소아류마치스열의 임상적 고찰

남성지 中央醫學社 1984 中央醫學 Vol.46 No.2

소아 류마치스열

남성지,안두홍 慶北大學校 醫科大學 1983 慶北醫大誌 Vol.24 No.2

A clinical observation was done on 30 children with rheumatic fever, who had been admitted to the Pediatric Department of Kyungpook National University Hospital from March 1978 to May 1983, and following results were obtained. Age distribution showed 43.6% in the age group of 6-10 years and 56.4%, 11-15 years. Male to female ratio was 1 2.9, and 18 patients (46.2%) experienced relapse more than one time. The common presenting symptoms were dyspnea on exertion in 79.5%, malaise in 69.2%, fever in 61.5%, arthralgia in 61.5%. palpitation in 53.6%, abdominal pain in 41.0%, and epistaxis in 10.3%. Physical examination showed cardiac murmur of mitral insufficiency in 100.O%, and hepatomegaly in 66.7%. frequency of major manifestations were carditis 100.0%, polyarthritis 15.4%, erythema marginatum 7.7%, subcutaneous nodules 5.1%, and chorea 5.l%. Laboratory findings showed leukocytosis in 48.7%, anemia in 43.6%, elevated erythrocyte sedimentation rate in 82.1%, antistreptolysin 0 titer over 300 units in 52.8%, and positive Creactive protein in 69.2%. Generalized cardiomegaly on chest radiogram was observed in 87.2%, left atrial enlargement on right anterior oblique view in 92.3%, and left ventricular hypertrophy in 84.6%. Electrocardiogram showed PR prolongation in 38.5%, QTc prolongation in 79.5%, ST and T wave change in 59.0%, left atrial enlargement in 56.4%, and left ventricular hypertrophy in 35.9%. In the majority of patients, clinical symptoms such as fever and resting dyspnea improved within 3 days of therapy with prednisolone and digitalis. However, elevation of peripheral venous pressure, increased ESR, and positive C-reactive protein returned gradually toward normal values requiring more than 10 days of treatment.

자연어처리를 이용한 비밀유지 계약서 분석

남민우,성지원 한국정책학회 2020 한국정책학회 동계학술발표논문집 Vol.2020 No.-

1980年度 痢疾樣 大便을 가진 患兒들에 對한 臨床的 細菌學的 觀察

趙龍勳,南聖枝,具滋薰,安斗洪,薛盛用 慶北大學校 醫科大學 1980 慶北醫大誌 Vol.21 No.2

1980年 1月부터 1980年 8月까지 滿 8個月間 痢疾樣 大便을 主訴로 本 小兒科에서 入院및 來院한 患兒 75名을 對象으로 臨床的, 細菌學的 觀察을 하여 다음과 같은 咸績을 얻었다. 年齡別 分布는 1歲에서 5歲 사이가 35例(47%)로 가장 높았으며 이들中 Shigella는 23例(30%), Entameba histolytica는 13例(17%)였고 Vibrio parahaemolyticus는 한 例도 檢出되지 않았다. 檢出된 Shigella 23菌株는 모두 Shigella flexneri 였다. 月別分布는 6月 16例(20%), 7月 30例(40%)로서 最多數를 占하였으나 細菌性 痢疾의 경우 月別에 관계없이 均等하게 分布하고 있었다. 臨床症狀및 理學的 所見으로는 細菌性痢疾의 경우 38℃ 以上의 發熱 19例(83%), 嘔吐 6例(26%), 腹痛 8例(35%), 痙攣 5例(22%)였으며, 아메바性 痢疾에서는 發熱 4例(31%), 痙攣 1例(8%)로서 細菌性 痢疾에서 아메바性 痢疾보다 發熱과 痙攣이 빈번히 나타났다. 泄瀉의 性狀에서는 細菌性 痢疾 23例中 血粘液性이 19例(83%)였는데 비해 아메바性 痢疾 13例에서는 粘液性이 8例(62%)였다. 泄瀉의 回數에서도 細菌性 痢疾에서는 대부분이 11回以上이었는데 比해 아메바性 痢疾에서는 대부분이 10回未滿이었다. 末梢血液에서의 白血球數는 全例의 35%에서 白血球 增多症을 보였다. 分離된 Shigella 23菌株에 對한 抗生劑 感受性 檢査를 平板混合포稀釋法에 依해 調査해 본 結果 kanamycin, gentamicin, amikacin, cephaloridine, rifampin이 100%의 感受性을 나타내어 가장 높았고, nalidixic acid에서도 87%의 感愛性을 나타냈으며, sulfonamide, chloramphenicol, streptomycin, tetracycline, ampicillin, bactrim 에서는 한 菌株를 제외한 모든 菌株에서 耐性을 나타냈다. 그리고 이들 Shigella 23菌株中 1菌株를 제외한 나머지 모든 菌株에서 6種 以上의 抗生物質에 對해 多抗生物質耐性을 보여 주었다. A clinical and laboratory study was conducted on 75 children with dysentery-like stool, who were admitted or visited to our pediatric department during 8 months period from January to August 1980. The following results were obtained: One to five years of age group was affected most frequently (47%). Shigella flexneri was identified by stool culture in 23 cases (30%) and Entameba hitolytica in 13 cases (17%). In bacillary dysentery group, fever was the most common symptom occuring in 83%, followed by abdominal pain in 35%, vomiting in 26% and convulsion in 22%. In amoebic dysentery group, fever was noted in 31% and convulsion in 8%, showing some contrast to the frequency of fever and CNS manifestation. About the character of diarrheal stools, 83% of bacillary dysentery group showed bloody, mucoid stool and 62% of amoebic dysentery group mucoid ones. Frequency of diarrhea was 11 times per day or more in 73% of bacillary dysentery patients, and 10 times per day or less in 92% of amoebic dysentery patients. The result of sensitivity test of isolated Shigella to various antibiotics were as follow: 100% sensitive to kanamicin, gentamicin, amikacin, cephaloridine and rifampin. 87% to nalidixic acid, and 4.3% to sulfonamide, chloramphenicol, streptomycin, tetracyclin, ampicillin and bactrim. And 22 out of 23 isolated Shigella strains revealed multiplydrug-resistance patterns to 6 or more antibiotics.

