detection kit. Results: LA significantly decreased cell viability in a dose-dependent manner, and the XTT50 value was determined to be 33.3 uM of LA. The cytotoxicity of LA was deemed highly toxic according to Borenfreund and Puerner's toxic criteria. The vitamin E antioxidant significantly increased cell viability damaged by LA-induced cytotoxicity in these cultures. For the protective effect of APV on LA-induced cytotoxicity, APV significantly increased not only cell viability, but also inhibition of LDH activity. From these results, it is suggested that oxidative stress is involved in the neurotoxicity of LA, and APV effectively protected against LA-induced cytotoxicity via an antioxidative effect as an inhibotory activity of LDH. Conclusions: Natural resources like APV may be putative therapeutic agents for the toxic diminution of environmental pollutants such as LA correlated with oxidative stress.
손영우,박수애,김용석,김찬 한국항공운항학회 2007 한국항공운항학회지 Vol.15 No.3
This research examined how pilots perceive risks when faced with emergency flight situations. We had 116 commercial airline pilots evaluate riskiness of 39 non-routine flight situations. The pilots' risk perception was analyzed as a function of their position (captain vs. first officer), expertise (expert vs. novice), and military flight experience (with vs. without military experience). Results showed that captains evaluated potential-risk situations and low-risk situations more dangerous than first officers. However, there were no differences between experts and novices, and between pilots having military flight experience and pilots not having military flight experience in risk perception. The analysis of multi-dimensional scaling revealed that the pilots used controllability as a key dimension for evaluating riskiness, though the other dimensions they used varied with their position, expertise, and military flight experience.
연구논문 : 프랑스 재외국민투표 참여 변화요인에 대한 분석: 제도요인 변화를 중심으로
손영우 한국의회발전연구회 2012 의정연구 Vol.18 No.3
본 연구는 지난 10년간 프랑스 재외국민투표에서 나타난 재외국민의 선거참여 변화 현상에 대해 분석한다. 특히 프랑스 정부는 재외국민의 참여 확대를 위해, 선거인명부의 통합과 행정절차의 간소화, 해외선거구 도입, 전자투표의 도입이라는 개혁을 진행하였는데, 이에 대한 효과를 분석하였다. 결국 선거인명부의 통합과 행정절차의 간소화를 통해 재외국민의 선거등록이 현격하게 상승하였다는 것을 알 수 있었지만, 해외선거구와 전자투표의 도입을 통한 투표율 상승효과는 발견할 수 없었다. 다만, 전자투표를 도입함에 따라 전자투표 이용자가 기존의 우편투표 이용자를 대부분 대체하는 모습을 보였다. 이러한 결과는 현재 재외국민투표를 막 도입하고 있는 우리나라에 선거등록제도 개선과 새로운 투표방식의 도입에 대한 고민에 중요한 시사점을 제공한다.