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Poly(2-Hydroxyethyl Methacrylate-co-2-Methacryloxyethyl-1,1,1-Trifluoroacetate)의 합성 및 물성에 관한 연구
성용길,성대경 동국대학교 1987 論文集 Vol.26 No.-
Swollen or unswollen synthetic polymeric films are suitable for separation techniques such as hyperfiltration, ultrafiltration, dialysis, electrodialysis, and piezodialysis. They have also found major uses in biomedical problems(artificial kidney membranes, etc.), enzyme related processes, ion-exchange, dental and pharmaceutical applications(controlled release system). Poly (2-hydroxyalkyl methacrylate)s are being considered as useful materials for various membranes and medical applications. The radical copolymerization of 2-hydroxyethyl methacrylate (HEMA) with 2-methacryloxyethyl-1, 1, 1-trifluoroacetate (METFA) has been investigated to understand their reactivities and to improve the physical properties of homopolymer. The monomer METFA was synthesized by esterification of 2-hydroxyethyl methacrylate with 1,1,1-trifluoroacetic acid(TFA). Azobisisobutyronitrile (AIBN) was used as an initiator in the radical copolymerization of HEMA with METFA. The compositions of unreacted monomers were determined by the intensity of each peak by gas chromatographic analysis. The monomer reactivity ratios were determined by Kelen-Tu¨do~s method. The values of the reactivity ratios are r_1=2.35 and r_2=0.21 for the HEMA(1)-METFA(2) system. The values of Q and e factors calculated by Alfrey-Price equation are 0.29 and-0.64, respectively. The characterization of the copolymers has been carried out by FT-IR spectrophotometer and thermal analysis techniques. The thermal stability and melting temperature(Tm) of the copolymers were increased, as the amounts of hydrophilic HEMA in the copolymers increased. The enthalpic changes associated with endothermic transition were evaluted by differential scanning calorimetry. The activation energies of poly (HEMA-co-METFA) were evaluated from the thermogravimetric data by Freeman and Carroll method. The equilibrium water swelling quantities of the homopolymers and copolymers are also measured and discussed on the basis of hydrophobicity and hydrophilicity.
성용길,송대경,이종섭 동국대학교 대학원 1991 大學院硏究論集-東國大學校 大學院 Vol.21 No.-
Poly(1,4-butanediol dilactate succinate)and poly (1,4-butanediol dilactate 2-acetoxy succinate) were prepared by the polycondensation of 1,4-butanediol dilactate with succinic anhydride and 2- acetoxy succinic acid. 1,4-Butanediol dilactate was synthesized from L-lactic acid in the presence of 1,4-butanediol as a difunctional initiator. 2-Acetoxy succinic acid was synthesized from L-malic acid by protecting hydroxyl group using acetic anhydride. The monomers and polymers were identified by ^1h-NMR spectrometer and FT-IR spectrophotometer. The molecular weights and molecular weight distributions of synthetic polymers were measured by gel permeation chromatography. The glass transition temperatures and thermal decomposition temperatures of the polymers were measured by differential scanning calorimetry and thermogravimetry, respectively.
약물전달계를 위한 공중합 폴리에스테르 미세입자의 제조 및 생분해성에 관한 연구
성용길,한승준 한국생체재료학회 2002 생체재료학회지 Vol.6 No.1
The hydrolytic polymer microspheres such as crosslinked polyethyleneglycolide- poly(glycerol-co-malate)s (XL-PEG-PGM)s by changing mole ratios of -COOH and -OH groups have been prepared for drug delivery systems. The hydrolytic degree and biodegradation of the microspheres have been characterized. The releases of drugs from the microspheres have been showed the tendency in order of XL-PEG-PGM10,000>XL-PEG-PGM3,400>XL-PEG-PGM1,000. The characteristics of drug releases from the microspheres are influenced largely by changing of pH and temperature in the solution. The drugs from the microsheres are released faster in basic condition than in acidic condition
成墉吉,白形基 동국대학교 1985 論文集 Vol.24 No.-
친수성 poly(2-hydroxyethyl methacrylate) (PHEMA)는 생체 적합성과 안전성이 있는 물질로 생의학적 적용을 하는 데 널리 사용되고 있으나 그 고분자의 기계적 성질과 혈액 적합성이 좋지 않은 것이 아직 개선되어야 할 문제점으로 남아 있다. 그 물질의 물성 및 순도의 문제점 등을 개선하기 위해서 2-hydroxyethyl methacrylate(HEMA)를 5, 6-dihydro-4H-1,3-oxazine(OZI) 및 2-phenyl-1, 3, 2-dioxaphospholane(ethylene phenylphosphonite, EPO)에 대해 촉매를 사용하지 않고 zwitterion 중간체를 경유하여 순수한 공중합체를 합성하였다. 합성된 공중합체들의 특성을 적외선 분광법, 핵자기 공명 분광법, 시차주사 열량계법 및 열무게 측정 분석법에 의해 확인하였고, 또한 그 공중합체들의 물에 대한 팽윤성도 연구 조사하였다. Hydrophilic poly(2-hydroxyethyl methacrylate) has been largely accepted as a biocompatible and stable material for biomedical applications. However, some of its relatively poor mechanical properties and blood compatibilities are still remained as problems to be improved. In order to improve its physical properties and purity problems, some pure copolymers of 2-hydroxyethyl methacrylate(HEMA) with, 5,6-dihydro-4H-1,3-oxazine(OZI) and 2-phenyl-1, 3, 2-dioxaphospholane(ethylene phenyl phosphonite, EPO) have been synthesized via zwitterion intermediates without catalysts. The synthesize copolymers were identified by infrared spectorscopy and nuclear magnetic resonance spectroscopy. the thermal properties of the copolymers were measured by differential scanning calorimetry and thermogravimetry. the swelling properties of the copolymers in water are also investigated.