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加味補陽還五湯이 高脂血症, 血栓, 高粘度血症, 高血壓 및 腦損傷에 미치는 影響
설인찬,김병탁 대한한방성인병학회 1998 韓方成人病學會誌 Vol.4 No.1
For the evaluation of effects of KBHT A including Salviae Radix and Achyranthis Radix, KBHT B including Mori Ramulus to KBHT A, experiments were done on hyperlipidemia induced by administration of cholesterol, thrombosis by dextran, hyperviscosity, hypertension and brain damage. The results were obtained as follows ; 1. In case of hyperlipidemia induced by cholesterol feed, serum cholesterol, triglyceride, and phospholipid were significantly decreased in both sample groups, while HDL-cholesterol and the number of platelets were significantly increased and also total lipid decreased only in sample B as compared with data of control. 2. In thrombosis by dextran, fibrinogen was significantly increased and aslo prothrombin time was significantly shortened in both sample groups, whereas numbers of platelet were significantly increased in sample A, but FDP was significantly decreased in sample B as compared with data of control. 3. In hyperviscosity by hydrocortisone acetate, fibrinogen, prothrombin time, viscosity of whole blood and serum were changed effectively with significance in both sample groups, while numbers of platelet and platelete aggregation were significantly increased in sample A and also hematocrit was decreased only in sample B as compared with data of control. 4. In experiment of hypertention, blood pressure was significnatly decreased in both sample groups on the first day after oral administration, while blood pressure was significnatly decreased in sample A on the 11th day after oral administration to SD rats as compared with data of control. 5. In damage of brain, shortening of coma duration by KCN, extension of suvival time to a lethal dose of KCN, extension of breathing time after decapitation and also after ligation of both common carotid arteries and extension of survival time after exposure to anoxia by Co2, N2 and vacuum pump were significantly exterted in both sample groups as compared with data of control. Above results suggest KBHT including Salviae Radix and Achyranthis Radix or Mori Ramulus has the posssiblty to be effectively applied to the cerebrocardiac diseases such as CVA and coronay diseases, which also need more clinical and experimental studies in future.
설인찬 ( In Chan Seol ) 대전대학교 한의학연구소 2009 한의학연구소 논문집 Vol.18 No.2
Most of the cholesterol is synthesized by liver in the body while about one of third is taken via dietary. The main functions of cholesterol is to protect membranes in cell surface, avoid the arterial bleeding by hypertension, and prolong the life of erythrocytes, and so on. However, overload of cholesterol leads to arteriosclerosis associated with leading death cause. Lack of physical activity, emotional and environmental stress, and low intake of protein or vitamin E induce the unbalance between HDL- and LDL-cholesterol so become a basis of ischemic disorders in heart, brain and elsewhere in the body. So far, four major classes of medications for hyperlipidemia are HMG-CoA reductase inhibitors (statins), bile acid sequestrants, nicotinic acid, and fibric acids. The statins can lower LDL and levels triglyceride, but may induce myopathy and an elevation of liver enzyme levels. The bile acid sequestrants lower LDL levels and raise HDL levels with no effect on triglyceride levels but side effects of gastrointestinal (GI) distress, constipation, and a decrease in the absorption of other drugs. Nicotinic acid and fibric acids lower LDL and triglyceride levels with showing flushing, hyperglycemia, hyperuricemia, GI distress, and hepatotoxicity dyspepsia, gallstones, myopathy, and unexplained noncardiac death as adverse effects. Above western drugs lower cholesterol by 15 to 30% while all have notable adverse effects. In traditional medicine, hyperlipidemia is regarded as retention of phlegm and fluid disease. Etiology and pathogenesis of hyperlipidemia is basically based on Spleen-Deficiency and Phlegm-Stagnation, accumulation and stasis of -heat, and Qi & blood stagnation induced by Phlegm-damp, water-dampness, and blood stasis. Thereby, strengthening Spleen and dissolving Phlegm, clearing away heat and diuresis, and supplementing Qi and activating blood circulation are commonly used therapeutic methods for hyperlipidemia. The traditional herbal medicine, have been used for patients with CVA, hypertension or hyperlipidemia in Oriental hospital or Oriental clinic. The lock and key theory is used to develop most of western medicine, however many diseases are caused by mixed factors in body-complex system. We expect that Oriental pharmacological theory could be newborn as a novel drug showing high advantage of blood levels of lipidsand QOL of performance without side effects.
