Estrogen의 白鼠의 排尿筋 收縮에 미치는 影響

薛鍾求,朴鍾雨 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.2

This study was attempted to investigate the influence of estrogen on the contractile function of rat urinary bladder. Animals were pretreated for 1,5 or 10 weeks with estrogen and the contractile response of the detrusor muscle was induced by the treatment with acetylcholine, phenylephrine, ATP or KC1. 3^H-nitrendipine binding was also carried out with the homogena of the rat urinary bladder. The results were as follows: 1. Acetylcholine (10^-6 or 5 × 10 exp (-6)M)-induced contraction was significantly increased in estrog treated group for 1 or 5 weeks (p<0.05), and atropine (10^-6M) completely inhibted the acti of acetylcholine in control and estrogen treated group. 2. Phenylephrine (10^-3M)-induced contraction was significantly increased in estrogen treated group for 1 or 5 weeks (p<0.05), and prazosin(2.2 × 10 exp (-6)M) inhibited the action of phenylephrin about 70-75% in both groups. 3. .ATP(10^-3M)-induced phasic contraction was significantly increased in estrogen treated group for 1, 5 or 10 weeks (p<0.05), and diltiazem(l0 ^-6M) inhibited the action of ATP about 45~74% in both groups. 4. KC1(27mM)-induced contraction was slightly increased in estrogen treated group, and diltiazem(10^-6M) inhibited the action of KCl about 72~75% in both groups. From the above results, it was suggested that the increased response to acetylycholine, phenyl ephrine, ATP or KC1, with the treatment of estrogen, may be related to the alteration of cell membrane and/or the numbers of calcium channels.

음낭피부판을 이용한 음경 육아종 수술적 치료방법

설종구,이강영,임재성 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

Penile foreign body is not rare and may cause poor, painful erection or serious complications even such as granuloma, embolism (paraffin or vaseline) or malignant neoplasm. However, the appropriate method of it's surgical management is not established. So we compare advantages and disadvantages of the each surgical methods using the scrotal skin flap in the treatment of penile foreign body granuloma.

전립선 비대증 및 전립선암에 있어서 경직장 초음파 소견

설종구,강순구 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

Transrectal ultrasonography can provide a precise image of the prostate, seminal vesicles and adjacent structure. It can play a valuable role in the diagnosis of prostatic diseases, particulary in the detection, staging and monitoring after treatment of prostatic cancer. Transrectal ultrasonography was taken in 51 patients with prostatism (34 cases of benign prostatic hyperplasia and 17 cases of prostatic cancer), and the results were compared with the pathologic results of prostatic tissue obtained by digitally guided biopsy or surgical specimens. The results were as follows: 1. The sensitivity, specificity, positive predictive value, and dectation rate of trasrectal ultrasonography for prostatic cancer were 88.2%, 97.1%, 93.8%, and 29.4%, and in digital rectal examination, sensitivity, specificity, positive predictive value and dectation rate were 64.7%, 97.1%, 91.7% and 21.6%, respectively. 2. Echogenecity of prostatic ultrasonography in prostatic cancer were hypoechoic in 12 cases(70.5%), hyperchoic in 3 cases(17.7%) and isoechoic in 2 cases(11.8%), and in benign prostatic hyperplasia, isoechoic in 33 cases(97.1%) and hyperechoic in 1 case(2.9%).

가토에 있어서 편측 요관 폐색시 환측, 반대측 요관에 대한 변화 : 조직학적 소견을 중심으로

설종구,김용웅,육승모,노안식,김홍식,김상현,이충식 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

This study was designed to clarify histological changes in the experimental rabbit ureter after unilateral prartial or complete ureteral obstruction. A total of 20 adult white rabbits were divided into 4 subgroups in the partial obstruction followed by 2 weeks, partial obstruction followed by 4 weeks, complete obstruction followed by 2 weeks, complete obstruction followed by 4 weeks. The normal control group consisted of 5 adult white rabbits. The H & E stain. light microscopy were used. Abnormal histological fingings were showed in ipsilateral ureter of all subgroups; dilatation of ureter, epithelial cell atrophy or loss, interstitial fibrosis, interstitial inflammation. These findings were most severe in the complete-obstructed ureter for 4 weeks. There were no significant changes in contralateral ureter of all subgroups. Despite of progressive histological changes in ipsilateral ureter no abnormal findings were showed in contralateral ureter. We suggest that long term experimental investigation for histological changes in ipsilateral ureter and compensatory changes in contralateral ureter should be done.

