우황(牛黃).웅담약침액(熊膽藥鍼液)(BU)의 급성독성(急性毒性)에 관한 실험적(實驗的) 연구(硏究)

소경순,정찬길,이상운,박병모,김재형,강대인,조후리,김광호,Soh, Kyung-Sun,Jeong, Chang-Gil,Lee, Sang-Woon,Park, Pyung-Mo,Kim, Jae-Hyung,Kang, Dae-In,Jo, Hoo-Lee,Kim, Kwang-Ho 대한약침학회 2001 Journal of pharmacopuncture Vol.4 No.3

This experiment was carried out to study on the safety assessment of Bas tures . Ursus thibetanus extract solution(BU) for Herbal acupuncture. SD rats and ICR mice were used for acute toxicity test the results were summerized as follows; 1. In rats and mice, LD50 value could not be measured. 2. There were no abnormal finding in acute toxicity test treated BU for Herbal-acupuncture.

사향약침액(麝香藥鍼液)이 Triton WR-1339로 유발된 흰쥐의 고지혈증(高脂血症)에 대한 실험적(實驗的) 연구(硏究)

소경순,정찬길,김광호,이상운,강대인,Soh, Kyung-Sun,Jeong, Chan-Gil,Kim, Kwang-Ho,Lee, Sang-Woon,Kang, Dae-In 대한약침학회 2003 Journal of pharmacopuncture Vol.6 No.1

In order to study the effects of Moschus Herbal-acupuncture on hyperlipidemia, we divided the rats into three groups(Normal group, Control group & Sample group) and performed the experimental research. Hyperlipidemia rats were induced by Triton WR-1339(150mg/kg) for 3days. Sample group was injected Moschus Herbal-acupuncture 0.1 ml/200g for 3 days and control group was injected equal dose of saline. And then we measured the amount of serum total cholesterol, triglyceride, phospholipid and HDL-cholesterol. The results were as follows : 1.Moschus Herbal-acupuncture showed decreasing effects on total cholesterol, triglyceride and phospholipid levels in serum significantly(p<0.05). 2.Moschus Herbal-acupuncture showed increasing effects on HDL-cholesterol level in serum significantly(p<0.05). According to the above results, Moschus Herbal-acupuncture showed significant decreasing effects on hyperlipidemia and it is considered that it is appropriate to apply for hyperlipidemia.

보폐탕이 이산화황에 폭로된 흰쥐의 호흡기 손상에 미치는 영향( I )

소경순,Soh Kyung-Sun 대한예방한의학회 1998 대한예방한의학회지 Vol.2 No.1

Surfur dioxide, one of the air pollutants, has been related increasing morbidity rates due to respiratory damages. To investigate the effect of Bopaetang(補肺湯) on rats induced by exposur of $SO_2$, an experimental study was done the changes on white blood cell(W5C), the content of glycoprotein in treachea and the edema, congestion, inflammatory infiltrates of trachea. The experimental groups are the normal group, control group and sample group( administered Bopaetang to rats induced by exposur of $SO_2$). The results were as follows; 1. The change on WBC on rats induced by exposur of $SO_2$ were made significant differences in sample group compared with control group. 2. The content of Glycoprotein In trachea were made significant differences in sample group compared with control group. 3. The edema, congestion, inflammatory infiltrates of treachea were made significant differences in sample group compared with control group.

희첨이 Endotoxin으로 유발(誘發)된 흰쥐의 혈전(血栓)에 미치는 영향(影響)

소경순,Soh Kyung-Sun 대한예방한의학회 1998 대한예방한의학회지 Vol.2 No.1

In order to investigate the effect of the Herba Segesbeckiae on the thrombosis induced by endotoxin in rats. The rats were treated with solid extract of Herba Siegesbeckiae 41.9mg /200g(Sample) which were administered orally. And the thrombosis was induced by injecting endotoxin in the caudal vein rats. And then the number of platelets, concentration of fibrinogen, prothrombin time and FDP(fibrinogen degradation product) were measured. The results were as follows; 1. Platelet was increased significantly in sample group compared with control group. 2. Prothrombin time was shortened significantly in sample group compared with control group. 3. Fibrinogen was increased significantly in sample group compared with control group. 4. FDP was decreased significantly in sample group compared with control group. According to the above results, Herba Siegesbeckiae had significant effects on number of Platelets, Prothrombin time, Fibrinogen and FDP. therefore, it is considered that Herba Siegesbeckiae can be applied to diseases related to thrombosis.