Facilitated Axonal Regeneration of Injured Sciatic Nerves by Yukmijihwang-tang Treatment
김정현,설인찬,유호룡,조현경,안정조,남궁욱,김윤식 한의병리학회 2008 동의생리병리학회지 Vol.22 No.4
Yukmijihwang-tang(YM) is used in Oriental medicine for treatments of diverse systemic symptoms including neurological dosorders. The present study was performed to examine potential effects of YM on growth-promoting activity of injured sciatic nerve axons. YM treatment in the injured sciatic nerve induced enhanced distal elongation of injured axons when measured 3 and 7 days after injury. Retrograde tracing of sciatic nerve axons showed YM-mediated increases in the number of DiI-labeled dorsal root ganglion (DRG) sensory neurons and spinal cord motor neurons at 3 days after injury. Hoechst nuclear staining showed that non-neuronal cell population was largely elevated by YM treatment in distal nerve area undergoing axonal regeneration. Furthermore, phospho-Erk1/2 protein levels were upregulated by YM treatment in the injured nerve area. These data suggest that YM may play a role in facilitated axonal regeneration in injured peripheral nerves. Further investigations of individual herbal components would be useful to explore effective molecular components and develop therapeutic strategies.
前胡藥鍼이 Ovalbumin-induced Asthma Mouse Model에 미치는 영향
노홍표,설인찬,김윤식 대한침구의학회 2005 대한침구의학회지 Vol.22 No.6
Objectives : The aim of this study was to investigate the effect of Peucedani Radix herbal acupuncture(PR-HA) at St36(joksamni) on ovalbumin-induced asthma in mice. Methods : C57BL/6 mice were sensitized and challenged with OVA(ovalbumin) for 12 weeks(once a week) C57BL/6 mice were injected, inhaled and sprayed with OVA for 12 weeks (3times a week). One of the two experimental groups was just treated with needle-prick on St36 and the other group was treated with 1% concentrations of PR-HAS at St36, for the later 8 weeks (3times /week). Results : 1. The weight and total cells of lung of the mice group treated with PR-HA decreased significantly compared with those of control group. 2. Total Leukocytes and Eosinophils in BALF of the mice group treated wtih PR-HA decreased significantly compared with those of control group. 3. Eosinophils in BALF of the mice group treated wtih PR-HA in Photomicrographs decreased significantly compared with those of control group. 4. According to Histological analysis of lung sections, it decreased significantly adhension of collagen in PR-HA than those of control group 5. The concentration of IgE, IL-4, IL-5, in BALF and IL-4, IL-5, Il-13 in serum of the mice group treated with PR-HA decreased significantly compared with that of control group. 6. The number of Gr-1+/CD11b+, CD11b+, CD3-/CCR3+, CD4+, CD3e+/CD69+ , CD23+/B220+ cells in the lungs of the mice group treated with PR-HA decreased significantly compared with those of control group. 7. The cytokine's manifestation of mRNA of the mice group treated with PR-HA with RT-PCR decreased significantly compared with that of control group. Conclusion : We conclude that PR-HA is effective on OVA-induced asthma of C57BL/6 mouse.
자오가피(刺五加皮) 약침액(藥針液)의 항(抗)알러지 효과(效果)에 대한 실험적(實驗的) 연구(硏究)
윤종태,설인찬,김동희,김성훈,김한성,Yoon, Jong-Tae,Seol, In-Chan,Kim, Dong-Hee,Kim, Sung-Hoon,Kim, Han-Sung 대한침구의학회 2001 대한침구의학회지 Vol.18 No.2
Objetives : This study was done to evaluate the antiallegic effect of medicinal acupuncture solution of Acanthopanax senticosus(Rupr. et Maxim;abbreviated as ASMA), studies were done experimentally. Methods : For this aim MTT assay, anaphylaxis reaction, DTH, histamine release, IgE production and vascular permability was evaluated. Results : ASMA didn't show an effective cytotoxicity on the mouse lung fibroblast. It insignifcantly suppressed histamine release from mast cells induced by compound 48/80, while it significantly reduced IgE production and SRBC-challenged DTH(Delayed type hypersensitivity). ASMA effectively suppressed anaphylactic reaction induced by compound 48/80. However, it didn't inhibit vascular permeability and contact dermatitis significantly. Conclusion:Medicinal acupucture solution had antialletgic effects. Acanthopanax senticosus medical acupuncture depress the allergy reaction. Especially in anaphylactic type, the effect was good.