Continent Ileal Diversion과 Noncontinent Ileal Diversion에 관한 임상적 연구

설종구 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.2

We records of the continent ileal diversion(12 cases) and noncontinent ileal diversion(31 cases) at/ the Chungnam National University Hospital were reviewed. The results were as followings; 1. There were 10 males and 2 females(ratio of 5 : 1) with the peak incidence in the 6 decades (7 cases) in the continent ileal diversion, and 24 males and 7 females(ratio of 3.4 : 1) with the peak incidences in the 6 decades(9 cases) and 7 decades (9cases) in the noncontinent ileal divers on. 2. The most common disease was bladder cancer in the continent and noncontinent ileal diversion. 3. The mean of the operating times, amounts of transfused blood and postoperative hospital dates were measured as 9.5 hours, 5.1 pints and 27.7 dates in the continent ileal diversion, and 5.4 hours, 3.5 pints and 22.2 dates in the noncontinent ileal diversion. 4. The postoperative complications were 2 urine leaks, 1 fecal fistular and 1 wound infection in the continent ileal diversion, and 5 fecal fistulars, 3 wound infections, 2 urine leaks and 1 intestinal obstruction in the noncontinent ileal diversion. 5. The incidences of the complication and death were 33.3% and 8.3% in the continent ileal diversion, and 35.3% and 9.7% in the noncontinent ileal diversion.

고환절제 후 백서의 복측 전립선에서의 병리학적 변화에 관한 연구

설종구,윤율로,이중화 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

The regulation of cell death and renewal is controlled by androgen in rat ventral prostate. So many studies on androgen block effects has been performed to understand the hormonal control in prostatic epithelial cell. Castration of rat results in activation of programmed cell death of ventral prostate. This response is related to activation of the calcium-magnesium dependent endonuclease. To observe the changes of regression of prostatic gland following androgen withdrawal, histologic examination was performed in rat ventral prostate after castration. The level of serum testosterone was rapidly decreased after castration from 5.9 ng/ml in normal rat to 1.6 ng/ml at 3hr castration. After 6hr postcastration its level was 0.01 ng/ml or below. The pathologic changes of ventral prostate was also observed after castration. Apoptosis in the ventral prostate appeared initially at 24hr postcastration but maximal apoptosis was noted at 6days. We confirmed the apoptotic bodies in light microscopic examination be electron microscopic observation.

자해에 의한 음경절단의 치험 1례

설종구,이철호,윤능수 大韓泌尿器科學會 1980 Korean Journal of Urology Vol.21 No.5

표재성 방광 이행상피세포암에 있어서 방광내 항암제주입요법 밀 면역요법

설종구,신보현,하용원,김윤종,노안식,손성용 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.2

Intravesical chemotherapy and immunotherapy will commonly eradicate residual papillary transitional cell carcinoma or carcinoma in situ(CIS) and clearly reduce the short-term incidence and rate of tumor recurrence. So I reviewed the effects and complications of different therapeutic agents(thiotepa, mitomycin-C, epirubicin, adriamycin, bacillus Cal mette-Cue'rin(BCG)) in superficial bladder cancer confirmed with histopathology, with the literatures. Bladder cancer were recurred more commonly in multiple tumors(50.6-56.3%), high grade tumors(52.6%) rather than in single(30.9%) and low grade(31.6%). And recurrence rates according to therapeutic agents were 83.3% in mitomycin-C, 71.4% in thiotepa, 50.0% in epirubicin, 46.6% in adriamycin and 32.6% in BCG. But incidence of complications were highest in BCG(50.5%). So sufficient preventive manuevers should be needed before intravesical theraphy, especially in BCG immunotherapy.

뇨로결석의 화학적 성분분석

설종구 大韓泌尿器科學會 1982 Korean Journal of Urology Vol.23 No.2

Modulith SL-20 體外衝擊波碎石機를 利用한 尿路結石의 治療

薛鍾求,羅容吉 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

Extracoporeal shock wave lithotripsy monotherapy was performed in 111 patients with Modulith SL-20 electromagnetic lithotriptor from January, 1994, to November, 1994, in our Department of Urology. Most of stones were distributed between 4th and 6th decades(67.4%), and male to female ratio was 1.3 : 1, and 111 patients have 117 stones, which were 76 cases of ureteral stone(65.0%), 28 cases of renal(23.9%), 11 cases of ureteropelvic junction(9.4%) and 2 cases of bladder(1.7%), 6 bilateral cases, and 0.6cm to 5.0cm in diameter. Of the 0.6cm to 5.0cm in diameter, stones were 1.0cm-1.9cm 54 cases(46.2%), 0.6cm-0.9cm 43 cases(36.8%), 2.0cm-2.9cm 12 cases(10.2%) and 8 cases (6.8%) in longer than 3cm. And treatment session was needed more and more in longer than 1.0cm. Complications were colicky pain(16 cases, 13.7%), severe gross hematuria(9 cases, 7.7%), fever and chill(2 cases, 1.7%), renal subcapsular hematoma(2 cases, 1.7%), residual stone(2 cases, 1.7%o), and steinstrasse(1 case, 0.9%). Therefore extracoporeal shock wave lithotripsy monotherapy is considered as a safety and non-invasive treatment method for all urinary stones.