맥진단기 채널의 ISI감소를 위한 적응필터

윤달황,정찬길,소경순 世明대학교 한의학연구소 1998 韓醫學硏究所 論文集 Vol.1 No.-

본 논문은 맥파검출기의 채널간에 발생하는 상호신호간섭을 감소시키기 위해 Sign 알고리듬을 적용한다. 이 알고리듬은 맥파가 저주파이고 매우 천천히 변하는 환경하에서 기존의 알고리듬과 비교하여 보다 유리한 성능을 가지며, 이를 이용하여 분할등화기를 구현한다. We propose the Sign algorithm and analyze the convergence characteristics of it. To evaluate the performance of proposed Sign algorithm, fractionally spaced equalizer is used. Especially, we present that this method have the advantages for the condition having the low-frequency and slow speed.

담관암 발생과정중 관찰되는 small cell과 oval cell의 면역조직화학

서일복,소경순 世明大學校 1998 世明論叢 Vol.7 No.-

This study was carried out to examine the immunohistochemical characteristic of the small cells and oval cellsin experimentally induced cholangiocarcinoma. Forty two female Syrian goldern hamsters were divided into two groups. Group I was served as experimentally induced cholangiocarcinoma group, which was infected orally with C. sinensis and given dimethylnitrosamine(15ppm) in drinking water. Group Ⅱ was served as contro. Five or six heads of hamsters in each group were sacrificed at 4, 7, 11 and 15 weeks after the begining of the experiment. The livers were examined grossly, histopathologically and immunohistochemically. The results obtained were as follows ; 1. Cholangiocarcinomas were occurred in 1 of 6 animals at 11 weeks and in 4 of 6 animals at 15 weeks. 2. Small cells and oval cells were proliferated around the portal triads from 4 weeks and peaked at 7 weeks and 11 weeks respectively, and decreased after then. 3. Any of the small cells not expressed cytokeratin. 4. Small cells divided into α-fetoprotein positive population and α-fetoprotein negeative population 5. Oval cells divided into α-fetoprotein positive population, α-fetoprotein negative population and cytokeratin positive population

3채널 맥파 검출장치의 GUI 개발

윤달환,정찬길,소경순 世明대학교 한의학연구소 1998 韓醫學硏究所 論文集 Vol.1 No.-

한의학은 개념적이고 주관적인 임상정보를 과학적 데이터화하여 환자를 치료하고자 한의의료장비의 응용에 많은 노력을 하고 있다. 맥파를 검출하기 위해서는 센서에 가해지는 압력, 센서 구동부의 운동 등 여러 가지 파라미터가 있다. 본 논문은 맥진의 정확한 맥상을 검출하기 위하여 3채녈 맥파검출 헤드장치 구동부를 유연하게 동작하도록 시스템을 개발하고, 기존의 양단 스위치 동작에 의한 헤드부의 모터운동을 제거함과 동시에 GUI형태로 맥진시스템을 구성한다. 특히 맥진정보를 받아들이는 寸ㆍ關ㆍ尺 헤드부의 정확한 동작이 맥진시스템의 성능을 향상시키는 역할을 하며, 이는 임상판정의 정확성을 기할 수 있도록 한다. In Oriental medicine, most of the medical examination of a patient depend on subjective explanation of self-patient. The application of an apparatus has an important significance in ensuring the objectivity of clinical information and in promoting the reproductivity and stability through the qualification and quantization. This paper development the pulse diagnostic apparatus of 3-channel type to detect exact pulsatory motion of a pulse wave, which is the type of GUI(graphic user interface) that one have the faculty of smoothing motor and the driving part of non-swich operating the sensor head. This system increase the function of pulse diagnosis and support the clinical decision.