최영,설인찬 대전대학교 한방병원 2000 惠和醫學 Vol.9 No.2
In the analysis of prescription in the Seup(濕) chapter of Donguibogam(東醫寶鑑), the following results were obtained. 1. According to the text, the efficacy of prescriptions is generaly to treat Seup(濕), and nothing to treat Pung(風). 2. The frequency of prescriptions is u˘ihakibmun(醫學入門), dangyesimbo˘b(丹溪心法), seu˘ideukhyobang(世醫得效方), u˘ihakjo˘ngjo˘n(醫學正傳) in sequence. 3. The classification of prescriptions by efficacy is haepyoyak(解表藥), boikyak(補益藥), cho˘ngyo˘lyak(淸熱藥), igiyak(理氣藥), isusamseupyak(利水渗濕藥), sahayak(瀉下藥), banghyanghwaseupyak(芳香化濕藥), onliyak(溫裏藥), etc. in sequence, and the prequency of used medicines is baekchul(白朮), changchul(蒼朮), bokryo˘ng(茯笭), go˘ngang(乾薑), hubak(厚朴), jinpi(陳皮), buja(附子), gangwhal(羌活), banha(半夏), etc., in sequence. 4. The so˘ng(性) of used medicines is mainly onso˘ng(溫性) and hanso˘ng(寒性), the mi(味) is sinmi(辛味), gomi(苦味) in sequence, the gwigyo˘ng(歸經) is bigyo˘ng(脾經), pyegyo˘ng(肺經), wigyo˘ng(胃經), singyo˘ng(腎經), gangyo˘ng(肝經), simgyo˘ng(心經), daejanggyo˘ng(大腸經), bangkwanggyo˘ng(膀胱經), etc., in sequence.
과루인 및 과루인청혈플러스가 인간 탯줄 정맥 내피 세포(Human umbilicl vein endothelial cells, HUVECs)에서 염증인자 발현 억제에 미치는 영향
김해융,설인찬,유호룡,김윤식,Kim, Hae-yoong,Seol, In-chan,Yoo, Ho-ryong,Kim, Yoon-sik 대한한방내과학회 2022 大韓韓方內科學會誌 Vol.43 No.4
Objective: To examine the effects of Trichosanthes kirilowii Maximowicz extract (TE) and Trichosanthes kirilowii Maxi mowicz Cheonghyeol Plus Phellinus linteus Cheonghyeol plus (TCP) on anti-inflammatory factor expression in human umbilical vein endothelial cells (HUVECs). Methods: HUVECs were activated with TNF-α and then treated with TE and TCP. The expression levels were then measured for intracellular genes (KLF2, eNOS, MCP-1, ICAM-1, and VCAM-1), proteins (KLF2, eNOS, MCP-1, ICAM-1, VCAM-1, ERK, and JNK, p38), and extracellular biomarkers (ICAM-1, VCAM-1, and MCP-1). Results: 1. TCP at concentrations of 100 ㎍/mL or greater significantly increased the expression of KLF2 and eNOS intracellular genes and significantly decreased the expression of ICAM-1, VCAM-1, and MCP-1 genes compared to the control group. 2. TCP at concentrations of 100 ㎍/mL or greater significantly increased the expression of KLF2, eNOS proteins compared to the control group, and significantly reduced the expression of VCAM-1, ICAM-1, MCP-1, ERK, and p38 proteins. However, JNK protein phosphorylation showed no significant change compared to the control group. 3. TCP at concentrations of 100 ㎍/mL or more significantly decreased the production of MCP-1, ICAM-1, and VCAM-1 extracellular biomarkers compared to the control group. 4. TE at a concentration of 100 ㎍/mL did not cause any significant change in the expression of intracellular genes or proteins, in the production of the extracellular biomarker MCP-1, or in the amount of JNK protein compared to the control group. Other intracellular genes, proteins, and extracellular biomarker expression showed the same trend as observed with TCP exposure. Conclusion: This study experimentally confirmed that TE and TCP could be effective in preventing or inhibiting various inflammatory vascular diseases due to their anti-inflammatory effects.