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원발성 유두 갑상선암의 수술적 치료 후 측경부 전이 림프절에서 발생한 미분화 갑상선암 3예
성태연,홍순원<SUP>1<.SUP>,강상욱,이승철,정종주,이용상,남기현,장항석,정웅윤,박정수,Tae-Yon Sung,Soon-Won Hong<SUP>1<.SUP>,Sang- Wook Kang,Seung Chul Lee,Jong Ju Jeong,Yong Sang Lee,Kee-Hyun Nam,Hang-Seok Chang,Woong Youn Chung,M.D. 대한갑상선-내분비외과학회 2008 The Koreran journal of Endocrine Surgery Vol.8 No.3
Anaplastic thyroid carcinoma (ATC) is a rare disease that shows very aggressive behavior. Most ATCs arise from pre-existing thyroid carcinomas. However, anaplastic transformation occurring in metastatic cervical nodes is extremely rare. We report herein on 3 cases of anaplastic transformation of metastatic lateral cervical lymph nodes from primary papillary thyroid carcinoma (PTC), which happened long after the initial surgical treatment. All the patients died of disease within 4 months in spite of aggressive treatment for the lesions. Our experience supports that appropriate lymph node dissection is mandatory at the time of initial surgery even for differentiated thyroid carcinomas. <B>(Ko</B><B></B><B>rean J Endocrine Surg 2008;8:210-214)</B>
성태연,최윤미,김원구,이유미,김태용,송영기,김원배,송동은 대한의학회 2017 Journal of Korean medical science Vol.32 No.5
The aim of this study is to describe rare variants of adrenocortical carcinoma (ACC) and to compare the prognosis with that of conventional ACC. We retrospectively reviewed 8 cases of myxoid variant, 1 sarcomatoid variant, and 14 cases of conventional ACC, who underwent surgical resection at the Asan Medical Center between 1996 and 2014. An analysis of the clinicopathological characteristics, including the Weiss score, Ki-67 labeling index, and reticulin framework assessment is presented. The mean age of patients with myxoid/sarcomatoid ACC was 45 years; 4 out of 9 patients were women. Mean primary tumor size was 12.9 cm and the mean weight was 702.4 g. Seven patients presented in an advanced stage (stage III/IV); 8 of these eventually developed distant metastasis. The mean Weiss score was 5.0 points and the Ki-67 labeling index was 15.6%. The extent of myxoid or sarcomatoid change on histological examination ranged from 10% to 75% of the examined tumor areas; reticulin framework alteration was observed in all cases. Four patients showed venous tumor thrombus. Most of the clinicopathological parameters were not significantly different from those of conventional ACC. However, myxoid or sarcomatoid variant (hazard ratios [HR], 3.59; 95% confidence intervals [CI], 1.13–11.38; P = 0.030) and Ki-67 labeling index (HR, 3.97; 95% CI, 1.18–13.41; P = 0.030) were independent predictors of overall survival after adjusting for age and sex. Myxoid or sarcomatoid histological features or an increased Ki-67 labeling index may be associated with poor overall survival in patients with ACC.
Innovative In Vitro Chemo-Hormonal Drug Therapy for Refractory Thyroid Carcinomas
성태연,최성호,Jung Min Lee,정종주,강상욱,정웅윤 대한의학회 2012 Journal of Korean medical science Vol.27 No.7
More than 95% of the thyroid carcinomas are well differentiated types showing favorable prognosis. However, only a few therapeutic options are available to treat the patients with undifferentiated thyroid carcinomas, especially with refractory thyroid carcinomas that are not amenable to surgery or radioiodine ablation. We investigated the anticancer effects of 20 chemotherapy and hormonal therapy drugs on 8 thyroid carcinoma cell lines. In vitro chemosensitivity was tested using the adenosine-triphosphate-based chemotherapy response assay (ATP-CRA). The tumor inhibition rate (TIR; or cell death rate) or half maximal inhibitory concentration (IC50) was analyzed to interpret the results. Of the 12chemotherapy drugs, etoposide (178.9 index value in follicular carcinoma cell line) and vincristine (211.7 in Hürthle cell carcinoma cell line) were the most active drugs showing the highest chemosensitivity, and of the 8 additional drugs, trichostatin A (0.03 μg/mL IC50in follicular carcinoma cell line) showed favorable outcome having the anticancer effect. In our study, the result of etoposide and vincristine show evidence as active anticancer drugs in thyroid carcinoma cell lines and trichostatin A seems be the next promising drug. These drugs may become an innovative therapy for refractory thyroid carcinomas in near future.
성태연,G. R. Booker,A. G. Norman,F. Glas,G. B. Stringfellow 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.2
We have investigated the modulated structures and its associated diffracted diffuse intensity, of organometallic vapor phase epitaxially grown GaPSb (001) layers by using transmission electron microscopy (TEM) and transmission electron diffraction (TED). The TEM results reveal the co-existence of a fine-scale modulated contrast and a fine-scale speckled contrast. In addition, a fine needle-like contrast is observed. The [001] TED results show lines of [110]-oriented diffuse intensity diffuse streaks passing through the fundamental reflections, satellite spots at 1/4g[220] positions, and a [010]-oriented diffuse intensity with spacing of 1/6g[040]. Simulations using the Valence Force Field model were performed to understand the origin of the diffracted features. The observed distributions of diffuse intensity are shown to be partially consistent with random disorder. Furthermore, the [110]-oriented diffuse lines are attributed to a static displacement of the sites of the mixed sublattices.
재발성 부갑상선암: 경부 재발의 검사 소견과 수술 소견의 불일치
성태연,윤종호,홍석준,Tae-Yon Sung,M.D.,Jong Ho Yoon,M.D. and Suck Joon Hong,M.D. 대한갑상선-내분비외과학회 2011 The Koreran journal of Endocrine Surgery Vol.11 No.1
Parathyroid carcinoma is a rare malignancy presenting hyperparathyroidism. At times, diagnosis and localization are difficult. The optimum treatment for parathyroid carcinoma is en bloc resection when malignancy is highly suspicious or diagnosed. However, even after the adequate surgical treatment, persistent or recurrent disease is well encountered. Here we report a case with recurred parathyroid carcinoma presenting discrepancy between image findings and operative findings. (Korean J Endocrine Surg 2011;11:35-37)