鹿蔘地黃湯이 抗老衰에 미치는 影響

蘇敬順,金光湖 慶熙大學校韓醫科大學韓醫學硏究所 1995 慶熙韓醫大論文集 Vol.18 No.2

It is a natural desire of a human being who lives through the life cycle of birth, growth, maturity, aging and death to retard and delay the aging process, and to live a long heathy life. For the purpose of longevity, in Korean Medicine, it is considered to be imported to augmentation of the spleen(補脾) and reinforcement of the kidney(益腎). In this research, we made the formula of Noksamjiwhangtang(鹿蔘地黃湯) that has the augmentation of the spleen and reinforcement of the kidney(補脾, 益腎). In experiment, Age-related changes were measured such as body weight, organ weight, RBC, MCV, total cholesterol of serum, IgG, and in 50 weeks of age, body weight, organ weight, RBC, MCV, total cholesterol of serum, IgG, BaSO₄ transport, oxigen consumption, PSP test, amount of exercise and state of fur. I found a correlation between organ weight and body weight ratio for RBC, MCV, total cholesterol of serum, IgG. The results were as follows; 1. In age-related changes, through 40 weeks and 50 weeks body weight, organ weight, RBC were decreased in the group C(not fed Noksamjiwhangtang)but group S-1 (fed Noksamjiwhangtang) continuously increased. And MCV, total cholesterol of serum, IgG increased in the group C but group S-1 was decreased. 2. In the check of body weigh, RBC, BaSO₄transport, PSP test, amount of exercise group S-1, S-2 were significantly increased in comparison with group C and in the time of oxigen consumption group S-1, S-2 were significantly decreased in comparison with group C and in the state of fur group S-1, 5-2 and group C were made differences. 3. In the check of body weight, RBC, BaSO₄transport, PSP test, amount of exercise group S-1, S-2 were made significant differences. 4. Correlation between counts of RBC, MCV, BaSO₄transport and PSP test was less related and total cholesterol of serum, IgG were not related and counts of RBC, MCV, total cholesterol of serum, IgG in comparison with body weight and between the organ weights were highly related. In conclusion, Noksamjiwhangtang(鹿蔘地黃湯) is considered to have the effect of delaying the ageing process and retarding senile. And it is considered that body weight ratio for counts of RBC, total cholesterol of serum, IgG and relation between organ weight are will be used for experiment or as an indicator of aging process.

송엽약침액(松葉藥鍼液)의 독성시험에 관한 실험적(實驗的) 연구(硏究)

김대현,소경순,Kim, Dae-Hyun,Soh, Kyung-Sun 대한예방한의학회 2006 대한예방한의학회지 Vol.10 No.1

This experiment was carried out to study on the safety assessment of Pinus densiflora Siebold et Zuccarini for Hebal-acupuncture. SD rats and ICR mice were used for acute toxicity test, the results were summerized as follows; 1. In rats and mice, $LD_{50}$ value could not be measured. 2. There were no abnormal finding in acute toxicity test treated Pinus densiflora Siebold et Zuccarini for Hebal-acupuncture.

정신양생(精神養生)에 관한 문헌적(文獻的) 고찰(考察)

금종철,소경순,김광호,Keum Jong-Chul,Soh Kyung-Sun,Kim Kwang-Ho 대한예방한의학회 1997 대한예방한의학회지 Vol.1 No.1

After examining the viewpoints of the mental cultivation of The yellow Emperor's Internal Bible(內徑), from the viewpoints of The yellow Emperor's Internal Bible, I studied the principles and methods of the mental cultivation(精神養生) which the Taoism School, the Confusian School and the past physicians proposed. And I studied the methods of mental cultivation of the child, the woman and the old by the differences of ages and sex. At the subject of health preservation(養生學) on the basis of concept of relevant adaptation of man to nature(天人相應思想), the mental cultivation(精神養生) was regard more important than the body cultivation(肉體養生) and it was considered that the success of health preservation depended on the state of mind. the basic principles of the mental cultivation is achivement of the mental internal keeping(精神內守) through the state of peace and tranquility without avarice and wild fancy(恬憺虛無). The ways of mental cultivation of the Taoism School, the Confusian School and the past physicians were in the category of The yellow Emperor's Internal Bible. 4. In the previous Jin dynasty(先秦時代), the important theoretical bases and practices to mental cultivation were made. In the Han dynasty(漢時代), the physicians attached importance to mental treaments. During the time from Sui dynasty to Tang Dynasty(隋唐時代), the mental cultivation was made perfect theoretically. During the Period from Song dynasty to Yuan Dynasty(宋元時代), Many methods of mental cultivation were newly created. During the Ming and the Qing Dynasties(明淸時代), the theory of health preservation and the methods of mental treaments were embodied. 5. Studying the mental cultivation by the differences of ages, the childhood(小兒期) is the spring of life. So the mental cultivation of this period put importance to the cultivation of Sh ng(養生). And the youth(靑年期) is the summer of life. So the mental cultivation of this period pill importance to the cultivation of Ch'ang(養長). And the middle age(中年期) is the autumn of life. So the mental cultivation of this period put imporance to the cultivation of Shou(養收). And the old age(老年期) is the winter of life. So the mental cultivation of this period put importance to the cultivation of Tsang(養藏). Studying the mental cultivation by the differences of sex, the man must do the mental cultivation through the dynamic nature(性情) of Yang(陽) and the woman must do the mental cultivation through the static nature of Yin(陰).