신생아의 저칼슘혈증

이강일,남성지,이원석,이건수,구자훈 慶北大學校 醫科大學 1981 慶北醫大誌 Vol.22 No.2

A clinical study about neonatal hypocalcemia utilizing Q-oTc interval was conducted on 174 sick babies and/or high risk infants from March 1980 to June 1981. Following results were obtained; Out of 43 hypocalcemic infants, 37 (86%) were early neonatal hypocalcemia and 6 (14%) late neonatal hypocalcemia. There was no sex difference noted. Affected rate in premature babies was 43% and low birth weight infants 36%. And in accordance with increasing gestational age and/or birth weight, the rate became gradually fallen. Poor sucking was the most common symptom of hypocalcemia occurring in 15 cases, followed by irritability, jitteriness and abnormal crying in 13, convulsion in 10, and vomiting, cyanosis and RDS in small number of cases. However, 14 hypocalcemic infants showed no symptom at all. The most common associated disorder was low birth weight, followed by "suspected sepsis", jaundice, asphyxia neonatorum, oral thrush, Placental dysfuntion, polycythemia, hypoglycemia, diarrhea, DIC, SIADH and partial type of DiGeorge syndrome, etc. At birth, abnormal maternal condition was seen in about half (48.8%) of the cases, these being toxemia, twin pregnancy, amnionitis, abruptio placenta, polyhydramnios, chronic hypertension and heart disease. Calcium therapy induced prompt response in the majority of cases, as normalization of Q-oTc interval in 50% and clinical improvement in 62% within 24 hours after starting calcium therapy, except 3 cases who expired due to severe complication such as sepsis, pneumonia and RDS.

퀴롤논 내성 Campylobacter jejuni의 분리와 항균제 감수성

김은철,심은숙,성지남,김신무 대한임상검사과학회 1999 대한임상검사과학회지(KJCLS) Vol.31 No.2

. Campylobacter spp. are frequent cause of enteric infecton. Increased resistance of human isolates of Campylobacter was considered in part due to widespread animal use of antimicrobial agents. In Korea, our knowledge on both human and animal carriage of Campylobacter is very limited. In this study, 260 stool specimens were taken from healthy subjects in Soonchun and Iksan city, and intestinal contents of 231 chickens during the period between August 1998 to July 1999. The Isolaton rate of Campylobacter from healthy subjects was 1.9%, and the rate was higher in ≤10-year-old children. The isolation rate from healthy chicken was 66.3%, and the rate was highest in August (80%) and lowest in December (56.5%). All of the C. jejuni from chicken were susceptible to amikacin, clindamycin and gentamicin. The resistance rates were 97% to tetracycline, 82% to ciprofloxacin,nalidixic acid and co-trimoxazloe, 65% to ampicillin. All of the C. jejuni isolates from human were resistant to ampicillin and co-trimoxazole, while the rates were 67% for both ciprofloxacin and tetracycline. For C. jejuni, antimicrobial agents with lower MICs were imipenem ≤0.06 μg⁄ml, gentamicin 0.25 μg⁄ml, amikacin 0.5-4 μg⁄ml and kanamycin 2-8μg⁄ml. MIC ranges of ciprofloxacin and nalidixic acid were 0.06-64 μg⁄ml and 32-64 μg⁄ml, respectively. Susceptibilities to nalidixic acid and to ciprofloxacin were identical Ampicillin and tetracycline resistance rates were higher among nalidixic acid-resistant isolates than susceptible ones. In conclusion, human carriage rate of Campylobacter is very low, while the rate in chickens is very high. Fluoroquinolone resistance rate of C. jejuni is very high, but amikacin and gentamicin can be used empirically without susceptibility testing as resistance to these antibiotics seem to be rare.